Xiao Yang

Shaanxi Normal University, Xi’an, Guangdong, China

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Publications (246)943.02 Total impact

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    ABSTRACT: We assessed the anti-inflammatory effect of peroxisome proliferator-activated receptor (PPAR)-γ agonist, rosiglitazone, in a lipopolysaccharide (LPS)-induced peritonitis rat model. LPS was intraperitoneally injected into rats to establish peritonitis model. Male Sprague-Dawley (SD) rats were assigned to normal saline (the solvent of LPS), LPS, rosiglitazone plus LPS, and rosiglitazone alone. A simple peritoneal equilibrium test was performed with 20 ml 4.25 % peritoneal dialysis fluid. We measured the leukocyte count in dialysate and ultrafiltration volume. Peritoneal membrane histochemical staining was performed, and peritoneal thickness was assessed. CD40 and intercellular adhesion molecule-1 messenger RNA (ICAM-1 mRNA) levels in rat visceral peritoneum were detected by reverse transcription (RT)-PCR. IL-6 in rat peritoneal dialysis effluent was measured using enzyme-linked immunosorbent assay. The phosphorylation of NF-κB-p65 and IκBα was analyzed by Western blot. LPS administration resulted in increased peritoneal thickness and decreased ultrafiltration volume. Rosiglitazone pretreatment significantly decreased peritoneal thickness. In addition to CD40 and ICAM-1 mRNA expression, the IL-6, p-p65, and p-IκBα protein expressions were enhanced in LPS-administered animals. Rosiglitazone pretreatment significantly decreased ICAM-1 mRNA upregulation, secretion of IL-6 protein, and phosphorylation of NF-κB-p65 and IκBα without decreasing CD40 mRNA expression. Rosiglitazone has a protective effect in peritonitis, simultaneously decreasing NF-κB phosphorylation, suggesting that NF-κB signaling pathway mediated peritoneal inflammation induced by LPS. PPAR-γ might be considered a potential therapeutic target against peritonitis.
    Inflammation 06/2015; DOI:10.1007/s10753-015-0193-2 · 1.92 Impact Factor
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    ABSTRACT: Keratocystic odontogenic tumors (KCOTs) are cystic epithelial neoplasms with a high recurrence rate. The molecular mechanisms underlying the initiation and progression of KCOTs are still largely unknown. Previous research showed that specific ablation of Smad4 in odontoblasts and dental epithelia resulted in spontaneous KCOTs in mice, and that constitutively activated Hedgehog (Hh) signaling was detected in the cyst epithelia of both Smad4(Co/Co) OC-Cre and Smad4(Co/Co) K5-Cre mice. Here, we ablated Smad4 in mouse odontoblasts and dental epithelia and compared the sizes and numbers of KCOTs. Both the number and size of KCOTs in Smad4(Co/Co) OC-Cre mice were larger than those in Smad4(Co/Co) K5-Cre mice, suggesting that paracrine signals from root odontoblasts play a more important role than those from Hertwig's epithelial root sheath (HERS) cells. Copyright © 2015. Published by Elsevier Inc.
    Biochemical and Biophysical Research Communications 05/2015; 463(3). DOI:10.1016/j.bbrc.2015.05.051 · 2.28 Impact Factor
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    Xiao Yang
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    ABSTRACT: Targeted mutagenesis based on homologous recombination has been a powerful tool for understanding the mechanisms underlying development, normal physiology, and disease. A recent breakthrough in genome engineering technology based on the class of RNA-guided endonucleases, such as clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9, is further revolutionizing biology and medical studies. The simplicity of the CRISPR-Cas9 system has enabled its widespread applications in generating germline animal models, somatic genome engineering, and functional genomic screening and in treating genetic and infectious diseases. This technology will likely be used in all fields of biomedicine, ranging from basic research to human gene therapy.
