Russell Steele

Jewish General Hospital, Montréal, Quebec, Canada

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Publications (88)268.26 Total impact

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    ABSTRACT: The purpose of this study was to validate a recently proposed return-to-play (RTP) decision model that simplifies the complex process into three underlying constructs: injury type and severity, sport injury risk, and factors unrelated to injury risk (decision modifiers). We used a cross-over design and provided clinical vignettes to clinicians involved in RTP decision making through an online survey. Each vignette included examples changing injury severity, sport risk (e.g. different positions), and non-injury risk factors (e.g. financial considerations). As the three-step model suggests, clinicians increased restrictions as injury severity increased, and also changed RTP decisions when factors related to sport risk and factors unrelated to sport risk were changed. The effect was different for different injury severities and clinical cases, suggesting context dependency. The model was also consistent with recommendations made by subgroups of clinicians: sport medicine physicians, non-sport medicine physicians, and allied health care workers.
    Scandinavian Journal of Medicine and Science in Sports 09/2014; · 3.21 Impact Factor
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    ABSTRACT: Objectives. To compare paramedics’ ability to minimize cervical spine motion during patient transfer onto a vacuum mattress with two stabilization techniques (head squeeze vs. trap squeeze) and two transfer methods (log roll with one assistant (LR2) vs. 3 assistants (LR4)). Methods. We used a crossover design to minimize bias. Each lead paramedic performed 10 LR2 transfers and 10 LR4 transfers. For each of the 10 LR2 and 10 LR4 transfers, the lead paramedic stabilized the cervical spine using the head squeeze technique five times and the trap squeeze technique five times. We randomized the order of the stabilization techniques and LR2/LR4 across lead paramedics to avoid a practice or fatigue effect with repeated trials. We measured relative cervical spine motion between the head and trunk using inertial measurement units placed on the forehead and sternum. Results. On average, total motion was 3.9° less with three assistants compared to one assistant (p = 0.0002), and 2.8° less with the trap squeeze compared to the head squeeze (p = 0.002). There was no interaction between the transfer method and stabilization technique. When examining specific motions in the six directions, the trap squeeze generally produced less lateral flexion and rotation motion but allowed more extension. Examining within paramedic differences, some paramedics were clearly more proficient with the trap squeeze technique and others were clearly more proficient with the head squeeze technique. Conclusion. Paramedics performing a log roll with three assistants created less motion compared to a log roll with only one assistant, and using the trap squeeze stabilization technique resulted in less motion than the head squeeze technique but the clinical relevance of the magnitude remains unclear. However, large individual differences suggest future paramedic training should incorporate both best evidence practice as well as recognition that there may be individual differences between paramedics.
    Prehospital Emergency Care 07/2014; · 1.86 Impact Factor
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    ABSTRACT: Research on psychological risk factors for injury has focused on stable traits. Our objective was to test the feasibility of a prospective longitudinal study designed to examine labile psychological states as risk factors of injury.
    BMC Medical Research Methodology 06/2014; 14(1):77. · 2.21 Impact Factor
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    ABSTRACT: A recent return to play decision-making (RTP-DM) model for sport medicine has organized the underlying concepts into 3 steps but has not yet been validated. To examine the validity of the 3-step RTP-DM model recently proposed. Repeated measures cross-over survey design. World-wide. American College of Sports Medicine clinicians involved in RTP-DM. We provided clinical vignettes of injuries and illnesses in athletes to participants through an online survey. Each vignette included examples of 3 factor types: increasing injury severity, changing risk associated with sport (e.g. different positions), and changing non-injury risk factors (e.g. financial considerations). For each vignette, participants indicated the level of activity restriction they would recommend (6 options from No Restrictions to No Activity) in accordance with the risk they placed on continued participation. We analyzed the data using multiple regression, adjusting for the correlated participant outcomes, to measure how changes in factors affected individual participants. The estimated participation rate for those involved in RTP decisions was 24.7%. As expected, we found that clinicians increase restrictions as injury severity increases. We also found that changing factors related to sport risk, and changing factors that are unrelated to sport risk will affect RTP decisions, although the effect is context-dependent and does not occur equally across all injury severities and clinical cases. The effect was also observed in each subgroup examined that included sex, age, specialty, region of training, academic status, and years of experience making RTP decisions. Our findings that clinicians from a wide variety of backgrounds will change RTP recommendations based on clinical vignettes with changing injury severity, sport risk modifiers and decision modifiers provides evidentiary support for the 3-step model for RTP decision making recently proposed.
