Kohei Marukawa

University of Yamanashi, Kōhu, Yamanashi, Japan

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Publications (75)98.48 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: The purpose of this study was to compare the recovery period of lower lip hypoesthesia between hybrid fixation and conventional fixation using absorbable plates and screw systems following sagittal split ramus osteotomy (SSRO).
    06/2014;
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    ABSTRACT: The purpose of this study was to evaluate the factors affecting the recovery period of lower lip hypoesthesia after sagittal split ramus osteotomy (SSRO) in mandibular prognathism patients using multivariate analysis, retrospectively.
    Journal of Cranio-Maxillofacial Surgery 06/2014; · 1.61 Impact Factor
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    ABSTRACT: This study evaluated bone regeneration by periosteal elevation using conventional orthodontic wire and an unsintered hydroxyapatite (u-HA)/poly-l-lactic acid (PLLA) mesh in rabbit frontal bone. Thirty two rabbits (12-16 weeks: 2.5-3.0 kg) were used in this study. In the experimental group, 1 week after the mesh was inserted under the periosteal membrane, it was elevated by traction using the mesh connected with wire and two anchor screws. In the control group, the mesh was kept inserted under the periosteal membrane. Four animals were killed in each period in both groups, at 2, 3, 5 and 9 weeks postoperatively. Operated parts in the frontal bone were removed and prepared for radiological and histological assessment. The distance between the mesh and pristine bone (elevation length), the bone area and the expression of BMP-2 were evaluated. The value in the experimental group was significantly higher when compared to the control group (length P < 0.0001, bone area P < 0.0010, BMP-2 P = 0.0015). The BMP-2 labelling index after 3 weeks tended to be the largest in both groups. This study suggests that bone regeneration can be induced by periosteal elevation using a conventional orthodontic wire and an uHA/PLLA mesh.
    06/2014;
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    ABSTRACT: Objectives The purpose of this study was to examine the changes with time in lip pressure after orthognathic surgery for skeletal Class III patients. Study design The subjects consisted of 63 patients (32 female and 31 male) diagnosed with mandibular prognathism who underwent sagittal split ramus osteotomy with and without Le Fort I osteotomy. Maximum and minimum lip closing forces were measured with Lip De Cum®. The changes with time were compared statistically. Results The maximum and minimum lip closing force increased time-dependently in men and women after surgery and there were significant differences between men and women with changes with time in the maximum lip closing force (P=0.0086) and the minimum lip closing force (P=0.0302). After 1 year, the Class III group maximum lip closing force was significantly smaller than the control group in both men (p<0.0001) and women (p<0.0001). Conclusions This study suggests that there was significant difference in over time in the lip closing force between men and women in Class III patients. Although the maximum lip closing force increased with time, it did not reach the level of the control group after 1 year.
    Journal of Cranio-Maxillofacial Surgery 01/2014; · 1.61 Impact Factor
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    ABSTRACT: Purpose The purpose of this study was to evaluate the relationship between lip closing force, occlusal contact area and occlusal force after orthognathic surgery in skeletal Class III patients. Subjects and Methods The subjects consisted of 54 patients (28 female and 26 male) diagnosed with mandibular prognathism who underwent sagittal split ramus osteotomy with and without Le Fort I osteotomy. Maximum and minimum lip closing forces, occlusal contact area and occlusal force were measured pre-operatively, 6 months and 1 year post-operative. Results Maximum and minimum lip closing forces, occlusal contact area and occlusal force increased with time after surgery, however a significant increase was not found in the occlusal contact area in women. In increased ratio (6 months/pre-operative and 1 year/pre-operative), the maximum lip closing force was significantly correlated with the occlusal contact area (P<0.0001). Conclusions This study suggested that orthognathic surgery could improve the occlusal force, contact area and lip closing force, and an increase ratio in maximum lip closing force was associated with an increased ratio in occlusal contact area.
