Publications (17)17.59 Total impact
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Article: Success of bone marrow transplantation in congenital Diamond-Blackfan anaemia: a case report.
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ABSTRACT: A 6-yr-old girl with congenital corticosteroid-resistant pure red cell aplasia was treated with bone marrow transplant from her HLA-identical, MLC-unreactive sister in November 1984 following conditioning with busulfan and cyclophosphamide. Full engraftment was obtained and the patient at 21 months post-transplant is in excellent clinical condition maintaining normal red cell counts. We conclude that BMT should be considered as a therapy for at least the most severe cases of Diamond-Blackfan anaemia resistant to corticosteroids. Successful outcome of this therapy provides an argument for the stem cell origin of this disorder.European Journal Of Haematology 03/1987; 38(2):204-6. · 2.61 Impact Factor -
Article: Hemopoiesis in mouse heterozygous for the W trait. Difference in postirradiation recovery related to the defect in formation of transient endogenous spleen colonies.
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ABSTRACT: The hemopoietic regeneration following midlethal irradiation in Wv/+ mice had similarly biphasic kinetics as in their hematologically normal +/+ littermates. The first abortive phase of regeneration was either severely reduced (formation of transient endogenous spleen colonies, reticulocyte count, granulocyte count) or absent (spleen and femur cellularity, platelet count, PCV) in Wv/+ mice, when compared to +/+ mice. The second phase leading to permanent recovery of hemopoiesis was in Wv/+ mice delayed in time. Moreover, although to a lesser extent the values of spleen and femur cellularity, PCV and platelet count were decreased in Wv/+ mice. Postirradiation bleeding, which stimulated particularly the 1st phase of regeneration both in Wv/+ and +/+ mice did not lead to the minimization of differences between above two genotypes. It is suggested that the observed differences in the abortive regeneration between Wv/+ and +/+ mice are primarily dependent on the presence in Wv/+ mice of selective defect of transient endogenous colony forming units (TE-CFUs). Moreover, it is possible that the differences in the second phase of regeneration leading to permanent recovery are secondarily dependent on the TE-CFUs defect, as most probably the TE-CFU is the step in stem cell differentiation to mature cells.Strahlentherapie 08/1985; 161(7):437-41. -
Article: Treatment with antitheta serum affects hemopoietic stem cell HSC proliferation in an in vivo culture system.
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ABSTRACT: Marrow cells from normal WBB6F1 +/+ mice were treated in vitro with either anti-Thy 1.2 serum and complement (C') or normal mouse serum (NMS) and C' and then they were cultured in diffusion chambers implanted into peritoneal cavity of Balb/c mice. Following 1-19 days of culture, chamber contents were injected into W/Wv mice to test for either the capacity to form spleen colonies or to cure the W/Wv anemia. In contrast to NMS-treated marrow, anti-Thy 1.2 serum treated marrow hemopoietic stem cells almost completely failed to proliferate in this system. Number of cells per chamber upon termination of culture was less affected.Biomedecine [?] Pharmacotherapy 02/1982; 36(5):236-9. · 2.00 Impact Factor -
Article: Modified megathrombocyte index in the diagnosis of thrombopoiesis injury produced by cancer chemotherapy.
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ABSTRACT: The border-line separating the normal platelet from the megathrombocyte was lowered from 2.5 microns, classically used, to 2 microns. This modification allowed more precise definition of normal frequency of megathrombocytes among platelets (megathrombocyte index--MI) which was 10-35%. The modified MI determination demonstrated the same kinetics of changes following the intensive cancer chemotherapy as the classical one and, moreover, enabled individual diagnosis of thrombopoiesis perturbation induced by chemotherapy which was not possible with the classical MI.Neoplasma 02/1982; 29(4):493-6. · 1.44 Impact Factor -
Article: Aplastic anaemia with marrow defective in formation of fibroblastoid cell colonies in vitro.
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ABSTRACT: The formation of fibroblastoid colonies by marrow cells in vitro has been used as a putative assay for a stem cell of haemopoietic stroma. Bone marrow from one patient with aplastic anaemic did not form any of these colonies, while its growth in diffusion chambers as an indirect measure of a haemopoietic stem cell was even better than normal. On the other hand, marrow from the other aplastic patient showed only quantitative decrease in the formation of fibroblastoid colonies and simultaneously grew very poorly in diffusion chambers. These patients were indistinguishable by the cytological examination of their marrow, however, the peripheral blood abnormalities were expressed less severely in the first patient. These results suggest the contribution of the defect in marrow cells, which form fibroblastoid colonies in vitro to the development of aplastic anaemia in these patients.Scandinavian journal of haematology 02/1982; 28(1):82-90. -
Article: Mobilization of the marginal pool of neutrophils with epinephrine. Results in healthy persons, patients with neutropenias, patients with neutrophilias, and patients with changes in neutrophil count induced by cancer chemotherapy.
Haematologica 11/1979; 64(5):586-96. · 6.42 Impact Factor -
Article: Hyperuricaemia as an index of the response to chemotherapy in solid tumors.
