Yoshihito Ide

Osaka City University, Ōsaka-shi, Osaka-fu, Japan

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Publications (35)18.96 Total impact

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    ABSTRACT: Purpose: To evaluate the effectiveness and safety of radiofrequency ablation(RFA)for liver metastases from colorectal cancer after chemotherapy. Patients: From January 2006 to June 2012, 27 tumors in 17 patients with liver metastases from colorectal cancer were treated using RFA after systemic chemotherapy. Results: The median tumor diameter after chemotherapy was 12(range: 3-35)mm, and the mean number of tumors was 1.6(range: 1-4).The median time without local recurrence was 21.3(range: 2.2-61.9)months, and the median overall survival time was 38.0(range: 5.9-66.3)months. One patient had a complication(liver abscess).Of the 27 tumors, 9 were larger than 20 mm in diameter, and 4 of these 9 tumors showed local recurrence after RFA. In tumors smaller than 20 mm in diameter, only 1 showed local recurrence. The local recurrence rate was significantly higher for tumors larger than 20 mm than for tumors smaller than 20 mm(44.4% vs 5.6%,p=0.030).Conclusion: RFA was an effective and safe method for treating liver metastases from colorectal cancer, especially for tumors smaller than 20 mm and in cases of less than 3 tumors after systemic chemotherapy.
    Gan to kagaku ryoho. Cancer & chemotherapy 11/2013; 40(12):1984-6.
  • Yoshihito Ide, Koji Mikami, Kohei Murata
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    ABSTRACT: Background: Central venous access port(CV port)is used for long-term treatment of patients with advanced colorectal cancer. To confirm a standard procedure of CV port implant, we analyzed long-term outcomes and complications of upper arm CV ports. Methods: Ninety patients implanted with CV ports in the upper arm between November 2006 and November 2009 were studied retrospectively. Results: There were no complications from the implanting procedure. Twenty patients (22. 2%)had complications, including infection(n=10), occlusion(n=7), thrombosis(n=4)and persistent pain(n=1) (there is some overlapping). Eighteen patients(20%)received surgery for removal of the ports. The median follow-up period was 160 days(range, 30-1,167days). Univariate and multivariate analysis indicated that patients with a catheter tip above the tracheal bifurcation had a significantly higher risk for complications than patients with a tip below bifurcation. Conclusion: Upper arm CV ports were implanted safely. For long-term use, it is important to place the catheter tip below the tracheal bifurcation.
    Gan to kagaku ryoho. Cancer & chemotherapy 03/2013; 40(3):331-335.
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    ABSTRACT: A man in his 60s was given an emergency operation 15 years ago for abdominal bleeding. His tumor of small intestine was resected and diagnosed as small intestinal leiomyosarcoma. He came to our hospital because of his abdominal masses 15 years after the initial operation. CT scan showed a 15 cm-sized solid and cystic tumor in the pelvic cavity. The tumor was diagnosed as GIST by PET-CT and MRI. The tumor was resected, and pathological findings led to the diagnosis of GIST with this tumor. Previous tumor cells were slightly-positive for kit immunohistological examination, but did not resemble this tumor cells morphologically. So genetic tests were performed and revealed two tumors had same mutations of c- kit. Finally, we could diagnose the tumor was recurrent metastases of small intestinal GIST 15 years after the initial surgery. kit mutation analysis was useful for a diagnosis of recurrences and predictions of the clinical response to imatinib in GISTs.
    Gan to kagaku ryoho. Cancer & chemotherapy 11/2011; 38(12):2208-10.
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    ABSTRACT: The case was a 60-year-old man. The patient with a main complaint of husky voice was introduced by a nearby doctor to our otolaryngology department at the end of August 2009. Because of the wall thickening image of the upper part (Ut domain) esophagus, left infraclavicular lymph node and mediastium lymphadenopathy syndrome observed by head and neck CT, the patient was transferred to surgery department. Squamous cell carcinoma was diagnosed based on the upper part gastrointestinal tract endoscopy showing a type-3 advanced cancer of the upper thoracic esophagus sized 25-30 cm from nostril. The patient was in PD, fever and coughing, though we performed 2 FAP therapies. A chest CT revealed that there was a passage between the trachea and esophagus. Then, radiation therapy( a total of 60 Gy, 2 Gy at a time) was enforced. After the radio therapy, a covered type Ultraflex esophagus stent was inserted due to a fistula, though the tumor was reduced to 6 mm in size. The patient was passed away five months after the stent custody; a solid food intake was possible until just before he died.