    05/2015; 2(1). DOI:10.1186/s40779-015-0038-1
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    ABSTRACT: High serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio has been found to be an independent predictor for cardiovascular events in the general population. We aimed to evaluate whether a high TG/HDL-C ratio was associated with an increased risk of mortality in patients on continuous ambulatory peritoneal dialysis (CAPD). In this single-center retrospective cohort study, 1170 incident patients on peritoneal dialysis (PD) from 1 January 2007 to 31 December 2011 were recruited and followed up until 31 December 31 2013. The mean age was 47.4 ± 15.2 years, and 24.7% were diabetic. During a median of the 34.5-month follow-up period, 213 (18.2%) deaths occurred, 121 of which (56.8%) were caused by cardiovascular disease (CVD). The serum median TG/HDL-C ratio at baseline was 2.57 (range: 0.06-39.39). On multivariate Cox regression analysis, the highest quartile of the TG/HDL-C ratio (≥4.19) was associated with increased risk of all-cause mortality (hazard ratio (HR) 1.98, 95% confidence interval (CI), 1.17-3.36; P = 0.011) and CVD mortality (HR 2.28, 95% CI, 1.16-4.47; P = 0.017). For female patients, each one-unit higher baseline TG/HDL-C was associated with 13% (95% CI 1.06-1.22; P = 0.001) increased risk of CVD mortality, whereas such an association was not observed for male patients, (HR 1.00, 95% CI 0.92-1.08; P = 0.977). A higher serum TG/HDL-C ratio was associated with an increased risk of all-cause and CVD mortality in PD patients. Moreover, the increased risk of CVD mortality was significantly higher in female than male PD patients. Copyright © 2015 Elsevier B.V. All rights reserved.
    Nutrition Metabolism and Cardiovascular Diseases 05/2015; DOI:10.1016/j.numecd.2015.05.006 · 3.88 Impact Factor
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    ABSTRACT: Arsenic, a ubiquitous presence in the biosphere, often occurs from both natural and anthropogenic sources. Bacterial biosensors based on genetically engineered bacteria have promising applications in detecting the chemical compound and its toxicity. However, most of the bactiria biosensor takes advantage of the existing wild-type substrate-induced promoters, which are often low in specificity, affinity and sensitivity, and thus limiting their applications in commercial or field use. In this study, we developed an in vivo evolution procedure with bi-directional selection scheme for improving the sensitivity of arsenite-responsive bacterial biosensor through optimization of the inducible operon. As a proof of concept, we evolved the arsenite-induced arsR operon for both low background and high expression through three successive rounds of fluorescence activated cell sorting (FACS) with bi-directional strategy. An arsR operon variant with 12-fold higher activity over the control was isolated, confirming multiple rounds of construction and screening of mutation library, as described here, can be efficiently applied to bacterial biosensor optimization. The evolved arsenite-responsive biosensor demonstrated an excellent performance in the detection of low trace arsenite in environmental water. These results indicate that the technologies of directed evolution could be used to improve the performance of bacterial biosensors, which will be helpful in promoting the practical application of bacterial biosensors.
    Environmental Science & Technology 04/2015; 49(10). DOI:10.1021/acs.est.5b00832 · 5.48 Impact Factor
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    ABSTRACT: Land-use and soil management affects soil organic carbon (SOC) pools, nitrogen, salinity and the depth distribution. The objective of this study was to estimate land-use effects on the distribution of SOC, labile fractions C, nitrogen (N) and salinity in saline-alkaline wetlands in the middle reaches of the Heihe River Basin. Three land-use types were selected: intact saline-alkaline meadow wetland, artificial shrubbery (planting Tamarix) and farmland (cultivated for 18 years) of soils previously under meadow wetland. SOC, easily oxidized carbon, microbial biomass carbon, total N, NO3--N and salinity concentrations were measured. The results show that SOC and labile fraction carbon contents decreased significantly with increasing soil depth in the three land-use wetlands. The labile fraction carbon contents in the topsoil (0–20 cm) in cultivated soils were significantly higher than that in intact meadow wetland and artificial shrubbery soil. The aboveground biomass and soil permeability were the primary influencing factors on the contents of SOC and the labile carbon in the intact meadow wetland and artificial shrubbery soil, however, the farming practice was a factor in cultivated soil. Agricultural measures can effectively reduce the salinity contents; however, it caused a significant increase of NO3--N concentrations which posed a threat to groundwater quality in the study area.
