L. Mécs

University of Szeged, Szeged, Csongrad megye, Hungary

Are you L. Mécs?

Claim your profile

Publications (19)44.15 Total impact

  • Gyöngyi Horváth, László Mécs
    [Show abstract] [Hide abstract]
    ABSTRACT: It is well known that a multitude of ligands and receptors are involved in the nociceptive system, and some of them increase, while others inhibit the pain sensation both peripherally and centrally. These substances, including neurotransmitters, neuromodulators, hormones, cytokines etc., may modify the activity of nerves involved in the pain pathways. It is also well known that the organism can express very effective antinociception in different circumstances, and during such situations the levels of various endogenous ligands change. Accordingly, a very exciting field of pain research relates to the roles of endogenous ligands. The peripheral action may possibly be extremely important, because low doses of the endogenous ligands may reduce pain without disphoric side-effects, and without the abused potential typical of centrally acting ligands. This review provides a comprehensive overview of the endogenous ligands that can induce antinociception, discusses their effects on different receptors and focuses on their action at peripheral level. We found 17 different endogenous ligands which produced antinociception after their topical administration. The results suggest an important direction for the development of pain strategies that focus on the local administrations of different endogenous ligands.
    Ideggyógyászati szemle 03/2011; 64(5-6):193-207. · 0.35 Impact Factor
  • Source
    Kálmin Tóth, László Mécs, Péter Kellermann
    [Show abstract] [Hide abstract]
    ABSTRACT: Bone saving hip athroplasty is a reasonable option for younger active patients, as they are potential candidates for subsequent revision arthroplasty. In this clinical and radiological study we have evaluated our first 41 consecutive cases of total hip arthroplasty including a DePuy Proxima short stem. Harris Hip Scores (HHS) were calculated preoperatively, and 6,12 and 24 months postoperatively. Mean age at surgery was 49 years (range : 35 to 60), mean follow-up was 26 months (range: 13 to 44). Mean Harris Hip scores increased by 39 and 50 points respectively at 6 and 24 months follow-up. No radiological loosening or migration was observed. In carefully selected young patients when resurfacing is contraindicated, use of the Proxima short stem appears as a simple and effective option for THA. However, longer follow-up time is required to analyse the results and to confirm the durability of the observed clinical out-comes.
    Acta orthopaedica Belgica 10/2010; 76(5):613-8. · 0.63 Impact Factor
  • Osteoarthritis and Cartilage 10/2010; 18. · 4.26 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: 1. Both cannabinoid and opioid receptors are localized at the peripheral level, and drugs acting on these receptors may produce antinociception after topical administration; however, the effect of endogenous ligands at these receptors is poorly understood. Our goal was to determine the antinociceptive potency of the endogenous cannabinoid 2-arachidonoyl-glycerol (2-AG), and its interaction with endomorphin-1 (EM1) at joint level in the rat inflammation model. 2. Mechanical hypersensitivity was produced by injection of carrageenan (300 microg/30 microL) into the tibiotarsal joint of the right hind leg. The mechanical threshold was assessed by von Frey filaments. 2-AG (3-200 microg), EM1 (100-300 microg) and their combinations in a fixed-dose ratio (1 : 10) were given into the inflamed joint, and the threshold was determined repeatedly for 105 min after the drug administrations. 3. Both ligands produced dose-dependent anti-hyperalgesia, and the highest doses caused prolonged effects, but they did not influence the degree of oedema and the withdrawal threshold at the non-inflamed side. EM1 had lower potency compared to 2-AG (ED(25): 233 (CI: 198-268) microg and 126 (CI: 88-162) microg, respectively; P < 0.05). The effects of EM1 and 2-AG were prevented by mu-opioid and cannabinoid 1 receptor antagonists, respectively. The ED(25) value for the combination (98 (CI: 80-112) microg) did not differ significantly from the value of 2-AG; however, the largest dose combination produced a significantly higher effect than the ligands by themselves. 4. Our data showed that 2-AG was an effective antinociceptive ligand at joint level, and its combination with EM1 produced long-lasting, effective antinociception.