    Gan to kagaku ryoho. Cancer & chemotherapy 11/2011; 38(12):2408-10.
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    ABSTRACT: For a woman with poorly-differentiated anal canal adenocarcinoma in acknowledgment of metastasis to right inguinal lymph node, we gave radiotherapy combined with capecitabine as chemotherapy. Then the next two months, we performed XELOX therapy. Subsequently, we performed laparoscopic rectal amputation+D1 dissection+right groin lymph node dissection. The effect of preoperative chemoradiotherapy and pathological examination of the main tumor was Grade 2. And the right inguinal lymph node showed only a mucous persistence. Capecitabine was given as an adjuvant postoperative treatment and did not show a recurrence for five months after the operation. For a treatment for anal canal adenocarcinoma in acknowledgment of metastasis to inguinal lymph node, preoperative chemoradiotherapy may be effective.
    Gan to kagaku ryoho. Cancer & chemotherapy 11/2011; 38(12):2048-50.
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    ABSTRACT: We have developed a pulmonary arterial infusion therapy for lung metastasis of colorectal cancer. Catheterization into pulmonary artery followed by occlusion with ballooning enabled the stasis of blood flow in the unilateral lung for 30 minutes. CDDP was infused via catheter to occluded pulmonary artery. Although no serious adverse events occurred in 5 cases, a tumor reduction in size was not observed. Loco-regional therapy for lung metastasis of colorectal cancer is limited because of recent progress of systemic therapy. However, a development of the procedure of pulmonary arterial infusion may enable a future success of local therapy for lung metastasis of colorectal cancer with a new drug, which is effective in such a short time disposure to tumor as 30 minutes.
    Gan to kagaku ryoho. Cancer & chemotherapy 11/2011; 38(12):1981-3.
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    ABSTRACT: A 75-year-old man underwent distal gastrectomy for gastric cancer (CY+, Stage IV) in June 2009. About 4 months after surgery, he had a strong pain in a right shoulder, and became writing difficulty. Some imaging examinations revealed multiple bone metastases, and it was diagnosed that the pain was caused by the tumor of cervical spine. Systemic chemotherapy was started using a regimen of S-1/CDDP, and radiotherapy (30 Gy) was performed for the cervical tumor at the same time. After two-course of the chemotherapy, the shoulder pain disappeared. About 12 months after surgery, he had a strong pain in a left leg, and became walking difficulty. Some imaging examinations revealed a progression of the tumor of lumbar spine. Radiotherapy (30 Gy) was demonstrated for the tumor. After the treatment, the leg pain disappeared. We experienced a case of multiple bone metastases successfully treated with chemo-radiotherapy.
    Gan to kagaku ryoho. Cancer & chemotherapy 11/2011; 38(12):2149-51.
  • Nippon rinsho. Japanese journal of clinical medicine 04/2011; 69 Suppl 3:599-602.
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    ABSTRACT: A patient was a 61-year-old male. In December 2005, abdominal computer tomography (CT) revealed at a 4 cm-in-diameter early enhanced lesion in S6 and a 1.5 cm-in-diameter early enhanced lesion in S5/8, which were diagnosed as hepatocellular carcinomas. He underwent S6 partial hepatectomy and S5/8 partial hepatectomy. However, multiple lung metastatic lesions and a peritoneal metastatic lesion were detected by computer tomography (CT) in July 2007, led to a diagnosis as recurrence of HCC. Although he received S-1/IFN-α combination systemic chemotherapy, no effect was shown and peritoneal metastatic lesion grew to 10 cm-in-diameter. We thought that this lesion might lead to ileus, therefore, he received peritoneal tumor resection in December 2007. Multiple lung metastases grew and he was dead 13 months after the surgery: no abdominal symptom and sign due to ileus was noted. In this case, it was considered that a resection of peritoneal metastasis might be attempted to prevent ileus, even if there were other metastatic lesions, such as multiple lung metastases.
