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ABSTRACT: Background: Given the increasing prevalence of dementia, any intervention that can effectively slow the deterioration of cognitive function is of great importance. Objective: This study investigated the efficacy of a human-computer interaction-based comprehensive cognitive training program in cognitively impaired elderly individuals living in a nursing home. Methods: All subjects, who were aged ≥70 years and had cognitive impairment, were randomly allocated to an intervention group (n = 19) or a control group (n = 14). The intervention group received human-computer interaction-based comprehensive cognitive training for 24 weeks. Neuropsychological examinations were conducted before and after this period. The intervention group was subdivided into two groups according to the scores of global cortical atrophy (GCA) to evaluate the impact of training effectiveness on GCA. Results: After 24 weeks, neither group showed a significant change compared with baseline cognitive examinations. However, there was a tendency for greater improvement in memory, language, and visuospatial abilities for the intervention group as compared with controls. Patients with mild cognitive impairment showed improvements in language and visuospatial capacity, while patients with dementia showed improvements in attention/orientation, memory, language, and fluency. However, none of these findings were statistically significant. The results for the intervention subgroups showed that visuospatial ability improvement was significantly greater among those with a global cortical atrophy score of ≤15 (p < 0.05). Conclusion: Human-computer interaction-based comprehensive training may improve cognitive functions among cognitively impaired elderly individuals. The training effect was most prominent among those with milder cerebral atrophy.
Journal of Alzheimer's disease: JAD 04/2013; · 3.74 Impact Factor
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ABSTRACT: BACKGROUND: Hereditary Spastic Paraplegia Type 35 is a complicated form of HSP characterized by progressive spastic paraparesis, dysarthria, and mild cognitive decline associated with leukodystrophy on brain imaging. Mutations in the fatty acid 2-hydroxylase (FA2H) gene have been associated SPG35. METHODS: Sequencing of FA2H gene was conducted in a Chinese non-consanguineous family with two affected siblings manifesting with typical clinical features of SPG 35. 100 healthy individuals were set for control. RESULT: Triple heterozygous mutations in FA2H gene (c.968C>A; c.976G>A; c.688G>A) were identified in the two affected siblings. All the mutations were not documented previously and were not detected among 100 healthy controls. CONCLUSION: In this study we identified the first SPG 35 family in Han population. Triple FA2H mutations seem to result in a severe phenotype while more patients are needed to establish the genotype-phenotype correlations.
Journal of the neurological sciences 04/2013; · 2.32 Impact Factor
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ABSTRACT: Alzheimer's disease (AD) is an age-related neurodegenerative disorder, characterized clinically by insidious onset of memory and cognition impairment, emergence of psychiatric symptoms and behavioral disorder, and impairment of activities of daily living (ADL). Traditional Chinese medicine (TCM) is practiced in the Chinese health care system for more than 2,000 years. In recent years, scientists have isolated many novel compounds from herbs, some of which improve dementia with fewer side effects than conventional drugs and are regarded as potential anti-AD drugs. In this review, we summarize the latest research progress on TCM showing their possible role of treatment of AD and other demented diseases and possible pharmacological actions.
Translational neurodegeneration. 02/2013; 2(1):6.
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ABSTRACT: Parkinson's disease (PD) is pathologically characterized by the presence of α-synuclein positive intracytoplasmic inclusions. The missense mutation, A53T α-synuclein is closely related to hereditary, early-onset PD. Accumulating evidences suggest that pathological accumulation of A53T α-synuclein protein will perturb itself to be efficiently and normally degraded through its usual degradation pathway, macroautophagy-lysosome pathway, therefore toxic effects on the neuron will be exacerbated. Based on the above fact, we demonstrated in this study that A53T α-synuclein overexpression impairs macroautophagy in SH-SY5Y cells and upregulates mammalian target of rapamycin (mTOR)/p70 ribosomal protein S6 kinase (p70S6K) signaling, the classical suppressive pathway of autophagy. We further found that curcumin, a natural compound derived from the curry spice turmeric and with low toxicity in normal cells, could efficiently reduce the accumulation of A53T α-synuclein through downregulation of the mTOR/p70S6K signaling and recovery of macroautophagy which was suppressed. These findings suggested that the regulation of mTOR/p70S6K signaling may be a participant of the accumulation of A53T α-synuclein protein-linked Parkinsonism. Meanwhile curcumin could be a candidate neuroprotective agent by inducing macroautophagy, and needs to be further investigated by clinical application in patients suffering Parkinson's disease.