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    ABSTRACT: Zfp57 is a maternal-zygotic effect gene that maintains genomic imprinting. Here we report that Zfp57 mutants exhibited a variety of cardiac defects including atrial septal defect (ASD), ventricular septal defect (VSD), thin myocardium, and reduced trabeculation. Zfp57 maternal-zygotic mutant embryos displayed more severe phenotypes with higher penetrance than the zygotic ones. Cardiac progenitor cells exhibited proliferation and differentiation defects in Zfp57 mutants. ZFP57 is a master regulator of genomic imprinting, so the DNA methylation imprint was lost in embryonic heart without ZFP57. Interestingly, the presence of imprinted DLK1, a target of ZFP57, correlated with NOTCH1 activation in cardiac cells. These results suggest that ZFP57 may modulate NOTCH signaling during cardiac development. Indeed, loss of ZFP57 caused loss of NOTCH1 activation in embryonic heart with more severe loss observed in the maternal-zygotic mutant. Maternal and zygotic functions of Zfp57 appear to play redundant roles in NOTCH1 activation and cardiomyocyte differentiation. This serves as an example of a maternal effect that can influence mammalian organ development. It also links genomic imprinting to NOTCH signaling and particular developmental functions.
    Proceedings of the National Academy of Sciences 04/2015; 112(16). DOI:10.1073/pnas.1415541112 · 9.81 Impact Factor
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    ABSTRACT: A novel kind of bifunctionalized conjugated microporous polymers containing sultone and hydroxyl groups has been synthesized via palladium-catalyzed Sonogashira–Hagihara cross-coupling reaction of bromophenol blue with 1,4-diethynylbenzene or 1,3,5-triethynylbenzene. The resulting polymers show high specific surface area up to 1470 m2 g−1 and good thermal stability. BFCMP-2 exhibits a hydrogen uptake ability of 156 cm3 g−1 (∼1.39 wt%) at 77 K/1.13 bar and a carbon dioxide uptake capacity of 2.77 mmol g−1 at 273 K/1.13 bar. Compared with most other reported non-functionalized conjugated microporous polymers, both of the bifunctionalized polymer networks show relatively high isosteric heat of CO2 adsorption (25 kJ mol−1) due to the introduction of the polar functional groups of sultone and hydroxy enhanced the binding affinity between the polymer networks and CO2 molecules. The results demonstrate that the introduction of strong polar groups into a polymer skeleton is an efficient strategy to produce CO2-philic microporous organic polymers with enhanced binding affinity with CO2 molecules.
    Polymer 03/2015; 61. DOI:10.1016/j.polymer.2015.01.072 · 3.77 Impact Factor
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    ABSTRACT: A series of copolymerized conjugated microporous polymers (CP-CMPs) has been synthesized by Suzuki cross-coupling copolymerization of 1,4-benzene diboronic acid with comonomers of 1,3,6,8-tetrabromopyrene and/or 1,3,6,8-tetrabromocarbazole at different ratios. These CP-CMPs are stable in common organic solvents and thermally stable. It was found that the ratio of comonomers has a large influence on the pore properties of these CP-CMPs such as apparent Brunauer-Emmet-Teller (BET) specific surface area, micropore surface area and micropore volume. CP-CMP5 with 60 mol% 1,3,6,8-tetrabromocarbazole shows a high BET specific surface area up to 2241 m2 g-1 and a high CO2 uptake ability of 4.57 mmol g-1 (1.13 bar/273 K) with a H2 uptake ability of 2.24 wt% (1.13 bar/77.3 K). These results demonstrate that copolymerization is an efficient strategy to tune the pore properties of microporous organic polymers, and would be promising for producing other type microporous organic polymers with high level of porosity and CO2 uptake ability.
