Young Mi Park

Inje University Paik Hospital, Sŏul, Seoul, South Korea

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Publications (42)92.16 Total impact

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    ABSTRACT: ABSTRACT Purpose: No previous study regarding the correlation between post-operative thyroid function and underlying thyroid histopathology has been published. This study assessed the relationship between postoperative thyroid function after lobectomy and multiple factors in papillary thyroid microcarcinoma (PTMC) patients. Materials and methods: From January 2010 to December 2010, 338 patients who had undergone thyroid lobectomy for PTMC were enrolled. Patients with pre-operative hyperthyroidism or those with hypothyroidism but no pre-operative serological data were excluded, leaving a cohort of 285 patients. The relationships between post-operative thyroid function (based on successful cessation of thyroxine replacement therapy) and multiple factors (patient age and sex, serological data, the Pre-operative anteroposterior diameter of the thyroid gland, underlying histopathology of the thyroid gland, and number of attempts to stop thyroxine replacement therapy) were analyzed. Results: Out of 285 patients, 157 attempted to stop thyroxine replacement therapy once or twice after lobectomy; 91 successfully stopped thyroxine replacement therapy during the study period. The final histopathologic diagnoses after surgery included Hashimoto's thyroiditis (n = 5), non-Hashimoto type of lymphocytic thyroiditis (n = 17), and normal thyroid parenchyma (n = 135). Pre-operative thyroid-stimulating hormone (TSH) levels differed significantly between patients with postoperative hypothyroidism and those with postoperative euthyroidism (univariate logistic regression analysis, p = 0.0028; multivariate logistic regression analysis, p = 0.0029). No statistically significant differences were found for any other factors. Conclusions: The study results demonstrated that the Pre-operative TSH level was the only predictor for the development of post-operative hypothyroidism after thyroid lobectomy in PTMC patients.
    Endocrine research. 08/2014;
  • Young Mi Park, Yun Wu, Wei Wei, Wei Tse Yang
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    ABSTRACT: OBJECTIVE. The purpose of this study was to evaluate the clinical, imaging, and histopathologic findings of primary neuroendocrine carcinoma of the breast. MATERIALS AND METHODS. A pathology database was searched for the records of patients with a histopathologic diagnosis of primary neuroendocrine carcinoma of the breast who had undergone mammography, sonography, or MRI between 1984 and 2011. The imaging studies of eligible patients were retrospectively reviewed according to the BI-RADS lexicon, and clinical presentation and histopathologic characteristics were documented. Imaging characteristics were compared with historical controls of invasive mammary carcinoma. RESULTS. Eighty-seven patients (84 women, three men; mean age, 62.9 years; range, 28-89 years) were included in the study. The mean tumor size was 3.1 cm (range, 0.6-11 cm). Sixty-five of 84 (77.4%) cancers were estrogen and progesterone receptor positive and ERBB2 negative. A palpable mass (55.8%) was a common clinical manifestation. A high-density, round or oval, or lobular mass with nonspiculated margins on mammograms and an irregular (65.4%), hypoechoic (78.4%) mass, with indistinct margins (43.5%), no or enhanced posterior acoustic features (77.9%) on sonograms were common findings. MRI revealed an irregular mass (83.3%), irregular margins (63.6%), and washout kinetics (85.7%). Neuroendocrine carcinoma presented more frequently as masses on mammograms. Calcifications were infrequent compared with their occurrence in invasive mammary cancer. CONCLUSION. Primary neuroendocrine carcinoma of the breast has mammographic features that differ from those of invasive mammary carcinoma. A round, oval, or lobular mass with nonspiculated margins, positive estrogen and progesterone receptor results, and negative ERBB2 results should raise suspicion of primary neuroendocrine carcinoma.
    AJR. American journal of roentgenology. 08/2014; 203(2):W221-W230.
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    ABSTRACT: This study aimed to evaluate the ultrasonographic findings for various types of vascular closure devices (VCDs) immediately after the angiographic procedure and at 6-month follow-up.