Journal of Neuroimmune Pharmacology 01/2013; · 4.57 Impact Factor
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ABSTRACT: Objective: A population-based survey was conducted to analyze the association of under-weight, blood pressure, glucose and lipid metabolism with cognitive impairment in people, 60 years and over, living in 2 towns of Shanghai. Methods: Face-to-face interviews were carried out to collect relevant information with questionnaires. Anthropometric indices of height, weight, waist circumference (WC) and hip circumference were measured. Multivariable logistic regression analyses were performed to evaluate the association of weight status with cognitive impairment. Results: Cognitive impairment were diagnosed in 198 (7.0%) of the 2 809 participants. Compared to the normal BMI category, the under-weight category was significantly associated with the risk of cognitive impairment (OR= 2.47, 95%CI: 1.46-5.23). Subjects with a high WC were 1.5 times (OR= 1.42, 95%CI: 1.10-2.67) more likely and subjects with a high WHR were 1.7 times (OR= 1.68, 95%CI: 1.05-2.84) more likely to be associated with cognitive impairment than the subjects in the reference group. This study demonstrates a significant interaction between hypertension, lipid disorder and WC or WHR on the risk of cognitive impairment in a rural population in Shanghai. Conclusions: Central obesity was significantly associated with the risk of cognitive impairment. A low BMI may be a risk factor for cognitive impairment. A significant interaction between hypertension, lipid disorder and WC or WHR on the risk of cognitive impairment in Shanghai rural population was found.
Asia Pacific Journal of Clinical Nutrition 01/2013; 22(1):74-82. · 1.13 Impact Factor
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Wei Chen,
Yu-Yan Tan,
Yun-Yun Hu,
Wei-Wei Zhan,
Li Wu,
Yue Lou,
Xi Wang,
Yi Zhou,
Pei Huang,
Yuan Gao,
Qin Xiao, Sheng-Di Chen
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ABSTRACT: Objectives: Both hyposmia and substania nigra (SN) hyperechogenicity on trascranial sonography (TCS) were risk markers for idiopathic Parkinson's disease (PD), which was beneficial to the differential diagnosis of the disease. However, each of their single diagnostic value is often limited. The purpose of present study was to explore whether the combination of olfactory test and TCS of SN could enhance differential diagnostic power in Chinese patients with PD. METHODS: Thirty-seven patients with PD and twenty-six patients with essential tremor (ET) were evaluated on 16-item odor identification test from extended version of sniffin' sticks and TCS of SN. The frequency of hyposmia and SN hyperechogenicity in each group was compared. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the two clinical biomarkers were analyzed. RESULTS: The frequency of hyposmia in patients with PD was significantly higher than in patients with ET (62.2% VS. 3.8%, P = 0.000). The frequency of SN hyperechogenicity in patients with PD was significantly higher than in ET subjects (48.6% VS. 15.4%, P = 0.006). The combination of hyposmia and SN hyperechogenicity (if either one or both present) discriminated patients with PD from ET with a sensitivity of 78.4% and 29.7%, specificity of 80.8% and 100%, PPV of 85.3% and 100%, and NPV of 72.4% and 50.0%, respectively. CONCLUSIONS: Our preliminary data suggested that the combination of hyposmia and SN hyperechogenicity could improve the diagnostic potential for discriminating Chinese patients with PD from ET.
Translational neurodegeneration. 12/2012; 1(1):25.
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Bin Liu,
Yu Zhang,
Ying Wang,
Qin Xiao,
Qiong Yang,
Gang Wang,
Jianfang Ma,
Jing Zhao,
Thomas J Quinn, Sheng-di Chen,
Jun Liu
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ABSTRACT: Recently, the angiogenin gene has been reported to be significantly associated with Parkinson's disease and amyotrophic lateral sclerosis in populations of European and American ancestry. But there have been no studies investigating the association between angiogenin and Parkinson's disease in the ethnic Chinese population. We conducted a case-control study to evaluate the association between angiogenin and Parkinson's disease in a Chinese population from mainland China. We sequenced the exons of angiogenin in 532 Parkinson's disease patients and 480 controls. We did not detect an angiogenin coding region mutation in either the patients or the controls. Our data do not support the association of angiogenin variants with PD in Han Chinese of mainland China.