    Gan to kagaku ryoho. Cancer & chemotherapy 11/2010; 37(12):2696-8.
  • Ryota Mukai, Yoshihito Ide, Kohei Murata
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    ABSTRACT: The patient was a 60-year-old man with lower rectum cancer invading into the prostate gland and urinary bladder. The tumor expanded locally and made perineal cutaneous fistula. We performed a total pelvic exenteration with extended resection of perineal skin and subcutaneous tissue, followed by reconstruction using vertical rectus abdominis myocutaneous flap (VRAM flap). Although a mild pelvic abscess developed after the operation, it was controllable by drainage because the dead cavity of pelvis was relatively small due to the filing effect of VRAM flap. The VRAM flap is useful for both pelvic and perineal skin defects due to the extended resection of rectal cancer invading skin and pelvic organs.
    Gan to kagaku ryoho. Cancer & chemotherapy 11/2010; 37(12):2294-6.
  • Yoshihito Ide, Kohei Murata
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    ABSTRACT: The purpose of this study was to review the outcomes of laparoscopic bowel resection for patients with Stage IV colorectal cancer. Twenty nine patients with cStage IV disease were undergone a bowel resection during the period from April 2006 to December 2009 in our hospital. Twenty one patients were undergone a laparoscopic resection and the other 8 for an open resection. Our data base was reviewed retrospectively regarding the patient demography, operation time, amount of bleeding, dissection level, stoma operation rate, perioperative morbidity and mortality, length of stay, induction rate for chemotherapy, the length between operation and chemotherapy and response rate for chemotherapy. Then the usefulness of laparoscopic resection and open resection were compared. There were significant differences in amount of bleeding, stoma operation rate, perioperative morbidity and the length of stay. Especially, the complication rate was significantly lower in those with laparoscopic resection than open resection (9.5% versus 63%). Hence, a laparoscopic bowel resection is safe and feasible option for Stage IV colorectal cancer patients.
    Gan to kagaku ryoho. Cancer & chemotherapy 11/2010; 37(12):2582-4.
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    ABSTRACT: We report two cases of lung cancer patients with postoperative solitary brain metastases obtaining long-term survival after gamma knife stereotactic radiosurgery. Both were seventies men and had good performance status without active extracranial disease. In one case, an asymptomatic metastatic brain tumor 1.8 cm in maximum diameter appeared one year and two months after the operation and was irradiated with gamma knife resulting in complete local control for seven years. He is alive with solitary lung metastasis in good performance status. In the other case, gamma knife was employed for a metastatic brain tumor 2.7 cm in maximum diameter that appeared nine months after the operation accompanying incomplete left hemiplegia. Six months later, the tumor was enlarged and gamma knife was repeated, but the tumor growth could not be suppressed. Following deterioration of hemiplegia and appearance of convulsion, he died of neurological disorder three years and two months after the onset of brain metastasis. Gamma knife stereotactic radiosurgery for metastatic brain tumors is less invasive and a repeatable technique, and is expected to provide a good local control and a survival benefit for appropriately selected patients.
    Gan to kagaku ryoho. Cancer & chemotherapy 11/2010; 37(12):2738-40.
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    ABSTRACT: We report a case of fifties man. He admitted to our hospital due to a hypochondralgia. Computed tomography revealed a tumor of right adrenal gland and a tumor of upper lobe of the right lung. Adrenal tumor had rapidly increased, so we performed adrenectomy. At first adrenal tumor was diagnosed as primary adrenal cancer because its histological findings did not coincide with those of common histologic types of lung cancer. As there were possibilities that one of adrenal or lung tumor was primary and the other was metastatic or both of the two were double primary, we performed right upper lobectomy. Lung tumor was diagnosed as primary pleomorphic carcinoma containing spindle-shaped tumor cells and adenocarcinoma, and then the diagnosis of adrenal tumor was corrected as metastasis of lung cancer. Two months after the lung operation, cervical lymph node swelling, metastasis of stomach and local recurrence of adrenal tumor appeared. After he underwent six courses of systemic chemotherapy of carboplatin and paclitaxel, a clinical complete response was obtained and no recurrence is observed for 4 years.