    Ultrasonography (Seoul, Korea). 07/2014;
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    ABSTRACT: Ischemic cerebral stroke is one of the leading global causes of mortality and morbidity. Ischemic preconditioning (IPC) refers to a sublethal ischemia and resulting in tolerance to subsequent severe ischemic injury. Although several pathways are reportedly involved in IPC-mediated neuroprotection, the functional role of astrocytes is not fully understood. Stromal cell-derived factor-1 (SDF-1), a CXC chemokine produced mainly in astrocytes, is a ligand for chemokine receptor CXCR4. SDF-1 is reported to play a critical role in neuroprotection after stroke by mediating the migration of neuronal progenitor cells. We hypothesized that stimuli derived from ischemic brain were involved in the protective effects of IPC. To investigate this hypothesis, the mechanism in which ischemic brain extract (IBE) induced SDF-1 expression was investigated in C6 astrocytoma cells. IBE treatment of C6 cells increased SDF-1 expression compared to that in untreated or normal brain extract (NBE)-treated cells by downregulating SDF-1 targeting miRNA, miR-27b. MiR-223 was inversely upregulated in IBE-treated cells; overexpression of miR-223 decreased the expression of miR-27b by suppressing IKKα expression. Analysis of cytokine array data revealed an IBE associated enhanced expression of CINC-1 (CXCL1) and LIX1 (CXCL5). Knockdown or inhibition of their receptor, CXCR2, abolished IBE-mediated increased expression of SDF-1. These results were confirmed in primary cultured astrocytes. Taken together, the data demonstrate that IBE-elicited signals increase SDF-1 expression through the CXCR2/miR-223/miR-27b pathway in C6 astrocytoma cells and primary astrocytes, supporting the view that increased expression of SDF-1 by ischemic insults is a possible mechanism underlying therapeutic application of IPC.
    Biochimica et biophysica acta. 07/2014;
  • Suk Jung Kim, Young Mi Park, Hyun Kyung Jung
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    ABSTRACT: Objectives- To compare the imaging and clinical features of benign and malignant nonmasslike lesions in the breast. Methods- During a 2-year period at a single institution, 186 nonmasslike lesions in 158 women were pathologically confirmed through surgery or sonographically guided biopsy. The sonographic patterns (mottled, geographic, and indistinct) and distributions (focal and regional) were compared between benign and malignant lesions. The presence of sonographically visible calcifications, amount of color Doppler signals, presence of positive findings on mammography, and presence of symptoms were also compared between the two groups. Results- A total of 156 lesions (84%) were confirmed as benign and 30 (16%) as malignant. On sonography, malignant nonmasslike lesions more frequently had mottled and geographic patterns and regional distribution than benign lesions (P < .0001). Malignant lesions also more frequently had sonographically visible calcifications (40% versus 0%; P < 0.0001) and a greater amount of color Doppler signals than benign lesions (P< .0001). On mammography, malignant lesions more frequently had densities and calcifications than benign lesions (30.4% versus 7.1%; P= 0.0052; 73.9% versus 6.1%; P < .0001, respectively). Clinically, malignant lesions were more frequently palpable and accompanied by localized pain than benign lesions (50% versus 2.6%; P< .0001; 13.3% versus 0.6%; P = .0025). Conclusions- The imaging and clinical features of malignant nonmasslike lesions differed significantly from those of benign nonmasslike lesions.
    Journal of ultrasound in medicine: official journal of the American Institute of Ultrasound in Medicine 03/2014; 33(3):421-30. · 1.40 Impact Factor
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    ABSTRACT: Ischemic cerebral stroke is one of the leading global causes of mortality and morbidity. Ischemic preconditioning (IPC) refers to a sublethal ischemia and resulting in tolerance to subsequent severe ischemic injury. Although several pathways are reportedly involved in IPC-mediated neuroprotection, the functional role of astrocytes is not fully understood. Stromal cell-derived factor-1 (SDF-1), a CXC chemokine produced mainly in astrocytes, is a ligand for chemokine receptor CXCR4. SDF-1 is reported to play a critical role in neuroprotection after stroke by mediating the migration of neuronal progenitor cells. We hypothesized that stimuli derived from ischemic brain were involved in the protective effects of IPC. To investigate this hypothesis, the mechanism in which ischemic brain extract (IBE) induced SDF-1 expression was investigated in C6 astrocytoma cells. IBE treatment of C6 cells increased SDF-1 expression compared to that in untreated or normal brain extract (NBE)-treated cells by downregulating SDF-1 targeting miRNA, miR-27b. MiR-223 was inversely upregulated in IBE-treated cells; overexpression of miR-223 decreased the expression of miR-27b by suppressing IKKα expression. Analysis of cytokine array data revealed an IBE associated enhanced expression of CINC-1 (CXCL1) and LIX1 (CXCL5). Knockdown or inhibition of their receptor, CXCR2, abolished IBE-mediated increased expression of SDF-1. These results were confirmed in primary cultured astrocytes. Taken together, the data demonstrate that IBE-elicited signals increase SDF-1 expression through the CXCR2/miR-223/miR-27b pathway in C6 astrocytoma cells and primary astrocytes, supporting the view that increased expression of SDF-1 by ischemic insults is a possible mechanism underlying therapeutic application of IPC.
    Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 01/2014; · 5.46 Impact Factor
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    ABSTRACT: Far-infrared (FIR) radiation is known to lessen the risk of angiogenesis-related diseases including cancer. Because deficiency of secretory clusterin (sCLU) has been reported to inhibit angiogenesis of endothelial cells (EC), we investigated using human umbilical vein EC (HUVEC) whether sCLU mediates the inhibitory effects of FIR radiation. Although FIR radiation ranging 3-25 μm wavelength at room temperature for 60 min did not alter EC viability, further incubation in the culture incubator (at 37 °C under 5% CO2) after radiation significantly inhibited EC proliferation, in vitro migration, and tube formation in a time-dependent manner. Under these conditions, we found decreased sCLU mRNA and protein expression in HUVEC and decreased sCLU protein secreted in culture medium. Expectedly, the replacement of control culture medium with the FIR-irradiated conditioned medium significantly decreased wound closure and tube formation of HUVEC, and vice versa. Furthermore, neutralization of sCLU with anti-sCLU antibody also mimicked all observed inhibitory effects of FIR radiation. Moreover, treatment with recombinant human sCLU protein completely reversed the inhibitory effects of FIR radiation on EC migration and angiogenesis. Lastly, vascular endothelial growth factor also increased sCLU secretion in the culture medium, and wound closure and tube formation of HUVEC, which were significantly reduced by FIR radiation. Our results demonstrate a novel mechanism by which FIR radiation inhibits the proliferation, migration, and angiogenesis of HUVEC, via decreasing sCLU.
    Cancer letters 12/2013; · 5.02 Impact Factor
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    ABSTRACT: PURPOSE To evaluate the frequency and MR characteristics of multi-banded anterior talofibular ligaments (ATFLs) in normal ankles and to characterize the tear types of multi-banded ATFLs in sprained ankles using a 3D isotropic proton density fast-spin echo (3D PD FSE) MR sequence. METHOD AND MATERIALS In the first session, 3D PD FSE MR imaging of 33 ankles was obtained from 20 asymptomatic volunteers. The number of bands in the ATFLs and locations of the ATFLs on orthogonal planes of the 3D PD FSE images and the signal intensity, depth, and width of each band on their multiplanar reformatted images parallel to the orientation of each band of the ATFL were evaluated by 2 readers. In the second session, 3D PD FSE MR imaging of 51 sprained ankles was evaluated by 2 readers for determining the number of bands in the ATFLs and the presence of tears in each band. RESULTS In the first session, 3 ATFLs were single-banded, 27 were double-banded, and 3 were triple-banded. In double-banded ATFLs, the superior band was about 2 times wider and thicker than the inferior band. The depth, width, and location of single-banded ATFLs and the superior band of double-banded ATFLs were not significantly different. In the second session, the most common type of injury in double-banded ATFLs was a 2-band tear. CONCLUSION In an evaluation using the 3D PD FSE sequence, most ATFLs consisted of 2 bands, and tears in both bands were the most common type of injury in double-banded ATFLs. CLINICAL RELEVANCE/APPLICATION 1. Most anterior talofibular ligaments consist of 2 bands. 2. Tears in both of 2 bands are the most common type of injury in the double-banded anterior talofibular ligaments.