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ABSTRACT: A transient increase in uric acid level following administration of high doses of Cyclophosphamide in the 1st course of cytostatic therapy applied for various solid tumors (mostly lung cancer) was observed in 10 patients with measurable disease simultaneously with complete or partial (above 50%) regression of the tumor. The same effect was noted in further 5 patients, who, however, had non-measurable disease. On the other hand, the clinical course of the disease and survival were similar in these 5 patients and in the former 10 patients. No corresponding increase in the uric acid level was observed in 87 patients with similar disease and treatment, but not responding to chemotherapy and with short survival. It is concluded, that hyperuricaemia may indicate responsiveness to chemotherapy in cancer patients with non-measurable disease.Neoplasma 02/1977; 24(4):457-60. · 1.44 Impact Factor -
Article: Proceedings: Effects of microwaves on the twenty-four-hour rhythm and twenty-four-hour urinary excretion of seventeen hydroxycorticoids and seventeen ketosteroids.
The Journal of microwave power 07/1976; 11(2):139-40. -
Article: Proceedings: Microwave radiation and other harmful factors of working environment in radiolocation: method of determination of microwave effects.
The Journal of microwave power 07/1976; 11(2):144-5. -
Article: Letter: Serum muramidase activity in untreated cancer.
British medical journal 04/1975; 1(5960):735-6. -
Article: [Lung scanning performed with the use of microspheres labeled with radioactive isotopes in the diagnosis and evaluation of therapeutic results in malignant neoplasms].
Polskie archiwum medycyny wewnȩtrznej 04/1975; 53(3):241-53. · 1.37 Impact Factor -
Article: Evaluation of the usefulness of nitroblue tetrazolium reduction test (NBT test) for detection of bacterial infection in cancer patients.
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ABSTRACT: False positivity of the NBT test in neoplastic diseases described by some authose may be a limitation in the use of the test for infection screening in cancer patients. For explaining this problem studies were performed in a group of 30 patients with various untreated malignancies without infection and in 20 of these with bacteriologically confirmed infections. The obtained results were compared with those in groups of normal persons without and with infection. Slightly modified Park method for spontaneous and stimulated NBT test was used. No significant differences between patients of both groups without infection were found. The increase in positivity of the test in presence of infection was lower in cancer patients than in normal subjects, however, it was non-significant. We did not observe any false-positive results in our patients, though one case of false negativity in myeloma is described separately. It is concluded that neoplastic disease does not cause, as such positivity of the NBT test. Because of similar response of NBT test to presence of infection, the NBT test is recognized as very useful for infection screening in cancer patients similarly as in normal persons.Neoplasma 02/1975; 22(3):323-8. · 1.44 Impact Factor -
Article: health surveillance of personnel occupationally exposed to microwaves. I. Theoretical considerations and practical aspects.
Aerospace medicine 11/1974; 45(10):1137-42. -
Article: Health surveillance of personnel occupationally exposed to microwaves. II. Functional disturbances.
Aerospace medicine 11/1974; 45(10):1143-5. -
Article: Health surveillance of personnel occupationally exposed to microwaves. III. Lens translucency.
Aerospace medicine 11/1974; 45(10):1146-8. -
Article: Value of the NBT test in the diagnosis of bacterial infection in untreated cancer patients and in those on radio- and/or chemotherapy.
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ABSTRACT: As the first step in the study, the results of the NBT test in 83 patients with various untreated neoplasms, including 20 lymphomas, without bacterial infections and in 35 neoplastic patients with this complications were compared with the results obtained in control groups. No significant differences in the results were found between the groups of neoplastic patients without or with bacterial infections and the controls. To evaluate the NBT test during radio- and/or chemotherapy, especially in neutropenia, 45 patients were NBT-monitored. During the study of 102 episodes of neutropenia 43 infections occurred and 30 were NBT-confirmed. In remaining 13 cases it was impossible to perform the test because of extremely low neutrophil count (below 500/mul). All 20 infections in patients with normal neutrophil count were NBT-positive. These results confirm the usefulness of the test for infection screening in untreated with malignancies, as well as in patients receiving radio- and/or chemotherapy. However, the test can be taken only in patients without severe neutropenia.Tumori 61(6):517-23. · 0.86 Impact Factor -
Article: Changes in peripheral blood composition following single and repeated courses of intermittent cancer chemotherapy.
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ABSTRACT: In fifteen patients treated for lung cancer with a combination of vincristine (VCR) (2 x 0.325 mg/kg), amethopterin (MTX) (3 x 0.4 mg/kg) and cyclophosphamide (CY) (30-50 mg/kg) at monthly intervals the peripheral blood parameters were determined every 2-4 days. The values of these parameters including neutrophils, lymphocytes, platelets, erythrocytes and reticulocytes decreased uniformly reaching the lowest level about the 11th day post each course of chemotherapy. Subsequently, by the 17th day, the values of all these parameters except the red cell count returned to the pretreatment levels. The only parameter whose nadir value was associated with known risk to the health was the absolute neutrophil count. The period of dangerous decrease of this count began on the 6th day and ended approximately on the 17th day after cyclophosphamide infusion. Repeated courses had no additive toxicity since the time interval between courses allowed for hematopoietic recovery. However, the gradual decrease in the red cell count was observed during intermittent chemotherapy.Médecine interne 20(4):289-94.
