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Yukiyoshi Okauchi,
Ken Kishida,
Tohru Funahashi,
Midori Noguchi, Tomoko Ogawa,
Kohei Okita,
Hiromi Iwahashi,
Tetsuya Ohira,
Akihisa Imagawa,
Tadashi Nakamura,
Iichiro Shimomura
[show abstract]
[hide abstract]
ABSTRACT: Circulating thiobarbituric acid-reacting substance (TBARS) levels, a marker of systemic oxidative stress, are predictive of cardiovascular events. However, they has not been evaluated in Japanese, especially with regard to the factors that contribute to the changes in circulating TBARS levels. We investigated the cross-sectional and longitudinal relationships between circulating TBARS levels and various clinicobiochemical parameters in middle-aged men.
In this population-based study (The Amagasaki Visceral Fat Study), 1,178 Japanese male urban workers who had undergone health check-ups in 2006, 2007 and 2008 and were not on medications for metabolic disorders during the follow-up period, were enrolled. Serum TBARS levels were measured by the method of Yagi. The estimated visceral fat area (eVFA) by bioelectrical impedance was measured annually. After health check-ups, subjects received health education with lifestyle modification by medical personnel.
The number of cardiovascular risk factors (hypertension, hyperglycemia, low HDL-C, hypertriglyceridemia, hyperuricemia, hyper-LDL-C and impaired renal function) augmented with the increases in log-eVFA (p < 0.0001) and log-TBARS (p < 0.0001). The combination of TBARS and eVFA had a multiplicative effect on risk factor accumulation (F value = 79.1, p = 0.0065). Stepwise multiple regression analysis identified log-eVFA, as well as age, log-body mass index (BMI), LDL-C, log-adiponectin, γ-glutamyl transpeptidase (γ-GTP) and uric acid as significant determinants of log-TBARS. Stepwise multiple regression analysis identified one-year changes in eVFA as well as BMI, γ-GTP and estimated glomerular filtration rate (eGFR) as significant determinants of one-year change in TBARS, and biennial changes in eVFA as well as BMI and γ-GTP, eGFR as significant determinants of biennial change in TBARS.
The present study showed a significant cross-sectional and longitudinal correlation between TBARS and eVFA, as well as BMI and γ- GTP, eGFR. Visceral fat reduction may independently associate with the improvement in systemic ROS in middle-aged Japanese men.
The Amagasaki Visceral Fat Study UMIN000002391.
Nutrition & Metabolism 11/2011; 8:82. · 2.88 Impact Factor
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Miwa Ryo,
Tadashi Nakamura,
Tohru Funahashi,
Midori Noguchi,
Ken Kishida,
Yukiyoshi Okauchi,
Hitoshi Nishizawa, Tomoko Ogawa,
Sumi Kojima,
Tetsuya Ohira,
Kohei Okita,
Hiromi Iwahashi,
Akihisa Imagawa,
Yuji Matsuzawa,
Iichiro Shimomura
[show abstract]
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ABSTRACT: The aim of this study was to evaluate the effects of health checkup and the health education "Hokenshido" program based on the concept that visceral fat accumulation causes metabolic syndrome (MetS), leading to cardiovascular disease (CVD).
Based on the Japanese definition of metabolic syndrome, in the annual health checkup for general subjects, the measurement of waist circumference and use of "Where am I?" chart on the way to develop atherosclerosis were introduced. The study group comprised 3,174 Japanese employees [2,440 males (46±11 years, mean ± SD), 734 females (43±10 years)], who underwent annual health checkup in 2003, 2004, and 2005. The medical staff provided "Hokenshido" for subjects assessed as having MetS and/or at high risk for CVD.
The prevalence of the MetS in 2003, 2004 and 2005 decreased in males (20.8%, 17.2%, 14.4%, p<0.001) and females (3.0%, 2.2%, 1.9%, p=0.359), respectively. Among subjects with MetS at baseline, the number of subjects with MetS significantly decreased in males (508, 287, 247, p<0.0001) and females (22, 8, 6, p<0.0001), respectively. Mean waist loss was 1.6 cm in males (<0.0001) and 1.5 cm in females (<0.001). Among subjects with metabolic syndrome at baseline, the mean waist loss was 2.5 cm in males (<0.0001) and 3.9 cm in females (<0.05). Fatal atherosclerotic vascular events were not recorded in this study period.
Health check-up and the "Hokenshido" program reduced the prevalence of the MetS, which might lead to prevention of CVD.