    Journal of Cranio-Maxillofacial Surgery 01/2014; · 1.61 Impact Factor
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    ABSTRACT: The purpose of this study was to evaluate bony change in an overlapped cortical bone area at the anterior site of the proximal segment after modified plate fixation with a bent plate in sagittal split ramus osteotomy (SSRO). The subjects were 66 patients (132 sides) who underwent bilateral SSRO setback surgery. After the surgery in SSRO, an overlapped area of cortical bone at the anterior site of the proximal segment was not removed to keep the contact area between the proximal and distal segments intact, and was fixed with a bent plate and 4 screws in each side of the mandible. At the posterior site, a 3-7 mm gap was maintained between the proximal and distal segments to prevent inward-rotation of the condylar long axis. Ramus width, lateral cortex width and lateral cortex step angle were assessed in a coronal image immediately after the surgery, and 1-year postoperative by computed tomography (CT). Ramus width after 1-year was significantly larger than that before surgery and smaller than that immediately after surgery in both sides (P < 0.0001). Lateral cortex width after 1-year was significantly larger than the preoperative value and smaller than that immediately after surgery in both sides (P < 0.0001). Lateral cortex angle after 1-year was significantly larger than the preoperative value in both sides (P < 0.0001). The above findings suggested that the overlapped cortical bone decreased thickness and the cortical bone step disappeared following favourable bone remodelling after 1-year, even though the cortical bone was not removed at the anterior site of the proximal segment.
    Journal of cranio-maxillo-facial surgery: official publication of the European Association for Cranio-Maxillo-Facial Surgery 09/2013; · 1.25 Impact Factor
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    ABSTRACT: To compare bone regeneration between local implantation of statin and low-intensity pulsed ultrasound (LIPUS), and the combination of statin with LIPUS in rabbit nasal bone using histological and immunohistochemical methods. Thirty-two adult male Japanese white rabbits (age: 12-16 weeks, weight: 2.5-3.0 kg) were used in this study. Two bone circular defects (5 mm in diameter) per rabbit were created in the nasal bone while preserving the nasal membrane. The two defects in each rabbit were filled with 2.5 mg/ml simvastatin in 0.2 ml water with an atelocollagen sponge (ACS) and ACS alone respectively. Sixteen rabbits (32 sides) received the LIPUS application; the remaining 16 rabbits (32 sides) did not. Therefore, the subjects composed of 4 groups, namely, (1) LIPUS + ACS + simvastatin (the LAS group), (2) LIPUS + ACS (the LA group), (3) ACS + simvastatin (the AS group) and (4) ACS alone (the A group). Four animals were killed in each period, at 1, 2, 4 and 8 weeks postoperative. The parts that had been operated on were removed and prepared for histological assessment. The expression of BMP-2 and the bone area ratio were evaluated using histological and immunohistochemical methods. Bone square in the LAS group was significantly larger than that in the AS group after 1 (P < 0.0001) and 2 week (P = 0.0113). The bone square in the LA group was significantly larger than that in the A group after 1 (P < 0.0001) and 2 weeks (P = 0.0090). However, there was no significant difference between the LAS and LA groups. In the number of cells that stained positive for BMP-2, the LAS group was significantly larger than that in the AS group after 1 (P < 0.0001) and 2 weeks (P = 0.0113). This study suggests that bone regeneration can be promoted by LIPUS alone and statin alone, respectively. However the combination use of LIPUS with statin does not differ from LIPUS alone or statin alone.
    Journal of cranio-maxillo-facial surgery: official publication of the European Association for Cranio-Maxillo-Facial Surgery 08/2013; · 1.25 Impact Factor
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    ABSTRACT: Objective: Inferior alveolar nerve (IAN) impairment is widely known as typical accident of dental implant treatment. The aim of this study was to examine whether immediate removal of implants promotes histological recovery after IAN injury caused by bone screw placement close to mental foramen in rabbit using histological and immuno-histochemical methods. Methods: 14 adult male Japanese white rabbits were used. Right side and left side were divided as the retention side and the removal side. On the retention side, a self-drilling bone screw was kept implanted at the superior site closely to the mental foramen. On the removal side, soon after implantation at a similar site, the screw was removed. Rabbits were sacrificed at 1, 2 and 4weeks postoperatively, and the IAN was extracted and prepared for assessments using the hematoxylin-eosin stain and immuno-histochemical β-nerve growth factor (β-NGF) stain. Results: There were significant differences between the retention side and the removal side in ratio of destruction of nerve fibers only at 2weeks, and in mean diameter of nerve fibers only at 4weeks, statistically (P<0.05). Neither number of nerve fibers nor ratio of disappearance of axons showed a significant difference between both sides in each period. Ratio of β-NGF positive cells did not show a significant difference between both sides either. Conclusion: This study suggested that IAN impaired by dental implant tends to recover histologically without implant removal.
