Ge Feng

Sichuan University, Hua-yang, Sichuan, China

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Publications (20)41.42 Total impact

  • Weina Zhang · Bin Gu · Jing Hu · Bin Guo · Ge Feng · Songsong Zhu
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    ABSTRACT: We retrospectively compared the clinical outcomes of autogenous coronoid process grafts (n=32) and costochondral grafts (n=28) in condylar reconstruction for the treatment of unilateral ankylosis of the temporomandibular joint (TMJ) in adults. Preoperative and postoperative assessments included diet scores, cone-beam computed tomography (CT), maximal interincisal opening, lateral excursion, and mandibular deviation on opening the mouth. There were no significant differences between the 2 groups in the measurements before and after the operation with respect to incisal opening, lateral excursion, mandibular deviation, diet scores, or recurrence rate, but in both the postoperative incisal opening, lateral excursion, and diet scores had improved significantly compared with preoperatively. After costochondral graft 3 patients developed intraoperative plural tears, and 6 had temporary pain at the donor site. The frontal branch of the facial nerve was temporarily affected in 5 patients after costochondral graft and 3 after coronoid process grafts, all of which recovered in 3-6 months. There was no recurrence after coronoid process grafting, and one after costochondral grafting. The clinical outcomes in both groups were satisfactory and comparable. Autogenous coronoid process grafting may therefore be a good alternative for condylar reconstruction in patients with ankylosis of the TMJ.
    British Journal of Oral and Maxillofacial Surgery 09/2014; 52(10). DOI:10.1016/j.bjoms.2014.08.018 · 1.08 Impact Factor
  • Jian Song · Songsong Zhu · En Luo · Jing Hu · Ge Feng
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    ABSTRACT: Purpose: This study was designed to investigate the stress and the displacement distributions of the mandible after mandibular angle ostectomy (MAO) by means of three-dimensional finite element analysis. Methods: On the basis of a female patient with a prominent angle of the mandible, the finite element models were generated by helical computed tomography and related software and were analyzed under muscle forces and 3 kinds of biting conditions, including intercuspal position (ICP), incisal clenching (INC), and right unilateral molar clenching (RMOL). The mandibular stress and displacement distributions were analyzed by Abaqus software. Results: In the model of MAO, the increased stress and the decreased displacement was found in ICP, INC, and RMOL at the area of mandibular angle. The stress and the displacement increased in ICP and RMOL, whereas the others remained unchanged in INC at the area of mandibular condylar neck. Conclusions: The results of this study have shown that MAO could alter biomechanical characteristics in the operated mandible, which suggested that a greater hit on face may lead to a higher incidence rate of condyle fracture and a lower incidence rate of angle fracture after MAO.
    Journal of Craniofacial Surgery 07/2014; 25(4):e375-e378. DOI:10.1097/SCS.0000000000000868 · 0.68 Impact Factor
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    ABSTRACT: Surgical correction of craniosynostosis in children is associated with substantial intraoperative bleeding. Intraoperatively administered tranexamic acid (TXA) can lessen blood loss during orthopedic and cardiovascular surgery, but its efficacy in craniosynostosis surgery is uncertain. Therefore, a meta-analysis performed with published comparative studies was to determine whether TXA could reduce packed red blood cells (or erythrocytes) (PRBCs) transfused and blood loss during pediatric craniosynostosis surgery. Two PubMed and EMBASE electronic databases were searched until June 2012. Eligible studies were restricted in comparative controlled trials. Four studies in 3 articles with 138 patients were included. The results showed that intraoperative administration of TXA can significantly reduce transfusion of PRBCs (weighed mean difference [WMD] = -10.81, 95% confidence interval [CI] = -16.84 to -4.78, P < 0.00001). In the level of blood loss, the meta-analysis on 4 studies showed that the difference was statistically significant (WMD = -20.53, 95% CI = -32.26 to -8.80, P = 0.0006) between the TXA groups and the control groups. However, the subgroup analysis on randomized controlled trials showed that TXA did not significantly reduce blood loss during surgery compared with the placebo group (WMD = -30.79, 95% CIs = -71.72 to 10.14, P = 0.14). Tranexamic acid can significantly reduce the transfusion of PRBCs in children undergoing craniosynostosis surgery. However, there is a controversy on the efficacy of TXA in reducing blood loss. Therefore, new randomized controlled trials to assess the effects of TXA in children with craniosynostosis surgery should be conducted.