Internal Medicine 01/2011; 50(16):1643-8. · 0.94 Impact Factor
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Yukiyoshi Okauchi,
Ken Kishida,
Tohru Funahashi,
Midori Noguchi, Tomoko Ogawa,
Miwa Ryo,
Kohei Okita,
Hiromi Iwahashi,
Akihisa Imagawa,
Tadashi Nakamura,
Yuji Matsuzawa,
Iichiro Shimomura
[show abstract]
[hide abstract]
ABSTRACT: The accumulation of Visceral fat is known to precede metabolic disorders and atherosclerosis. This study aimed to determine the relationships between body mass index (BMI), waist circumference (WC), estimated visceral fat area (eVFA) measured by bioelectrical impedance analysis (BIA), and obesity-related cardiovascular risk factors.
The study population was 2,870 middle-aged Japanese employees (males/females=2,322/ 548), who had undergone a health check-up.
In the receiver operating characteristic (ROC) curve, the cutoff levels yielding maximal sensitivity plus specificity for predicting the prevalence of ≥ 2 risks were, 24.5 kg/m(2) for BMI, 84.6 cm for WC, and 111 cm(2) for eVFA in males, and 23.6 kg/m(2), 81.5 cm, and 67 cm(2) in females. The average number of risk factors was over 1.0 in those with a BMI ≥ 25 kg/m(2) and with a WC ≥ 85 cm for males, ≥ 28 kg/m(2) and ≥ 95 cm respectively for females, and those with an eVFA ≥ 100 cm(2) for both males and females. In males, it was around 1.0 with cutoff levels of BMI, WC, and eVFA from the ROC curve. However, in females, it was around 0.6, because the prevalence of subjects with obesity and multiple risks was very low.
These results suggested that the cutoff level for visceral fat reduction should be set based on an absolute value of risk factors, rather than a calculated value. In regular health check-up, it may be useful to set an absolute cutoff value for eVFA at 100 cm(2) as criteria to screen for multiple obesity-related cardiovascular risk factors.
Journal of atherosclerosis and thrombosis 12/2010; 17(12):1237-45. · 2.69 Impact Factor
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Etsuko F Akita,
Hiromi Iwahashi,
Yukiyoshi Okauchi,
Kohei Okita,
Midori Noguchi, Tomoko Ogawa,
Miwa Ryo,
Ken Kishida,
Tohru Funahashi,
Tadashi Nakamura,
Yuji Matsuzawa,
Akihisa Imagawa,
Iichiro Shimomura
[show abstract]
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ABSTRACT: Aims/Introduction: The aim of the present study was to determine the predictors of deterioration of glucose tolerance in individuals with normal glucose tolerance (NGT) and abdominal obesity, and whether a lifestyle intervention to reduce visceral fat is effective in these individuals.Materials and Methods: The study subjects were 251 individuals who had abdominal obesity with certain risk factors (hypertension, high fasting plasma glucose (FPG), elevated hemoglobin A1c (HbA1c), dyslipidemia and hyperuricemia) and underwent oral glucose tolerance test (OGTT) in 2004 and 2005.Results: Using the area under the receiver operating characteristic curve, we found that PG at 0 min, 60 min, and area under the curve (AUC) of glucose from 0 to 120 min (AUC [glucose0–120]) in OGTT were significant predictors of deterioration of glucose tolerance, with optimal cut-off values of 95 mg/dL, 158 mg/dL and 271 mg h/dL, respectively. Although the rate of deterioration of glucose tolerance didn’t decrease with reductions in visceral fat area (VFA) over the 1-year period in subjects with NGT, the rate tended to decrease with reductions in VFA in high-risk NGT subjects (PG at 0 min > 95 or at 60 min > 158, or AUC [glucose0–120] > 271).Conclusions: These results suggest that reduction of visceral fat over 1 year might not be beneficial in all subjects with NGT, but is beneficial in high-risk NGT. We propose that individuals with values of the aforementioned predictors higher than the cut-off levels, even those with NGT, should receive a lifestyle intervention program aimed at reducing visceral fat to prevent deterioration of glucose tolerance. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2010.00080.x, 2011)
Journal of Diabetes Investigation. 11/2010; 2(3):218 - 224.