    British journal of sports medicine 04/2014; 48(7):661. · 3.67 Impact Factor
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    ABSTRACT: Objective. The aim of this study was to compare oral abnormalities and oral health-related quality of life (HRQoL) of patients with SSc with the general population.Methods. SSc patients and healthy controls were enrolled in a multisite cross-sectional study. A standardized oral examination was performed. Oral HRQoL was measured with the Oral Health Impact Profile (OHIP). Multivariate regression analyses were performed to identify associations between SSc, oral abnormalities and oral HRQoL.Results. We assessed 163 SSc patients and 231 controls. SSc patients had more decayed teeth (SSc 0.88, controls 0.59, P = 0.0465) and periodontal disease [number of teeth with pocket depth (PD) >3 mm or clinical attachment level (CAL) ≥5.5 mm; SSc 5.23, controls 2.94, P < 0.0001]. SSc patients produced less saliva (SSc 147.52 mg/min, controls 163.19 mg/min, P = 0.0259) and their interincisal distance was smaller (SSc 37.68 mm, controls 44.30 mm, P < 0.0001). SSc patients had significantly reduced oral HRQoL compared with controls (mean OHIP score: SSc 41.58, controls 26.67, P < 0.0001). Multivariate regression analyses confirmed that SSc was a significant independent predictor of missing teeth, periodontal disease, interincisal distance, saliva production and OHIP scores.Conclusion. Subjects with SSc have impaired oral health and oral HRQoL compared with the general population. These data can be used to develop targeted interventions to improve oral health and HRQoL in SSc.
    Rheumatology (Oxford, England) 01/2014; · 4.24 Impact Factor
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    ABSTRACT: The present study involved an in vitro examination of spinal cord interstitial pressure (CIP) during distraction before and after durotomy in three spinal cord segments obtained from five pigs. To determine whether durotomy can be used to decrease the elevated CIP associated with spinal cord distraction. Spinal cord distraction is a known cause of spinal cord injury. Several articles describing the pathophysiology of cord distraction injuries suggest that the underlying mechanism of injury is a microvascular ischemic event. The authors have previously described an increase in CIP with spinal cord distraction, with average pressures of 23 mmHg at loads of 1,000 g. To date, there are no published studies that have evaluated the efficacy of intentional durotomies as a treatment for elevated CIP. A total of 15 spinal cord sections were harvested from pigs and distracted while immersed in saline, using a fixed 1,000 g distraction force. The CIP decay was then measured at 30-s intervals for 10 min. The distraction/relaxation maneuver was performed six times with continuous CIP monitoring and was subsequently followed by durotomy. The pressure-decay curves were similar for each specimen, but varied according to individual pigs and anatomical levels. CIP decayed over the first 4 min of distraction and remained constant for the final 6 min. Longitudinal durotomy led to a dramatic drop in CIP toward baseline and appeared to be as effective as transverse durotomy with regard to the normalization of pressure. Spinal cord distraction causes elevations in CIP. Durotomy lowers elevated CIP in vitro and may be effective at lowering CIP in vivo. Further study is required to evaluate the usefulness of durotomy in vivo.
    European Journal of Orthopaedic Surgery & Traumatology 01/2014; · 0.18 Impact Factor
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    ABSTRACT: The aim of this cluster randomized trial was to evaluate the effectiveness of a school-based theatre intervention program for immigrant and refugee youth in special classes for improving mental health and academic outcomes. The primary hypothesis was that students in the theatre intervention group would report a greater reduction in impairment from symptoms compared to students in the control and tutoring groups.