    IADR Asia/Pacific Region (APR) Regional Meeting and Co-Annual Scientific Meeting of IADR Divisions 2013; 08/2013
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    ABSTRACT: Objective: To compare bone regeneration among local implantation of statin and low-intensity pulsed ultrasound(LIPUS), and the combination of statin with LIPUS in rabbit nasal bone using histological and immunohistochemical methods. Method: Thirty two adult male Japanese white rabbits were used in this study. Two bone circular defects (5 mm in diameter) per rabbit were created in the nasal bone while preserving the nasal membrane. The two defects in each rabbit were filled with 2.5 mg/ml simvastatin in 0.2 ml water with an atelocollagen sponge (ACS) and ACS alone respectively. Sixteenrabbits (32 sides) received the LIPUSapplication, the remaining 16 rabbits (32 sides) did not. Therefore, the subjects composed of 4 groups, namely, (1) LIPUS +ACS{simvastatin (the LAS group), (2) LIPUS+ACS(the LA group), (3) ACS{simvastatin (the AS group) and (4) ACS alone (the A group). Four animals were killed in each period, at 1, 2, 4 and 8 weeks postoperative. The parts that had been operated on were removed and prepared for histological assessment. The expression of BMP-2 and the bone area ratio were evaluated using histological and immunohistochemical methods. Result: Bone square in the LAS group was significantly larger than that in the AS group after 1 (P<0.0001) and 2 week (P=0.0113). The bone square in the LA group was significantly larger than that in the A group after 1 (P<0.0001) and 2 weeks (P=0.0090). However, there was no significant difference between the LAS and LA groups. In the number of cells that stained positive for BMP-2, the LAS group was significantly larger than that in the AS group after 1 (P<0.0001) and 2 weeks (P=0.0113). Conclusion: This study suggests that bone regeneration can be promoted by LIPUS alone and statin alone, respectively. However the combination use of LIPUS with statin does not differ from LIPUS alone or statin alone.5
    IADR Asia/Pacific Region (APR) Regional Meeting and Co-Annual Scientific Meeting of IADR Divisions 2013; 08/2013
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    ABSTRACT: Objective: The purpose of this study was to examine the changes in border movement of the mandible before and after mandibular ramus osteotomy in patients with prognathism. Method: The subjects were 73 patients with mandibular prognathism who underwent sagittal split ramus osteotomy (SSRO with and without Le Fort I osteotomy. Border movement of the mandible was recorded with a mandibular movement measure system (K7) preoperatively and at 6 months postoperative. Maximum vertical opening, maximum antero-posterior movement from the centric occlusion, maximum lateral deviation on the left and right, and centric occlusion to maximum opening were compared between the pre and post-operative states, and the differences analyzed statistically. Result: There was no significant difference between SSRO alone and SSRO with Le Fort I osteotomy in the time-course change. The values at 6 months postoperative were significantly lower than the pre-operative values in the maximum vertical opening (P=0.0066), maximum antero-posterior movement from the centric occlusion (P=0.0425) and the centric occlusion to the maximum opening (P=0.0300). Conclusion: This study suggests that postoperative temporary reduction of the border in mandibular movement could recover by 1.5 years postoperative, and additional procedure of Le Fort I osteotomy did not affected the recovery of mandibular motion after SSRO.
