B C Koner

Maulana Azad Medical College, New Dilli, NCT, India

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Publications (52)77.67 Total impact

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    ABSTRACT: Contrast-induced acute kidney injury (AKI) is diagnosed by estimating serum creatinine at 48-72h after diagnostic or interventional coronary angiography. It is too late for an early intervention. Neutrophil gelatinase associated lipocalin (NGAL) and cystatin C are novel markers of AKI. We determined the optimum cut off level of NGAL and cystatin C in early diagnosis and prediction of AKI in patients undergoing coronary angiography followed by angioplasty. In a nested case control study, serum NGAL, cystatin C by ELISA and serum creatinine by Jaffe's kinetic method were estimated at 0, 4, 24 and 48h of coronary angiography followed by angioplasty in 30 cases who developed contrast-induced AKI and 30 subjects who did not develop AKI. eGFR was estimated for both cases and controls by the MDRD equation. ROC was used to determine optimum cut-off. Serum NGAL increased sharply at 4h after the procedure and then gradually declined to near normal level at 48h in AKI cases. The rise in cystatin C peaked at 24h and then declined but remained high till 48h. In controls, they remained static. Optimum cut-off of serum NGAL and cystatin C was 155.2ng/ml and 0.517mg/l respectively at 4h and 89.5ng/ml and 0.99mg/l respectively at 24h of angiography. Odds ratio for hypertensives to develop AKI was 3.57 (CI: 1.2-11.1, P=0.03). Serum NGAL and cystatin C may act as early markers of contrast-induced AKI in patients undergoing percutaneous coronary intervention. Patients with hypertension are susceptible to develop contrast-induced AKI.
    Clinica chimica acta; international journal of clinical chemistry 05/2014; · 2.54 Impact Factor
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    ABSTRACT: The present study evaluated the effect of psychological stress on male fertility hormones and seminal quality in male partner of infertile couples. Seventy male partners of infertile couples were evaluated for level of psychological stress using Hospital Anxiety and Depression Score (HADS) questionnaire, serum total testosterone, luteinising hormone (LH) and follicle-stimulating hormone (FSH) by electrochemiluminescence assay and serum GnRH by ELISA. Seminal analysis was performed as per WHO guideline. Nineteen (27%) of them had HADS anxiety and depression score ≥8 (abnormal HADS score). The persons having abnormal HADS had lower serum total testosterone, higher serum FSH and LH than those of persons having normal HADS. Serum total testosterone correlated negatively with HADS, but LH and FSH correlated positively. There was no change in GnRH with the change in stress or testosterone levels. Sperm count, motility and morphologically normal spermatozoa were lower in persons having abnormal HADS. Sperm count correlated positively with total testosterone and negatively with FSH and LH. Abnormal sperm motility and morphology were related to lower testosterone and higher LH and FSH levels. Psychological stress primarily lowers serum total testosterone level with secondary rise in serum LH and FSH levels altering seminal quality. Stress management is warranted for male infertility cases.
    Andrologia 03/2014; · 1.55 Impact Factor
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    ABSTRACT: Background Contrast-induced acute kidney injury (AKI) is diagnosed by estimating serum creatinine at 48–72 h after diagnostic or interventional coronary angiography. It is too late for an early intervention. Neutrophil gelatinase associated lipocalin (NGAL) and cystatin C are novel markers of AKI. We determined the optimum cut-off level of NGAL and cystatin C in early diagnosis and prediction of AKI in patients undergoing coronary angiography followed by angioplasty. Methods In a nested case control study, serum NGAL, cystatin C by ELISA and serum creatinine by Jaffe's kinetic method were estimated at 0, 4, 24 and 48 h of coronary angiography followed by angioplasty in 30 cases who developed contrast-induced AKI and 30 subjects who did not develop AKI. eGFR was estimated for both cases and controls by the MDRD equation. ROC was used to determine the optimum cut-off. Results Serum NGAL increased sharply at 4 h after the procedure and then gradually declined to near normal level at 48 h in AKI cases. The rise in cystatin C peaked at 24 h and then declined but remained high till 48 h. In controls, they remained static. The optimum cut-off of serum NGAL and cystatin C was 155.2 ng/ml and 0.517 mg/l respectively at 4 h and 89.5 ng/ml and 0.99 mg/l respectively at 24 h of angiography. Odds ratio for hypertensives to develop AKI was 3.57 (CI: 1.2–11.1, p = 0.03). Conclusion Serum NGAL and cystatin C may act as early markers of contrast-induced AKI in patients undergoing percutaneous coronary intervention. Patients with hypertension are susceptible to develop contrast-induced AKI.
