Ping Zhang

Inner Mongolia University for Nationalities, Pai-an-ta-la, Inner Mongolia, China

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Publications (6)14.96 Total impact

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    ABSTRACT: This report reviews biologically active secondary metabolites from marine-derived members of the fungal genus Aspergillus. Pharmacological activities and biological roles of the secondary metabolites from marine-derived Aspergillus spp. were addressed in respect of pharmaceutical potential.
    Marine Biotechnology 05/2013; DOI:10.1007/s10126-013-9506-3 · 3.15 Impact Factor
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    ABSTRACT: In the course of our search for bioactive metabolites from marine organisms, new hexylitaconic acid derivatives (1-4), along with (3S)-hexylitaconic acid (5), were isolated from a sponge-derived fungus Penicillium sp. Based on the NMR and MS data, the structures of compounds 1-4 were defined as α,β-dicarboxylic acid derivatives, such as hexylitaconic acid and tensyuic acids which were previously reported as metabolite of Aspergillus niger, Penicillium striatisporum, or Apiospora montagnei. The isolated compounds were evaluated for cytotoxicity against a panel of five human solid tumor cell lines, and for anti-inflammatory activity gauged by their inhibitory effects on the production of major pro-inflammatory mediators (nitric oxide (NO), interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β) in murine macrophage cells. Compounds 1 and 4 showed weak inhibition of IL-1β production at the concentration of 200 µM.
    Chemical & pharmaceutical bulletin 08/2011; 59(1):120-3. DOI:10.1002/chin.201132197 · 1.70 Impact Factor
  • ChemInform 01/2010; 41(9). DOI:10.1002/chin.201009203
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    ABSTRACT: In the course of our search for bioactive metabolites from a colonial tunicate of the family Polyclinidae, six new (1-6) cyclic fatty acid derivatives were isolated. Their planar structures were established on the basis of NMR and MS spectroscopic analyses. The relative configuration was determined by NOESY experiment. Compounds 1-6 represent a fused bicyclic skeleton possibly derived from alpha,omega-dicarboxylic acids such as eicosanedioic acid or docosanedioic acid via a Diels-Alder type of cyclization. Compounds 1-4 and 6 showed mild cytotoxicity against a panel of five human solid tumor cell lines.
    Bioorganic & medicinal chemistry letters 09/2009; 19(21):6205-8. DOI:10.1016/j.bmcl.2009.08.094 · 2.65 Impact Factor
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    ABSTRACT: In the course of our search for bioactive metabolites from a sponge-derived fungus Acremonium sp., new sesquiterpenoids (1-4) were isolated along with known derivatives by bioactivity-guided fractionation. The unique cyclic skeleton of compounds 2 and 3 is unprecedented. The absolute configurations were determined by modified Mosher's method and CD spectroscopy, along with comparison of (1)H and (13)C NMR spectroscopic data and specific optical rotation values with those reported. The anti-inflammatory activity of the isolated compounds (1, 5, 7-13) was evaluated by measuring their inhibitory effects on the production of pro-inflammatory mediators (NO, IL-6, and TNF-alpha) in RAW 264.7 murine macrophage cells. Among the compounds tested, compounds 7 and 9 significantly inhibited the production of NO and TNF-alpha at the concentration of 100 microM, while compounds 11 and 12 showed selective inhibition of NO production at the same concentration.
    Journal of Natural Products 02/2009; 72(2):270-5. DOI:10.1021/np8006793 · 3.95 Impact Factor
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    ABSTRACT: Seven (1-7) monoindole derivatives were isolated from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS spectroscopic analyses. Compounds 1-5 are unique indole pyruvic acid derivatives. Compounds 1-2 and 4-6 are isolated for the first time from a natural source although they were previously reported as synthetic intermediates. Compound 3 was defined as a new compound. Co-occurring bisindoles such as hamacanthins and topsentins might be biosynthesized by condensation of two units of these compounds. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines, and compound 7 displayed weak activity.
    Marine Drugs 02/2007; 5(2):31-9. DOI:10.3390/md502031 · 3.51 Impact Factor
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Publication Stats

30 Citations
14.96 Total Impact Points

Institutions

  • 2013
    • Inner Mongolia University for Nationalities
      Pai-an-ta-la, Inner Mongolia, China
  • 2007–2009
    • Pusan National University
      • College of Pharmacy
      Pusan, Busan, South Korea