Lizhen Xu

Publications (12)20.03 Total impact

• Article: Prospective comparison of laparoscopic uterine artery occlusion plus myomectomy with classic intrafascial supracervical hysterectomy for symptomatic fibroid treatment: differences in post-operative quality-of-life measures.

  Mingmin Liu, Zhongping Cheng, Yu Zhu, Hong Dai, Liping Hu, Lizhen Xu
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  ABSTRACT: Prospective comparison of laparoscopic uterine artery occlusion plus myomectomy (LUAO+M) with classic intrafascial supracervical hysterectomy (CISH) for symptomatic fibroid treatment, regarding differences in post-operative quality-of-life measures. Three hundred and thirty-two women with symptomatic fibroids who met the inclusion criteria were prospectively randomized into two treatment groups. The study group consisted of 158 women treated with LUAO+M. The control group contained 174 women treated with CISH. Quality of life was measured before surgery and at 2- and 24-month follow-up visits with the World Health Organization Quality of Life-BREF (WHOQOL-BREF), 4-domain questionnaire adapted for Chinese-speaking patients. By age, education, operation time, operative blood loss, and pre-operative WHOQOL-BREF 4-domain and overall scores, both groups were statistically equivalent, demonstrating that the randomization process worked. At 24 months, overall scores were improved for both the study group and control group patients (P<0.01). At 2 months post-surgery, physical domain and social relationship domain scores were statistically higher in the study group than the control group patients (P<0.01). By 24 months, the study group patients' overall scores were statistically higher than the control group scores (P<0.01) because of greater improvements in the physical, psychological, and social relationship domain scores. Only in the environmental domain were the study group and the control group scores statistically equivalent. At 24-month follow-up, the study group patients had a fibroid recurrence rate of only 2.53%-low by historical standards. At 24-month follow-up, overall WHOQOL-BREF scores were statistically improved for the study group and control group patients. At the same statistical level, however, women in the study group had greater overall improvement than women in the control group because of higher scores in three of the four questionnaire domains. Women treated with LUAO+M have a very low fibroid recurrence rate at 24 months.
  European journal of obstetrics, gynecology, and reproductive biology 01/2011; 155(1):79-84. · 1.97 Impact Factor
• Article: Laparoscopic uterine vessels occlusion for the treatment of interstitial pregnancy.

  Zhongping Cheng, Lizhen Xu, Yu Zhu, Hong Dai, Xiaoyan Qu, Jun Gong
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  ABSTRACT: Interstitial pregnancy is a rare form of ectopic pregnancy, but it results in significant maternal morbidity and mortality. In this paper, describe a case of interstitial pregnancy that was successfully managed by laparoscopic occlusion of the ipsilateral ascending branch of uterine artery and the communication of the ovarian artery. It would help to minimize the active bleeding and allow removing the gestation sac, placental tissue, and repair the interstitial tube. In this case, the operative bleeding was 80 mL only, and the operative time was 70 minutes. The patient shared good postoperative recovery, and serum beta human chorionic gonadotropin decreased to below normal levels within 1 month after the operation. This procedure should be considered as a treatment option for unruptured interstitial pregnancy and may allow for conserving the patient's uterus and fallopian tube and preserving the future fertility.
  Journal of Laparoendoscopic & Advanced Surgical Techniques 05/2009; 19(4):509-12. · 1.40 Impact Factor
• Article: [Studies on chemical constituents from leaves of Cassia alata].

  An Liu, Lizhen Xu, Zhongmei Zou, Shilin Yang
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  ABSTRACT: To isolate and identify chemical constituents of Cassia alata. Compounds were separated and purified by column chromatography with silica gel and Sephadex LH-20, elucidated by spectroscopic methods including 1D and 2D NMR, IR and MS techniques. Twelve compounds were isolated from C. alata, which were identified as chrysoeriol (1), kaempferol (2), quercetin (3), 5,7,4'-trihydroflavanone (4), kaempferol-3-O-beta-D-glucopyranoside (5), kaempferol-3-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside (6), 17-hydrotetratriacontane (7), n-dotriacontanol (8), n-triacontanol (9), palmitic acid ceryl ester (10), stearic acid (11), palmitic acid (12). Compounds 3-12 were isolated from C. alata for the first time.
  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 05/2009; 34(7):861-3.
• Article: [Studies on chemical constituents of Uvaria tonkinensis var. subglabra].

  An Liu, Lizhen Xu, Zhongmei Zou
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  ABSTRACT: To isolate and identify chemical constituents of Uvaria tonkinensis var. subglabra. The column chromatographic techniques were applied to isolate constituents, and their structures were elucidated by means of spectral data analysis including 1D and 2D NMR, IR and MS techniques. Seven compounds were isolated and identified as subglain C (1), beta-senepoxide (2) , 2, 4-dioxohexahydro-1, 3-diazepin (3), kaempferol-3, 7-di-O-alpha-L-rhamnoside (4), anolobine (5), (-)-lyoniresinol (6) and schizandriside (7). Compound 1 was the new natural product; compounds 2-7 were isolated for the first time from U. tonkinensis var. subglabra.
  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 04/2009; 34(5):567-70.
• Article: Structure analysis of triterpene saponins in Polygala tenuifolia by electrospray ionization ion trap multiple-stage mass spectrometry.