    Clinica Chimica Acta. 01/2014; 435:48–52.
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    ABSTRACT: OBJECTIVE: To study the renal function in term newborns with perinatal asphyxia including urinary excretion of β2 microglobulin (β2M). METHODS: This case control study included 50 term newborn babies with perinatal asphyxia and 50 normal babies as matched controls. In all cases, asphyxia grading (using Apgar score) and Hypoxic ischemic encephalopathy (HIE) staging (Sarnat and Sarnat) were done. Blood and urinary parameters (including β2M) for renal function were done in all and Fractional excretion of sodium (FENa) and Renal failure index (RFI) were calculated. The renal parameters were compared within subgroups as well as controls using analysis of variance test and the independent samples t test. RESULTS: Acute kidney Injury (AKI) was noted in 56 % of cases (24 % prerenal and 32 % intrinsic type). All 9 babies who died had AKI. Serum parameters like urea, creatinine, sodium and potassium had better correlation with the renal function as compared to urine parameters. All individual urine parameters except β2M showed wide variations. FENa, RFI and urinary β2M increased with increasing severity of asphyxia and HIE staging. CONCLUSION: AKI is common in term babies with perinatal asphyxia. FENa and RFI are useful parameters for assessing the renal function and urinary β2M is a good biomarker for diagnosis and prognosis of acute tubular injury in term babies with perinatal asphyxia.
    The Indian Journal of Pediatrics 06/2013; · 0.72 Impact Factor
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    ABSTRACT: INTRODUCTION: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphism, FokI, is reported to increase the risk of many cancers. Role of vitamin D and its receptor polymorphisms in ovarian cancer has not been clearly defined. OBJECTIVE: To study the levels of serum vitamin D and occurrence of vitamin D receptor gene polymorphism (FokI) in cases of ovarian cancer. MATERIAL AND METHODS: FokI genotyping was done by PCR-RFLP technique and vitamin D levels were estimated by chemiluminescence immunoassay. RESULTS: Serum vitamin D levels were significantly (p < 0.03) lower in ovarian cancer cases as compared to controls. The homozygous (TT) and heterozygous (CT) genotype predispose to the development of ovarian cancer in Indian population (OR: 2.37, 95% CI: 1.04-5.44) as compared to the homozygous (CC) genotype. Vitamin D deficiency and VDR gene polymorphism (FokI) act non-synergistically (p value < 0.4). CONCLUSION: Low blood levels of vitamin D and VDR receptor polymorphism (FokI) might be a risk factor for the development of ovarian cancer. Other novel ligands of vitamin D receptor might be responsible for the non-synergistic effect.
    Journal of Ovarian Research 05/2013; 6(1):37. · 2.43 Impact Factor
  • Padmanaban S Suresh, Bidhan Chandra Koner
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    ABSTRACT: Total and differential leucocyte count (TLC and DLC) in blood circulation influence humoral immune response and stress alters TLC and DLC by leucocyte misdistribution. Chlordiazepoxide, a widely used benzodiazepine anti-stress agent, is reported to reverse suppression of antibody response induced by acute stress but not by chronic stress. The effect of chlordiazepoxide on the changes in leucocyte count by acute and chronic stress has not been clearly defined. We examined the effect of restraint stress (1 h/day) for 6, 10, 14 and 21 days on TLC and DLC and their modulation by chlordiazepoxide pretreatment (10 mg/kg/day) 1 h before exposure to stress in albino rats. Acute stress, i.e. restraint stress (1 h/day) for 6 and 10 days with or with out chlordiazepoxide pretreatment did not alter TLC and DLC. Chronic stress, i.e. restraint stress (1 h/day) for 14 and 21 days significantly decreased TLC and the percentage of lymphocytes in comparison to control. Pretreatment with chlordiazepoxide reversed these changes. We conclude that chlordiazepoxide, a benzodiazepine, reverses changes in TLC and DLC probably by improving chronic stress-induced leucocytes misdistribution.
