Alexander Pazoki

Loyola University Maryland, Baltimore, Maryland, United States

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Publications (12)9.17 Total impact

  • Rui Fernandes · Nikolaos G Nikitakis · Alexander Pazoki · Robert A Ord
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    ABSTRACT: Osteosarcomas (OS) of all sites account for approximately 40% to 60% of primary malignant bone tumors. About 10% of OS occur in the head and neck; most are located in the mandible or maxilla. Jaw lesions are diagnosed on average 2 decades later than their long bone counterparts, which have a peak incidence between the ages of 10 and 14 years. Head and neck OS are associated with a lower metastatic rate than long bone OS, and they have a better 5-year survival rate, ranging between 27% and 84%. We present our experience at the Department of Oral and Maxillofacial Surgery, University of Maryland, Baltimore, MD, with 16 patients with OS of the jaw during a period from 1993 to 2003. In a retrospective chart review, 16 cases of OS of the jaw were identified. Patients ranged in age from 14 to 51 years (mean age, 41 years). The gender distribution consisted of 10 females and 6 males, at a ratio of 1.6:1. Evaluation of site distribution revealed a more frequent occurrence in the mandible than in the maxilla (9 and 7 cases, respectively). The main histologic subtype was chondroblastic (8 cases), followed by osteoblastic (4 cases). According to histologic grading, 8 tumors were high grade, 1 intermediate, 5 low grade, and 2 unknown. Overall, the primary treatment modality consisted of surgery in all 14 patients treated at the University of Maryland; 2 patients opted for treatment at other institutions. Chemotherapy, consisting primarily of cisplatin and Adriamycin (doxorubicin hydrochloride; Pharmacia, Kalamazoo, MI), was used as adjuvant treatment in 4 cases of high-grade OS. Follow-up ranges from 14 months to 108 months (mean, 46 months). To date, of the 14 patients treated at our institution, 12 (86%) had no evidence of disease at last appointment, and 2 patients died of the disease. In light of the rarity of this disease, this series represents a large single-center experience with OS of the jaw. Our data show an older patient population, different gender distribution, and higher survival rate compared with overall published reports.
    Journal of Oral and Maxillofacial Surgery 08/2007; 65(7):1286-91. DOI:10.1016/j.joms.2006.10.030 · 1.43 Impact Factor
  • S. McClure · A. Salama · R. Ord · A. Pazoki
    Oral Oncology Supplement 05/2007; 2(1):102-102. DOI:10.1016/S1744-7895(07)70186-4
  • Antonia Kolokythas · Rui P Fernandes · Alexander Pazoki · Robert A Ord
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    ABSTRACT: We discuss the outcome of 2 well-established and widely accepted methods used for the treatment of odontogenic keratocyst (OKC), enucleation with peripheral ostectomy or resection and decompression followed by enucleation and peripheral ostectomy. A retrospective chart review of all cases of OKC treated in the University of Maryland's Department of Oral and Maxillofacial Surgery between 1994 and 2004 was undertaken. A total of 31 patients with OKCs was identified. Three of these patients diagnosed with basal cell nevus syndrome and multiple OKCs and 6 patients who did not have adequate follow-up were excluded from this study; thus, 22 patients were evaluated. Of these 22 patients, 11 were treated with resection or enucleation with peripheral ostectomy (group I) and 11 were treated with decompression followed by enucleation when indicated (group II). A total of 22 patients with biopsy-proven OKC ranging in age from 18 to 90 years were separated into 2 treatment arms. Group I comprised 6 females and 5 males, age 18 to 71 years, with 6 OKCs located in the mandible and 5 in the maxilla. Group II comprised 6 females and 5 males, age 24 to 90 years, with 10 OKCs in the mandible and 1 in the maxilla. The choice of treatment approach was based on the size of the cyst, recurrence status, and radiographic evidence of cortical perforation. The last follow-up revealed no recurrences in group I and 2 recurrences in group II. Both patients with recurrence in group II had undergone enucleation of the same lesion in the past, and both cysts recurred within 2 years after initial treatment. Our study results concur with the literature regarding recurrence rates of OKC. The aggressive nature of some OKCs necessitates equally aggressive treatment, whereas long-term follow up even for nonsyndromic patients with single lesions is of paramount importance. Age of the patient and the site and histological characteristics of the treated lesions were not significantly associated with the incidence of recurrence.