    Clinical and Experimental Pharmacology and Physiology 05/2010; 37(5-6):544-50. · 2.41 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Several data suggest that both opioid and N-methyl-d-aspartate (NMDA) receptors are localized at the peripheral level, and drugs acting on these receptors may produce antinociception after topical administration; however, the antinociceptive effect of endogenous ligands at these receptors is poorly clarified. Our goal in this study was to determine the antinociceptive potency of the endogenous opioid peptide, endomorphin-1 (EM1), and the endogenous NMDA receptor antagonist, kynurenic acid (KYNA), and their interaction at the peripheral level in the rat inflamed joint model. Mechanical hypersensitivity was produced by injection of carrageenan (300 microg/20 microL) into the tibiotarsal joint of the right hind leg. The mechanical pain threshold was assessed by von Frey filaments (0.064-110 g). EM1 (30, 100, and 200 microg), KYNA (30, 100, 200, and 400 microg), and their combinations in a fixed-dose ratio (1:1) were injected into the inflamed joint, and the pain threshold was determined repeatedly for 75 min after the drug administrations. Neither EM1 nor KYNA administered to the inflamed joint influenced the pain threshold at the noninflamed side. Both ligands produced dose-dependent antihyperalgesia, and the highest doses caused a prolonged effect. EM1 had higher potency (30% effective dose [ED(30)] and 50% effective dose [ED(50)] values were 112 microg [confidence interval {CI}: 80-146] and 167 microg [CI: 135-220], respectively) compared with KYNA (ED(30) and ED(50) values were 204 microg [CI: 160-251] and 330 microg [CI: 280-407], respectively). The antinociceptive effect of EM1 was prevented by subcutaneous naltrexone pretreatment. The coadministration of EM1 with KYNA caused an enhanced and/or prolonged antinociceptive effect. The ED(30) and ED(50) values of the combination were 141 microg [CI: 83-182] and 231 microg [CI: 190-293], respectively, which did not differ significantly from the theoretically additive values (ED(30) and ED(50) values were 145 microg [CI: 68-237] and 220 microg [CI: 144-230], respectively), thus the interaction between these ligands is additive. None of the treatments caused any sign of side effects. Peripherally administered endogenous opioid agonist and NMDA receptor antagonist ligands might be beneficial in inflammatory pain. Because both drugs barely cross the blood-brain barrier, their local administration causes no central side effects.
    Anesthesia and analgesia 10/2009; 109(4):1297-304. · 3.08 Impact Factor
  • Osteoarthritis and Cartilage 09/2009; 17. · 4.26 Impact Factor
  • Osteoarthritis and Cartilage 09/2009; 17. · 4.26 Impact Factor
  • Osteoarthritis and Cartilage 09/2009; 17. · 4.26 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The purpose of this investigation was to further elucidate calorimetric properties of cartilage samples from femoral head necrosis and osteoarthritis from live surgeries. The natural course of this disease is one of steady progression with eventual collapse of the femoral head, followed by secondary osteoarthritis in the hip joint. All samples showed a clear denaturation peak on the calorimetric curve. Cartilage obtained from necrotic femoral head required the lowest amount of energy for decomposition. The use differential scanning calorimetry as part of thermal analysis was a reliable method for differentiating.
    Journal of Thermal Analysis and Calorimetry 03/2009; 95(3):801-804. · 1.98 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The purpose of this study was to further characterize the altered metabolism spondylolisthesis that promotes disease progression. Degenerative human cartilage (intervertebral disc, facet joint and vertebral end-plate) was obtained during 15 posterior lumbar spine interbody fusion procedures performed at the University of Szeged. The thermal properties of samples were determined by differential scanning calorimetry (Mettler-Toledo DSC 821e). Greatest change in the enthalpy was observed in the intervertebral disc samples: −1600.78 J g−1. Denaturation caused by heating in the normal human hyaline cartilage needed −1493.31 J g−1 energy. Characterization of the altered metabolism that promotes disease progression should lead to future treatment options.