    PLoS ONE 01/2014; 9(8):e104704. · 3.73 Impact Factor
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    ABSTRACT: Objective To examine the association between anti-Ro antibodies, namely anti-Ro60/SS-A and anti-Ro52/TRIM21, together and separately, and a prolonged QT interval corrected for heart rate (QTc) in systemic sclerosis (SSc) patients. Methods 689 SSc patients enrolled in a multi-center cohort study underwent a 12-lead resting EKG at baseline. The QTc interval was measured and a QTc ≥ 440 ms was considered prolonged. Detailed clinical data and sera for these patients were collected and positivity for anti-Ro60/SS-A and anti-Ro52/TRIM21 antibodies was determined using an addressable laser-bead immunoassay (ALBIA). Results QTc prolongation was common in this SSc cohort (25%). In univariate analysis, Ro antibodies, together or separately, were not associated with prolongation of the QTc interval (mean difference in QTc in anti-Ro antibody positive versus negative subjects -2.2 ms (p=0.5748), in anti-Ro60/SS-A antibody positive versus negative subjects 1.3 ms (p=0.8616) and in anti-Ro52/TRIM21 antibody positive versus negative subjects -3.3 ms (p=0.4106)). In multivariate logistic regression analysis adjusting for possible confounders, there was no association between prolonged QTc and anti-Ro antibodies (odds ratio (OR) 0.74, 95% confidence interval (CI) 0.45, 1.22), anti-Ro60/SS-A antibodies (OR 1.57, 95% CI 0.72, 3.41) and anti-Ro52/TRIM21 antibodies (OR 0.76, 95% CI 0.46, 1.26). However, in both univariate and multivariate analyses, QTc prolongation was associated with longer disease duration, greater disease severity and the presence of anti-RNA polymerase III antibodies. Conclusions QTc prolongation is common in SSc, although anti-Ro antibodies do not seem to be associated with it as is the case in systemic lupus erythematosus. The reasons for this difference as well as the cause of abnormalities in cardiac repolarization in SSc will require additional studies.
    Seminars in Arthritis and Rheumatism. 01/2014;
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    ABSTRACT: The objectives of this study were to develop a standard classification of digital ulcers (DUs) in systemic sclerosis (SSc) for use in observational or therapeutic studies and to assess the reliability of these definitions as well as of the measurement of ulcer area. Ten North American rheumatologists with expertise in SSc reviewed multiple photos of DUs, examined four SSc subjects with DUs, and came to a consensus on the definitions for digital, active, healed, and indeterminate ulcers. These ten raters then examined the right hand of ten SSc subjects twice and the left hand once to classify ulcers and to measure ulcer area. Weighted and Fleiss kappa were used to calculate intra- and interrater agreement on classification of ulcers, and intraclass correlation coefficient (ICC) was used to assess agreement on ulcer area. Because the traditional ICC calculations relied on a small number of ulcers, ICCs were recalculated using the results of linear mixed models to evaluate the variance components of observations on all the data. Intrarater kappa for classifying DU as not an ulcer/healed ulcer versus active/indeterminate ulcer was substantial (0.76), and interrater kappa was moderate (0.53). The ICC for ulcer area using the linear mixed models was moderate both for intrarater (0.57) and interrater (0.48) measurements. A consensus for the classification of DUs in SSc was developed, and after a training session, rheumatologists with expertise in SSc are able to reliably classify DUs and to measure ulcer area.