    The Journal of craniofacial surgery 01/2013; 24(1):299-303. DOI:10.1097/SCS.0b013e3182710232 · 0.68 Impact Factor
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    Song-Song Zhu · Ge Feng · Ji-Hua Li · En Luo · Jing Hu
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    ABSTRACT: This study was to describe the use of inverted-L osteotomy of ramus and iliac bone graft for the management of mandibular deficiency in adult patients. From 2008 to 2010, 11 patients (aged 19 to 29 years) with mandibular deficiency underwent intraoral or extraoral inverted-L osteotomy of ramus and iliac crest bone grafting. Data were collected from the patients' records, photographs and radiographs. The height and width of the ramus were successfully expanded by inverted-L osteotomy and iliac crest bone grafting with minimal complications in all patients, resulting in significant improvement in occlusion and facial appearance. Our early results showed that the inverted-L osteotomy of ramus and iliac crest bone grafting is safe and effective, and should be considered as a good alternative for the patients with mandibular deficiency.International Journal of Oral Science advance online publication, 21 December 2012; doi:10.1038/ijos.2012.75.
    International Journal of Oral Science 12/2012; 4(4). DOI:10.1038/ijos.2012.75 · 2.53 Impact Factor
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    ABSTRACT: Transforming growth factor-beta (TGF-β) plays an important part in the repair of cartilage in osteoarthritis. It has been hypothesised that intra-articular injection of TGF-β(1) promotes repair of cartilage and protects the subchondral bone from damage in osteoarthritic temporomandibular joints (TMJs). We made bilateral partial perforations of the disc to induce osteoarthritic joints in 36 rabbits. TGF-β(1) 20, 40, or 80ng were injected into the right joint, and vehicle alone was injected into the left joint. Four additional animals were used as normal controls. Microcomputed tomography was used to quantify the three-dimensional microarchitecture of subchondral bone, followed by assessment of the proteoglycan content. All joints treated with TGF-β(1) were covered by a layer of well-organised fibrocartilage, and had increased proteoglycan content and normal microarchitectural properties, whereas the joint treated by vehicle alone had typical osteoarthritis-related degradation of cartilage and sclerosis of subchondral bone. These results suggested that TGF-β(1) is an effective way of treating osteoarthritis of the TMJ.
    British Journal of Oral and Maxillofacial Surgery 07/2012; 51(3). DOI:10.1016/j.bjoms.2012.05.014 · 1.08 Impact Factor
  • Xudong Li · Ge Feng · Songsong Zhu · Jihua Li · En Luo · Jing Hu
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    ABSTRACT: Orthopedic surgeons and dentists often implant materials to repair bone tissue defects and restore physiological functions of bone organs. The clinical success depends on adequate bone formation in operation sites. However, the real cause of osteogenesis has not yet been fully elucidated. To investigate the bone response to implanted materials, this study examined the bone tissue reaction in rat femoral medullary canal, which received gelatin and collagen as foreign-body materials. A total of 36 six-month-old Sprague-Dawley rats were randomly and meanly divided into three groups. In the gelatin group, the bilateral femora received gelatin material; in the collagen group, they were implanted with type I collagen, and in the control group, the femora suffered from sham operation with no materials inserted. After 2, 4, 8, and 12 weeks, specimens were harvested and subjected to a series of examinations. After 2 weeks of healing, a significant upregulation of both alkaline phosphatase and osteocalcin by both kinds of implanted materials relative to the control (sham implantation group) was seen in gene expression analysis. Strong reactivity of osteoprotegerin and receptor activator of NFκB ligand was detected in the two test groups in immunohistochemistry at 4 weeks of healing. Also, micro-CT revealed an increase in cortical bone thickness in the two test groups as compared to the control group. Densitometry showed increased bone mineral density in the bone receiving materials after 12 weeks, leading to the enhanced maximum load in the test groups. These results indicated that the implanted materials led to an osteogenesis response in rat femoral medullary canal. Thus, we probably should reconsider the potential cascades of tissue reaction when utilizing orthopedic and dental implants and other materials to recover bone related-organ function and repair bone defects.