    03/2015; 6(17). DOI:10.1039/C5PY00295H
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    ABSTRACT: Stimulator of interferon genes (STING, also known as MITA and ERIS) is critical in protecting the host against DNA pathogen invasion. However, the molecular mechanism underlying the regulation of STING remains unclear. Here, we show that PPM1A negatively regulates antiviral signaling by targeting STING in its phosphatase activity-dependent manner, and in a line with this, PPM1A catalytically dephosphorylates STING and TBK1 in vitro. Importantly, we provide evidence that whereas TBK1 promotes STING aggregation in a phosphorylation-dependent manner, PPM1A antagonizes STING aggregation by dephosphorylating both STING and TBK1, emphasizing that phosphorylation is crucial for the efficient activation of STING. Our findings demonstrate a novel regulatory circuit in which STING and TBK1 reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A dephosphorylates STING and TBK1, thereby balancing this antiviral signal transduction.
    PLoS Pathogens 03/2015; 11(3):e1004783. DOI:10.1371/journal.ppat.1004783 · 8.06 Impact Factor
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    ABSTRACT: To perform a profiling analysis of changes in intestinal microRNA (miRNA) expression during hypothermic circulatory arrest (HCA). A total of eight piglets were randomly divided into HCA and sham operation (SO) groups. Under general anesthesia, swine in the HCA group were subjected to hypothermic cardiopulmonary bypass at 24 °C followed by 80 min of circulatory arrest, and the reperfusion lasted for 180 min after cross-clamp removal. The counterparts in the SO group were only subjected to median sternotomy. Histopathological analysis was used to detect mucosal injury, and Pick-and-Mix custom miRNA real-time polymerase chain reaction (PCR) panels containing 306 unique primer sets were utilized to assay unpooled intestinal samples harvested from the two groups. The intestinal mucosa of the animals that were subjected to 24 °C HCA exhibited representative ischemic reperfusion injury of grade 2 or 3 according to the Chiu score. Such intestinal mucosal injuries, with the subepithelial space and epithelial layer lifting away from the lamina propria, were accompanied by shortened and irregular villi. On the contrary, the intestinal mucosa remained normal in the sham-operated animals. In total, twenty-five miRNAs were differentially expressed between the two groups (15 upregulated and 10 downregulated in the HCA group). Among these, eight miRNAs (miR-122, miR-221-5p, miR-31, miR-421-5p, miR-4333, miR-499-3p, miR-542 and let-7d-3p) were significantly dysregulated (four higher and four lower). The expression of miR-122 was significantly (5.37-fold) increased in the HCA group vs the SO group, indicating that it may play a key role in HCA-induced mucosal injury. Exposure to HCA caused intestinal miRNA dysregulation and barrier dysfunction in swine. These altered miRNAs might be related to the protection or destruction of the intestinal barrier.
    World Journal of Gastroenterology 02/2015; 21(7):2183-90. DOI:10.3748/wjg.v21.i7.2183 · 2.43 Impact Factor
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    ABSTRACT: Protein-energy wasting (PEW) is strongly associated with high mortality in continuous ambulatory peritoneal dialysis (CAPD) patients. However, its clinical assessment has not been well defined. The aim of the present study was to investigate the relationship between combined nutritional indicators and mortality in CAPD patients. In the present retrospective cohort study, a total of 885 incident CAPD patients were enrolled. Nutritional status at the initiation of CAPD was assessed by BMI and biochemical indices (serum albumin, prealbumin, transferrin, creatinine and total cholesterol). The primary outcome was all-cause mortality. Principal components factor analysis was used to identify the combined nutritional parameters. Their association with mortality was examined by multivariable-adjusted Cox models. The mean age was 47·4 (sd 14·8) years, 59·2 % (n 524) were male and 24·6 % (n 218) were diabetic. Of the total patients, 130 (14·7 %) had BMI < 18·5 kg/m2, 439 (49·6 %) had albumin < 38 g/l ( < 3·8 g/dl), 303 (34·2 %) had prealbumin < 300 mg/l ( < 30 mg/dl), 404 (45·6 %) had transferrin < 2 g/l ( < 200 mg/dl), 501 (56·6 %) had total cholesterol < 5·2 mmol/l ( < 200 mg/dl) and 466 (52·7 %) had creatinine < 707 μmol/l ( < 8 mg/dl). Overall, three components such as visceral proteins, muscle-mass surrogate and BMI were extracted, which explained 69·95 % of the total variance of the nutritional parameters. After adjusting for demographic variables, co-morbid conditions, Hb, TAG and high-sensitivity C-reactive protein, the factor score of visceral proteins including albumin, prealbumin and transferrin was independently associated with mortality (hazard ratio 0·73, 95 % CI 0·60, 0·89; P= 0·002). Lower visceral protein concentrations may be independently associated with higher mortality in incident CAPD patients. Simultaneous measurements of serum albumin, prealbumin and transferrin could be helpful to monitor PEW.
