Katherine Ogando

Publications (3)4.43 Total impact

• Article: Transfusion associated microchimerism: a heretofore little-recognized complication following transfusion.

  Vijayalakshmi Kunadian, Cafer Zorkun, William J Gibson, Navin Nethala, Caitlin Harrigan, Alexandra M Palmer, Katherine J Ogando, Leah H Biller, Erin E Lord, Scott P Williams, Michelle E Lew, Lauren N Ciaglo, Jacqueline L Buros, Susan J Marble, C Michael Gibson
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  ABSTRACT: Potent antiplatelet and antithrombotic agents have significantly reduced mortality in the setting of acute coronary syndromes and percutaneous coronary intervention. However these agents are associated with increased bleeding which is in turn associated with adverse clinical outcomes. In many centers, transfusion is often used to correct for blood loss. Blood transfusion in the setting of acute coronary syndrome has been associated with adverse clinical outcomes including increased mortality. Transfusion associated microchimerism (TA-MC) is a newly recognized complication of blood transfusion. There is engraftment of the donor's hematopoietic stem cells in patients who then develop microchimerism. This article discusses the association of bleeding/blood transfusion with adverse outcomes and the potential role of TA-MC in clinical outcomes.
  Journal of Thrombosis and Thrombolysis 10/2008; 27(1):57-67. · 1.48 Impact Factor
• Article: Intracoronary pharmacotherapy in the management of coronary microvascular dysfunction.

  Vijayalakshmi Kunadian, Cafer Zorkun, Scott P Williams, Leah H Biller, Alexandra M Palmer, Katherine J Ogando, Michelle E Lew, Navin Nethala, William J Gibson, Susan J Marble, Jacqueline L Buros, C Michael Gibson
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  ABSTRACT: Although percutaneous coronary intervention restores optimal epicardial blood flow in most cases, abnormal myocardial perfusion may still persist. This might be as a result of macro and microembolization, neutrophil plugging, vasoconstriction, myocyte contracture, local intracellular and interstitial edema, intramural haemorrhage, and endothelial blistering. Local delivery of intracoronary pharmacotherapy via the coronary arteries may increase local drug concentration several fold, and may improve drug efficacy. Several pharmacological agents such as adenosine, calcium channel blockers, alpha blockers, beta2 receptor activators, vasodilators, antithrombotics, and antiplatelet agents have been used to treat coronary microvascular dysfunction. This article reviews the results of trials of intracoronary pharmacotherapy to date.
  Journal of Thrombosis and Thrombolysis 10/2008; 26(3):234-42. · 1.48 Impact Factor
• Article: Use of the TIMI frame count in the assessment of coronary artery blood flow and microvascular function over the past 15 years.

  Vijayalakshmi Kunadian, Caitlin Harrigan, Cafer Zorkun, Alexandra M Palmer, Katherine J Ogando, Leah H Biller, Erin E Lord, Scott P Williams, Michelle E Lew, Lauren N Ciaglo, Jacqueline L Buros, Susan J Marble, William J Gibson, C Michael Gibson
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  ABSTRACT: Since its introduction, the TIMI frame count method has contributed to the understanding of the pathophysiology of coronary artery disease. In this article, the evolution of the TFC method and its applicability in the assessment of various therapeutic modalities are described.
  Journal of Thrombosis and Thrombolysis 05/2008; 27(3):316-28. · 1.48 Impact Factor