N Ghariani

Publications (27)20.06 Total impact

• Article: Reduction of palmoplantar keratoderma Buschke-Fischer-Brauer locus to only 0.967 Mb.

  O Mamaï, L Boussofara, L Adala, A Amara, I Ben Charfeddine, N Ghariani, B Sriha, M Denguezli, A Mili, T Belazreg, A Saad, J Fischer, M Gribaa
  Journal of dermatological science 07/2012; 67(3):210-2. · 3.71 Impact Factor
• Article: [Analysis of 18 Tunisian cases of mycetoma at the Sousse hospital (1974-2010).]

  A Aounallah, L Boussofara, Z Ben Saïd, N Ghariani, W Saidi, M Denguezli, C Belajouza, R Nouira
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  ABSTRACT: Mycetoma are inflammatory pseudotumors, due to infection by bacterial (Actinomycetoma) or fungal (Eumycetoma) agent. A retrospective study was conducted during 34 years. Our aim was to study epidemiologic, clinic, therapeutic and microbiologic characteristics. Eighteen patients were assessed. Sex-ratio H/F was 2. The mean age was 43.6 years. Principal localization was the feet. Our study was characterized by majority of actinomycetoma found in 15 cases (Actinomadura madurae in 14 cases and Nocardia sp. in one case). Eumycetoma were diagnosed in 3 cases (Madurella mycetomatis in twocases and Pseudallesheria in one case). All patients received medical treatment associated with surgical treatment in 11 cases.
  Bulletin de la Société de pathologie exotique 05/2012;
• Article: [Aggressive universal calcinosis complicating dermatomyositis].

  F Bayou, C Belajouza, L Boussofara, N Ghariani, M Denguezli, E Bouajina, R Nouira
  Annales de Dermatologie et de Vénéréologie 11/2011; 138(11):758-60. · 0.72 Impact Factor
• Article: [Adams-Oliver syndrome].

  F Bayou, L Boussofara, Z Lahmam Bennani, N Ghariani, W Saïdi, C Belajouza, M Denguezli, R Nouira
  Annales de Dermatologie et de Vénéréologie 10/2011; 138(10):712-4. · 0.72 Impact Factor
• Article: [Childhood cutaneous Abrikossoff tumor].

  Z Lahmam Bennani, L Boussofara, W Saidi, F Bayou, N Ghariani, C Belajouza, B Sriha, M Denguezli, R Nouira
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  ABSTRACT: Granular cell tumor (GCT), also known as Abrikossoff tumor, is a rare and benign neoplasm that more commonly affects the oral cavity in adults. We report here 2 childhood cases of a cutaneous granular cell tumor. An 8- and a 12-year-old girl, with no past medical history, presented with pigmented nodular lesions located, respectively, in the left scapular region and the left iliac crest. Histological examination showed sheets and clusters of infiltrating tumor cells with morphologic and immunohistochemical features consistent with granular cell tumor. In both cases, the lesions were excised with 2-cm margins. The patients are presently being reviewed at 6-month and 2-month intervals to evaluate for recurrence and any malignant transformation. They were in good health with no signs of further tumor development. GCT is a relatively uncommon benign neoplasm probably of neural origin derived from Schwann cells. The tongue and buccal mucosa are commonly affected. It develops between the second and sixth decades of life, more frequently among women and blacks. It can also occur in childhood, but this is rare. The cutaneous forms, as in the present observations, are exceptional. Benign granular cell tumours are generally seen as a solitary asymptomatic nodule less than 3 cm in size involving the subcutaneous or submucosal tissues. Histologically, the tumor is not encapsulated but is well circumscribed. The tumor cells may show a degree of infiltration of the surrounding connective tissue. The cells are polygonal, have abundant cytoplasm, are granular and weakly eosinophilic. The nuclei are small, vesicular, and highly chromatic. Mitotic figures are rare. A key element for the histological diagnosis is the expression of S100 protein, neuron specific enolase (NSE), and vimentin on immunohistochemistry. The treatment of choice is a conservative surgical excision of the lesion. However, as the GCT has a poorly defined margin, it is suggested that the tumor should be excised along with portions of adjacent tissue. A low rate of recurrence of the lesion has been reported. The specific value of these rare cases is the occurrence in 2 children and the cutaneous location.
  Archives de Pédiatrie 07/2011; 18(7):778-82. · 0.30 Impact Factor
• Article: [Nevus lipomatosus cutaneous superficialis].