    Immunopharmacology and Immunotoxicology 01/2012; 34(4):586-9. · 1.36 Impact Factor
  • S Asmathulla, Bidhan Chandra Koner, D Papa
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    ABSTRACT: Pregnancy-induced hypertension (PIH) is associated with oxidative stress and low plasma proteins. This study explored the effect of oxidative stress on plasma protein level in PIH. Serum total proteins (TP), albumin, globulin, malondialdehyde, protein carbonyls (PC) and protein bound sialic acid (PBSA) were measured in gestational hypertensive, pre-eclamptic, eclamptic and healthy pregnant women (n=20/group). Serum proteins were separated by electrophoresis for assessing protein damage. Serum TP and albumin decreased and malondialdehyde, PC & PBSA increased significantly in all PIH subgroups as compared to healthy pregnant subjects. Serum globulin levels decreased only in eclampsia. Malondialdehyde and PC negatively correlated with albumin level. Protein fragmentation and aggregation in eclampsia were evident from electrophoretogram. We conclude that oxidative damages to proteins contribute to decreased serum protein levels in PIH and hypersialylation of plasma proteins is probably body’s protective mechanism to combat oxidative protein damage in PIH.
    Acta Physiologica Hungarica 09/2011; 98(3):339-46. · 0.88 Impact Factor
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    ABSTRACT: Matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9, have been reported as putative tumor markers because of their involvement in cancer invasion and metastasis. The aim of our study was to elucidate the possible role of MMP-2 and -9 as serum prognostic biomarker for breast cancer classification and correlate it with the clinicopathological variables. Our study consisted of 60 females with primary breast cancer, 40 cases of benign breast disease and 60 healthy female volunteers as controls. The serum MMP-2 and -9 levels were quantitatively measured by ELISA technique. A significantly raised MMP-2 and MMP-9 levels were observed in breast cancer patients. Significant rise in serum MMP-9 concentration was found in patients presenting with metastasis as well as in those cases who presented with a duration of less than 1year. ROC analyses depicted a serum cutoff value of 315ng/mL for MMP-9 to discriminate the breast cancer patients from the control group. Our results suggest that serum MMP-9 level is a better marker than serum MMP-2 in predicting the breast cancer development and progression.
    Clinical biochemistry 07/2011; 44(10-11):869-72. · 2.02 Impact Factor
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    ABSTRACT: Lead poisoning is most commonly caused by occupational exposure. It presents with a myriad of signs and symptoms ranging from mild anemia to frank encephalopathy, depending on the blood lead levels as well as the duration of exposure. Intake of herbal/Ayurvedic medicine may also lead to plumbism as heavy metals are often incorporated in such medications with the belief that such metals have medicinal properties. We report a case of lead poisoning caused by Ayurvedic medication. The patient presented with symptoms of intestinal obstruction to the surgical casualty. The patient presented with symptoms that mimicked intestinal obstruction. No specific etiology could be determined. Serum lead levels were determined and diagnosis of lead poisoning ascertained. The lead content of the medicine was analyzed and it contained 30% w/w lead. The diagnosis of heavy metal poisoning consequent to intake of alternative medicine must be kept in mind when a patient presents with vague complaints.
    Clinica chimica acta; international journal of clinical chemistry 10/2010; 412(1-2):213-4. · 2.54 Impact Factor
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    ABSTRACT: This study was carried out to assess whether the postprandial urinary alkaline tide, as a marker for the completeness of vagotomy, is dependent on the nature of the test meal, whether it is affected by proton pump inhibitor therapy, and whether it is reliable. The postprandial urinary alkaline tide (PUAT) pattern was prospectively assessed in three different study groups and one control group of healthy volunteers. The three study groups were as follows; A (n = 20) i.e. the Proton Pump Inhibitor (PPI) Group; B (n = 25) i.e. the Truncal Vagotomy (TV) Group; and C (n = 5) i.e. the Recurrent Ulcer (RU) Group. Urinary pH was measured by a pocket digital pH meter. Postprandial urinary alkaline tide in the control group was significantly higher compared to the fasting levels. Liquid diet did not elicit a significant urinary alkaline tide response. There was a statistically significant fall in both fasting urinary pH (5.34 +/- 0.70 vs. 4.80 +/- 0.61, p = 0.031) and the postprandial alkaline tide (6.99 +/- 0.79 vs. 4.94 +/- 0.63, p = 0.0001) after taking proton pump inhibitors. In the truncal vagotomy and gastrojejunostomy group it was found that there was a significant fall in both the mean fasting (5.28 +/- 0.58, vs. 4.92 +/- 0.66, p = 0.032) and the postprandial urinary pH (6.29 +/- 0.92 vs. 5.09 +/- 0.73, p = 0.0001) following surgery. This study establishes that simple measurement of the urinary pH before and after a standard test meal can be used as an accurate routine test for the completion of vagotomy. It also showed that proton pump inhibitors abolish the alkaline tide and therefore must be discontinued before measuring the alkaline tide. Liquid test meal was not effective in eliciting an alkaline tide as compared to a solid meal.
