Nawfel Ben Rais

Military Academy, Tunisia, Naboel, Nābul, Tunisia

Are you Nawfel Ben Rais?

Claim your profile

Publications (32)19.16 Total impact

  • [show abstract] [hide abstract]
    ABSTRACT: To compare bipolar with standard monopolar transurethral resection of the prostate (TURP). A prospectively randomized study was conducted between January 2010 and September 2011. Primary end points studied were efficacy (maximum flow rate [Qmax], International Prostate Symptom Score) and safety (adverse events, decline in postoperative serum sodium [Na+] and haemoglobin [Hb] levels). Secondary end points were operation time and duration of irrigation, catheterization, and hospitalization. Sixty consecutive patients were randomized and completed the study, with 29 patients in the monopolar TURP group and 31 in the TURIS group. At baseline, the two groups were comparable in age, prostate volume, mean prostate-specific antigen value, International Prostate Symptom Score, and they had at least 12months of follow-up. Declines in the mean postoperative serum Na+ for bipolar and monopolar TURP groups were 1.2 and 8.7mmol/L, respectively. However, there was no statistical difference in the decline in postoperative Hb between the two groups. The mean catheterization time was 26.6 and 52hours in the bipolar and standard groups, respectively. This difference was statistically significant as was the difference in the time to hospital discharge. The IPSS and Qmax improvements were comparable between the two groups at 12months of follow-up. No clinically relevant differences in short-term efficacy are existed between the two techniques, but bipolar TURP is preferable due to a more favorable safety profile and shorter catheterization duration.
    Progrès en Urologie 02/2014; 24(2):121-6. · 0.80 Impact Factor
  • [show abstract] [hide abstract]
    ABSTRACT: Purpose To compare bipolar with standard monopolar transurethral resection of the prostate (TURP). Material and methods A prospectively randomized study was conducted between January 2010 and September 2011. Primary end points studied were efficacy (maximum flow rate [Qmax], International Prostate Symptom Score) and safety (adverse events, decline in postoperative serum sodium [Na+] and haemoglobin [Hb] levels). Secondary end points were operation time and duration of irrigation, catheterization, and hospitalization. Results Sixty consecutive patients were randomized and completed the study, with 29 patients in the monopolar TURP group and 31 in the TURIS group. At baseline, the two groups were comparable in age, prostate volume, mean prostate-specific antigen value, International Prostate Symptom Score, and they had at least 12 months of follow-up. Declines in the mean postoperative serum Na+ for bipolar and monopolar TURP groups were 1.2 and 8.7 mmol/L, respectively. However, there was no statistical difference in the decline in postoperative Hb between the two groups. The mean catheterization time was 26.6 and 52 hours in the bipolar and standard groups, respectively. This difference was statistically significant as was the difference in the time to hospital discharge. The IPSS and Qmax improvements were comparable between the two groups at 12 months of follow-up. Conclusion No clinically relevant differences in short-term efficacy are existed between the two techniques, but bipolar TURP is preferable due to a more favorable safety profile and shorter catheterization duration.
    Progrès en Urologie. 01/2014; 24(2):121–126.
  • Progrès en Urologie. 11/2012; 22(13):765.
  • Source
    [show abstract] [hide abstract]
