Danusa Arcego

Publications (3)7.01 Total impact

• Article: Erratum to: Interactions Between Chronic Stress and Chronic Consumption of Caffeine on the Enzymatic Antioxidant System.

  Cristie Grazziotin Noschang, Rachel Krolow, Leticia Ferreira Pettenuzzo, Mônica Colpini Avila, Andrelisa Fachin, Danusa Arcego, Eduardo von Pozzer Toigo, Leonardo Machado Crema, Luísa Amália Diehl, Deusa Vendite, Carla Dalmaz
  Neurochemical Research 12/2009; · 2.24 Impact Factor
• Article: Sex-specific differences on caffeine consumption and chronic stress-induced anxiety-like behavior and DNA breaks in the hippocampus.

  Cristie Grazziotin Noschang, Leticia Ferreira Pettenuzzo, Eduardo von Pozzer Toigo, Ana Cristina Andreazza, Rachel Krolow, Andrelisa Fachin, Mônica Colpini Avila, Danusa Arcego, Leonardo Machado Crema, Luísa Amália Diehl, Carlos Alberto Gonçalvez, Deusa Vendite, Carla Dalmaz
  [show abstract] [hide abstract]
  ABSTRACT: Caffeine is widely consumed in beverages and food, and its consumption in high doses is associated with anxiety increase. Stress situations are often associated to coffee consumption, and have a strong influence on oxidative DNA damage. As there are sex-specific differences in many metabolic, neurochemical and behavioral aspects, the aim of this study is to verify the interaction between chronic consumption of caffeine and chronic stress on anxiety and DNA breaks in the hippocampus on male and female rats. Wistar rats were submitted to restraint stress for at least 50 days. The diet consisted of standard rat chow and caffeine 0.3 or 1 g/L in drinking water "ad libitum" as the only drinking source. Controls received tap water. Anxiety-like behavior and DNA breaks in the hippocampus were evaluated. Caffeine consumption and chronic stress increased anxiety-like behavior as well as DNA breaks in the hippocampus of male rats. No effect on these parameters was observed in females. These results may be related to the presence of estradiol, which may have anxiolytic and neuroprotective properties.
  Pharmacology Biochemistry and Behavior 08/2009; 94(1):63-9. · 2.53 Impact Factor
• Article: Interactions between chronic stress and chronic consumption of caffeine on the enzymatic antioxidant system.

  Cristie Grazziotin Noschang, Rachel Krolow, Leticia Ferreira Pettenuzzo, Mônica Colpini Avila, Andrelisa Fachin, Danusa Arcego, Eduardo von Pozzer Toigo, Leonardo Machado Crema, Luísa Amália Diehl, Deusa Vendite, Carla Dalmaz
  [show abstract] [hide abstract]
  ABSTRACT: We studied the effect of chronic caffeine on parameters related to oxidative stress in different brain regions of stressed and non-stressed rats. Wistar rats were divided into three groups: control (receiving water), caffeine 0.3 g/L and caffeine 1.0 g/L (in the drinking water). These groups were subdivided into non-stressed and stressed (repeated restraint stress during 40 days). Lipid peroxide levels and the total radical-trapping potential were assessed, as well as antioxidant enzyme activities superoxide dismutase, gluthatione peroxidase, and catalase in hippocampus, striatum and cerebral cortex. Results showed interactions between stress and caffeine, especially in the cerebral cortex, since caffeine increased the activity of some antioxidant enzymes, but not in stressed animals. We concluded that chronic administration of caffeine led, in some cases, to increased activity of antioxidant enzymes. However, these effects were not observed in the stressed animals.
  Neurochemical Research 04/2009; 34(9):1568-74. · 2.24 Impact Factor