    British Journal Of Nutrition 01/2015; 113(04):1-7. DOI:10.1017/S0007114514004061 · 3.34 Impact Factor
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    ABSTRACT: The terminal differentiation of hypertrophic chondrocytes is a tightly regulated process that plays a pivotal role in endochondral ossification. As a negative regulator, Sox9 is essentially downregulated in terminally differentiated hypertrophic chondrocytes. However, the underlying mechanism of Sox9 silencing is undefined. Here we show that the zinc finger protein Zbtb20 regulates the terminal differentiation of hypertrophic chondrocytes by repressing Sox9. In the developing skeleton of the mouse, Zbtb20 protein is highly expressed by hypertrophic chondrocytes from late embryonic stages. To determine its physiological role in endochondral ossification, we have generated chondrocyte-specific Zbtb20 knockout mice and demonstrate that disruption of Zbtb20 in chondrocytes results in delayed endochondral ossification and postnatal growth retardation. Zbtb20 deficiency caused a delay in cartilage vascularization and an expansion of the hypertrophic zone owing to reduced expression of Vegfa in the hypertrophic zone. Interestingly, Sox9, a direct suppressor of Vegfa expression, was ectopically upregulated at both mRNA and protein levels in the late Zbtb20-deficient hypertrophic zone. Furthermore, knockdown of Sox9 greatly increased Vegfa expression in Zbtb20-deficient hypertrophic chondrocytes. Our findings point to Zbtb20 as a crucial regulator governing the terminal differentiation of hypertrophic chondrocytes at least partially through repression of Sox9. © 2015. Published by The Company of Biologists Ltd.
    Development 01/2015; 142(2):385-393. DOI:10.1242/dev.108530 · 6.27 Impact Factor
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    ABSTRACT: As a master component of endosomal sorting complex required for transport proteins, hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) participates multiple cellular behaviors. However, the physiological role of Hgs in smooth muscle cells (SMCs) is by far unknown. Here we explored the in vivo function of Hgs in SMCs by using a conditional gene knockout strategy. Hgs deficiency in SMCs uniquely led to a progressive dilatation of esophagus with a remarkable thinning muscle layer. Of note, the mutant esophagus showed a decreased contractile responsiveness to potassium chloride and acetylcholine stimulation. Furthermore, an increase in the inhibitory neurites along with an intense infiltration of T lymphocytes in the mucosa and muscle layer were observed. Consistently, Hgs deficiency in SMCs resulted in a disturbed expression of a set of genes involved in neurotrophin and inflammation, suggesting that defective SMC might be a novel source for excessive production of cytokines and chemokines which may trigger the neuronal dysplasia and ultimately contribute to the compromised esophageal motility. The data suggest potential implications in the pathogenesis of related diseases such as gastroesophageal reflux disease.