    Radiological Society of North America 2013 Scientific Assembly and Annual Meeting; 12/2013
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    ABSTRACT: PURPOSE To evaluate and compare the morphology and position of the rotator cables in normal shoulders and tendinosis, partial-thickness tears and full-thickness tears of supraspinatus-infraspinatus tendons (SST-IST) on direct or indirect MR arthrography of the shoulders METHOD AND MATERIALS On the review of direct or indirect MR arthrography by two musculoskeletal radiologists, 30 MR images of normal shoulders and 74 of tendinosis in SST-ISTs were included. Thirty-seven MR images of partial thickness tears in SST-ISTs and 65 of full-thickness tears in SST-ISTs, which were confirmed by arthroscopic surgery, were obtained. On these types of shoulder MR imaging, the visibility, depth, and width of rotator cables, and the distance between the lateral edge of rotator cables and medial aspect of the footprints were measured and these were compared between the types by using Mann-Whitney test and Kruskal-Wallis test. RESULTS In every type, all rotator cables were visible on the sagittal planes of MR imaging. However, on the coronal planes, rotator cables in 11 (37%) of normal shoulders, 42 (57%) of tendinosis, 26 (70%) of partial thickness tears, and 57 (88%) of full thickness tears were detectable. Rotator cables were significantly thinner in normal shoulders (1.1 mm, 0.6–1.7 mm) and significantly thicker in the full-thickness tears of SST-ISTs (2.1 mm, 0.8–4.1 mm) than the others (tendinosis, 1.5 mm, 0.7–3.6 mm; partial-thickness tears, 1.6 mm, 0.9–2.5 mm). In full-thickness tears of SST-ISTs, rotator cables were significantly narrower (7.7 mm, 4.5–13.9 mm) than the others (normal shoulders,11.3 mm, 8.75–16.6 mm; tendinosis, 10.3 mm, 6.5–17.2 mm; partial-thickness tears, 9.5 mm, 5.9–13.0 mm) and the distance between the lateral edge of rotator cables and medial aspect of the footprints (21.1 mm, 5.7–45.6 mm) was significantly longer than that the others (normal shoulders; 9.0 mm, 6.7–12.3 mm; tendinosis, 8.5 mm, 3.5–12.2 m; partial-thickness tears, 10.5 mm, 7.2–15.7 mm). CONCLUSION On the sagittal planes of direct or indirect MR arthrography, all rotator cables were visible. Rotator cables were significantly thinner in normal shoulders and significantly thicker and narrower in full-thickness tears than other types of shoulders. CLINICAL RELEVANCE/APPLICATION 1. Every rotator cable is visible on MR imaging. 2. MR imaging is useful to evaluate the rotator cable.
    Radiological Society of North America 2013 Scientific Assembly and Annual Meeting; 12/2013
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    ABSTRACT: PURPOSE Analyze microcalcifications (MC) on mammography (M) in patients with pure ductal carcinoma in situ (DCIS) by nuclear grade (G), comedonecrosis (CN), estrogen receptor (ER) status, patient age and surgical outcome. METHOD AND MATERIALS An institutional review board approved retrospective single institution database search was performed from January 1, 1996 to July 31, 2009 of patients with pure DCIS who underwent preoperative M. All M and, when available, ultrasound (US) images were reviewed according to the ACR BIRADS® lexicon. Imaging findings were analyzed in respect to clinical, histopathologic, and biologic characteristics. Statistical analyses used multiple logistic regression with model selection via AIC or Pearson’s chi-squared test for marginal homogeneity or linear dependence. RESULTS There were 1911 patients with pure DCIS. Patients with negative M (n=98) and noncalcified lesions (n=155) were excluded, 1658 patients were included in final analysis. M was performed in all patients; US in 506 (31%) patients. Mean age at diagnosis was 55 years (SD, 11.0). G3 lesions were associated with fine linear morphology and segmental distribution of MC (p<0.05), larger in size on M (p<0.05), and more visible on US (p<0.005) than G 1/2 lesions. CN was associated with MC that had linear or segmental distribution (p<0.05), were large in size (p<0.005) on M, and visible on US (p<0.02). Masslike appearance of MC on US decreased odds of CN (p<0.05). Fine linear and fine pleomorphic MC morphology was associated with segmental distribution (p<0.0001. ER (-) lesions were more visible on US (p=0.002), and associated with G3 and CN . Dense breasts were associated with ER (-) lesions with CN, and with close surgical margins (p<0.05). Multicentricity was associated with US visibility (p<0.02), close surgical margins (p<0.01), and dense parenchyma (p<0.02). Pathologic size was associated with M and US size (p<0.0001) and decreased with patients age (p<0.005). CONCLUSION G3 DCIS and CN are associated with fine linear MC, segmental distribution, large size, ER (-) lesions, and visibility on US. Dense breasts are associated with multicentricity and close surgical margins. CLINICAL RELEVANCE/APPLICATION Patients with dense breasts should be carefully evaluated for multicentricity and the possibility of close surgical margins, and might benefit from supplemental imaging.