    Journal of Orthopaedic Science 06/2012; 17(5):626-33. DOI:10.1007/s00776-012-0254-4 · 0.94 Impact Factor
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    ABSTRACT: Strontium ranelate (SrR) was an effective anti-osteoporotic drug to increase bone formation and decrease bone resorption. However, reports about the effect of SR on osteoblastic and adipocytic differentiation from bone marrow mesenchymal stem cells (BMMSCs) are limited. The purpose of this study is to evaluate whether SrR affects the ability of BMMSCs to differentiate into osteoblasts or adipocytes. Rat BMMSCs were identified by flow cytometry and exposed to SR (0.1 and 1.0mMSr(2+)) under osteogenic or adipogenic medium for 1 and 2weeks. The proliferation and differentiation of BMMSCs were analyzed by MTT, alkaline phosphatase (ALP), Oil red O staining, quantitative real-time RT-PCR and Western blot assays. SrR significantly inhibited the proliferation, increased osteoblastic but decreased adipocytic differentiation of rat BMMSCs dose-dependently. In osteogenic medium, SrR increased the expression of ALP, the mRNA levels of Cbfa1/Runx2, bone sialoprotein, and osteocalcin by RT-PCR, and the protein levels of Cbfa1/Runx2 by Western blot. In adipogenic medium, SrR decreased the mRNA levels of PPARγ2, adipocyte lipid-binding protein 2 (aP2/ALBP), and lipoprotein lipase (LPL) by RT-PCR, and the protein expression of PPARγ in Western blot analysis. These results indicated that the effects of SrR to promote osteoblastic but inhibit adipocytic differentiation of BMMSCs might contribute to its effect on osteoporosis treatment.
    Biochemical and Biophysical Research Communications 02/2012; 418(4):725-30. DOI:10.1016/j.bbrc.2012.01.088 · 2.30 Impact Factor
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    ABSTRACT: Treatment of adult patients with temporomandibular joint (TMJ) ankylosis and secondary deformities is a challenging problem. Although various techniques, including arthroplasties, orthognathic surgery, autogenous bone graft, and distraction osteogenesis, have been described for the management of patients with this condition, an appropriate treatment protocol has not been established. The purpose of this report is to describe a 2-stage treatment protocol, comprising TMJ reconstruction as the initial surgery, followed by orthodontic treatment, and correction of secondary deformities as the second surgery, for the management of TMJ ankylosis with secondary deformities in adults. From January 2003 to December 2009, 24 adult patients (30 joints) with TMJ ankylosis and secondary deformities underwent TMJ reconstruction as the initial surgery, followed by orthodontic treatment and correction of secondary deformities as the second surgery. Clinical outcome was assessed based on oral function, radiography, and medical photography. Patients were followed up for a minimum of 12 months to a maximum of 32 months (mean, 18.6 months). No relapse of TMJ ankylosis occurred in any patient during the follow-up period. Oral function and skeletal deformities were significantly improved in all patients. Satisfactory occlusion was achieved with the help of orthodontic treatment. Most of the patients were satisfied with the final outcome. The 2-stage treatment protocol described not only restores oral function but also improves the patient's esthetic appearance. We believe that it is a good approach for management of TMJ ankylosis with secondary deformities in adult patients.
    Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 12/2011; 69(12):e565-72. DOI:10.1016/j.joms.2011.07.025 · 1.43 Impact Factor
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    ABSTRACT: The aims of this study were to investigate the impact of dentofacial deformities on quality of life in Chinese patients and to make a comparison between facial deformities that do and do not involve the occlusion. Consecutive patients with dentofacial deformities requiring surgical correction were divided into 2 groups. Group A represented those who had undergone presurgical orthodontic treatment, and group B represented patients with square faces or prominent zygoma. All subjects were assessed by the 36-item Short-Form Health Survey (SF-36) and the 22-item Orthognathic Quality of Life Questionnaire (OQLQ-22) during 2 time periods: preoperatively and 6-8 months postoperatively. The SF-36 revealed that there was significant difference in role physical and bodily pain (P < .05) preoperatively between the 2 groups, whereas postoperatively the difference was not significant. Preoperatively, there was significant difference in oral function and facial esthetics components of OQLQ (P < .001), whereas postoperatively only the oral function domain showed significant difference. Orthognathic surgery had a positive impact on patients' quality of life regardless of the type of deformity. OQLQ showed better discerning ability and was able to point out the subtle differences between the 2 groups.
    Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 03/2011; 112(6):719-25. DOI:10.1016/j.tripleo.2011.01.002 · 1.46 Impact Factor
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    ABSTRACT: To evaluate the the feasiblility and effectiveness of narrowing and sliding genioplasty combined with mandibular outer cortex ostectomy technique to reshape a square jaw in short face. From July 2005 to October 2009, a total of 57 patients received narrowing and sliding genioplasty combined with mandibular outer cortex ostectomy procedure to correct square jaw in short face. All the patients had standard frontal and lateral cephalometric radiographs, panoramic radiographs, and were photographed preoperatively and postoperatively to assess their face contour. The alteration of mandibular angle, mental contour and width of lower face was observed for 6 to 24 months postoperatively. Questionnaires were used to assess the patients' satisfactory. It showed that the postoperative lower face had narrowed and become softer, slender and oval, with a slick mental region. The final aesthetic outcomes were quite satisfactory in all cases from both the view of surgeons and patients. Narrowing and sliding genioplasty combined with mandibular outer cortex ostectomy procedure could efficiently adjust the shape and position of chin to obtain a good proportion of the lower face, and to change square and short face to slender oval one by single operation in accordance with the fashionable aesthetics in orientals.
    Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery 01/2011; 27(1):15-8.
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    ABSTRACT: This study was designed to investigate the effects of strontium-substituted hydroxyapatite coatings with 10 mol% Ca(2+) replaced by Sr(2+) (10% SrHA) on implant fixation in ovariectomized (OVX) rats. Coatings of HA and 10% SrHA were prepared on the surface of titanium implant using sol-gel dip methods, and then characterized by Scanning Electron Microscope, Atomic Force Microscope, X-ray diffraction, X-ray Photoemission Spectroscopy, and an automatic scratch tester. Twelve weeks after bilateral ovariectomy, twenty OVX rats accepted implant insertion in the proximal tibiae, half with HA-coated implants and the other half with 10% SrHA coated implants. After 12-week healing period, 10% SrHA coated implants revealed improved osseointegration compared to HA, with the bone area ratio and bone-to-implant contact increased by 70.9% and 49.9% in histomorphometry, the bone volume ratio and percent osseointegration by 73.7% and 45.2% in micro-CT evaluation, and the maximal push-out force and ultimate shear strength by 107.2% and 132.9% in push out test. These results demonstrated that 10% SrHA coatings could enhance implant osseointegration in OVX rats, and suggested the feasibility of using SrHA coatings to improve implant fixation in osteoporotic bone.
    Biomaterials 12/2010; 31(34):9006-14. DOI:10.1016/j.biomaterials.2010.07.112 · 8.56 Impact Factor
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    ABSTRACT: This study aimed to investigate the effects of hydrofluoric acid (HF) treatment of grit-blasted Ti implants on osseointegration in ovariectomized (OVX) rats. After blasting with aluminium oxide particles, half implants were treated with 0.2 vol.% HF, and the other half were kept non-modified as control. The topographical and chemical changes of implant surface were determined by Scanning Electron Microscope, Atomic Force Microscope, and X-ray Photoemission Spectroscopy. 12 Weeks after bilateral ovariectomy, each rat accepted two implants in distal femora, with the control implant on the left and the fluoride-modified on the right. As a result, fluoride modification induced markedly changed surface topography and chemical composition. 12 Weeks after implant insertion, the fluoride-modified implants showed improved osseointegration compared to control, with the bone area ratio and bone-to-implant contact increased by 0.9- and 1.4-fold in histomorphometry, the bone volume ratio and percent osseointegration by 0.8- and 1.3-fold in micro-CT evaluation, and the maximal push-out force and ultimate shear strength by 1.2- and 2.0-fold in biomechanical test. These promising results indicated that HF treatment of Ti surface improved implant osseointegration in OVX rats, and suggested the feasibility of using fluoride modification to improve Ti implant osseointegration in osteoporotic bone.
    Biomaterials 04/2010; 31(12):3266-73. DOI:10.1016/j.biomaterials.2010.01.028 · 8.56 Impact Factor
  • Ying Gao · Songsong Zhu · En Luo · Jihua Li · Ge Feng · Jing Hu
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    ABSTRACT: Basic fibroblast growth factor (bFGF) has high potential for tissue regeneration; however, its in vivo effects are unpredictable due to the short-term survival. This study sought to evaluate the effects of bFGF suspended in Matrigel on the implant fixation in ovariectomized (OVX) rats. In vitro, the release kinetics of bFGF was tested using an immuno-ligand-assay. In vivo, eighty titanium implants were randomly divided into 4 groups and inserted in the tibiae of forty OVX rats: no treatment group, bFGF alone group, Matrigel alone group and bFGF+Matrigel group. At 3 months after implantation, tibiae were examined by histology, micro-CT and push-out test. We found that Matrigel could prolong the life span of bFGF in vitro with a sustained release during the 21 days. In vivo, bFGF or Matrigel alone had little effect on the fixation of implant in OVX rats, but bFGF suspended in Matrigel induced nearly 2-fold of peri-implant new bone formation and 4-fold of implant mechanical stability when compared to other 3 groups. The results of this study suggest that Matrigel could be used as a carrier of bFGF and prolonged its release around implant, which may improve implant fixation, especially in site of post-menopausal osteoporosis.