    Tropical gastroenterology: official journal of the Digestive Diseases Foundation 01/2010; 30(2):91-4.
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    ABSTRACT: Oxidative stress is implicated as a common pathologic mechanism contributing to the initiation and progression of hepatic damage in a variety of liver disorders. Present study attempts to evaluate the hepatoprotective activity of picroliv, curcumin and ellagic acid in comparison to silymarin using paracetamol (PCM) induced acute liver damage. Hepatotoxicity was induced by administering a single oral dose of PCM (500 mg/kg) and was assessed by quantifying the serum enzyme activities, phenobarbitone induced sleeping time and histopathological analysis of liver tissues. The antioxidant parameters, malondialdehyde (MDA), reduced glutathione (GSH) and catalase of the liver tissue were also assessed. The herbal drugs were administered for 7 days by oral route at 50 and 100 mg/kg. PCM induced hepatic damage was manifested by a significant increase in the activities of marker enzymes (alanine transaminase, aspartate transaminase and alkaline phosphatase) in serum and MDA level in liver. There was also a significant decrease in activity of GSH and catalase levels. The histopathological examination on toxic models revealed centrizonal necrosis and fatty changes. Pretreatment of mice with picroliv, curcumin and ellagic acid reversed these altered parameters towards normal values, which were compared with silymarin. The normalization of phenobarbitone induced sleeping time suggests the restoration of liver cytochrome P450 enzymes. This study supports the use of these active phytochemicals against toxic liver injury, which may act by preventing the lipid peroxidation and augmenting the antioxidant defense system or regeneration of hepatocytes. These active phytochemicals may be developed as drugs for the treatment of liver diseases.
    Fundamental and Clinical Pharmacology 08/2009; 23(6):735-45. · 1.99 Impact Factor
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    ABSTRACT: Polyherbal formulations available with a wide range of indications like protective to liver, appetite and growth promoters, gastrointestinal and hepatic regulator, as treatment for hepatic dysfunction, for hepatic regeneration as well as liver stimulant and tonic. Despite the widespread use, there is a lack of scientific evidence on their efficacy and safety. This study was undertaken to evaluate the hepatoprotective activity of six commercially available formulations, namely Liv 52, Livergen, Livokin, Octogen, Stimuliv and Tefroliv in acute liver toxicity in mice model induced by paracetamol (PCM). Swiss albino mice of either sex were used, divided in 28 groups with six in each group. The dose of the polyherbal formulations was calculated from human dose (20 ml/day) using a standard conversion table. They were given as pretreatment (2.60 ml/kg/day) for 7 days by oral route twice a day prior to PCM administration. Hepatotoxicity was induced by administering a single oral dose of PCM (500 mg/kg bw) on day 8. The study parameters were conducted on day 9. The biochemical parameters included liver enzyme levels alanine tranaminases (ALT), aspartate transaminases (AST) and alkaline phosphatase (ALP). The pharmacological and pathological parameters were phenobarbitone sleeping time and macroscopic and microscopic changes of liver tissues respectively. PCM toxicity significantly increased ALT, AST and ALP (321.00 +/- 87.93, 273.17 +/- 45.68, 257.50 +/- 17.64 IU/l vs normal control, 33.33 +/- 0.61, 89.33 +/- 9.50, 152.17 +/- 11.40 IU/l respectively, P<0.05), prolonged phenobarbitone induced sleeping time (from 277.50 +/- 8.04 min to 335.83 +/- 7.00 min, P<0.05). When PCM higher dose (1g/kg p.o. single dose) was used, the liver tissue, in macroscopic appearance, showed extensive necrosis associated with haemorrhages. Low dose (500 mg/kg p.o. single dose) showed punctate haemorrhagic necrosis of liver tissue. In the microscopic studies, PCM induced toxicity showed haemorrhages, fatty changes and necrosis. The pretreatment in low doses (2.6 ml/kg/day) with liquid formulations of Liv 52 and Livergen reversed the PCM induced liver toxicity. At higher doses (5.2 ml/ kg/day), all the six herbal formulations conclusively showed marked beneficial effects in the studied pharmacological, biochemical and histological parameters. The present findings demonstrated the efficacy of polyherbal liquid formulations at two dose levels in PCM induced hepatotoxicity in mice. However, it suggests that a dose adjustment may be necessary to optimize the effects in clinical settings.