    Radiological Society of North America 2013 Scientific Assembly and Annual Meeting; 12/2013
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    ABSTRACT: PURPOSE Sonographic (US) findings in 691 pure ductal carcinoma in situ (DCIS) lesions were retrospectively analyzed by estrogen receptor (ER) status, nuclear grade, and comedonecrosis to evaluate the prognostic value of US as an adjunct to mammography (M). METHOD AND MATERIALS An institutional review board approved retrospective single institution database search performed for patients with pure DCIS evaluated from January 1996 to July 2009 who underwent pre-operative M and whole-breast US. Images were reviewed per ACR BI-RADS lexicon. Pathologic features recorded were ER status, nuclear grade, and comedonecrosis. ER+ was defined as nuclear staining in at least 1% of cells. Statistical comparisons were made using t-test, Chi-square, Fisher’s exact test, Kruskal-Wallis or Wilcoxon rank-sum test. RESULTS There were 1911 pure DCIS patients identified; those with incomplete data (n=5), lacking pre-operative US (n=1214) or M (n=1) were excluded leaving 691 patients for analysis. Of 691 lesions, 304 (44%) were visible on M and US, 315 (46%) visible on M only, 58 (8%) visible on US only, and 14 (2%) visible on neither M nor US. There were 425 (62%) ER+, 104 (15%) ER-, and 162 (23%) lesions with unknown ER. Comedonecrosis was present in 296 (43%) lesions, absent in 395 (57%). There were 334 (48%) non-high grade (nuclear grade I/II) lesions, 353 (51%) high-grade (III), and 4 (1%) of unknown grade. ER- lesions were more frequently visible on US than ER+ lesions (62% vs. 48%, p<0.05). An irregular non-circumscribed hypoechoic mass with no posterior features or enhancement was the most common US finding, regardless of histopathologic features. A shadowing US mass was more frequently high grade or ER- (p<0.05). A nonmass US lesion or calcifications were more frequently detected in high grade or comedo DCIS (p<0.0001). A round or oval US mass was more likely non-high grade (p<0.05). Average US lesion size was larger in ER-, high grade, and necrotic lesions (p<0.05). CONCLUSION ER- DCIS is more likely visible on US than ER+ DCIS. A shadowing US mass is more frequently high grade or ER-. While a mass is the most common US finding of DCIS regardless of histopathologic features, nonmass lesions are more likely to be associated with high-grade tumors and comedonecrosis. CLINICAL RELEVANCE/APPLICATION A shadowing mass on US should raise suspicion for ER- DCIS which provides imaging-based prognostic and biologic information during cancer diagnosis and work-up.
    Radiological Society of North America 2013 Scientific Assembly and Annual Meeting; 12/2013
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    ABSTRACT: PURPOSE The purpose of this study was to evaluate the usefulness of breast ultrasonography (US) for the evaluation of pathologic nipple discharge, as compared with galactography. METHOD AND MATERIALS 117 cases in 105 patients (all women; mean, 43.2 years; range, 20 - 76years) with pathologic nipple discharge were enrolled in this study, who had underwent US and galactography between 2004 and 2012. Eighty three cases were pathologically proved by surgical excision (n=66), or US-guided core needle biopsy (n=17), and the remaining cases were followed up for mean 24 months by US and mammography. Two radiologists retrospectively reviewed and compared US and galactography images with regard to detectability of lesion and evaluation of disease extent. RESULTS The lesions were depicted at galactography in 98 cases (83.8%), at US in 96 cases (82.1%) and both examinations in 85 cases (72.6%). Eight cases (6.8%) showed poor visualization of lesions at both examinations. The lesions were depicted at galatography only in 13 cases (11.1%) and US only in 11 cases (9.4%), of which galactograms were negative (n=1), only ductal dilatations (n=3), or failure of procedure (n=7). In 85 cases which abnormalities were visualized at both examinations, the evaluation of lesion extent was superior at US in 19 cases and superior at galactogram in 12 cases. Of 117 cases, US was superior or equal to galactography in 88 cases (75.2%) with respect to detection of lesion and extent evaluation. Galactography was superior or equal to US in 57 cases (48.7%). CONCLUSION Breast US is useful to detect the causes of pathologic nipple discharge and to evaluate the lesion extent exactly. Therefore, in the evaluation of patients with pathologic nipple discharge, we suggest that galactography may be skipped if the lesion is well detected at US. CLINICAL RELEVANCE/APPLICATION Galactography may be skipped in the evaluation of patients with pathologic nipple discharge if the lesion is well detected at ultrasonography.