    IADR Asia/Pacific Region (APR) Regional Meeting and Co-Annual Scientific Meeting of IADR Divisions 2013; 08/2013
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    ABSTRACT: Objective: The purpose of this study was to evaluate bone regeneration by periosteal expansion using conventional orthodontic wire and an unsintered hydroxyapatite (u-HA) / poly-L-lactic acid (PLLA) mesh in rabbit nasal bone. Method: Thirty two adult male Japanese white rabbits (12–16 weeks: 2.5–3.0 kg) were used in this study. In the expansion group, 1 week after the mesh was inserted under the periosteal membrane, it was expanded by traction using the mesh connected with ‚‡wire and two bone screws as anchors. In the control group, the mesh was kept inserted under the periosteal membrane. Four animals were killed in each period in both groups, at 2, 3, 5 and 9 weeks postoperatively. Operated parts in the nasal bone were removed and prepared for histological assessment. The distance between the mesh and mother bone (expansion length), the bone area ratio and the expression of BMP-2 were evaluated using histological and immune-histochemical methods. Result: The expansion length and the bone area in the expansion group was significantly increasedmore than that in the control group in the time-course change (length P<0.0001, bone area P<0.0010). Significant difference was found in the BMP-2 labeling index between the expansion group and the control group in the time-course change (P=0.0015), although the value after 3 weeks tended to be the largest in both groups. Conclusion: This study suggests that bone regeneration can be induced by periosteal expansion using a conventional orthodontic wire and an uHA/PLLA mesh.
    IADR Asia/Pacific Region (APR) Regional Meeting and Co-Annual Scientific Meeting of IADR Divisions 2013; 08/2013
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    ABSTRACT: The purpose of this study was to examine the changes in border movement of the mandible before and after mandibular ramus osteotomy in patients with prognathism. The subjects were 73 patients with mandibular prognathism who underwent sagittal split ramus osteotomy (SSRO) with and without Le Fort I osteotomy. Border movement of the mandible was recorded with a mandibular movement measure system (K7) preoperatively and at 6 months postoperatively. Of the 73 patients, 21 had measurements taken at 1.5 years postoperative. Data were compared between the pre- and postoperative states, and the differences analyzed statistically. There was no significant difference between SSRO alone and SSRO with Le Fort I osteotomy in the time-course change. The values at 6 months postoperative were significantly lower than the preoperative values for maximum vertical opening (P=0.0066), maximum antero-posterior movement from the centric occlusion (P=0.0425), and centric occlusion to maximum opening (P=0.0300). However, there were no significant differences between the preoperative and 1.5 years postoperative measurements. This study suggests that a postoperative temporary reduction in the border movement of the mandible could recover by 1.5 years postoperative, and the additional procedure of a Le Fort I osteotomy does not affect the recovery of mandibular motion after SSRO.
    International Journal of Oral and Maxillofacial Surgery 08/2013; · 1.52 Impact Factor
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    ABSTRACT: The purpose of this study was to compare the temporal changes in condylar long axis and skeletal stability after sagittal split ramus osteotomy (SSRO) with the hybrid fixation technique and the conventional plate fixation. Of 44 Japanese patients diagnosed with mandibular prognathism, 22 underwent SSRO with the conventional plate fixation (1 u-HA/PLLA plate and 4 monocortical screws in each side) and 22 underwent SSRO with a hybrid fixation technique (1 u-HA/PLLA plate and 4 monocortical screws and bicortical screw in each side). The temporal changes in condylar long axis and skeletal stability were assessed by axial, frontal, and lateral cephalograms. After surgery, breakage of the plate and screws was checked by 3-dimensional computed tomography (3DCT). Although there was a significant difference between the groups regarding Me-Ag in T1 (P = 0.0138), there were no significant differences between the groups for the other measurements in lateral, frontal and axial cephalometric analysis in each time interval. In two cases, 4 sides in the conventional plate fixation group, failure of the absorbable plate was found by 3DCT. However, there was no breakage in the hybrid fixation group. This study suggested that there were no significant differences in the postoperative temporal changes between the two groups in mandibular setback surgery.
    Journal of cranio-maxillo-facial surgery: official publication of the European Association for Cranio-Maxillo-Facial Surgery 07/2013; · 1.25 Impact Factor
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    ABSTRACT: PURPOSE:: The purpose of this study was to compare the bone regenerative capability of using unsintered hydroxyapatite/poly-L-lactic acid (uHA/PLLA) mesh and titanium mesh. MATERIALS AND METHODS:: Adult male white rabbits (n = 24) were divided into 2 groups. After incising along the mandible, 3 × 5 mm bone defects were made in both sides and covered by an uHA/PLLA mesh (n = 12) or a titanium mesh (n = 12) on the right side but no mesh on the left side (n = 12). The rabbits were sacrificed at 1, 2, and 4 weeks postoperatively, and formalin-fixed specimens were embedded in acrylic resin. The specimens were stained with hematoxylin and eosin. For immunohistochemical analysis, the specimens were treated with BMP-2. RESULTS:: The titanium group and uHA/PLLA group were significantly larger than the control group regarding the bone area ratio postoperatively at 2 and 4 weeks. However, there were no significant differences between the uHA/PLLA group and titanium group regarding the BMP-2. CONCLUSIONS:: This study suggested that the uHA/PLLA mesh could increase new bone formation more than the absence of a mesh in bone defects. However, there was no significant difference between uHA/PLLA mesh and the titanium mesh in bone augmentation.