    ABSTRACT: INTRODUCTION Tumor Necrosis Factor (TNF) receptor associated factors (TRAFs) have emerged as the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like receptor super-family (Wajant & Scheurich, 2001). TNF-· binding to its receptor TNFR-1 induces the activation of TRAF-2 (one of the six members of the TNF recep-tor associated factors) (Bradley & Pober, 2001). The signaling pathways activated by TRAF-2 results in different cell responses including survival, prolifera-tion and apoptosis. TRAF-2 activated two major trans-cription factors: ∞ctivator Protein-1 (AP-1) and Nu-clear Factor-ÎB (NF-ÎB) (Chung et al., 2002; Wajant et al., 2003; Hayden & Ghosh, 2008). Both transcrip-tion factors are activated through the activation of JNK/p38 or IkB kinases (Liu et al., 2000). The TRAF-2-mediated NF-ÎB activation promotes the prolife-ration by expression of genes involved in inflamma-tory and anti apoptotic responses (Bonizzi & Karin, 2004). Alternatively, TRAF-2 has also been shown to associate with Apoptosis Signal-regulating Kinase 1 (ASK1) and MEK-6 to induce p38 activation (Liu et al., 2000). p38 is required for expression of TNF· and IL-1 inflammatory responses and most stimuli that activate p38 also induce expression of the p38 protein which regulates many transcription factors (including ELK-1, ATF-2, NF-ÎB), cell cycle and a-poptotic mediators (Zarubin & Han, 2005; Royuela et al., 2008; Thornton & Rincon, 2009; Whyte et al., 2009). Prostate cancer progression was characterized by activation of several signaling pathways, leading to the loss of proliferation and cell death balance (Ram-say & Leug, 2009; Culig & Puhr, 2011). These signal-ing are mainly induced by the expression of growth factors and pro-inflammatory cytokines (Ghosh et al., This study was designed in order to analyze the expression of the transduction pathways TRAF-2/ASK-1/MEK-6/Pp38 and NF-ÎB/p65, involved in the proliferation/apoptosis equilibrium in normal and pathological conditions. The study was carried out in 5 Normal Prostates (NP), 24 Benign Prostate Hyperplasia (BPH) and 19 Prostate Cancers (PC). Immunohistochemical and Western blotting analysis was performed. Western Blotting analysis revealed immunoexpression of TRAF-2, ASK-1, MEK-6 and Pp38 in BPH and PC. MEK-6 and NF-ÎB/p65 were absent in NP. Immunohistochemical analysis showed significant weak optical density to ASK-1 in PC compared to NP and BPH. Optical densities to MEK-6 and NF-ÎB/p65 were significantly in-tense in PC. p38 activation in prostate cancer could have apoptotic and proliferation role de-pending on the activation of its upstream and downstream component.
    Journal of Biological Research 01/2012; · 0.62 Impact Factor
  • La Tunisie médicale 12/2011; 89(12):948-9.
  • La Tunisie médicale 12/2011; 89(12):945-6.
  • [show abstract] [hide abstract]
    ABSTRACT: Involvement of NF-κB (nuclear factor κB) mediated by IL-1β (interleukin-1β) on cell proliferation and PSA (prostate-specific antigen) production of LNCaP prostate cell lines and the possible cross-talk with Akt (also known as protein kinase B) signalling pathway has been investigated. NF-κB and Akt were analysed by Western blotting from LNCaP cells treated by IL-1β before proliferation and PSA production were measured. IL-1β inhibited proliferation and decreased PSA production. The Akt pathway was not sensitive, whereas NF-κB phosphorylation occurred as a result of treatment. PSA production and proliferation of LNCaP cells were down-regulated by NF-κB mediated by IL-1β promoting anti-apoptotic signalling and co-suppressor factors of PSA expression. IL-1β through NF-κB activation provides a rationale for therapeutic approaches in the anticancer treatment of prostate.
    Cell Biology International 11/2011; 36(5):449-54. · 1.64 Impact Factor
  • [show abstract] [hide abstract]