Parkinsonism & Related Disorders 12/2012; · 3.80 Impact Factor
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ABSTRACT: BACKGROUND: To explore current status and choices regarding diagnosis and treatment of Parkinson's disease (PD) among physicians, general neurologists and movement disorders specialists in China via a national survey. METHODS: The cross-sectional questionnaire-based survey was conducted from November, 2010 to July, 2011. Six hundreds and twelve doctors from different cities in China were recruited for this study. RESULTS: 68.6% (n=420) and 23.9% (n=146) of doctors have read the national and international guidelines, respectively. There was a larger proportion of movement disorders specialists reading the guidelines, in contrast to physicians and general neurologists (P<0.001). Up to 76.4% (n=465) and 81.8% (n=498) of doctors would choose standard oral levodopa test and conventional MRI(with T1 and T2), respectively; Whereas susceptibility weighed imaging(SWI)(16.1%; n=98), transcranial sonography (TCS) (1.8%; n=11) and functional neuroimaging test, such as single photon emission computed tomography(SPECT) (10.2%; n=62) and positron emission tomography(PET)(13.3%; n=81) were less used for suspected patients with PD in clinical practice. Doctors at different levels or from different hospitals and cities would choose different medication for motor complications and non-motor symptoms of patients with PD, in addition to initial drug selection for newly diagnosed PD. Doctors who had read the guidelines had significantly better knowledge of medication selections for PD under specific circumstances. CONCLUSIONS: Compared with commonly employed standard oral levodopa test and conventional MRI, SWI complements MRI, TCS and functional neuroimaging were less performed for diagnosis of PD in clinical practice in China. The choices of diagnostic methods and therapeutic strategy of PD vary among physicians, general neurologists and movement disorders specialists. Guideline awareness is markedly beneficial to reasonable PD medications strategy in China.
BMC Neurology 12/2012; 12(1):155. · 2.17 Impact Factor
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Jun-Peng Zhuang,
Gang Wang,
Qi Cheng,
Li-Ling Wang,
Rong Fang,
Li-Hua Liu,
Rang Xiong,
Yu Zhang,
Ya-Xin Gui,
Wen-Yan Kang,
Hui-Dong Tang, Sheng-Di Chen
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ABSTRACT: Objectives
Our study aimed to investigate the prevalence of cognitive impairment(CI) and the associated risk factors among elderly people in Shanghai urban area, China. METHODS: A population-based survey was conducted among people aged 55 years or older in urban areas of Shanghai. Face-to-face interviews were carried out to collect information including demographic characteristics, medical history, and medication use, etc. The validated Chinese version of the Mini-Mental State Examination(MMSE) was used to screen subjects with CI, and the criteria of CI were adjusted for education levels. RESULTS: A total of 3,176 home-living residents (>=55 years old) were included in the study. Among them, 266 people (102 men and 164 women) were identified as cognition impaired, with a prevalence of 8.38% (266/3,176, 95% CI: (8.26, 8.49)) for both genders, 9.24% (102/1,103,95% CI: (9.18, 9.33)) for men and 7.93% (164/2,069, 95% CI: (7.80, 8.09)) for women, respectively. Furthermore, we found that several significant risk factors, including social factors(education, number of children, marriage status, and family structure), physiological factors (age, blood glucose level, and obesity), factors on living styles(physical exercise, diet & chronic diseases), and genetic factor(ApoE), associated with CI onset. CONCLUSIONS: This study confirms the high prevalence of CI among the elderly population in the Shanghai urban in China, similar to previous epidemiologic studies in Western countries. The putative risk factors associated with CI merit further investigated.
Translational neurodegeneration. 11/2012; 1(1):22.
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ABSTRACT: BACKGROUND: Hereditary spastic paraplegia is a clinically and genetically heterogeneous neurodegenerative disorder characterized by progressive spasticity of the lower limbs. Mutations in SPG11 gene have been recently identified as a major cause of hereditary spastic paraplegia with thin corpus callosum. METHODS: Two unrelated Chinese families were examined by clinical evaluation, mutation analysis of SPG11, detailed neuropsychological assessment and diffusion tensor imaging. RESULTS: Both patients presented with spastic paraparesis and learning disability. Two novel and one known mutations in SPG11 were detected through genetic analysis. Cognitive impairment was found with severe deficits in domains such as executive functions and memory. Magnetic resonance imaging showed thin corpus callosum while diffusion tensor imaging revealed increased mean diffusion and decreased fractional anisotropy in the corpus callosum and subcortical white matter in frontal, temporal lobe compared with the healthy controls. CONCLUSIONS: This study widens the spectrum of mutations in SPG11. The application of detailed neuropsychological tests and diffusion tensor imaging could detect cerebral subtle involvement even in early stage of the disease.
