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ABSTRACT: A simple "proof-of-principle" concept for the monitoring of G-quadruplex formation and nuclease activity based on the unique self-assembly properties of a platinum(II) terpyridyl complex, has been demonstrated.
Chemical Communications 08/2009; · 6.17 Impact Factor
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ABSTRACT: Glucose binding to boronic acid functional groups attached to a synthetic polymer in an aqueous solution effectively turns the polymer into a polyanion, which induces the aggregation of the positively charged trimethylpentylammonium pyrene derivative, leading to a strong excimer emission and the development of a ratiometric fluorescence glucose probe.
Chemical Communications 04/2009; · 6.17 Impact Factor
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ABSTRACT: Polyelectrolytes carrying multiple negative charges were found to induce the aggregation and self-assembly of the positively charged platinum(II)-terpyridyl complexes in aqueous media. The aggregation and self-assembly of the complexes were driven by electrostatic interactions between the polymer and the complex, and by terpyridine ligand pi-pi stacking and platinum-platinum (metal-metal) interactions. As a result, remarkable UV/Vis and emission spectral changes were observed. The spectroscopic property changes were related to the structural properties of the metal complexes as well as the polyelectrolytes. The induced self-assembly of the platinum complexes was also strongly affected by the solution properties of the aqueous media, for example, the solution pH, ionic strength, and the percentage of organic solvent added.
Chemistry 02/2008; 14(15):4577-84. · 5.93 Impact Factor
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ABSTRACT: Single-stranded nucleic acids, which carry multiple negative charges in an aqueous medium at near neutral pH, are found to induce the aggregation and self-assembly of the positively charged alkynylplatinum(II) terpyridyl complexes via electrostatic binding of the platinum complexes to the single-stranded nucleic acids, as revealed by the appearance of new UV-vis absorption and emission bands upon addition of single-stranded nucleic acids to a buffer solution of the complex. Changes in the intensity and pattern of circular dichroism (CD) spectroscopy are also observed, many of which are consistent with the assembly of the platinum complexes into helical structures, via metal...metal and pi...pi stacking interactions. The induced spectroscopic property changes are found to depend on the structural properties of the nucleic acids.
Proceedings of the National Academy of Sciences 01/2007; 103(52):19652-7. · 9.68 Impact Factor
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Angewandte Chemie International Edition 02/2005; 44(5):791-4. · 13.45 Impact Factor