  Jiangyun Liu, Xuedong Yang, Jiuming He, Min Xia, Lizhen Xu, Shilin Yang
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  ABSTRACT: Eighteen different triterpene saponins isolated from Polygala tenuifolia were investigated by electrospray ionization ion trap multiple-stage mass spectrometry (ESI-ITMS(n)) in positive and negative ion modes. MS(1)-MS(3)/MS(4) spectra of the both modes were analyzed, and they all gave fragments in line and shared common fragmentation patterns. Key fragments from MS(n) spectra of both the modes and their proposed fragmentation pathways were constructed with examples illustrated for the formation of characteristic fragments in the saponins. Two special fragmentation patterns were proposed: (1) the formation of fragments by cleavage of CH(2)O from Delta(12)-14alpha-CH(2)OH of the oleanene-type saponin aglycone in both positive and negative MS(n) (n > or = 2) modes; (2) the occurrence of fragments by cleavage of CO(2) and 3-glucose as the characteristic structure feature of 23-COOH at the oleanene-type saponin aglycones coupled with 3-Glc substitutes in the negative MS(n) (n > or = 2) modes. Peak intensities in MS(n) spectra were also correlated with structural features and fragmentation preferences of the investigated saponins, which are discussed in detail. In general, fragments formed predominantly by cleavages of glycosidic bonds in the positive mode, while selective cleavages of acyl bonds preceded that of glycosidic bonds in negative MS(n) (n > or = 2) mode, both of which could well be applied to the structural analysis of these saponins. Interpretation of MS(n) spectra presented here provided diagnostic key fragment ions important for the structural elucidation of saponins in P.tenuifolia.
  Journal of Mass Spectrometry 07/2007; 42(7):861-73. · 3.27 Impact Factor
• Article: One new triterpenoid saponin from Lysimachia davurica.

  Lin Zhang, Jingkui Tian, Lizhen Xu, Zhongmei Zou, Shilin Yang
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  ABSTRACT: One new saponin named davuricoside N (1) was isolated from the whole plants of Lysimachia davurica, the structure was determined by 1D and 2D NMR, ESI-MS techniques, and chemical methods.
  Natural Product Research 03/2007; 21(2):106-10. · 1.01 Impact Factor
• Article: Isolation and characterization of two new saponins from Lysimachia capillipes.

  Bo Liang, Lin Zhang, Jingkui Tian, Lizhen Xu, Shilin Yang
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  ABSTRACT: Two new saponins, capilliposide K (1) and capilliposide L (2), were isolated from the whole plants of Lysimachia capillipes. Their structures were established by spectral and chemical techniques.
  Carbohydrate Research 11/2006; 341(14):2444-8. · 2.33 Impact Factor
• Article: Genome-wide analysis of the expression profile of Saccharomyces cerevisiae in response to treatment with the plant isoflavone, wighteone, as a potential antifungal agent.

  Hongying Yin, Yongchao Zhao, Yan Zhang, Hongwu Zhang, Lizhen Xu, Zhongmei Zou, Weiping Yang, Jing Cheng, Yuxiang Zhou
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  ABSTRACT: The limitations of currently available antifungal agents and the rapid emergence of drug-resistant strains necessitate more efficient approaches to screening and developing novel antifungal drugs. The antifungal activity of the natural products of a series of plants was evaluated and wighteone, 5, 7, 4'-trihydroxy-6-(gamma,gamma-dimethylallyl)isoflavone showed excellent anti-yeast activity (MIC against Saccharomyces cerevisiae was 4 microg/ml). Transcriptome profiling of wighteone-treated S. cerevisiae indicated that wighteone is different from commonly used antifungal compounds in its mode of action.
  Biotechnology Letters 02/2006; 28(2):99-105. · 1.68 Impact Factor
• Article: Effects of cerebral ischemia-reperfusion on pharmacokinetic fate of paeoniflorin after intravenous administration of Paeoniae Radix extract in rats.

