Publications (12)25.94 Total impact
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Article: Induced lentiginosis with use of topical calcineurin inhibitors.
Archives of dermatology 06/2012; 148(6):766-8. · 4.76 Impact Factor -
Article: Cutaneous reaction to inhaled treprostinil.
Journal of the American Academy of Dermatology 10/2011; 65(4):e123-4. · 3.99 Impact Factor -
Article: Febrile ulceronecrotic Mucha-Habermann disease in a 34-month-old boy: a case report and review of the literature.
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ABSTRACT: We report a case of febrile ulceronecrotic Mucha-Habermann disease (FUMHD) in a 34-month-old boy. Our patient had a history of biopsy-proven pityriasis lichenoides et varioliformis acuta (PLEVA) since age 2. At 34 months, his skin lesions rapidly progressed to ulceration and necrosis in the setting of high fever. Skin biopsy revealed an intense lichenoid infiltrate with parakeratosis at the edges of areas of epidermal necrosis consistent with FUMHD, which is the severe variant of PLEVA. Despite initial treatment with prednisolone, his disease progressed to involve more than 50% of his body surface area. In addition to corticosteroids, he was treated with intravenous immunoglobulin, dapsone, and acyclovir, without complete resolution of disease. Methotrexate successfully cleared his skin disease and systemic symptoms. This patient highlights the exceptional response of FUMHD to methotrexate. Based on our review of the literature, this also represents the youngest reported case of FUMHD.Pediatric Dermatology 09/2011; 29(1):53-8. · 1.07 Impact Factor -
Article: Leclercia adecarboxylata cellulitis in a child with acute lymphoblastic leukemia.
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ABSTRACT: Leclercia adecarboxylata is a rare, gram-negative rod that has been infrequently reported in the literature. The organism has been documented to cause solitary infections in immunocompromised hosts and polymicrobial wound infections in the immunocompetent. We present a case of an 8-year-old boy with significant past medical history of acute lymphoblastic leukemia who developed cellulitis due to local infection by L. adecarboxylata. This case is presented to raise awareness of this rare organism's ability to cause common cutaneous disease, especially in the immunocompromised.Pediatric Dermatology 03/2011; 28(2):162-4. · 1.07 Impact Factor -
Article: Picture of the month--quiz case. Halo scalp ring.
Archives of pediatrics & adolescent medicine 07/2010; 164(7):673. · 3.73 Impact Factor -
Article: Terminology used to describe vascular anomalies.
Archives of pediatrics & adolescent medicine 02/2010; 164(2):203-4; author reply 204-5. · 3.73 Impact Factor -
Article: Picture of the month. Eyelid pilomatricoma.
Archives of pediatrics & adolescent medicine 10/2009; 163(10):955-6. · 3.73 Impact Factor -
Article: Stevens-Johnson syndrome and toxic epidermal necrolysis: consequence of treatment of an emerging pathogen.
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ABSTRACT: We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection. Although the association between SJS/TEN and the sulfonamide class of antibiotics is well established, the increasing prevalence of CA-MRSA has left practitioners with limited regimens to effectively treat skin and soft tissue infections (SSTIs) in the outpatient setting. In the case of SSTIs, alternative treatment of these infections should be considered, especially when the bacterial pathogen is unknown. Future investigations evaluating the efficacy of adjunctive antibiotics for purulent SSTIs and monitoring the incidence of SJS/TEN in the era of CA-MRSA are necessary to reduce unnecessary use of sulfonamide drugs. The potential development of SJS/TEN, a severe life-threatening illness, emphasizes the need for judicious use of TMP-Sx and close monitoring and follow-up for patients who were given TMP-Sx for SSTIs.Pediatric emergency care 09/2009; 25(8):519-22. · 0.92 Impact Factor -
Article: Beyond first-line treatment: management strategies for maintaining acne improvement and compliance.
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ABSTRACT: The management of acne vulgaris is a long-term process that must be individualized to each patient. Relevant factors influencing treatment include the age and gender of the patient, the severity and extent of disease, the efficacy and tolerability of prior interventions, and the degree of compliance with recommended therapies. The follow-up phase of acne management requires a framework for approaching treatment modification that may include concepts such as up-titration, add-on, or switching of available agents to improve efficacy and tolerability. Whenever oral antibiotics are used, abrupt discontinuation in favor of topical maintenance therapy rather than gradual tapering is recommended. Strategies for assessing and optimizing medical adherence are reviewed.Cutis; cutaneous medicine for the practitioner 09/2008; 82(2 Suppl 1):18-25. · 0.81 Impact Factor -
Article: Antimicrobial peptides: effectors of innate immunity in the skin.
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ABSTRACT: The ability of the cutaneous barrier to help defend the body against pathogens relies on both acquired and innate immune responses. Recently, a large body of research has suggested that a critical component of the innate immune response in the skin is 3 antimicrobial peptides: the cathelicidins, defensins, and dermcidins. These 3 classes of peptides have been shown to act as antimicrobials by directly inhibiting pathogen growth as well as potentiating other branches of the innate, humoral, and cell-mediated immune system. Here, we review the antimicrobial peptides with an emphasis on their role in the cutaneous immune response. We present an overview of defensin, cathelicidin, and dermcidin physiology, elucidating their various functions. In addition, we delve into the role of these peptides in specific dermatologic conditions including wound healing, atopy, and microbial infection. Finally, we discuss the future of antimicrobial peptide research including therapeutic options.Advances in Dermatology 02/2005; 21:357-74. -
Article: Nonpigmenting confluent and reticulated papillomatosis.
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ABSTRACT: We report three teenaged Caucasian patients with confluent and reticulated papillomatosis whose presentation was atypical due to the absence of hyperpigmentation and presence of a fine white scale.Pediatric Dermatology 23(5):497-9. · 1.07 Impact Factor -
Article: Ulceroglandular tularemia.
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ABSTRACT: A 14-year-old boy presented with fevers and nonspecific flu-like symptoms, as well as an enlarging ulcerated plaque involving the upper back, lymphadenopathy, and bilateral pulmonary nodules. Bacterial cultures of ulcer tissue grew Francisella tularensis on enriched chocolate agar plates. Making the diagnosis requires a high index of suspicion, and communication with the laboratory to successfully and safely culture these highly pathogenic bacteria is imperative.Pediatric Dermatology 28(3):318-20. · 1.07 Impact Factor
Top co-authors
Top Journals
Institutions
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2011
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University of Pennsylvania
- Department of Medicine
Philadelphia, PA, USA
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2008–2011
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The Children's Hospital of Philadelphia
- Department of Pediatrics
Philadelphia, PA, USA
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