    Journal of Controlled Release 06/2009; 139(1):15-21. DOI:10.1016/j.jconrel.2009.05.032 · 7.71 Impact Factor
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    ABSTRACT: Increased bone turnover with excessive bone resorption and decreased bone formation is known to impair implant fixation. Strontium ranelate is well known as an effective antiosteoporotic agent by its dual effect of antiresorbing and bone-forming activity. This study was designed to evaluate the effect of systemic strontium ranelate (SR) treatment on fixation of hydroxyapatite (HA)-coated titanium screws in ovariectomized (OVX) rats. Twelve weeks after being OVX (n=30) or sham (n=10) operated, 40 female Sprague-Dawley rats received unilateral implants in the proximal tibiae. The OVX rats were randomly divided into the following groups: OVX, OVX+SRL ("L" refers to low SR dose of 500 mg/kg/day), OVX+SRH ("H" refers to high SR dose of 1000 mg/kg/day).Twelve weeks after treatment, bone blocks with implants were evaluated with micro-CT and biomechanical push-out tests. Compared to OVX animals, SR treatment increased the bone volume ratio by 51.5% and 1.1-fold, the percentage osteointegration by 1.0-fold and 1.9-fold in micro-CT evaluation, and the maximal force by 1.9-fold and 3.3-fold in biomechanical push-out test, for the low and high dose of SR, respectively. Significant correlation between micro-CT and biomechanical properties demonstrated that trabecular parameters played an important role in predicting the biomechanical properties of implant fixation. Our findings suggest that SR treatment can dose-dependently improve HA-coated screw fixation in OVX rats and facilitate the stability of the implant in the osteoporotic bone.
    Journal of Orthopaedic Research 01/2009; 28(5):578-82. DOI:10.1002/jor.21050 · 2.99 Impact Factor
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    ABSTRACT: This article describes the clinical effects of condylar reconstruction by free grafting of autogenous coronoid process in patients with temporomandibular joint (TMJ) ankylosis. Fifteen cases of uni- or bilateral TMJ ankylosis during a 3-year period from March 2004 to March 2007 were surgically treated, and the average observation period was 22 months. All patients were treated by condylar reconstruction of immediate autogenous coronoid process grafts. Temporal muscle myofascial flaps or native articular disc was used as an interpositional tissue. Clinical examination, radiographs, and photographs were used postoperatively to evaluate the grafts and TMJ function. Satisfactory mouth opening was achieved in 14 cases, and 1 patient showed signs of reankylosis of the joint (20 mm mouth opening). Radiographic examination showed that bone union occurred between the grafts and the ramus in all cases. Some bony resorption of the grafted coronoid process was observed in all patients, but no occlusal changes were noted. Satisfactory clinical outcomes are obtained after the condylar reconstruction by free grafting of autogenous coronoid process. Therefore, autogenous coronoid process may be a suitable bone resource for condylar reconstruction in patients with TMJ ankylosis.
    Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 08/2008; 106(5):662-7. DOI:10.1016/j.tripleo.2008.03.028 · 1.46 Impact Factor
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    ABSTRACT: To study the drug resistance changes in Tca8113 cell lines by exposing to carboplatin. The concentration of carboplatin added to Tca8113 cells was increased gradually and continually, which was to induce the carhoplatin-resistance in Tca8113 cells. The sensibility to drugs of the cells was analyzed by MTT method. Immunocytochemistry and RT-PCR were utilized to examine the expression of multidrug resistance proteins and genes. After exposing to carboplatin, the Tca8113/CBP cells had higher drug-resistance to CBP, MTX, PYM, VCR and higher expression of MRP, GST-pi than Tca8113 cells. Multidrug resistance of Tca8113/CBP is associated with over expression of MRP, GST-pi and MDR. Tca8113/CBP can provide an ideal model for multidrug resistance research.
    Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 05/2007; 25(2):184-7.