Parkinsonism & Related Disorders 10/2012; · 3.80 Impact Factor
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ABSTRACT: Although the pathogenesis of Alzheimer's disease (AD) is still not fully understood, it is acknowledged that intervention should be made at the early stage. Therefore, identifying biomarkers for the clinical diagnosis is critical. Metabolomics, a novel "omics", uses methods based on low-molecular-weight molecules, with high-throughput evaluation of a large number of metabolites that may lead to the identification of new disease-specific biomarkers and the elucidation of pathophysiological mechanisms. This review discusses metabolomics investigations of AD and potential future developments in this field.
Neuroscience Bulletin 10/2012; 28(5):641-8. · 1.31 Impact Factor
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ABSTRACT: Parkinson's disease (PD) is pathologically characterized by the presence of α-synuclein (α-syn)-positive intracytoplasmic inclusions named Lewy bodies in the dopaminergic neurons of the substantia nigra. A series of morbid consequences are caused by pathologically high amounts or mutant forms of α-syn, such as defects of membrane trafficking and lipid metabolism. In this review, we consider evidence that both point mutation and overexpression of α-syn result in aberrant degradation in neurons and microglia, and this is associated with the autophagy-lysosome pathway and endosome-lysosome system, leading directly to pathological intracellular aggregation, abnormal externalization and re-internalization cycling (and, in turn, internalization and re-externalization), and exocytosis. Based on these pathological changes, an increasing number of researchers have focused on these new therapeutic targets, aiming at alleviating the pathological accumulation of α-syn and re-establishing normal degradation.
Neuroscience Bulletin 09/2012; 28(5):649-57. · 1.31 Impact Factor
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ABSTRACT: Embryonic stem cells (ESC) transplantation is a potential therapeutic approach for Parkinson's disease (PD). However, one of the main challenges to this therapy is the post-transplantation survival of dopaminergic (DA) neurons. In this study, mouse ESC were differentiated into DA neurons by a modified serum free protocol. These ESC-derived neurons were then transplanted into striatum of 6-OHDA lesioned rat. The viability of grafted DA neurons was decreased, accompanied by activated microglia and high levels of proinflammatory factors, such as TNF-α and iNOS, in the graft niche. This suggested that the local neuroinflammation might be involved in the reduced cells viability. Selenite, the source of essential micronutrient selenium, could inhibit NF-κB p65 nuclear translocation and subsequently reduce iNOS, COX-2 and TNF-α expression in LPS-treated BV2 cells in a dose dependant manner. Before the transplantation of ESC-derived DA neurons, 6-OHDA lesioned rats were intraperitoneally injected with selenite. The expression levels of TNF-α and iNOS were decreased by 30% and 50%, respectively, in selenite treated group. The survival of implanted DA neurons and the rotational behavior of transplanted rats were also remarkably improved by selenite treatment. To sum up, selenite might benefit ESCs transplantation therapy in PD through anti-inflammation effects.
Current Molecular Medicine 07/2012; 12(8):1005-14. · 5.10 Impact Factor
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ABSTRACT: Complex molecular mechanisms underlying the pathogenesis of Parkinson's disease (PD) are gradually being elucidated. Accumulating genetic evidence implicates dysfunction of kinase activities and phosphorylation pathways in the pathogenesis of PD. Causative and risk gene products associated with PD include protein kinases (such as PINK1, LRRK2 and GAK) and proteins related phosphorylation signaling pathways (such as SNCA, DJ-1). PINK1, LRRK2 and several PD gene products have been associated with mitogen-activated protein (MAP) and protein kinase B (AKT) kinase signaling pathways. C-Jun N-terminal kinase (JNK), extracellular signal-regulated kinases (ERK) and p38, signaling pathways downstream of MAP, are particularly important in PD. JNK and p38 play an integral role in neuronal death. Targeting JNK or p38 signaling may offer an effective therapy for PD. Inhibitors of the ERK signaling pathway, which plays an important role in the development of l-DOPA-induced dyskinesia (LID), have been shown to attenuate this condition in animal models. In this review, we summarize experimental evidence gathered over the last decade on the role of PINK1, LRRK2 and GAK and their related phosphorylation signaling pathways (JNK, ERK, p38 and PI3K/AKT) in PD. It is speculated that improvement or modulation of these signaling pathways will reveal potential therapeutic targets for attenuation of the cardinal symptoms and motor complications in patients with PD in the future.