    International journal of biological sciences 01/2015; 11(7):794-802. DOI:10.7150/ijbs.12248 · 4.37 Impact Factor
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    ABSTRACT: Accumulating evidence indicates that some miRNAs could form feedback loops with their targets to fine-tune tissue homeostasis, while disruption of these loops constitutes an essential step towards human tumorigenesis. In this study, we report the identification of a novel negative feedback loop formed between miR-139 and its oncogenic target Jun. In this loop, miR-139 could inhibit Jun expression by targeting a conserved site on its 3'-UTR, whereas Jun could induce miR-139 expression in a dose dependent manner through a distant upstream regulatory element. Interestingly, aberration in this loop was found in human gastric cancer, where miR-139 was down-regulated and inversely correlated with Jun expression. Further functional analysis showed that restored expression of miR-139 in gastric cancer cells significantly induces apoptosis, and inhibits cell migration and proliferation as well as tumour growth through targeting Jun. Thus, our data strongly suggests a role of aberrant miR-139/Jun negative feedback loop in the development of human gastric cancer and miR-139 as a potential therapeutic target for gastric cancer. Given that miR-139 and Jun are deregulated in many cancers, our findings here might have broader implication in other types of human cancers.
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 12/2014; 1853(2). DOI:10.1016/j.bbamcr.2014.12.002 · 5.30 Impact Factor
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    ABSTRACT: A series of conjugated microporous polymers (CMPs) from 1,3,6,8-tetrabromocarbazole and its alkylated derivative is synthesized via Suzuki cross-coupling polycondensation. These polymer networks are stable in common organic solvents and thermally stable. The pore properties (pore size and surface area) of this kind of CMPs can be tuned by using either a linker with different geometries or carbazole substituted with alkyl groups. All of the polymers show high isosteric heats of CO2 adsorption (27.1-30.8 kJ mol(-1)) because the incorporation of nitrogen atoms into the skeleton of the CMP enhances the interaction between the pore wall and CO2 molecules. The polymer PPTBC shows a high Brunauer Emmett Teller specific surface area up to 917 m(2) g(-1) with a high CO2 uptake ability of 2.93 mmol g(-1) at 1.13 bar/273 K. These data show that these materials are potential candidates for applications in post-combustion CO2 capture and sequestration technology.
    Macromolecular Chemistry and Physics 12/2014; 216(5). DOI:10.1002/macp.201400508 · 2.45 Impact Factor
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    ABSTRACT: Two hypercrosslinked microporous organic polymer networks from carbazole derivatives have been synthesized via Friedel-Crafts alkylation using a formaldehyde dimethyl acetal crosslinker promoted by anhydrous FeCl3. Both of the polymer networks are stable in various solvents and thermally stable. The polymer network FCTCz produced from a dendritic carbazole building block shows much higher Brunauer-Emmet-Teller specific surface area of 1845 m(2) g(-1) than the dicarbazolic polymer network of FCBCz (1067 m(2) g(-1)). FCTCz exhibits a high carbon dioxide uptake ability of 4.63 mmol g(-1) at 1.13 bar and 273 K with a hydrogen uptake ability of 1.94 wt% (1.13 bar/77 K). In addition, both of the polymer networks exhibit good ideal CO2/N-2 selectivity (26-29) and CO2/CH4 selectivity (5.2-5.8) at 273 K. These results demonstrated that this kind of polymer network is a very promising candidate for potential applications in post-combustion carbon dioxide capture and sequestration technology.