    Radiological Society of North America 2013 Scientific Assembly and Annual Meeting; 12/2013
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    ABSTRACT: Metastatic relapse of primary lung cancer leads to therapeutic resistance and unfavorable clinical prognosis; therefore, identification of key molecules associated with metastatic conversion has significant clinical implications. We previously identified a link between early brain metastasis of lung adenocarcinoma (ADC) and amplification of the alpha-smooth muscle actin (ACTA2) gene. The aim of present study was to investigate the prognostic and functional significance of ACTA2expression in cancer cells for the metastatic potential of lung ADCs. ACTA2 expression was analyzed in tumor cells from 263 patients with primary lung ADCs by immunohistochemistry, and was correlated with clinicopathological parameters. The expression of ACTA2 in human lung ADC cells was modulated with shRNAs and siRNAs specifically targeting ACTA2. The patients with lung ADCs with high ACTA2 expression in tumor cells showed significantly enhanced distant metastasis and unfavorable prognosis. ACTA2 downregulation remarkably impaired in vitro migration, invasion, clonogenicity, and transendothelial penetration of lung ADC cells without affecting proliferation. Consistent with the in vitro results, depletion of ACTA2 in human lung ADC PC14PE6 cells significantly reduced their metastatic potential without altering their tumorigenic potential. Expression of c-MET and FAK in lung ADC cells was also reduced by ACTA2-targeting siRNAs and shRNAs, and was accompanied by a loss of mesenchymal characteristics. These findings indicate that ACTA2 regulates c-MET and FAK expression in lung ADC cells, which positively and selectively influence metastatic potential. Therefore, ACTA2 could be a promising prognostic biomarker and/or therapeutic target for metastatic lung ADC.
    Clinical Cancer Research 08/2013; · 7.84 Impact Factor
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    ABSTRACT: The clinicopathologic, mammographic, and sonographic findings in patients with pure ductal carcinoma in situ (DCIS) were assessed by estrogen receptor (ER) expression. After institutional review board approval, patients with pure DCIS evaluated from January 1996 to July 2009 with known ER status and available imaging were identified. Images were reviewed as per the ACR BI-RADS(®) lexicon (4th edition). Clinical, pathologic, and imaging characteristics were analyzed by ER status using t test, Chi square test, and Fisher's exact test. Of 1,219 patients with pure DCIS and known ER status identified, 1,187 with complete data were included. Mammography was performed in all 1,187 patients and sonography in 519 (44 %). There were 972 (82 %) patients with ER-positive and 215 (18 %) with ER-negative disease. ER-negative DCIS was more likely to be high grade (93 vs 44 %, p < 0.0001), associated with comedonecrosis (64 vs 29 %, p < 0.0001), and multifocal (23 vs 15 %, p = 0.009). On sonography, ER-negative DCIS was more likely to be visible (61 vs 46 %, p = 0.004), larger (mean size, 2.3 vs 1.6 cm, p = 0.006), and show posterior shadowing (53 vs 28 %, p = 0.006). Mastectomy was more frequently performed for ER-negative DCIS (47 vs 37 %, p = 0.008). Palpable DCIS was visible on sonography in 55 % of cases and mammography in 81 %. Compared with ER-positive palpable DCIS, ER-negative palpable DCIS was larger and more likely to be visible on sonography. Compared with ER-positive noncalcified DCIS, ER-negative noncalcified DCIS was less likely to be visible on mammography. ER-positive and ER-negative pure DCIS have different clinicopathologic and imaging characteristics. ER-negative DCIS is associated with worse prognostic factors than ER-positive DCIS. On sonography, ER-negative DCIS is more frequently visible than ER-positive DCIS, tends to be larger, and more frequently demonstrates posterior shadowing.
    Breast Cancer Research and Treatment 06/2013; · 4.47 Impact Factor
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    ABSTRACT: OBJECTIVE: This article reviews the imaging and histopathologic findings of various axillary diseases and suggests management guidelines for radiologists based on imaging findings with clinical correlation. CONCLUSION: Although axillary diseases may reveal nonspecific imaging findings, a knowledge of the characteristic radiologic manifestations of specific diseases according to anatomic origin (nodal, accessory breast, adipocytic, fibrous, nerve, vascular, stromal, and dermal) and postsurgical lesions aids in establishing an appropriate differential diagnosis and determining whether intervention is necessary.
    American Journal of Roentgenology 02/2013; 200(2):W130-42. · 2.90 Impact Factor
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    ABSTRACT: PURPOSE.: The purpose of our study was to evaluate the imaging features of benign adenomyoepithelioma of the breast with a focus on sonographic (US) appearances. METHODS.: Ten benign adenomyoepitheliomas in 9 patients were included in this study. Mammographic and US findings were analyzed retrospectively by 2 radiologists according to the Breast Imaging-Reporting and Data System (BI-RADS) lexicon. The BI-RADS final assessment category was also recorded. RESULTS.: Of the 8 lesions for which mammography was available, 4 lesions presented with abnormal findings. Two lesions presented with an indistinct, irregular, isodense mass and a circumscribed, oval, isodense mass. The other 2 lesions presented with areas of focal asymmetry and asymmetry, respectively. On US, all of 10 lesions presented as a mass. The masses measured 0.5-1.2 cm (mean, 0.8 cm), were irregular (n = 8) or oval (n = 2) with microlobulated (n = 5), indistinct (n = 3), or angular (n = 2) margins. They were all hypoechoic, had non parallel orientation in 6 cases, and increased peripheral vascularity in 7 cases. The BI-RADS final assessment category was 4B in 6, and 4A in 4. CONCLUSIONS.: Mammographic findings of benign adenomyoepithelioma were nonspecific. An irregular, non parallel orientation, microlobulated or indistinct margin, hypoechogenicity, and increased peripheral vascularity were the most frequent US features. © 2013 Wiley Periodicals, Inc. J Clin Ultrasound, 2013.
