Peter Andreas Fasching

Publications (3)5.84 Total impact

• Article: Preoperative pain and recurrence risk in patients with peritoneal endometriosis.

  Stefan Peter Renner, Susanne Rix, Alexander Boosz, Johannes Hugo Lermann, Pamela L Strissel, Falk Clemens Thiel, Peter Oppelt, Matthias W Beckmann, Peter Andreas Fasching
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  ABSTRACT: Pain symptoms in endometriosis patients do not necessarily correlate with the extent of the disease, and there is little evidence regarding the recurrence risk. Aim of this study was to assess the risk factors for the recurrence of endometriosis, with regard to preoperative and postoperative pain. Retrospective observational study. Single institution study. A total of 150 patients were followed up for recurrence after surgical treatment for endometriosis. The patients were interviewed retrospectively to obtain information about pain levels during the course of the disease. Disease free survival. High preoperative pain levels were associated with a higher risk of recurrence after 4 years of follow-up. The hazards ratio was 2.30 (95% CI, 1.22-4.31; p = 0.009). None of the other parameters assessed for medical history, reproductive history, or lifestyle was associated with the recurrence risk. The risk for recurrence after surgery for endometriosis may be substantially influenced by the patients' perception of pain. Risk classifications for the recurrence risk in endometriosis are nonexistent. Developing these is imperatively needed soon to improve further treatment and/or prophylaxis for patients after surgery. A classification might be improved by adding sensory testing before surgery.
  Gynecological Endocrinology 09/2009; 26(3):230-5. · 1.58 Impact Factor
• Article: Acceptance for preventive genetic testing and prophylactic surgery in women with a family history of breast and gynaecological cancers.

  Sven Ackermann, Michael Patrick Lux, Peter Andreas Fasching, Pamela Strissl, Stefan Peter Renner, Uwe Poehls, Hans-Georg Bender, Matthias Wilhelm Beckmann
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  ABSTRACT: The fear of family members of patients with breast or gynaecologic cancer of developing a similar disease is often high. We investigated the acceptance for genetic testing of untested women with a positive family history and their attitude for prophylactic surgery. A total of 659 women with a familial history of breast or gynaecologic cancer were asked to answer a questionnaire regarding their interest in genetic testing for breast cancer as well as for gynaecologic carcinoma and their interest in prophylactic surgery. Genetic testing is seen to be accepted by the majority of participants: 85.0 and 77.8% chose a genetic test for breast and gynaecologic cancer, respectively. Prophylactic surgery was much less chosen; prophylactic mastectomy as well as prophylactic hysterectomy or bilateral prophylactic oophorectomy was an option only for a minority of women. Genetic testing for risk assessment of healthy women with a positive family history was observed to be accepted by a majority of participants. Prophylactic surgery was an option only for a minority and was not acceptable for most of the women.
  European Journal of Cancer Prevention 01/2007; 15(6):474-9. · 2.13 Impact Factor
• Article: Age of uptake of early cancer detection facilities by low-risk and high-risk patients with familial breast and ovarian cancer.

  Michael Patrick Lux, Sven Ackermann, Mayada R Bani, Caroline Nestle-Krämling, Timm O Goecke, Dieter Niederacher, R Bodden-Heidrich, Hans-Georg Bender, Matthias Wilhelm Beckmann, Peter Andreas Fasching
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  ABSTRACT: Some 5-10% of all cases of breast cancer and ovarian cancer have a hereditary genesis. In the setting of an interdisciplinary cancer genetics clinic, a study of the age at which patients first take advantage of early cancer detection (ECD) facilities was conducted in order to assess the influence of familial risk on health issues. The study included 556 women who fulfilled the inclusion criteria (IC) for genetic analysis of the BRCA1 and BRCA2 genes, as well as 205 who did not meet these criteria but attended the primary consultation. Consulters who met the inclusion criteria took advantage of nearly all methods of ECD at an earlier time than women who did not. A comparison of consulters with or without breast cancer showed that those without breast cancer participated in all methods of ECD at an earlier time. Methods of improving and increasing participation in ECD facilities, and of encouraging women who are at risk to start on such programs at a younger age, need to be discussed. In this study, familial risk already resulted in a younger age of uptake of ECD facilities.
  European Journal of Cancer Prevention 01/2006; 14(6):503-11. · 2.13 Impact Factor