Progress in Neurobiology 06/2012; 98(2):207-21. · 8.87 Impact Factor
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ABSTRACT: The aim of this study was to investigate the serum concentration of interleukin (IL)-6 in patients with relapsing-remitting MS (RR-MS), compare the difference between males and females, and explore the correlation between the serum concentration of IL-6 and clinical parameters like the current age, the age at onset, disease duration, disability (expanded disability status scale, EDSS), and the number of relapse. We compared the serum concentration of IL-6 in 39 patients with MS and 39 healthy controls matched with sex and age. The serum IL-6 concentration was measured by FlowCytomix. Compared to healthy controls, both the frequency of subjects with detectable level of IL-6 (P=0.005) and the serum concentration of IL-6 (P=0.004) were significantly higher in MS patients. When data were analyzed by gender, statistical significances between MS patients and healthy controls were observed only in females, although the frequency with detectable level and the serum concentration of IL-6 were higher in male MS patients than male controls. The serum level of IL-6 was found to be significantly positively correlated with the number of relapse for female MS patients (r(s)=0.511, P=0.009), with the current age for male MS patients (r(s)=0.700, P=0.005), and with the age at onset for all MS patients (r(s)=0.351, P=0.028). Our results may support that IL-6 is involved in the pathogenesis of MS and indicate that differences exist between male and female patients.
Journal of neuroimmunology 05/2012; 249(1-2):109-11. · 2.84 Impact Factor
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Pei-Jing Cui,
Li Cao,
Ying Wang,
Yu-Lei Deng,
Wei Xu,
Gang Wang,
Yu Zhang,
Lan Zheng,
Qing-Zhou Fei,
Ting Zhang, Sheng-Di Chen
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ABSTRACT: Several previous studies on the relationship between the insulin-degrading enzyme (IDE) gene and Alzheimer's disease (AD) have connected certain genetic variants to late-onset AD, in the absence of the apolipoprotein E (APOE)ε4 allele. However, the conclusions of these studies remain controversial. We investigated the association between two polymorphisms of IDE with AD in the Chinese population and found that the T/A genotype of rs4646958 had an important role in AD (adjusted p=0.007, odds ratio [OR]=2.796, 95% confidence interval [CI]=1.330-5.878), under the co-dominant genetic model. The T/C genotype of rs1887922 was also significantly associated with AD compared to the T/T genotype (adjusted p=0.003, OR=2.644, 95% CI=1.407-4.970). The C allele of rs1887922 conferred a higher risk of AD under the dominant genetics model (adjusted p=0.001, OR=2.719, 95% CI=1.472-5.022). Compared with the two other variant genotypes, the T/T genotype showed a protective effect in both polymorphisms (adjusted p=0.007, OR=0. 358, 95% CI=0.170-0.752 for rs4646958; adjusted p=0.001, OR=0. 368, 95% CI=0.199-0.679 in rs1887922). In the context of APOEε4-negative status, both variants were significantly associated with AD in some genetic models.
Journal of Clinical Neuroscience 05/2012; 19(5):745-9. · 1.25 Impact Factor
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ABSTRACT: SK channels are small conductance calcium-activated potassium channels that are widely expressed in different neurons with
distinct subtypes. They play an important role in modulating synaptic plasticity, dopaminergic neurotransmission, and learning
and memory. The present review was mainly focused on the recent findings on the contradictory roles of SK channels in modulating
dopaminergic neurons in substantia nigra and in the pathogenesis of Parkinson’s disease (PD). Besides, whether modulation
of SK channels could be a potential target for PD treatment was also discussed.