    Journal of Thermal Analysis and Calorimetry 02/2009; 95(3):809-811. · 1.98 Impact Factor
  • Osteoarthritis and Cartilage 01/2009; 17. · 4.26 Impact Factor
  • Osteoarthritis and Cartilage 01/2009; 17. · 4.26 Impact Factor
  • Frontiers in Systems Neuroscience 01/2009;
  • [Show abstract] [Hide abstract]
    ABSTRACT: 1. Although it is well known that the combined administration of synthetic or plant-originated opioids with cannabinoids (CB) results in synergistic antinociception, the effects of combined administration of endogenous ligands acting at micro-opioid and CB receptors are not known. The aim of the present study was to determine the interaction between anandamide (AEA; a CB(1) receptor agonist) and endomorphin-1 (EM-1; a micro-opioid receptor agonist) after intrathecal administration. 2. Nociception was assessed by the paw-withdrawal test after carrageenan-induced inflammation in male Wistar rats. 3. Endomorphin-1 (16.4 pmol to 16.4 nmol) and AEA (4.3-288 nmol) alone dose-dependently decreased carrageenan-induced thermal hyperalgesia, although the highest dose of AEA also exhibited pain-inducing potential. The potency of AEA was approximately 59-fold lower than that of EM-1 (35% effective dose (ED(35)) 194.4 vs 3.3 nmol, respectively). Coadministration of these ligands revealed that combinations of 16.4 pmol EM-1 plus 28.8 or 86.5 nmol AEA were more effective than either drug alone, but other combinations were no more effective than the administration of EM-1 itself. Therefore, coadministration of AEA did not significantly shift the dose-response curve to EM-1. 4. The results of the present study indicate that the coadministration of AEA and EM-1 results in potentiated antihyperalgesia only for a combination of specific doses. Because AEA activates other receptor types (e.g. TRPV1) in addition to CB(1) receptors, the results of the present suggest that, after the coadministration of EM-1 and AEA, complex interactions ensue that may lead to different outcomes compared with those seen following the injection of exogenous ligands.
    Clinical and Experimental Pharmacology and Physiology 11/2008; 36(4):400-5. · 2.41 Impact Factor
  • L. Mécs, G. Sohár, K. Tóth
    Osteoarthritis and Cartilage 01/2008; 16. · 4.26 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A 65-year-old patient presented with severe osteoarthritis of the knee, 47 years after a severe polytrauma in which he had presented diaphyseal fractures of the left femur and tibia. These fractures had been treated conservatively and had healed with major deformities. He underwent total knee arthroplasty with navigation assistance. This allowed for optimal component positioning and restoration of a correct limb alignment. The early functional result was excellent. Navigation assistance appears of particular interest for total knee arthroplasty in such cases with complex post-traumatic diaphyseal deformities.
    Acta orthopaedica Belgica 09/2007; 73(4):536-40. · 0.63 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Authors describe a method of therapy of hallux valgus not yet published in this country. Its advantage is that as a consequence of the shortening of the proximal phalanx the tension of the soft tissues is decreased and as a final result the movement occurs between the original cartilaginous surfaces.
    Magyar traumatológia, orthopaedia és helyreállító sebészet 02/1992; 35(2):126-30.
  • I Jókai, K Tóth, L Mécs
    Magyar traumatológia, orthopaedia és helyreállító sebészet 02/1990; 33(1):60-2.
  • [Show abstract] [Hide abstract]
    ABSTRACT: A case with diabetic osteoarthropathy, destruction of the talus and medial dislocation of the ankle joint is presented. After cleaning up a purulent skin process above the lateral malleolus, caused by the malposition, a calcaneocrural arthrodesis was performed, with a fixateur externe. In the authors' opinion therapy should aim to preserve the limb; this is to be preferred to amputation even in cases with very severe deformities. An arthrodesis with correction of the malposition is recommended as the method of choice.
    Zeitschrift für Orthopädie 127(6):701-5. · 0.86 Impact Factor