    Journal of Clinical Ultrasound 01/2013; · 0.70 Impact Factor
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    ABSTRACT: OBJECTIVE: To evaluate retrospectively whether symptomatic acromioclavicular joints can be differentiated from asymptomatic acromioclavicular joints on 3-T MR imaging. METHODS: This study included 146 patients who underwent physical examination of acromioclavicular joints and 3-T MR imaging of the shoulder. Among them, 67 patients showing positive results on physical examination were assigned to the symptomatic group, whereas 79 showing negative results were assigned to the asymptomatic group. The following MR findings were compared between the symptomatic and asymptomatic groups: presence of osteophytes, articular surface irregularity, subchondral cysts, acromioclavicular joint fluid, subacromial fluid, subacromial bony spurs, joint capsular distension, bone edema, intraarticular enhancement, periarticular enhancement, superior and inferior joint capsular distension degree, and joint capsular thickness. The patients were subsequently divided into groups based on age (younger, older) and the method of MR arthrography (direct MR arthrography, indirect MR arthrography), and all the MR findings in each subgroup were reanalyzed. The meaningful cutoff value of each significant continuous variable was calculated using receiver operating characteristic analysis. RESULTS: The degree of superior capsular distension was the only significant MR finding of symptomatic acromioclavicular joints and its meaningful cutoff value was 2.1mm. After subgroup analyses, this variable was significant in the older age group and indirect MR arthrography group. CONCLUSION: On 3-T MR imaging, the degree of superior joint capsular distension might be a predictable MR finding in the diagnosis of symptomatic acromioclavicular joints.
    European journal of radiology 12/2012; · 2.65 Impact Factor
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    ABSTRACT: PURPOSE The clinico-pathological, mammogram (M), and ultrasound (US) findings in patients with pure ductal carcinoma in situ (DCIS) were assessed by estrogen receptor (ER) expression. METHOD AND MATERIALS A retrospective single institution database search was performed from January 1, 1996 to July 31, 2009 of patients with pure DCIS and known ER status who had imaging (M or US) available for review. All M and US images were reviewed according to the ACR BIRADS® lexicon. Clinical, pathologic, and imaging characteristics were analyzed with respect to ER status. T-test, Chi-square, and Fisher’s exact tests were used for statistical analysis. RESULTS There were 1219 patients with pure DCIS and known ER status; 32 were excluded due to incomplete data leaving 1187 patients for final analysis. M was performed in all 1187 (100%) patients; US in 519 (44%) patients. There were 972 (82%) patients with ER+ and 215 (18%) with ER- disease. The mean age at diagnosis was 56 years (SD 11). ER- DCIS was more likely to be high grade (93% vs 44%, p<0.001), comedo type (64% vs 29%, p<0.0001), with necrosis (65% vs 38%, p<0.0001), multifocal and multicentric (both 23% vs 15%, p<0.05). By US, ER- DCIS was more likely to be visible (61% vs 46%, p<0.01), larger (2.3 vs 1.6 cm, p<0.01), and show posterior shadowing (53% vs 28%, p<0.05). By M, coarse heterogeneous and linear branching calcifications were more frequently associated with ER- tumors (34% vs 27%, p<0.05). Mastectomy was more frequently performed for ER- DCIS (47% vs 37%, p<0.01). At histopathology, solid pattern was prevalent in ER- tumors (78% vs 61%, p<0.0001) and cribriform pattern more common in ER+ tumors (65% vs 40%, p<0.0001). CONCLUSION ER- DCIS is more likely to be high grade tumor with comedo necrosis, more likely associated with coarse heterogeneous and linear branching calcifications on M, and more likely to be a mass with shadowing and larger in size when detected on US. ER- DCIS is more likely multifocal or multicentric than ER+ tumors, and is more frequently associated with mastectomy. CLINICAL RELEVANCE/APPLICATION To our knowledge, this is the first clinical study describing clinicopathologic and imaging differences associated with biologic subtypes of DCIS that may impact diagnosis, staging, and therapy.