    Clinical Rheumatology 12/2013; · 2.04 Impact Factor
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    ABSTRACT: In this article, we study finite mixtures of linear mixed-effects (FMLME) models that are useful for longitudinal regression modelling in the presence of heterogeneity in both fixed and random effects. These models are computationally challenging when the number of covariates is large, and traditional variable selection techniques become expensive to implement. We introduce a penalized likelihood approach, and propose a nested EM algorithm for efficient numerical computations. The resulting estimators are shown to possess consistency and sparsity properties, and to be asymptotically normally distributed. We illustrate the performance of our method through simulations and a real data example. The Canadian Journal of Statistics 41: 596–616; 2013 © 2013 Statistical Society of Canada Résumé Dans cet article, les auteurs étudient des mélanges finis de modèles linéaires à effets mixtes, qui sont utiles pour la régression de données longitudinales en présence d'hétérogénéité des composantes fixes et aléatoires. Lorsque le nombre de covariables est élevé, ces modèles sont exigeants sur le plan calculatoire et les techniques classiques de sélection de variable deviennent laborieuses. Les auteurs présentent une approche de vraisemblance pénalisée et proposent un algorithme EM emboî té afin de procéder aux calculs numériques de façon efficace. Ils démontrent les propriétés de convergence, d’éparpillement et de normalité asymptotique des estimateurs. Ils illustrent leur méthode à l'aide de données simulées et réelles. La revue canadienne de statistique 41: 596–616; 2013 © 2013 Société statistique du Canada
    Canadian Journal of Statistics 12/2013; 41(4). · 0.59 Impact Factor
  • Ian Shrier, Russell J Steele
    British journal of sports medicine 10/2013; · 3.67 Impact Factor
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    ABSTRACT: Most methodologists recommend intention-to-treat (ITT) analysis in order to minimize bias. Although ITT analysis provides an unbiased estimate for the effect of treatment assignment on the outcome, the estimate is biased for the actual effect of receiving treatment (active treatment) compared to some comparison group (control). Other common analyses include measuring effects in (1) participants who follow their assigned treatment (Per Protocol), (2) participants according to treatment received (As Treated), and (3) those who would comply with recommended treatment (Complier Average Causal Effect (CACE) as estimated by Principal Stratification or Instrumental Variable Analyses). As each of these analyses compares different study subpopulations, they address different research questions. For each type of analysis, we review and explain (1) the terminology being used, (2) the main underlying concepts, (3) the questions that are answered and whether the method provides valid causal estimates, and (4) the situations when the analysis should be conducted. We first review the major concepts in relation to four nuances of the clinical question, 'Does treatment improve health?' After reviewing these concepts, we compare the results of the different analyses using data from two published randomized controlled trials (RCTs). Each analysis has particular underlying assumptions and all require dichotomizing adherence into Yes or No. We apply sensitivity analyses so that intermediate adherence is considered (1) as adherence and (2) as non-adherence. The ITT approach provides an unbiased estimate for how active treatment will improve (1) health in the population if a policy or program is enacted or (2) health of patients if a clinician changes treatment practice. The CACE approach generally provides an unbiased estimate of the effect of active treatment on health of patients who would follow the clinician's advice to take active treatment. Unfortunately, there is no current analysis for clinicians and patients who want to know whether active treatment will improve the patient's health if taken, which is different from the effect in patients who would follow the clinician's advice to take active treatment. Sensitivity analysis for the CACE using two published data sets suggests that the underlying assumptions appeared to be violated. There are several methods within each analytical approach we describe. Our analyses are based on a subset of these approaches. Although adherence-based analyses may provide meaningful information, the analytical method should match the clinical question, and investigators should clearly outline why they believe assumptions hold and should provide empirical tests of the assumptions where possible.
    Clinical Trials 10/2013; · 2.20 Impact Factor
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    ABSTRACT: In systemic sclerosis (SSc), impaired diffusing capacity for carbon monoxide (DLCO) can indicate interstitial lung disease (ILD), pulmonary hypertension (PH), and/or other disease manifestations, including anemia. We undertook this study to compare the various measures of DLCO in the setting of a complex disease like SSc. We analyzed the pulmonary function tests of a cohort of SSc subjects, as a whole and among subjects with isolated PH and ILD separately. Associations were assessed using Spearman correlation coefficients, Student’s t tests, and F tests by one-way ANOVA. P values <0.05 were considered statistically significant. This study included 225 subjects (mean age, 57 years; 88 % women; mean disease duration, 9.6 years; 32 % with diffuse disease, 44 % with ILD, and 17 % with PH). Mean percent predicted DLCO values were 75 % for DLCOsb and 83 % for DLCOrb. Adjustment for alveolar volume (VA) resulted in near normalization of both DLCOsb/VAsb (91 %) and DLCOrb/VArb (91 %). Subjects with ILD had significantly lower DLCOsb but not DLCOsb/VAsb, whereas those with PH had significantly lower DLCOsb and DLCOsb/VAsb. Among the various measures of DLCO, DLCOsb had the strongest and most consistent associations with clinical outcomes of interest. Adjusting for alveolar volume dampened the associations except with PH, with which DLCOsb/VAsb was more strongly associated than DLCOsb. Low DLCOsb is the most sensitive measure to detect abnormalities in gas exchange in SSc but reflects both parenchymal lung disease and pulmonary vascular disease. Low DLCOsb/VAsb is more specific for pulmonary vascular disease and should be the preferred measure of gas exchange in SSc.