    ABSTRACT: To evaluate the Oncological and functional results and to clear risk factors of biochemical recurrence in patients with prostate cancer treated by retropubic prostatectomy. Retrospective analysis of 50 consecutive retropubic radical prostatectomies performed between January 1999 and january 2008. Biochemical recurrence was defined by PSA > 0.2 ng/ml. Univariate analysis of prognostic factors of biochemical recurrence was performed. The study of the urinary continence and the sexuality is essentially based on a meticulous interrogatory. The biochemical recurrence-free survival was 68%. Significant risk factors on univariate analysis were: number of positive biopsy, the percentage of positive biopsy, perineural invasion, Gleason score, clinical stage, pathological stage, and tumour volume. On the functional plan, only one patient is totally incontinent. The return to a normal sexuality appears uncertain, the sexual potency was satisfactory among 5 patients (10% of the patients operated and 55,5% of the patients having had a nervesparing techniques) Our oncological results is acceptable and are quite comparable to literature. This while guaranteeing the satisfactory functional results essentially basing on an acquirement of a continence quasi-perfect.
    La Tunisie médicale 09/2011; 89(8-9):703-8.
  • [show abstract] [hide abstract]
    ABSTRACT: The aim of this work was to characterise the immunoexpression of NF-κB (p50/p65) in human prostatic pathologies and to study its profiles of activation among sera prostate specific antigen antigen (PSA) according the three groups: 0-4ng/mL, 4-20ng/mL and >20ng/mL. Twenty-four men with benign prostate hyperplasia (BPH); 19 men with prostate cancer (PC) and five men with normal prostates (NP). Immunohistochemical and western blot analysis was performed. Serum levels of PSA were assayed by immulite autoanalyser. In BPH and PC samples, immunoexpressions were observed for NF-κBp65 and NF-κBp50; while in NP samples, only were detected NF-κBp50. PC samples showed immunoreactions to NF-κBp65 and NF-κBp50 more intense (respectively 24.18±0.67 and 28.23±2.01) than that observed in BPH samples (respectively18.46±2.04 and 18.66±1.59) with special localisation in the nucleus. Different profiles of NF-κBp65 immunoexpressions were observed and BPH patients with sera PSA levels between 0-4ng/mL presented a significant weak percentage compared to BPH patients with sera PSA levels between 4-20ng/mL and >20ng/mL. No immunoreactions to NF-κBp65 were observed in PC patients with sera PSA levels between 4-20ng/mL. The sensibility of both NF-κB and PSA to inflammation allowed confirming the relationship between these two molecules and its involvement in prostatic diseases progression (inflammatory and neoplasic).
    Pathologie Biologie 08/2011; 60(5):301-5. · 1.67 Impact Factor
  • [show abstract] [hide abstract]
    ABSTRACT: Renal colics due to urinary stones are also common in women of childbearing age whether pregnant or not. AIM : Through a review of literature, we evaluated diagnostic and therapeutic approaches in renal colic in pregnancy and lactation. Review of literature. The clinical diagnosis is sometimes difficult requiring additional medical imaging based on ultrasound. Other radiological investigations using X-rays are formally forbidden. The prescription of analgesic treatment during pregnancy and lactation must take into account mainly the teratogenic risk in addition to maternal risk by altering drug pharmacokinetics during pregnancy. During pregnancy, NSAIDs are prohibited because of their teratogenicity effect. Salicylates and opiates should be used with care, especially in cases of threat of confinement. Paracetamol remains the treatment of choice. Salicylates and corticosteroids should be used with caution during lactation.
    La Tunisie médicale 07/2011; 89(7):593-7.
  • La Tunisie médicale 06/2011; 89(6):576.
  • [show abstract] [hide abstract]
    ABSTRACT: To evaluate the efficacy and side-effects of Polidocanol used as sclerosing agent for testicular hydrocele. One hundred and ninety men, with a median age of 55,9 years (40-89), treated for idiopatic hydrocele were assessed. After puncture and aspiration, the empty sac was instilled with 3% Polidocanol. We recorded recurrence, complications and associated pain on a visual analogue scale. With a median follow-up of 19 months, The cure rate of hydroceles after one sclerotherapy session was 62,1%, and the overall cure rate using the procedure was 82,6%. Re-instillation was done for recurrences in 41% of patients. Polidocanol therapy was almost pain-free. A low rate of complications was observed. Polidocanol is a useful sclerosing agent for treating testicular hydrocele. Due to its ease of administration, low frequency of complications, high rate of effectiveness, and excellent tolerability; we recommend sclerotherapy with polidocanol as the primary treatment for hydroceles.