    RSC Advances 11/2014; 4(105):61051-61055. DOI:10.1039/C4RA09394A · 3.71 Impact Factor
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    ABSTRACT: In mouse, continuous growth of the postnatal incisor is coordinated by two populations of multipotent progenitor cells, the dental papilla mesenchymal cells and dental epithelial stem cells, residing at the proximal end of the incisor, yet the molecular mechanism underlying the cooperation between mesenchymal and epithelial cells is largely unknown. Here, TGF-β type II receptor (Tgfbr2) was specifically deleted within the postnatal dental papilla mesenchyme. The Tgfbr2-deficient mice displayed malformed incisors with wavy mineralized structures at the labial side as a result of increased differentiation of dental epithelial stem cells. We found that mesenchymal Tgfbr2 disruption led to upregulated expression of Wnt5a and downregulated expression of Fgf3/10 in the mesenchyme, both of which synergistically enhanced Lrp5/6-β-catenin signaling in the cervical loop epithelium. In accord with these findings, mesenchyme-specific depletion of the Wnt transporter gene Wls abolished the aberrant mineralized structures caused by Tgfbr2 deletion. Thus, mesenchymal TGF-β signaling provides a unifying mechanism for the homeostasis of dental epithelial stem cells via a Wnt signaling mediated mesenchymal–epithelial cell interaction. Stem Cells 2014
    Stem Cells 11/2014; 32(11). DOI:10.1002/stem.1772 · 7.70 Impact Factor
  • Xueqing Yu, Xiao Yang
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    ABSTRACT: Due to limited medical and economic resources, particularly in the countryside and remote areas, the proportion of individuals with end-stage kidney disease who are treated with dialysis in China is only about 20%. For the rest, renal replacement therapy currently is not available. Peritoneal dialysis (PD) has been developed and used for more than 30 years in China to treat patients with end-stage kidney disease. Several national PD centers of first-rate scale and quality have sprung up, but the development of PD varies widely among geographic regions across China. The Chinese government has dedicated itself to continually increasing the coverage and level of medical service for patients with end-stage kidney disease. Under the guidance of the government and because of promotion by kidney care professionals, presently there are more than 40,000 prevalent PD patients in China, representing approximately 20% of the total dialysis population. Recently, a National Dialysis Unit Training Program for countywide hospitals has been initiated. Through the efforts of programs like this, we believe that awareness of PD and advances in the underlying technology will benefit more patients with end-stage kidney disease in China. Copyright © 2014 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
    American Journal of Kidney Diseases 11/2014; 65(1). DOI:10.1053/j.ajkd.2014.08.023 · 5.76 Impact Factor
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    ABSTRACT: To compare the effects of different volumes of fluorescein on tear breakup time (FTBUT) and to investigate if and to what extent the tear breakup time determined by an automated noninvasive instrument (NITBUT) differs from FTBUT.
    Optometry and vision science: official publication of the American Academy of Optometry 10/2014; DOI:10.1097/OPX.0000000000000418 · 2.04 Impact Factor

Publication Stats

4k Citations
943.02 Total Impact Points


  • 2014–2015
    • Shaanxi Normal University
      Xi’an, Guangdong, China
  • 2004–2015
    • Sun Yat-Sen University
      • • Department of Medical Oncology
      • • The First Affiliated Hospital
      Shengcheng, Guangdong, China
  • 2009–2014
    • Chinese Academy of Sciences
      • Graduate School
      Peping, Beijing, China
    • 307 Hospital of the Chinese People's Liberation Army
      Peping, Beijing, China
    • Beijing Institute Of Technology
      Peping, Beijing, China
  • 2001–2014
    • Fuerkang Beijing Institute of Biotechnology
      Peping, Beijing, China
  • 2010–2013
    • Shanghai Jiao Tong University
      Shanghai, Shanghai Shi, China
    • Lanzhou University
      • School of Life Science
      Lanzhou, Gansu Sheng, China
  • 2007–2013
    • Shanghai University
      • Department of Automation
      Shanghai, Shanghai Shi, China
    • University of Rochester
      Rochester, New York, United States
  • 2012
    • Xinqiao Hospital
      Ch’ung-ch’ing-shih, Chongqing Shi, China
  • 2000–2012
    • Academy of Military Medical Sciences
      T’ien-ching-shih, Tianjin Shi, China
  • 2011
    • Hunan University
      Ch’ang-sha-shih, Hunan, China
  • 2002–2010
    • Sun Yat-Sen University of Medical Sciences
      • • Department of Nephrology
      • • First Affiliated Hospital
      Shengcheng, Guangdong, China
  • 2003–2009
    • Government of the People's Republic of China
      Peping, Beijing, China
    • Henan Provincial People’s Hospital
      Cheng, Henan Sheng, China
  • 2006
    • Peking Union Medical College Hospital
      Peping, Beijing, China
  • 2005
    • Second Military Medical University, Shanghai
      Shanghai, Shanghai Shi, China
    • Guangzhou First People's Hospital
      Shengcheng, Guangdong, China
  • 1997–2002
    • National Institutes of Health
      • • Branch of Genetics of Development and Disease (GDDB)
      • • Laboratory of Metabolism
      Bethesda, MD, United States