    Implant dentistry 02/2013; · 1.51 Impact Factor
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    ABSTRACT: Purpose The purpose of this study was to investigate the effects of alar base cinch suture in Le Fort I osteotomy in mandibular prognathism with and without asymmetry. Material and Methods Forty patients who underwent Le Fort I osteotomy were divided into an asymmetry group and a symmetry group (n = 20 each). Computed tomography (CT) was taken in allpatients before and 1 year after surgery. The CT-3D volume rendering data with Aquarius Net(TeraRecon, Foster City, CA, USA) was reconstructed and the soft tissue was measured as follows, thedistance between the bilateral alar base (Alar base width), the distance between the bilateral alar (Alarwidth), the angles between the FH plane and the line between the bilateral alar base (Alar base angle),the angle between the FH plane and the line between the bilateral alar (Alar angle), the angle betweenthe FH plane and the line between the bilateral corners of the mouth (Lip angle), and the anglebetween the perpendicular line to the FH plane and the Philtrum (Philtrum angle). Results Significant differences were observed in the Alar width (P=0.0448), the Alar angle (P=0.0044),the Lip angle (P<0.0001), and the Philtrum angle (P=0.0057) between before and after surgery in theasymmetry group. Conclusions This study suggested that the alar base cinch suture could prevent increases in the alarbase width in both groups and help to improve the angle of soft tissue in the asymmetry group,although alar width significantly increases after surgery.
    Journal of Cranio-Maxillofacial Surgery 01/2013; · 1.61 Impact Factor
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    ABSTRACT: Sinusitis of dental origin is a relatively frequent entity, and odontomas are considered to be the most common odontogenic tumors of the oral cavity. Eruption and infection of odontomas are extremely rare. Here, we report an interesting case where odontoma was found in the wake of the maxillary sinusitis onset.
    Case reports in dentistry. 01/2013; 2013:834715.
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    ABSTRACT: The purpose of this study was to compare retrospectively postoperative differences in maxillary stability after Le Fort I osteotomy and fixation with an unsintered hydroxyapatite (u-HA)/poly-l-lactic acid (PLLA) plate with or without self-setting α-tricalcium phosphate (Biopex(®)) as interpositional material. Subjects comprised 45 patients diagnosed with mandibular prognathism with maxillary retrognathism and mandibular prognathism with bimaxillary asymmetry. All patients underwent Le Fort I osteotomy and bilateral sagittal split ramus osteotomy with fixation by uHA/PLLA plates. Patients were divided into 4 groups consisting of 9 maxillary impaction cases with Biopex(®) (group 1) to fill the gap between the bone segments, 14 maxillary advancement cases with Biopex(®) (group 2), 8 maxillary impaction cases without Biopex(®) (group 3) and 14 maxillary advancement cases without Biopex(®) (group 4). Changes in cepahalometric parameters at time intervals (1, 3 and 12 months) between the groups were compared. Results showed that stability did not depend on the use or otherwise of Biopex(®).