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Atherosclerosis 10/2010; 212(2):698-700. · 3.79 Impact Factor
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Diabetes care 08/2010; 33(8):e110-1. · 8.09 Impact Factor
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Sachiko Tamba,
Hideaki Nakatsuji,
Ken Kishida,
Midori Noguchi, Tomoko Ogawa,
Yukiyoshi Okauchi,
Hitoshi Nishizawa,
Akihisa Imagawa,
Tadashi Nakamura,
Yuji Matsuzawa,
Tohru Funahashi,
Iichiro Shimomura
[show abstract]
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ABSTRACT: Chronic kidney disease including microalbuminuria relates to cardiovascular disease (CVD). Microalbuminuria is also known to be a marker of generalized endothelial dysfunction. The metabolic syndrome which encompasses visceral fat accumulation and various metabolic disorders, has also an increase in albuminuria and relates to CVD. However, the relationship between visceral fat accumulation and albuminuria remains to be defined. The present study investigated the relationship between visceral fat accumulation and urinary albumin-creatinine ratio (UACR) in Japanese men.
This study group comprised 1990 Japanese male subjects, who were employees of a city office, had undergone annual health check-up. Urinary albumin was collected from a single spot urine specimen collected anytime between morning and afternoon. Visceral fat area was estimated (eVFA) by the bioelectrical impedance analysis method.
Log-UACR correlated with age, log-body mass index (BMI), log-waist circumference (WC), log-eVFA, log-adiponectin, blood pressure, serum lipids and hemoglobin A1c (HbA1c). Stepwise multiple regression analysis identified log-eVFA, as well as HbA1c, blood pressure, log-TG, and age, as a significant determinant of log-UACR. Moreover, subjects with eVFA > or = 100 cm(2) had significantly higher UACR than those with eVFA <100 cm(2), irrespective of BMI. UACR was significantly worse in subjects with high numbers of metabolic risk factors, and moreover in subjects with eVFA > or = 100 cm(2) than in those with eVFA <100 cm(2).
These results suggested that visceral fat accumulation is associated with an increase in UACR. Evaluation of both visceral fat accumulation and urinary albumin may be important for preventing atherosclerotic diseases.
Atherosclerosis 03/2010; 211(2):601-5. · 3.79 Impact Factor
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Yukiyoshi Okauchi,
Ken Kishida,
Tohru Funahashi,
Midori Noguchi, Tomoko Ogawa,
Miwa Ryo,
Kohei Okita,
Hiromi Iwahashi,
Akihisa Imagawa,
Tadashi Nakamura,
Yuji Matsuzawa,
Iichiro Shimomura
Diabetes care 10/2009; 32(10):e122. · 8.09 Impact Factor
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Sachiko Tamba,
Hitoshi Nishizawa,
Tohru Funahashi,
Yukiyoshi Okauchi, Tomoko Ogawa,
Midori Noguchi,
Koichi Fujita,
Miwa Ryo,
Shinji Kihara,
Hiromi Iwahashi,
Kazuya Yamagata,
Tadashi Nakamura,
Iichiro Shimomura,
Yuji Matsuzawa
[show abstract]
[hide abstract]
ABSTRACT: Visceral fat accumulation is an underlying component of the metabolic syndrome (MetS). Hypoadiponectinemia is one of the key molecules of the MetS. In the present study, we investigated the relationship between the serum uric acid level, visceral fat accumulation and serum adiponectin concentration in Japanese men.
The study group comprised 1,520 Japanese employed men (mean age: 45.6+/-10.4 years, +/- SD), who had undergone an annual health check-up both in 2004 and 2005. In addition to parameters measured in the annual health check-up, visceral fat area (VFA) and serum adiponectin concentration were measured by the bioelectrical impedance analysis method and a sandwich enzyme-linked immunosorbent assay (ELISA) system, respectively.
Visceral fat accumulation was identified in 56.1% of the subjects with hyperuricemia. There was significant positive correlation between visceral fat area and serum uric acid levels (r=0.223, p<0.0001), and negative correlation between serum adiponectin concentration and serum uric acid levels (r=-0.198, p<0.0001). The one-year change in VFA was associated with the one-year change in serum uric acid levels. Stepwise multiple regression analysis showed that VFA and the serum adiponectin concentration were significant explanatory variables for serum uric acid levels.
Hyperuricemia is significantly associated with visceral fat accumulation and hypoadiponectinemia in Japanese men.
Internal Medicine 01/2008; 47(13):1175-80. · 0.94 Impact Factor
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Yukiyoshi Okauchi,
Hitoshi Nishizawa,
Tohru Funahashi, Tomoko Ogawa,
Midori Noguchi,
Miwa Ryo,
Shinji Kihara,
Hiromi Iwahashi,
Kazuya Yamagata,
Tadashi Nakamura,
Iichiro Shimomura,
Yuji Matsuzawa
Diabetes care 10/2007; 30(9):2392-4. · 8.09 Impact Factor