    La Tunisie médicale 05/2011; 89(5):440-4.
  • [show abstract] [hide abstract]
    ABSTRACT: Eosinophilic cystitis is a rare inflammatory pathology. It remains a poorly understood entity. To report a series of adult cases of eosinophilic cystitis mimicking a bladder tumor. Retrospective study of cases of eosinophilic cystitis collected in an urology department. Diagnosis was established on a spontaneous bladder perforation in one case and on hematuria in the eight other cases. Histopatholgy studies confirmed the diagnosis. Eight patients underwent an endoscopic resection of bladder lesions followed by medical therapy with nonsteroidal anti-inflammatory drugs and cortimoxazole. An ileal bladder enlargement was performed in one case. Regular follow-up didn't reveal any recurrence. Eosinophilic cystitis is a rare disease simulating a tumor of bladder. Its clinical presentation is not specific and final diagnosis is based on pathology. Endoscopic resection will help to pathologic diagnosis. Associated to corticoids and antihistaminic drug endoscopic resection constitute the treatment of choice.
    La Tunisie médicale 04/2011; 89(4):360-3.
  • [show abstract] [hide abstract]
    ABSTRACT: Frequently met in clinical sexology as in general medicine, ejaculatory troubles had a multifactorial etiopathogeny and are subjects to controversies. Their therapies remain difficult despite different possible approaches.
    La Tunisie médicale 12/2010; 88(12):869-75.
  • Source
    [show abstract] [hide abstract]
    ABSTRACT: To increase the detection rate of prostate cancer in recent years, we examined the increase in the number of cores taken at initial prostate biopsy. We hypothesized that an increasing number of cores may undermine the accuracy of models predicting the presence of prostate cancer at initial biopsy in patients submitted to 20-core initial biopsy. A total of 232 consecutive patients with prostate-specific antigen (PSA) between 4 and 20 ng/mL and/or abnormal digital rectal examination (DRE) underwent 12-core prostate biopsy protocol (group 1) or 20-core prostate biopsy protocol (group 2). The patients were divided into subgroups according to the results of their serum PSA and prostate volume. We evaluated the cancer detection rate overall and in each subgroup. Clinical data were analyzed using chi-square analysis and the unpaired t-test or 1-way ANOVA with significance considered at 0.05. The 2 groups of patients were not significantly different with regard to parameters (age, abnormal DRE and serum PSA), although median prostate volume in group 1 (57.76 +/- 26.94 cc) were slighter greater than in group 2. Cancer detection rate for patients submitted to 20 prostate biopsy was higher than patients submitted to 12 prostate biopsy (35.2% vs. 25%, p = 0.095). Breakdown to PSA level showed a benefit to 20 prostate biopsy for PSA <6 ng/mL (37.1% vs. 12.9%, p = 0.005). Stratifying results by prostate volume, we found that the improvement of cancer detection rate with 20 prostate biopsy was significant in patients with a prostate volume greater than 60 cc (55% in 20 prostate biopsy vs. 11.3% p < 0.05). Morbidity rates were identical in groups 1 and 2 with no statistically significant difference. There appeared to be no greater risk of infection and bleeding with 20 prostate biopsy protocol. The 20-core biopsy protocol was more efficient than the 12-core biopsy protocol, especially in patients with prostate specific antigen <6 ng/mL and prostate volume greater than 60 cc.
    Canadian Urological Association journal = Journal de l'Association des urologues du Canada 04/2010; 4(2):100-4. · 1.66 Impact Factor
  • Urology 01/2010; 76(3). · 2.42 Impact Factor