    International Journal of Oral and Maxillofacial Surgery 11/2012; · 1.52 Impact Factor
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    ABSTRACT: PURPOSE: The purpose of this study was to evaluate hypoesthesia of the upper lip and bone formation using self-setting α-tricalcium phosphate (Biopex(®)) between the segments following Le Fort I osteotomy with bent absorbable plate fixation. SUBJECTS AND METHODS: The subjects were 47 patients (94 sides) who underwent Le Fort I osteotomy with and without mandibular osteotomy. They were divided into a Biopex(®) group (48 sides) and a control group (46 sides). The Biopex(®) was inserted into the anterior part of the gap between the segments in the Biopex(®) group. Trigeminal nerve hypoesthesia at the region of the upper lip was assessed bilaterally by the trigeminal somatosensory-evoked potential (TSEP) method. The area of the Biopex(®) at the anterior part in the maxilla was assessed immediately after surgery and 1 year postoperatively by computed tomography (CT). RESULTS: The mean measurable period and standard deviation were 13.2 ± 18.5 weeks in the control group, 14.5 ± 17.9 weeks in the Biopex(®) group, and there was no significant difference in TSEP. The area of the Biopex(®) after 1 year was significantly smaller than that immediately after surgery (right side: P = 0.0024, left side: P = 0.0001) and bone defects between the segments could not be found in the Biopex(®) group. In the control group, although the areas of bone defect after 1 year were significantly smaller than that immediately after surgery on the right side (P = 0.0133) and left side (P = 0.0469) in the frontal view, complete healing of the bone defects could be seen in 12 of 46 sides after 1 year. CONCLUSION: This study suggested that inserting Biopex(®) in the gap between the maxillary segments was useful for new bone formation and it did not prevent the recovery of upper lip hypoesthesia after Le Fort I osteotomy with absorbable plate fixation.
    Journal of cranio-maxillo-facial surgery: official publication of the European Association for Cranio-Maxillo-Facial Surgery 07/2012; · 1.25 Impact Factor
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    ABSTRACT: It is very important to clarify the relationship between a dentofacial structure and a temporomandibular joint (TMJ) structure in orthognathic surgery. Recently, it was reported that the skeletal and occlusal patterns were associated with the TMJ morphology, including the disk position. In orthognathic surgery, some surgeons state that alterations in the condylar position from surgery can lead to malocclusion associated with the risk of early relapse, and also favor the development of temporomandibular disorders. For these reasons, several positioning devices have been proposed and applied, but now there is no scientific evidence to support the use of condylar positioning devices. There are some reasons why scientific evidence cannot be obtained; however, it also includes the question of whether the preoperative position of the condyle is the desired postoperative position. The purpose of this study was to verify the desired condylar position in orthognathic surgery, based on literature on the postoperative condylar position in orthognathic surgery. From the studies reviewed, it was suggested that the preoperative position of the condyle was not the desired postoperative position in orthognathic surgery.
    Oral surgery, oral medicine, oral pathology and oral radiology. 07/2012; 114(5):567-76.
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    ABSTRACT: The purpose of this study was to compare postoperative changes in maxillary stability after Le Fort I osteotomy in three groups: with an unsintered hydroxyapatite (u-HA)/poly-L-lactic acid (PLLA) plate; a PLLA plate; and a titanium plate. Subjects comprised 60 Japanese patients diagnosed with mandibular prognathism. All patients underwent Le Fort I osteotomy and bilateral sagittal split ramus osteotomy. All patients were randomized in groups of 20 to a u-HA/PLLA group, a PLLA plate group and a titanium plate group. Changes in postoperative time intervals between the plate groups were compared using lateral and posteroanterior cephalography. The uHA/PLLA group had significantly larger values than the PLLA group regarding change of mx1-S perpendicular to SN between 3 and 12 months (T3) (P=0.0269). The uHA/PLLA group had a significantly larger value than the PLLA group regarding change of S-A perpendicular to SN between baseline and 1 month (T1) (P=0.0257). There was no significant difference in the other measurements. This study suggests that maxillary stability with satisfactory results could be obtained in the u-HA/PLLA, PLLA plate and titanium plate groups, although there was a slight difference between the u-HA/PLLA and PLLA plate systems in Le Fort I osteotomy.
    International Journal of Oral and Maxillofacial Surgery 04/2012; 41(8):942-8. · 1.52 Impact Factor

Publication Stats

533 Citations
98.48 Total Impact Points

Institutions

  • 2014
    • University of Yamanashi
      • Department of Oral and Maxillofacial Surgery
      Kōhu, Yamanashi, Japan
  • 2001–2011
    • Kanazawa University
      • Department of Oral and Maxillofacial Surgery
      Kanazawa, Ishikawa, Japan
  • 2009
    • Gazi University
      • Department of Oral and Maxillofacial Surgery
      Ankara, Ankara, Turkey
  • 2005
    • Kanazawa Medical University
      • Department of Oral and Maxillofacial Surgery
      Kanazawa, Ishikawa, Japan