    Clinical Rheumatology 06/2013; · 2.04 Impact Factor
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    ABSTRACT: Psychosocial and rehabilitation interventions are increasingly used to attenuate disability and improve health-related quality of life (HRQL) in chronic diseases, but are typically not available for patients with rare diseases. Conducting rigorous, adequately powered trials of these interventions for patients with rare diseases is difficult. The Scleroderma Patient-centered Intervention Network (SPIN) is an international collaboration of patient organisations, clinicians and researchers. The aim of SPIN is to develop a research infrastructure to test accessible, low-cost self-guided online interventions to reduce disability and improve HRQL for people living with the rare disease systemic sclerosis (SSc or scleroderma). Once tested, effective interventions will be made accessible through patient organisations partnering with SPIN. SPIN will employ the cohort multiple randomised controlled trial (cmRCT) design, in which patients consent to participate in a cohort for ongoing data collection. The aim is to recruit 1500-2000 patients from centres across the world within a period of 5 years (2013-2018). Eligible participants are persons ≥18 years of age with a diagnosis of SSc. In addition to baseline medical data, participants will complete patient-reported outcome measures every 3 months. Upon enrolment in the cohort, patients will consent to be contacted in the future to participate in intervention research and to allow their data to be used for comparison purposes for interventions tested with other cohort participants. Once interventions are developed, patients from the cohort will be randomly selected and offered interventions as part of pragmatic RCTs. Outcomes from patients offered interventions will be compared with outcomes from trial-eligible patients who are not offered the interventions. The use of the cmRCT design, the development of self-guided online interventions and partnerships with patient organisations will allow SPIN to develop, rigourously test and effectively disseminate psychosocial and rehabilitation interventions for people with SSc.
    BMJ Open 01/2013; 3(8). · 1.58 Impact Factor
  • The International Journal of Biostatistics 01/2013; 9(2):307-313. · 1.28 Impact Factor
  • Brian Leung, Russell J. Steele
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    ABSTRACT: Aim: Conservation managers are typically faced with limited resources, time and information. The philosophy underlying risk assessment should be robust to these limitations. While there is a broad support for the concept of risk assessments, there is a tendency to rely on expert opinion and exclude formal data analysis, possibly because available information is often scarce. When data analyses are conducted, often much simplified models are advocated, even though this means excluding processes believed by experts to be important. In this manuscript, we ask: should statistical analyses be conducted and decisions modified based on a single datum? How many data points are needed before predictions are meaningful? Given limited data, how complex should models be? Location: World-wide. Methods: We use simulation approaches with known 'true' values to assess which inferences are possible, given different amounts of information. We use two metrics of performance: the magnitude of uncertainty (using posterior mean squared error) and bias (using P—P plots). We assess six models of relevance to conservation ecologists. Results: We show that the greatest reduction in uncertainty occurred at the smallest sample sizes for models examined, and much of parameter space could be excluded. Thus, analyses based on even a single datum potentially can be useful. Further, with only a few observations, the predicted distribution of outcomes matched the probabilities of actual occurrences, even for relatively complex state-space models with multiple sources of stochasticity. Main conclusions: We highlight the utility of quantitative analyses even with severely limited data, given existing practices and arguments in the conservation literature. The purpose of our manuscript is in part a philosophical discourse, as modifications are needed to how conservation ecologists are often trained to think about problems and data, and in part a demonstration via simulation analysis.