小电导钙激活钾通道也即SK 通道, 其广泛表达于不同亚型的神经元中, 在调节突触可塑性、学习与记忆和多巴胺能神经传递过程中发挥重要作用。 本文重点讨论了SK通道调节黑质多巴胺能神经元的作用及其在帕金森病发病机制中的争议性角色, 并对调控SK 通道是否可成为一种新的治疗帕金森病的方法进行了探讨。
Keywordssmall-conductance calcium-activated potassium channel-Parkinson’s disease-afterhyperpolarization-dopaminergic neuron
关键词小电导钙激活钾通道-帕金森病-后超级化-多巴胺能神经元
Neuroscience Bulletin 04/2012; 26(3):265-271. · 1.31 Impact Factor
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ABSTRACT: Microglia are the representative myeloid cells in the brain, and their over-activation plays an important role in the pathogenesis
of Parkinson’s disease (PD). Microglia activation is believed to be regulated by the CD200-CD200R signaling. As the peripheral
counterpart of microglia, monocyte-derived macrophages (MDMs) share the same progenitor and antigen markers, and they have
similar biological behaviors and mirror microglial function in the brain. Here, we studied CD200R expression and its regulation
in MDMs from 32 PD cases, 27 age-matched old controls, and 28 young controls. We found that the basal CD200R expression is
similar in MDMs from young control, old control and PD patients. However, the induction of CD200R expression in MDMs under
various conditions is impaired in the old groups, especially in PD patients. There was a selective decrease in CD200R expression
induced by co-culture with dying PC12 cells in MDMs from PD cases, as compared with MDMs from the age-matched controls. We
also found that the inducible CD200R expression correlated inversely with the onset age of PD and to tumor necrosis factor-α
(TNF-α) released from MDMs. These results suggest an intrinsic abnormality in the CD200-CD200R signaling in MDMs during aging
and, especially, in PD. We speculate that in the PD brain, microglia might undergo abnormalities similar to MDMs.
KeywordsCD200 receptor-Macrophages-Parkinson’s disease
Neurochemical Research 04/2012; 35(4):540-547. · 2.24 Impact Factor
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ABSTRACT: The ATP-sensitive potassium (KATP) channels which extensively distribute in diverse tissues (e.g. vascular smooth muscle, cardiac cells, and pancreas) are
well-established for characteristics like vasodilatation, myocardial protection against ischemia, and insulin secretion. The
aim of this review is to get insight into the novel roles of KATP channels in Parkinson’s disease (PD), with consideration of the specificities KATP channels in the central nervous system (CNS), such as the control of neuronal excitability, action potential, mitochondrial
function and neurotransmitter release.
ATP 敏感性钾通道已被证实广泛分布于血맜平滑肌、 心肌、 胰腺等组织, 发挥 着诸如血맜舒张、 心肌缺血的保护及胰岛素分泌等作用。 本综述旨在阐明ATP敏感性钾通道在帕金森病发病机制中参与调控神经元电兴奋性、 线粒体功能及神经递质释放的独特角色,
以揭示对其进行深入研究的意义及作为帕金森病治疗靶点的可能性和潜在价值。
Neuroscience Bulletin 04/2012; 23(6):370-376. · 1.31 Impact Factor
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ABSTRACT: The growth factor receptor-bound protein 2 (Grb2)-associated binder (Gab) proteins are intracellular scaffolding/docking molecules,
and participate in multiple signaling pathways, usually acting as the downstream effector of proteintyrosine kinases (PTKs)-triggered
signal transduction pathway. When phosphorylated by PTKs, Gab proteins can recruit several signaling molecules (p85, SHP2,
and Crk), and subsequently activate multiple transmitting signals that are critical for cell growth, survival, differentiation
and apoptosis. Recently, it has been reported that Gab2 polymorphism is associated with the increase in the risk of Alzheimer’s disease (AD) and is involved in the pathogenesis
of AD. This review mainly focuses on the structure and function of Gab2 protein and its role in the pathogenesis of AD.
作为一类骨架/接头蛋白, 生长因子受体结合蛋白2 (Grb2)的相关结合蛋白家族(Grb2-associated binder protein) 参与了细胞内多种信号转导通路, 是酪氨酸激酶(PTKs)激活的下游信号转导通路的关键分子。 Gab2是这个家族的重要成员,
可被PTKs 磷酸化激活, 进而招募多种信号分子(如p85、 SHP2 和Crk), 在细胞增殖、 存活、 分化和凋亡等过程中发挥重要作用。 最近研究表明, Gab2 基因多态性可增加阿尔茨海默病(Alzheimer’s disease, AD)的患病风险, 从而与AD的发病密切相关。 本文拟对Gab2 的结构特点、 相关信号转导通路及其在AD发生过程中可能扮演的角色作一系统综述。
关键词
Gab2 基因-信号转导通路-阿尔茨海默病-载脂蛋白E
Keywords
Gab2
-signal transduction-Alzheimer’s disease-
ApoE
Neuroscience Bulletin 04/2012; 26(3):241-246. · 1.31 Impact Factor