  • Source
    [show abstract] [hide abstract]
    ABSTRACT: The present study was undertaken to relate the co-expression of prostate-associated antigens, PSMA and PSA, with the degree of vascularization in normal and pathologic (hyperplasia and cancer) prostate tissues to elucidate their possible role in tumor progression. The study was carried out in 6 normal, 44 benign prostatic hyperplastic and 39 cancerous human prostates. Immunohistochemical analysis were performed using the monoclonal antibody CD34 to determine the angiogenic activity, and the monoclonal antibodies 3E6 and ER-PR8 to assess PSMA and PSA expression, respectively. In our study we found that in normal prostate tissue, PSMA and PSA were equally expressed (3.7 ± 0.18 and 3.07 ± 0.11). A significant difference in their expression was see in hyperplastic and neoplastic prostates tissues (16.14 ± 0.17 and 30.72 ± 0.85, respectively) for PSMA and (34.39 ± 0.53 and 17.85 ± 1.21, respectively) for PSA. Study of prostate tumor profiles showed that the profile (PSA+, PSMA-) expression levels decreased between normal prostate, benign prostatic tissue and primary prostate cancer. In the other hand, the profile (PSA-, PSMA+) expression levels increased from normal to prostate tumor tissues. PSMA overexpression was associated with high intratumoral angiogenesis activity. By contrast, high PSA expression was associated with low angiogenesis activity. These data suggest that these markers are regulated differentially and the difference in their expression showed a correlation with malignant transformation. With regard to the duality PSMA-PSA, this implies the significance of their investigation together in normal and pathologic prostate tissues.
    Journal of Experimental & Clinical Cancer Research 01/2010; 29:171. · 3.07 Impact Factor
  • European Urology Supplements - EUR UROL SUPPL. 01/2010; 9(2):84-84.
  • La Tunisie médicale 04/2009; 87(4):296-9.
  • [show abstract] [hide abstract]
    ABSTRACT: The aim of this study was determined the expression of pro inflammatory cytokines in prostate epithelial cells. Furthermore, we analysed the relation between these cytokines and sera PSA levels according the three groups: 0-4, 4-20 and >20 ng/mL. The study was carried out in five normal prostate (NP), 27 benign prostate hyperplastic (BPH) and 18 prostate cancer (PC). Immunohistochemical and Western blot analysis was performed. Serum levels of PSA were assayed by Immulite autoanalyser. The western Blotting analysis revealed an immunoexpression of IL-1alpha, IL-6 and TNFalpha in BPH and PC. IL-1alpha, was absent in NP. Immunohistochemical analysis showed significant high optical density to IL-1alpha and IL-6 in cancer epithelial cells (19.45 +/- 3.25 and 26.2 +/- 3.19) compared to normal cells (1.73 +/- 1.51 and 4.83 +/- 2.65). While, TNFalpha optical densities were not significant in NP (12.03 +/- 2.9), BPH (9.87 +/- 3.85) and PC (13.34 +/- 2.34). The different profiles of cytokines according sera PSA levels showed a high immunoexpression of the profile (IL-6+, IL-1alpha+) in BPH patients with PSA between 0-4 and 4-20 ng/mL. However, PC patients with sera PSA between 4 and 20 ng/mL, showed a significant high immunoexpression of the profile (IL-6+, IL-1alpha-). This data demonstrate a locally production of pro-inflammatory cytokines by prostate epithelial cells and a cross talk between PSA and these cytokines in prostate pathologies.
    Inflammation 04/2009; 32(3):202-10. · 2.46 Impact Factor

Publication Stats

65 Citations
221 Downloads
2k Views
19.16 Total Impact Points

Institutions

  • 2012
    • Military Academy, Tunisia
      Naboel, Nābul, Tunisia
  • 2011
    • University of Tunis El Manar
      Tunis-Ville, Tūnis, Tunisia
    • La Rabta Hospital Tunis
      Tunis-Ville, Tūnis, Tunisia
  • 2010–2011
    • University of Carthage
      • Faculty of Sciences, Bizerte
      Carthage, Gouvernorat de Tunis, Tunisia
  • 2008–2011
    • Military Hospital of Instruction of Tunis
      Tunis-Ville, Tūnis, Tunisia