    Diversity and Distributions 01/2013; 19(5):617-628. · 6.12 Impact Factor
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    ABSTRACT: Depressive symptoms following myocardial infarction (MI) are often assessed using self-report questionnaires, such as the Beck Depression Inventory (BDI). No studies have examined whether depressive symptom scores assessed by self-report questionnaires during hospitalization post-MI are influenced by factors related to the acute event or hospitalization compared to subsequent outpatient assessments of the same patients. The objective of this study was to compare BDI total scores, somatic scores, and cognitive/affective scores among post-MI patients in-hospital versus at post-discharge follow-up. Secondary analysis of data from two existing cohorts of post-MI patients (Groningen, The Netherlands and Toronto, Canada). In-hospital BDI scores and follow-up scores were compared using paired samples t-tests. There were 1556 patients from the Groningen sample with BDI data in-hospital and at 3-months post-MI and 229 patients from Toronto with data in-hospital and at 6-months post-MI. BDI total, somatic, and cognitive/affective scores did not differ significantly between in-hospital and follow-up assessments in either sample. Similarly, there were no substantive differences in symptom composition in either sample. Somatic symptoms accounted for 66.3% of total BDI scores in-hospital versus 64.9% at 3-months post-MI for Groningen patients and for 62.1% of total scores in-hospital versus 64.3% at 6-months post-MI for Toronto patients. Overall BDI total scores, somatic scores, and cognitive/affective scores did not differ between in-hospital and subsequent outpatient assessments. The timing of when depressive symptoms are assessed post-MI does not appear to influence the overall level of BDI scores or the composition of symptoms that are reported.
    Journal of psychosomatic research 11/2012; 73(5):356-61. · 2.91 Impact Factor
  • Michael J Tessler, Ian Shrier, Russell J Steele
    Anesthesiology 11/2012; 117(5):1139. · 5.16 Impact Factor
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    ABSTRACT: Objective. Fatigue is a common and important problem in SSc. No studies, however, have compared the properties of fatigue measures in SSc. The objective of this study was to compare the performances of the Short Form-36 (SF-36) Vitality subscale and Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT) in SSc.Methods. Cross-sectional, multi-centre study of Canadian Scleroderma Research Group Registry patients. The associations of the two instruments with other patient-reported outcome measures, as well as physician- and patient-rated disease variables were compared. Item response theory models were used to compare the degree to which items and the total scores of each measure effectively covered the full spectrum of fatigue levels.Results. There were 348 patients (297 women, 85%) in the study. The instruments correlated at r = 0.65 with each other. The FACIT tended to correlate slightly higher than the SF-36 Vitality subscale with physician- and patient-rated disease variables and patient-reported physical function and disability, whereas the SF-36 Vitality subscale correlated minimally higher with mental health measures. The FACIT had markedly better discrimination across the range of fatigue, particularly at average to high fatigue levels, whereas the SF-36 Vitality subscale discriminated well only among patients in the low to average range.Conclusion. The FACIT discriminates better than the SF-36 Vitality subscale at average to high ranges of fatigue, which is common in SSc, suggesting that it is preferred for measuring fatigue in SSc.
    Rheumatology (Oxford, England) 08/2012; · 4.24 Impact Factor
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    Marie Hudson, Russell Steele, Murray Baron
    Journal of Cell Communication and Signaling 08/2012;

Publication Stats

580 Citations
268.26 Total Impact Points

Institutions

  • 2010–2014
    • Jewish General Hospital
      Montréal, Quebec, Canada
    • The University of Calgary
      • Faculty of Medicine
      Calgary, Alberta, Canada
  • 2006–2014
    • McGill University
      • • Department of Mathematics and Statistics
      • • Division of Rheumatology
      • • Centre for Clinical Epidemiology and Community Studies
      Montréal, Quebec, Canada
  • 2009–2013
    • Lady Davis Institute for Medical Research
      Montréal, Quebec, Canada
  • 2011
    • Université de Sherbrooke
      • Department of Surgery
      Sherbrooke, Quebec, Canada
    • Brigham and Women's Hospital
      • Department of Medicine
      Boston, MA, United States
  • 2001
    • University of Washington Seattle
      Seattle, Washington, United States