Xuanzhi Zhang

Central South University, Changsha, Hunan, China

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Publications (5)4.41 Total impact

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    ABSTRACT: The X-ray repair cross-complementing group 3 (XRCC3), one of the DNA repair genes, was suggested to play an imperative role in the development of carcinogenesis. The objective of this study was to evaluate the role of the XRCC3 T241M polymorphism in bladder cancer susceptibility in a Chinese population. We genotyped 150 bladder cancer cases and 150 healthy controls who had been frequency matched to cases by age and sex. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism analysis. A significant association was found between smoker and bladder cancer [odds ratio (OR)=1.97, 95% confidence interval (CI)=1.24-3.13, p=0.004]. The XRCC3 241MM genotype was more frequent in the bladder cancer group than in the healthy controls group (OR=3.22, 95% CI=1.14-9.11, p=0.03). There were no significant associations between any genotypes and the stage, grade, and histological type of bladder cancer. Our study suggested an increased risk role of XRCC3 241MM genotype in bladder cancer susceptibility in a Chinese population.
    Genetic Testing and Molecular Biomarkers 02/2012; 16(6):640-3. · 1.44 Impact Factor
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    ABSTRACT: To review the technical details of retroperitoneoscopic ureterolithotomy and evaluate the clinical effect. Between June 2004 and December 2008, 69 patients (55 males and 14 females) with upper ureteral calculus received retroperitoneal laparoseopic ureterolithotomy (40 left sides and 29 right sides). The stone size ranged from 1.5 to 3.1 cm [(2.2±0.6) cm]. All the patients underwent retroperitoneoscopic ureterolithotomy. The operation time was 40-295 (63.1±19.8) min,and the blood loss was 30-150 (57.2±23.0) mL.The hospital stay was 5-8 (6.7±1.3) d. During the followup, there was neither ureteral stricture nor recurrent calculus. Retroperitoneoscopic ureterolithotomy is safe, effective and minimally invasive, which may replace the conventional open surgery.
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 08/2011; 36(8):791-3.
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    ABSTRACT: To observe the effect of extracorporeal shock wave lithotripsy (ESWL) on residual stones after different methods of surgery. Clinical resources of 100 patients with residual stones after different methods of surgery treated with extracorporeal shock wave lithotripsy from May 2006 to May 2008 were retrospectively studied. Of the 100 patients, ureteroscopic laser lithotripsy was used for 15 patients (Group I), ureteroscopic pneumatic lithotripsy was used for 25 (Group II), mini-percutaneous nephrolithotomy (MPCNL) with holmium laser for 11 (Group III), mini-percutaneous nephrolithotomy (MPCNL) with air pressure path lithotripter for 12 (Group IV), open surgery for the other 37 (Group V). About 94% of the residual stones were shattered, and 86% of the residual stones were cleared successfully. The clearance rate of residual stones from Group Ito V was 100%, 100%, 81.8%, 83.3%, and 73.0%, respectively. The clearance rate of residual stones in Group I+II was higher than that of Group III+IV and Group V(P<0.05). Extracorporeal shock wave lithotripsy is good for the treatment of residual stones after different methods of surgery, especially the management of residual stones after trans-urethral ureteroscope technique.
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 07/2009; 34(7):634-7.
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    ABSTRACT: Leiomyosarcoma is a rarely seen neoplasm of the ureter, with less than 20 cases being reported in the literature to date. It is important to distinguish leiomyosarcoma from rhabdomyosarcoma, with the aid of immunohistochemical markers. We report the clinical features, histology, imaging and treatment of ureteral leiomyosarcoma in a female patient.
    Asian Journal of Surgery 11/2008; 31(4):191-4. · 0.54 Impact Factor
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    ABSTRACT: Penile amputation and successful replantation is very uncommon, and routine standardized procedures for dealing with this medical condition do not exist. A case of a penile amputation and successful replantation is presented. This report presents the microsurgical procedure and postoperative care that led to successful engraftment and function. Of particular interest was the use of hyperbaric oxygen to accelerate the healing process. A review of the published data and future methods of increasing success of such surgical procedures is provided.
    Urology 06/2007; 69(5):983.e3-5. · 2.42 Impact Factor