    Journal of Oral and Maxillofacial Surgery 05/2007; 65(4):640-4. DOI:10.1016/j.joms.2006.06.284 · 1.43 Impact Factor
  • Oral Oncology Supplement 04/2005; 1(1):131-132. DOI:10.1016/S1744-7895(05)80332-3
  • R. Fernandes · A. Kolokythas · A. Pazoki · R. A. Ord
    Oral Oncology Supplement 04/2005; 1(1):117-118. DOI:10.1016/S1744-7895(05)80288-3
  • R. Fernandes · J. Bailey · A. Pazoki · R. A. Ord
    Oral Oncology Supplement 04/2005; 1(1):131-131. DOI:10.1016/S1744-7895(05)80329-3
  • Robert A Ord · Alexander E Pazoki
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    ABSTRACT: Lower lip reconstruction is ideally achieved with innervated flaps that supply mucosa, functional muscle, and skin. These flaps should be capable of being used when vermilionectomy is necessary. The size and shape of the defect determine the optimal flap. This article illustrates the flaps used by the authors for particular reconstructive problems.
    Oral and Maxillofacial Surgery Clinics of North America 12/2003; 15(4):497-511, v. DOI:10.1016/S1042-3699(03)00068-2 · 0.58 Impact Factor
  • Alexander Pazoki · Pornchai Jansisyanont · Robert A Ord
    Journal of Oral and Maxillofacial Surgery 02/2003; 61(1):112-7. DOI:10.1053/joms.2003.50018 · 1.43 Impact Factor
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    ABSTRACT: Although liposarcoma is one of the most common soft tissue sarcomas, its location in the oral cavity is very rare. To our knowledge, only 43 cases of liposarcoma originating in the oral tissues have been reported in the English-language literature. In this article, we report a case of well-differentiated liposarcoma affecting the cheek of a 28-year-old man and review the oral liposarcoma literature. Immunohistochemical analysis of the tumor revealed an MDM2+/CDK4+/p53+ immunophenotype that is consistent with the immunohistochemical profile of well-differentiated liposarcoma originating in other areas of the body. Quantitative polymerase chain reaction analysis of the DNA levels of the MDM2 (human homologue of the murine double-minute type 2), CDK4 (cyclin-dependent kinase 4), and SAS (sarcoma amplified sequence), genes was performed, revealing only SAS gene amplification. The possibility of misdiagnosis of oral liposarcoma because of its sometimes inconspicuous clinical and microscopic features is emphasized. Careful pathologic examination of liposarcoma is essential for discrimination from benign adipose tissue neoplasms and for precise histologic classification, both of major prognostic significance. Possible implications of molecular and cytogenetic analysis for unraveling the pathogenesis and determining the prognosis of liposarcoma are discussed.
    Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 09/2001; 92(2):194-201. DOI:10.1067/moe.2001.116815 · 1.46 Impact Factor
  • Pornchai Jansisyanont · Alexander Pazoki · Robert A. Ord · Michael Zak
    Journal of Oral and Maxillofacial Surgery 05/2001; 59(4):415-20. DOI:10.1053/joms.2001.21880 · 1.43 Impact Factor
  • Pornchai Jansisyanont · Alexander Pazoki · Robert A. Ord
    Journal of Oral and Maxillofacial Surgery 12/2000; 58(12):1454-1457. DOI:10.1053/joms.2000.19212 · 1.43 Impact Factor
  • M A Lopes · A E Pazoki · R A Ord
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    ABSTRACT: Proliferative verrucous leukoplakia (PVL) is a particularly aggressive form of oral leukoplakia that is resistant to treatment and presents a high risk of recurrence and malignant transformation. This article describes the microscopic and clinical characteristics of one case of PVL, which initially presented as hyperkeratosis with mild dysplasia and posteriorly developed multifocal areas and verrucous carcinoma despite treatment.
    General dentistry 01/2000; 48(6):708-10.