    The Indian Journal of Medical Research 06/2009; 129(5):569-78. · 2.06 Impact Factor
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    ABSTRACT: To evaluate pretreatment of six polyherbal liquid formulations (PLFs) commercially available in India, on CCl4-induced liver injury, Swiss albino mice were treated for 7 days with distilled water or PLFs (2.6 and 5.2 ml/kg body weight/day, po) followed by single sc injection of 50% (v/v) CCl4 in arachis oil at a dose of 1 ml/kg. The serum biochemical parameters such as alanine transaminases, aspartate transaminases and alkaline phosphatase were estimated. Phenobarbitone-induced sleeping time and liver histopathology were also carried out. CCl4-treated animals showed significant increase in the levels of liver enzymes, phenobarbitone-induced sleeping time and revealed fatty changes and centrizonal necrosis on histological examination of liver indicating hepatic damage. When pretreated with PLFs at a dose of 5.2 ml/kg body weight/day, the CCl4-induced changes were significantly reversed. The pretreatment with PLFs can prevent acute liver damage induced by CCl4 only at a higher dose. Therefore, it is suggested that a dose adjustment of these PLFs may be necessary for their optimal effects in human liver diseases.
    Indian journal of experimental biology 05/2009; 47(4):257-63. · 1.20 Impact Factor
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    P. DOURERADJOU, BIDHAN CHANDRA KONER
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    ABSTRACT: Sunflower, coconut, palm and sesame oils were evaluated for heat induced peroxidation as assessed from malondialdehyde (MDA) generation when heated in iron, copper, stainless steel, aluminium and glass vessels on a controlled flame for 0, 5, 10 and 20 min. The MDA generation on heating was time dependent in all the oils. The extent of heat-induced change was the least in coconut oil followed by sesame oil. The heat induced MDA generation was the maximum in sunflower oil. The change was very less in aluminium and glass vessel but was very high in iron and copper vessels. The results show that aside from the level of anti-oxidants and unsaturation of oils, the transitional element used in cooking vessels also determine the extent of heat-induced peroxidation of oils, the impact of which is discussed in light of the harmful effects of MDA on health.PRACTICAL APPLICATIONSContrary to the view that unsaturated oils are better than saturated oils, the present study shows that MDA generation on heating in relatively saturated oil, like coconut oil, is less in comparison to unsaturated oils. So for frying purposes, coconut oil may be better than other unsaturated oils. In spite of high unsaturation level, heat-induced MDA generation in sesame oil was lower in comparison to sunflower oil probably because of the presence of more antioxidants. Sesame oil may be better than sunflower oil for frying purpose. In view of harmful effects of MDA, heating oil for frying of foodstuffs in vessels made up of transitional metal(s) is probably not a good practice. Aluminium or glass vessel may be better for this purpose.
    Journal of Food Biochemistry 11/2008; 32(6):740 - 751. · 0.76 Impact Factor
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    ABSTRACT: A computer program down loaded from the Internet was used as a tutorial to teach the structure-function relationship of MHC molecule to MBBS students of BPKIHS, a medical college in Nepal. The computer-aided teaching session, with a facilitator from the biochemistry faculty, was found to be more interesting to the students although learning outcomes were not enhanced by comparison to sessions using only conventional tools. A non-subject expert presenting the computer tutorial failed to generate interest in the topic, and the achievement of learning objectives by the students was inferior. We conclude that the interaction with a biochemistry subject expert was crucial for success in our use of computer-aided teaching sessions on the structure-function relationship of proteins. The results are discussed with attention to the role of computer-aided instruction in medical colleges in a developing country (Nepal). © 2001 IUBMB. Published by Elsevier Science Ltd. All rights reserved.
    Biochemistry and Molecular Biology Education 10/2008; 29(4):137 - 141. · 0.70 Impact Factor
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    ABSTRACT: We evaluated the effect of restraint stress (1 hr/day) for 6, 10, 14 and 21 days on antibody response against sheep RBC (SRBC) and modulation by chlordiazepoxide (CDP) pretreatment (10 mg/kg/day) in albino rats. Anti-SRBC titer was significantly decreased with increase in number of days of restraint stress exposure. CDP pretreatment significantly reversed the effects of 6, 10 and 14 (but not of 21) days of restraint stress. CDP treatment for 21 days per se suppressed immune response, but no additive effect was observed. CDP was not effective in chronic stress (i.e., 21 days of stress). Hence, the rationale behind benzodiazepines therapy in chronic stress needs to be evaluated.
