Publications (11)26.88 Total impact
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Article: Peroxynitrite-scavenging constituents from the brown alga Sargassum thunbergii
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ABSTRACT: Peroxynitrite formationin vivo is implicated in numerous human diseases and there is considerable interest in the use of antioxidants and natural products for their treatment. The three components (1–3) isolated fromSargassum thunbergii as well as the organic solventsoluble fractions and the aqueous layer ofS. thunbergii were evaluated for their potential to scavenge authentic ONOO and ONOO derived from 3-morpholinosydnonimine (SIN-1). The antioxidant activity of the individual fractions was in the order of 85% aquaous (aq.) MeOH>n-BuOH>n-hexane> H2O. The three known compounds sargahydroquinoic acid (1), sargaquinoic acid (2) and sargachromenol (3) showed peroxynitrite-scavenging activities comparable to those of L-ascorbic acid and penicillamine. These results showed a possible antioxidant activity in major constituents ofS. thunbergii.Biotechnology and Bioprocess Engineering 04/2012; 9(3):212-216. · 1.28 Impact Factor -
Article: Screening of Korean marine plants for their inhibitory effect on histamine release from RPMCin vitro
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ABSTRACT: Allergy, meaning ‘heightened reactivity’ of a host on being exposed to an antigen, is an immediate reaction which included anaphylaxis following contact with an antigen. An anaphylatic reaction is caused by the release of pharmacological mediators, like histamine, from mast cells. The potential anti-allergic activities of 27 seaweed and 19 salt marsh extracts collected from the coast of Korea were tested against the inhibition of histamine release in rat peritoneal mast cells (RPMCs). Among them, three salt marsh plants (Persicaria lapathifolia, Ixeris tamagawaensis, andSalsola komarovir) significantly showed more than 75% of inhibition of the histamine release at a concentration of 100 μg/mL, and also three salt marsh (Messerschmidia sibirica, Rosa rugosa, andPortulaca oleraceae) and three seaweed (Colpomenia bullosa, Derbesia marina, andSargassum thunbergii) extracts exhibited moderately inhibition effects when compared to the control.Biotechnology and Bioprocess Engineering 04/2012; 11(1):80-83. · 1.28 Impact Factor -
Article: A new cytotoxic spiroketal from the myxobacterium Sorangium cellulosum.
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ABSTRACT: A new spiroketal, spirodienal B (1), was isolated from culture extracts of S. cellulosum. Its structure was elucidated by spectroscopic analysis. In addition to 1, the strain produced a second, closely related antibiotic, spirodienal. Both compounds demonstrated potent cytotoxicity against human tumor cells. Against human tumor cells such as HCT-15, the activity of 1 was more than 4000 times stronger than that of doxorubicin in terms of IC(50).Archives of Pharmacal Research 07/2009; 32(6):841-4. · 1.59 Impact Factor -
Article: Sorangiadenosine, a new sesquiterpene adenoside from the myxobacterium Sorangium cellulosum.
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ABSTRACT: Sorangiadenosine (1), a novel nucleoside possessing a bicyclic, eudesmane-type sesquiterpene as an auxiliary component, was isolated from the culture broth of the gliding bacterium Sorangium cellulosum KM1003, collected from Korean soil. The chemical structure of this compound was determined by combined spectroscopic and chemical analyses. The new compound exhibited moderate antibacterial activity against a wide range of bacterial strains.Organic Letters 04/2008; 10(6):1167-9. · 5.86 Impact Factor -
Article: Soraphinol C, a new free-radical scavenger from Sorangium cellulosum.
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ABSTRACT: A new compound named soraphinol C (1) was isolated from myxobacteria Sorangium cellulosum KM1001 a soil isolate, together with a structurally related known compound, 4-hydroxysattabacin (2). These compounds were isolated by silica gel column chromatography and recycling preparative HPLC, consecutively. The structures of the compounds were determined on the basis of combined spectroscopic analyses. Compounds 1 and 2 exhibited antioxidant activity as a radical scavenger in the experiment using a hydrophilic free-radical initiator, 2,2'-azobis(2-amidinopropane)dihydrochloride with ORAC values of 0.956 and 0.617, respectively.Journal of Microbiology and Biotechnology 04/2008; 18(3):520-2. · 1.38 Impact Factor -
Article: Bithiazole metabolites from the myxobacterium Myxococcus fulvus.