    Gan to kagaku ryoho. Cancer & chemotherapy 11/2010; 37(12):2747-9.
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    ABSTRACT: We report 8 cases of hepatic resection after systemic chemotherapy for metastatic colorectal cancer. Three patients had unresectable hepatic lesions, and 5 patients were given neoadjuvant chemotherapy. The mean age was 69 (range: 55-81). Five patients received an oxaliplatin based regimen, 4 patients received irinotecan based regimen and 1 patient received UFT/LV. Four patients were treated with bevacizumab, and 2 patients with cetuximab. Duration of chemotherapy was 12 weeks (the mid range of 7-90 weeks). Six patients were PR, and 2 were SD. Although 1 patient had a minor biliary fistula, no major complications were observed. The duration of postoperative hospital stay was 17 (the average range of 13-22). Our results suggest that preoperative chemotherapy for hepatic resection of metastatic colorectal cancer is safe and has no adverse effect on surgery.
    Gan to kagaku ryoho. Cancer & chemotherapy 11/2010; 37(12):2566-8.
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    ABSTRACT: Neoadjuavnt chemotherapy for liver metastasis of colorectal cancer implies issues about timing for resection and management for adverse events due to chemotherapy. CASE: A 50-year-old male patient with synchronous liver metastasis from rectal cancer had a surgery for primary lesion followed by neo-adjuvant chemotherapy for liver resection. Chemotherapy of bevacizumab + mFOLFOX6 achieved a partial response for liver metastasis. When we planned a liver resection, platelet count decreased to 1.4 × 10(4)/µL. The patient was diagnosed as idiopathic thrombocytopenic purpura (ITP) by several examinations but medical control including steroids failed. Partial splenic artery embolization could recover platelet count successfully. However, during the period of therapy for ITP, liver metastasis became unresectable. The patient is currently treated by FOLFIRI and with stable disease for three months. CONCLUSION: NeoPyloriadjuvant chemotherapy for respectable liver metastasis should be considered carefully in terms of timing for resection and prompt management for adverse events.
    Gan to kagaku ryoho. Cancer & chemotherapy 11/2010; 37(12):2605-7.
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    ABSTRACT: We report a case of superior sulcus tumor performed chemoradiation followed by operation obtaining a long-term survival without relapse. A case is a male of fifties, who visited our hospital with the complaint of numbness in the ulnar side of the left arm and scapular pain. Computed tomography revealed a mass, 4 cm in diameter in the apical portion of the left lung extending to superior sulcus and supraclavicular region. The tumor decreased in size by 2 cm after induction chemoradiotherapy under clinical diagnosis of T3N0M0 superior sulcus tumor and then the apex of the lung and the chest wall was resected with some superior mediastinal lymph nodes. No residual viable tumor cells were seen in the resected tissues. He was followed-up by CT without adjuvant therapy and is alive with no sign of relapse 6 years after the operation, so the effect of induction chemoradiotherapy is evaluated to be complete response. Multimodality therapy with induction chemoradiation and surgery for superior sulcus tumor without lymph node metastasis appears promising.
    Gan to kagaku ryoho. Cancer & chemotherapy 11/2009; 36(12):2121-3.
  • Yoshihito Ide, Koji Mikami, Kohei Murata
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    ABSTRACT: We report 5 cases of metastatic colorectal cancer with intermittent hepatic arterial infusion (HAI) and systemic chemotherapy (CPT-11, biweekly) in 2006-2008. Two patients with poor performance status were for systemic chemotherapy, and 3 patients were initiated as third-line treatment or more. Among the 5 patients, 2 patients were recorded as PR, 2 patients were as SD, and 1 patient was as NE. Three patients are alive with a mean follow-up of 19 months. HAI is intended to have few side effects compared with the systemic chemotherapy, and the treatment methods for these cases were not indicated for any of standard chemotherapies. But HAI alone is considered as insufficient treatment for unresectable liver metastasis, because HAI cannot be proved to have an apparent survival benefit. It is possible that a combination of regional and systemic drug treatments will be more effective than systemic treatment alone for unresectable colorectal cancer.