  Xihui He, Dongming Xing, Yi Ding, Yaping Li, Lizhen Xu, Lijun Du
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  ABSTRACT: The objective of the present study was to investigate the effects of cerebral ischemia-reperfusion on pharmacokinetics of paeoniflorin after intravenous administration of Paeoniae Radix extract (PRE) in rats. The cerebral ischemia-reperfusion rats were induced by occluding the bilateral carotid arteries of normal rats for 2 h, followed by reperfusion. The resultant animals were immediately administrated by PRE (at a dose of 60 mg/kg of paeoniflorin) via the femoral vein, whilst the same dose was injected to the normal rats. Plasma samples were collected at different time to construct pharmacokinetic profiles by plotting drug concentration versus time. Quantification of paeoniflorin in rat plasma was achieved by using a simple and rapid high-performance liquid chromatographic method. In normal rats, the major parameters of distribution half-life (t1/2alpha), elimination half-life (t1/2beta), area under the plasma concentration-time (AUC), mean retention time (MRT), and clearance (CL), estimated by an open two-compartmental model, were 0.69, 18.77 min, 5338.71 (microg min)/ml, 18.13 min and 0.0162 mg/(kg min), respectively. However, in ischemia-reperfusion rats, the corresponding parameters were 2.04, 24.51 min, 9626.00 (microg min)/ml, 29.75 min and 0.0071 mg/(kg min), respectively. The results showed that ischemia- reperfusion significantly increased AUC values, decreased CL values, and prolonged the terminal half-life of paeoniflorin. These findings suggest that the injuries of ischemia-reperfusion could play an important role in pharmacokinetic process of paeoniflorin.
  Journal of Ethnopharmacology 11/2004; 94(2-3):339-44. · 3.01 Impact Factor
• Article: Capillary electrophoretic behaviors of pharmacologically active xanthones from Securidaca inappendiculata with beta-cyclodextrin as a buffer additive.

  Tao Bo, Yongfa Huang, Xuedong Yang, Ke An Li, Huwei Liu, Lizhen Xu
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  ABSTRACT: The capillary electrophoretic (CE) behaviors of ten xanthones in the presence of beta-cyclodextrin (CD) are investigated, and apparent analyte-selector binding constants between beta-CD and the xanthones in the CE running buffer are calculated to elucidate the migration order. Also, the separation selectivity with beta-CD additive is compared with that of sulfated beta-CD additive. It is indicated that beta-CD can greatly change the separation selectivity of xanthones, and the electrophoretic behaviors of xanthones are rather different when using beta-CD from that when using sulfated beta-CD as an additive.
  Journal of chromatographic science 05/2003; 41(4):182-6. · 0.88 Impact Factor
• Article: Comparison of micellar electrokinetic chromatography and microemulsion electrokinetic chromatography for separation of pharmacologically active xanthones from Securidaca inappendiculata

  Tao Bo, Xuedong Yang, Ke An Li, Lizhen Xu, Huwei Liu
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  ABSTRACT: Micellar electrokinetic chromatography (MEKC) and microemulsion electrokinetic chromatography (MEEKC) have been investigated for the separation of nine xanthones from Securidaca inappendiculata, based on the systematic optimization of such parameters as pH, concentration of borate buffer, and sodium dodecyl sulfate (SDS) concentration. The study indicated that, in MEKC, although the addition of modifiers including organic solvents and cyclodextrins (CDs) could greatly affect the separation selectivity of xanthones, the baseline separation for nine xanthones could not be completed. As a special variant of electrokinetic chromatography (EKC), MEEKC successfully achieved the baseline separation of nine xanthones with satisfactory repeatability. Compared with MEKC, MEEKC showed better separation selectivity and higher separation efficiency.
  Journal of Separation Science 01/2003; 26(1‐2):133 - 136. · 2.73 Impact Factor
• Article: Controlled clinical trial assessing the effect of laparoscopic uterine arterial occlusion on ovarian reserve.

  Xiaoyan Qu, Zhongping Cheng, Weihong Yang, Lizhen Xu, Hong Dai, Liping Hu
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  ABSTRACT: To assess the effect on ovarian reserve function after laparoscopic uterine artery occlusion (LUAO) compared with laparoscopic surgery supracervical hysterectomy (LSH) and laparoscopic myomectomy (LM). Prospective cohort study (Canadian Task Force classification II-1). Hospital with experience in gynecologic minimal access surgery. Ninety patients with uterine myomas operated on from August through December 2007. Ninety patients were divided into 3 groups of 30 patients each: the study group underwent LUAO and myomectomy (LUAO-M), control group 1 underwent LSH, and control group 2 underwent LM only. Blood samples were collected before surgery and at 1, 3, and 6 months postoperatively. Concentrations of follicle-stimulating hormone (FSH), leuteinizing hormone (LH), and estradiol (EZ) were determined using an immunoassay, and serum inhibin B (INHB) concentration was evaluated using an enzyme-linked immunosorbent assay. No significant differences in preoperative hormone concentrations between the 3 groups were found (p>.05). In the LSH group, FSH, LH, and E2 concentrations were significantly increased, whereas the INHB concentration was significantly decreased at 1 month postoperatively (p<.05); after 3 months, only the INHB concentration was significantly decreased (p<.05). However, in the LOUA-M and LM groups, there were no significant differences between preoperative and postoperative hormone concentrations (p>.05). Serum concentrations of FSH, LH, and INHB in the LSH group were significantly different from those in the study group at 1 and 3 months postoperatively (p<.05); however, the differences in postoperative hormone concentrations between the study group and the LM group were not significant (p>.05). At short-term follow-up, no significant effect on ovarian reserve in patients with myoma who underwent LUAO was found.
  Journal of Minimally Invasive Gynecology 17(1):47-52. · 1.74 Impact Factor