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ABSTRACT: Two new bithiazole metabolites (3, 4) along with the previously reported compounds (1, 2) were isolated from the culture broth of the gliding bacterium Myxococcus fulvus collected from a Korean soil. The structures of these compounds were determined to be analogous to myxothiazole A on the basis of combined spectroscopic analyses. The new compounds exhibited significant cytotoxicity and moderate antifungal activity against the mouse fibloblast cell-line L929 and Candida albicans, respectively. These data were consistent with the previous finding that the bioactivity of myxothiazoles was highly dependent on the presence of terminal methoxy enol functionality.CHEMICAL & PHARMACEUTICAL BULLETIN 04/2007; 55(3):477-9. · 1.59 Impact Factor -
Article: Isolation of tetraprenyltoluquinols from the brown alga Sargassum thunbergii.
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ABSTRACT: Thunbergols A (4) and B (5), tetraprenyltoluquinols, along with three known compounds (1-3) have been isolated from the brown alga Sargassum thunbergii. The structures of these two new compounds were determined to be 9-(3,4-dihydro-2,8-dimethyl-6-hydroxy-2H-1-benzopyran-2-yl)-6-methyl-2-(4-methyl-3-pentenyl)-(2E,6E)-nonadienoic acid (4) and 10-(2,3-dihydro-5-hydroxy-7-methyl-1-benzofuran-2-yl)-10-hydroxy-6-methyl-2-(4-methyl-3-pentenyl)-(2E,6E)-undecadienoic acid (5), respectively, by combined spectroscopic methods. Both of them exhibited significant scavenging activities on radical and potently inhibited generation of ONOO(-) from morpholinosydnonimine (SIN-1).CHEMICAL & PHARMACEUTICAL BULLETIN 01/2007; 54(12):1730-3. · 1.59 Impact Factor -
Article: New macrolides from the sponge Chondrosia corticata.
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ABSTRACT: Three new oxazole-containing metabolites, neohalichondramide (5), (19Z)-halichondramide (6), and secohalichondramide (7), along with four previously reported compounds of the same structural class were isolated from the marine sponge Chondrosia corticata collected from Guam. The structures of novel compounds were determined on the basis of combined spectroscopic analyses. These compounds exhibited significant cytotoxicity and antifungal activity toward the human leukemia cell-line K562 and Candida albicans, respectively.Journal of Natural Products 12/2004; 67(11):1889-92. · 3.13 Impact Factor -
Article: New sesterterpenes from the sponge Smenospongia sp.
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ABSTRACT: Five new sesterterpenes, three scalarane-type (1-3) and two linear furanosesterterpenes (4, 5), were isolated from the marine sponge Smenospongia sp. collected from Gagu-Do, Korea. The structures of the new compounds, which exhibited moderate cytotoxicity toward the human leukemia cell line K562, were determined from an analysis of spectroscopic data.Journal of Natural Products 11/2004; 67(10):1748-51. · 3.13 Impact Factor -
Article: New sesterterpenes from the Antarctic sponge Suberites sp.
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ABSTRACT: Suberitenones C and D and suberiphenol, three new sesterterpenes of the suberitane class, were isolated from the sponge Suberites sp. collected from Antarctica. The structures of these compounds were determined on the basis of combined spectral and chemical analyses.Journal of Natural Products 05/2004; 67(4):672-4. · 3.13 Impact Factor -
Article: A New Monoterpene Glucoside from Portulaca oleracea
ChemInform 01/2004; 35(10). -
Article: Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation.
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ABSTRACT: Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC(50)=520 nM) without cytotoxicity. In vivo and in vitro angiogenesis experiments showed HC as a new candidate for anti-angiogenic agent.Bioorganic & Medicinal Chemistry 10/2002; 10(9):2987-92. · 2.92 Impact Factor
Top co-authors
Top Journals
Institutions
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2007–2012
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Korea Maritime University
Pusan, Busan, South Korea
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2008–2009
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Sungkyunkwan University
Seoul, Seoul, South Korea
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2002
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Korea Research Institute of Chemical Technology
Taiden, Daejeon, South Korea
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