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    ABSTRACT: To study the effect of hyperthermia on expressions of multidrug resistance (MDR) genes in tongue squamous cell carcinoma cell line Tca8113 and its MDR cell line Tca8113/CBDEA and intracellular ADM concentration. Cell lines were hyperthermia-treated (42 degrees C for 0.5 h), 4 h and 24 h later real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) detected expressions of MDR relative genes (MDR1, MRPI, GST-pi) and HTS 7000 Plus Bio Assay Reader measured intracellular ADM concentration. Expressions of MDR1, MRPI, GST-'pi genes in Tca8113/CBDEA significantly descended at 4 h and 24 h post-hyperthermia (P < 0.01). Expressions of MDR1, MRP1 genes in Tca8113 significantly descended at 4 h and 24 h post-hyperthermia (P < 0.05), but there was not statistical difference between 4 h and 24 h post-hyperthermia. GST-pi expression had not statistical descent at 4 h, but there was significantly descend at 24 h post-hyperthermia (P < 0.01). Drug tolerance decreased and hyperthermia increased intracellular drug concentration in Tca8113/CBDEA and Tca8113 (P < 0.01). Hyperthermia enhance chemotherapy effect and reverse MDR genes expression in tongue squamous cell carcinoma cell line. It is suggested that hyperthermia could be used as a method to overcome MDR, which is worth more investigation.
    Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 10/2006; 24(5):447-50.
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    ABSTRACT: The aim of this study was to investigate the mechanism(MDR) of multidrug resistance(MDR) of mucoepidermoid carcinoma in salivary gland. 40 cases of mucoepidermoid carcinoma in salivary gland were examined the MDR gene product P-glycoprotein using a monoclonal antibody JSB-1. And 10 of them were also investigated by detecting the expression of GST-pi. All the cases had not been accepted any therapy before the samples were collected. 1. Positive expression of JSB-1 was observed in 27 of the 40 specimens. The positive expression was related not only with clinical stage, but also with differentiation degree. 2. The GST-pi positive expression was found in 9 of 10 cases. There was no significant different between the positive expression of JSB-1 and GST-pi. JSB-1 and GST-pi play an important role in MDR of mucoepidermoid carcinoma.
    Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 05/2004; 22(2):115-6, 151.
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    ABSTRACT: To study the treatment outcome of rhabdomysarcoma(RMS). 74 cases of RMS with definite pathologic diagnosis treated in our department during the past 20 years were investigated. The relationship between the therapy and prognosis was analyzed. 52 cases among the 74 patients received different surgical treatment and post-operative radiotherapy. 22 cases received radiotherapy or chemoradiotherapy without surgical treatment. The survival rates demonstrated great differences depending on the different clinical stages and therapy. The combined therapy including radiotherapy after surgical treatment may increase 5-year survival rate.
    Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 05/2004; 22(2):129-31.
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    ABSTRACT: To explore the correlation of chemotherapy efficacy in tongue squamous cell carcinoma(SCC) with expression level of P-glycoprotein(Pgp), multidrug resistance-associated protein (MRP), lung resistance-related protein (LRP), glutathiones-tranferase (GST-pi), DNA topo-isomerase II alpha (Topo II alpha). The expression patterns of Pgp, MRP, LRP, GST-pi and Topo II alpha in 40 patients (pre and post-chemotherapy, respectively) with tongue SCC were examined by immunohistochemically labelled streptavidin bioein method (LsAB). The expression ratios of Pgp, MRP, LRP, GST-pi and Topo II alpha in pre-chemotherapy cases were 47.5%, 50%, 35%, 45%, 82.5%, respectively. No relations between expression of Pgp, MRP, LRP, GST-pi, Topo II alpha and clinic indexes were established (P > 0.05). Expression ratios of Pgp, MRP in post-chemotherapy cases were higher than that in pre-chemotherapy cases (P < 0.05). Expression of Pgp and MRP showed relevance with drug resistance (P < 0.05). The co-expression was common, the ratios of co-expression of Pgp, MRP, GST-pi and MRP, GST-pi in chemotherapy non-responders were 40% and 50%, respectively, but 0 in responders. The intrinsic multidrug resistance of tongue SCC is relevant to the effects of Pgp, MRP, GST-pi.
    Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 02/2004; 22(1):23-5.

Publication Stats

180 Citations
41.42 Total Impact Points


  • 2004–2014
    • Sichuan University
      • • Department of Oral and Maxillofacial Surgery
      • • State Key Laboratory of Oral Diseases
      • • Key Laboratory of Oral Biomedical Engineering
      Hua-yang, Sichuan, China
  • 2006
    • West China Hospital of Stomatology
      Hua-yang, Sichuan, China