    Immunopharmacology and Immunotoxicology 09/2008; 30(4):701-9. · 1.36 Impact Factor
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    ABSTRACT: Perinatal asphyxia (PA) associated with multi-organ damage is a leading cause of neonatal mortality and morbidity. We evaluated if urinary malondialdehyde:creatinine (UMDA:Cr), uric acid:creatinine (UUA:Cr) and protein:creatinine (UP:Cr) vary with the severity of PA and if these parameters can predict the impending death in PA. Study included 20 asphyxiated and 20 healthy newborn males. Hypoxic-ischemic encephalopathy (HIE) staging, APGAR (activity, pulse, grimace, appearance and respiration) score and urinary protein, uric acid, creatinine and MDA were evaluated. UMDA:Cr, UUA:Cr and UP:Cr were significantly higher and correlated with APGAR and HIE in PA. By regression analysis also, urinary parameters were found to have significant association with HIE stage and APGAR in PA. Receiver operating characteristics (ROC) curve of UP:Cr, UUA:Cr and UMDA:Cr showed area under curve of 0.896 (p=0.003), 0.859 (p=0.008) and 0.849 (p=0.010) with cut-off value of 9.04 mg, 2.34 mg and 3.49 microg/mg of creatinine respectively that can optimally predict the impending death in PA. SDS-PAGE of unconcentrated urine detected both high (73 kDa and 68 kDa) and low molecular weight proteins (52 kDa, 47 kDa, 25 kDa and 20 kDa) in PA but not in controls. Urinary excretion rate of uric acid, MDA and proteins is higher and has potential to act as biochemical markers for severity evaluation and death prediction in PA.
    Clinical biochemistry 09/2008; 41(12):968-73. · 2.02 Impact Factor
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    ABSTRACT: Caregiving to a family member with advanced cancer can be stressful. Stress leads to psychological changes, oxidative stress and increased glomerular permeability to proteins. To find out their association with stress, we assessed anxiety and depression by the hospital anxiety and depression scale (HADS), urinary malondialdehyde:creatinine ratio (UMDA:Cr), urinary protein:creatinine ratio (UP:Cr) and SDS-polyacrylamide gel electrophoresis (SDS-PAGE) profile of urinary proteins in 31 family caregivers of advanced cancer patients and 31 matched controls. HADS, UMDA:Cr and UP:Cr were significantly higher in the caregivers as compared to the controls. These parameters were significantly correlated. Besides an increase in albumin excretion, a few higher and lower molecular weight proteins were detected in the urine of caregivers. These results indicate that the family caregivers of advanced cancer patients undergo anxiety and depression associated with stress leading to increased oxidative stress and glomerular permeability to proteins. These changes might have health implications, warranting appropriate stress management counseling for them.
    Biological psychology 07/2008; 79(2):234-8. · 4.36 Impact Factor
  • Indian Journal of Pathology and Microbiology 05/2008; 51(2):310-1. · 0.68 Impact Factor
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    ABSTRACT: Microscopically abnormal (n = 26) semen showed significantly higher levels of malondialdehyde (MDA), protein carbonyl (PC) and protein-bound sialic acid (SA) in seminal plasma as compared with normal semen (n = 24). The percentage of nonmotile spermatozoa showed significant (P < 0.01) positive correlation with MDA (r = 0.5) and PC (r = 0.49). Sperm counts showed a significant negative correlation with MDA (r = -0.63, P < 0.001) level of seminal plasma. SA correlated (r = 0.56, P < 0.01) with MDA. The receiver operating characteristic (ROC) curve of MDA and SA showed that MDA of 3.15 micromol l(-1) and SA of 3.85 micromol l(-1) were optimum cut-off limits to discriminate abnormal semen from normal. In conclusion, high SA might be a protective response against prevailed oxidative stress in abnormal semen. Seminal plasma MDA and SA may act as potential markers of abnormal semen.
    Andrologia 03/2008; 40(1):56-7. · 1.75 Impact Factor

Publication Stats

425 Citations
77.67 Total Impact Points

Institutions

  • 2013–2014
    • Maulana Azad Medical College
      • Department of Biochemistry
      New Dilli, NCT, India
  • 2012
    • VIT University
      Velluru, Tamil Nādu, India
  • 2008–2010
    • Jawaharlal Institute of Postgraduate Medical Education & Research
      • • Department of Surgery
      • • Department of Biochemistry
      Pondicherry, Union Territory of Puducherry, India
  • 1999–2002
    • B.P. Koirala Institute of Health Sciences
      • Department of Biochemistry
      Dharān Bāzār, Nepal