    Radiological Society of North America 2012 Scientific Assembly and Annual Meeting; 11/2012
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    ABSTRACT: Primary lung tumors, breast tumors, and melanoma metastasize mainly in the brain where therapy is limited to surgery and radiation. To investigate the molecular basis of brain metastases, we isolated brain-trophic metastatic MDA-MB-435-LvBr2 (LvBr2) cells via left ventricle (LV) injection of MDA-MB-435 cells into immunodeficiency (NOD/SCID) mice. Whereas parent MDA-MB-435 cells displayed an elongated morphology, LvBr2 cells were round and displayed an aggregated distribution. LvBr2 cells expressed lower β-catenin levels and higher heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNPC) levels than parental cells. Since microRNAs are known to play an important role in cancer progression including metastasis, we screened microRNAs expressed specifically in brain metastases. MicroRNA-146a was almost undetectable in LvBr2 cells and highly expressed in the parental cells. Overexpression of miR-146a increased β-catenin expression and suppressed the migratory and invasive activity of LvBr2 cells. The miR-146a-elicited decrease in hnRNPC in turn lowered the expression of MMP-1, uPA, and uPAR and inhibited the migratory and invasive activity of LvBr2 cells. Taken together, our findings indicate that miR-146a is virtually absent from brain metastases and can suppress their metastatic potential including their migratory and invasive activities associated with upregulation of β-catenin and downregulation of hnRNPC.
    Molecules and Cells 09/2012; 34(3):329-34. · 2.21 Impact Factor
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    ABSTRACT: This study was conducted to investigate sex pheromone composition of Ascotis selenaria (Lepidoptera: Geometridae) in Korea. Two sex pheromone compounds such as (Z,Z)-6,9-cis-3,4-epoxynonadecadiene (6Z,9Z-cis-3,4-epoxy-19:H) and (Z,Z,Z)-3,6,9-nonadecatriene (3Z,6Z,9Z-19:H) were identified in the glands of A. selenaria females by gas chromatography–mass spectrometry analysis. However, the component 3Z,6Z,9Z-19:H neither elicited an electroantennogram response nor increased the attractiveness for A. selenaria males in the field. The role of 3Z,6Z,9Z-19:H seems to be as an antagonistic signal for mating behavior of A. selenaria males.The blend ratios of two 6Z,9Z-cis-3,4-epoxy-19:H isomers such as, 6Z,9Z-cis-3R,4S-epoxy-19:H and 6Z,9Z-cis-3S,4R-epoxy-19:H, were critical to attract A. selenaria males. The blend ratios of the two isomers showing peak catch of A. selenaria males had large variations among the locations investigated. A. selenaria populations in Gunwi showed peak activity at ratios of 0.9:0.1 and 0.8:0.2, whereas the populations in Goheung, Yeongam, and Jeju (Aewol and Harye) showed peak activity at a 0.5:0.5 ratio. In Changnyeong, the peak activity occurred in a bimodal form at ratios of 0.7:0.3 and 0.4:0.6. Such variation was partially explained by geographical isolation due to mountain ranges. Consequently, the results of our study should be useful for designing a region-specific pheromone lure for successful A. selenaria monitoring.
    Journal of Asia-Pacific Entomology 09/2012; 15(3):413–418. · 0.80 Impact Factor

Publication Stats

271 Citations
92.16 Total Impact Points

Institutions

  • 2013–2014
    • Inje University Paik Hospital
      • Department of Radiology
      Sŏul, Seoul, South Korea
  • 2012–2014
    • Sungkyunkwan University
      Sŏul, Seoul, South Korea
    • Case Western Reserve University School of Medicine
      • Department of Molecular Medicine
      Cleveland, Ohio, United States
  • 2012–2013
    • Ewha Womans University
      • School of Medicine
      Sŏul, Seoul, South Korea
  • 2009–2012
    • Lerner Research Institute
      • Department of Cellular and Molecular Medicine
      Cleveland, Ohio, United States
  • 2008–2012
    • Yonsei University Hospital
      • Department of Internal Medicine
      Seoul, Seoul, South Korea
  • 2011
    • Chung-Ang University
      Sŏul, Seoul, South Korea
  • 2010
    • Pusan National University
      • College of Nursing
      Tsau-liang-hai, Busan, South Korea
  • 2004–2005
    • Yonsei University
      • • Department of Forensic Medicine and Brain Korea 21 Project for Medical Science
      • • College of Medicine
      Seoul, Seoul, South Korea