    Gan to kagaku ryoho. Cancer & chemotherapy 11/2009; 36(12):2172-4.
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    ABSTRACT: The patient was a 55-year-old female. In 1997, she was diagnosed as type-I glycogen storage disease (von Gierke disease). In March 2002, abdominal ultrasound tomography revealed an early enhanced lesion at liver S2, which suspected to a well differentiated hepatocellular carcinoma (HCC) with super-paramagnetic iron oxide (SPIO) enhanced magnetic resonance imaging (MRI). From 2002 to 2006, she received three times trans-arterial chemo-embolization (TACE) at enhanced lesions. But abdominal computer tomography (CT) revealed a 3.6 cm-in diameter early enhanced lesion near this tumor at S2, which was suspected to a diagnosis of recurrent HCC in December 2008. Therefore, she received a partial hepatectomy at S2. This resected specimen was diagnosed as poorly differentiated HCC. This patient is still alive with no recurrence after 6 months from operation. In conclusion, it might be effective for an early detection of recurrent HCC to see the doctor for a long regular checkup, because the growth of HCC with glycogen storage disease would be very slow.
    Gan to kagaku ryoho. Cancer & chemotherapy 11/2009; 36(12):2362-4.
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    ABSTRACT: Intrapleural hypotonic cisplatin treatment, which was introduced by Ichinose and colleagues, was performed for 5 cases of primary lung cancer with carcinomatous pleuritis: one case intraoperatively, one case postoperatively and 3 unresected cases. Fifty microg/mL of cisplatin distilled water solution was administered into pleural cavity and drained 10 minutes later in the intraoperative case or 30 minutes later in the bedside cases. No adverse effect was observed. For 2 dissemination- dominant cases, 2 regimens of single cytotoxic agent followed by gefitinib were administered, and the two patients died in 26 and 69 months, respectively. For one case with dissemination and effusion, 5 regimens including combination chemotherapy were administered, and the patient died in 41 months. For 2 effusion-dominant cases, gefitinib was administered and one case is still in PR status for 21 months, and the other was alive for 19 months. Ipsilateral pleural effusion was controlled in all 5 cases. This therapy is helpful for systemic chemotherapy as a main therapeutic means in cases of lung cancer with carcinomatous pleuritis by controlling malignant pleural effusion and relieving dyspnea.
    Gan to kagaku ryoho. Cancer & chemotherapy 11/2009; 36(12):2124-6.
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    ABSTRACT: Cetuximab in Japan is currently approved as a second or more line therapy for advanced metastatic colorectal cancer. We report a case of liver metastasis of colon cancer effectively treated by cetuximab after the progression and prolonged neural toxicity of the prior chemotherapy including oxaliplatin and irinotecan. A 61-year-old female suffered from unresectable multiple liver metastases of sigmoid colon cancer. She had already received irinotecan+S-1, mFOLFOX6+bevacizumab, FOLFIRI+bevacizumab, and hepatic arterial infusion of 5-FU+systemic infusion of irinotecan. Although liver metastases were stably controlled by those therapies, her peripheral neural symptom, initially caused by oxaliplatin, became worse after infusion of irinotecan. We decided to give her cetuximab monotherapy in the fifth-line setting. We investigated K-ras gene status on her colon cancer tissue previously resected, which showed a wild-type. Her liver tumor showed a partial response evaluated with RECIST, and the status was maintained for more than four months. Cetuximab monotherapy can be used for those with prolonged neurotoxicity and might be effective for the patients with second or more line setting.
    Gan to kagaku ryoho. Cancer & chemotherapy 11/2009; 36(12):2155-7.