  I Ghali, L Boussofara, N Ghariani, W Saidi, A Ben Abdelkader, C Belajouza, M Denguezli, R Nouira
  Annales de Dermatologie et de Vénéréologie 01/2011; 138(1):77-8. · 0.72 Impact Factor
• Article: [Acute generalized exanthematous pustulosis following a spider bite: three cases from Tunisia].

  Z Ben Said, W Saidi, L Boussofara, N Ghariani, C Belajouza, B Sriha, M Denguezli, R Nouira
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  ABSTRACT: acute generalized exanthematous pustulosis (AGEP) is a severe eruption induced in most cases by medication; more rarely, it is associated with viral infection, food allergens or toxins. The literature contains only very rare reports of AGEP caused by a spider bite. We describe three cases of AGEP in Tunisian women following a spider bite. three Tunisian women were hospitalized in the dermatology department during the summer months presenting acute febrile pustulosis and rash occurring after a spider bite. The diagnosis of AGEP was confirmed with certainty based on the EuroSCAR score. Two patients presented marked eosinophilia. The outcome was favourable in all cases after symptomatic treatment. the factors militating in favour of spider-bite origin in these three patients were: (1) the presence of skin lesions characteristic of a spider bite; (2) the chronology of events, with eruption occurring 24 to 48 hours after the bite; and (3) the exclusion of the common causes of AGEP and the presence of marked eosinophilia in two of the cases. Our cases and the few cases published in the literature indicate that spider bites may be added to the list of the possible causes of AGEP.
  Annales de Dermatologie et de Vénéréologie 12/2010; 137(12):813-8. · 0.72 Impact Factor
• Article: [Pityriasis versicolor in a 3-month-old boy].

  Z Ben Said, L Boussofara, W Saidi, N Ghariani, M Denguezli, C Belajouza, R Nouira
  Archives de Pédiatrie 05/2010; 17(7):1110-1. · 0.30 Impact Factor
• Article: [Tumour on the arm].

  H Akkari, W Saidi, L Boussofara, N Ghariani, C Belajouza, B Sriha, M Denguezli, R Nouira
  Annales de Dermatologie et de Vénéréologie 05/2010; 137(5):393-4. · 0.72 Impact Factor
• Article: [Clinical and genetic characteristics of Buschke-Fischer-Brauer's disease in a Tunisian family].

  I El Amri, O Mamai, N Ghariani, M Denguezli, B Sriha, L Adala, A Saad, M Gribaa, R Nouira
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  ABSTRACT: Punctate palmoplantar keratoderma (PPPK), or Buschke-Fischer-Brauer's disease, is a rare form of genodermatosis with autosomal dominant transmission and with variable penetrance. Its molecular basis remains unknown. Two loci were found to be linked to this disease: one on 15q22 and the other on 8q24. We report the clinical and genetic characteristics of PPPK in a Tunisian family. A Tunisian family with PPPK was identified through a proband. As far as possible, history taking, physical examination, histopathological tests and blood sampling for DNA extraction were carried out for each patient. Seventeen patients were included in this study. Age ranged from 15 to 81 years with a sex-ratio of 3.2 m/f. Lesions appeared between the ages of 10 and 65 years and at a mean of 28 years. Clinically, lesions ranged from few keratotic papules on the palms to coalescence of lesions in plaques over palmar and/or plantar surfaces. Hyperhydrosis, hypopigmented macules and nail dystrophy were frequently associated. In all patients, histopathological examination revealed thickening of the epidermis with compact orthohyperkeratosis overlying a small and sharply demarcated area of depressed epidermis. Mechanical measures and keratolytic ointments proved non-beneficial. Genotyping for chromosomes 8 and 15 as well as LOD scores confirmed genetic linkage with the suspected locus on chromosome 15q, with the interval of the locus in question reduced to 3.26 Mb. This region is flanked by markers D15S987 and D15S153. Our study of this family confirmed the classical characteristics of KPP-BFB as well as demonstrating several associated clinical signs of which the significance will be determined in subsequent studies. Further screening studies to identify mutated genes in the region of interest will help us to understand the molecular basis of this disease and hopefully to propose suitable treatment.
  Annales de Dermatologie et de Vénéréologie 04/2010; 137(4):269-75. · 0.72 Impact Factor
• Article: [Lichen planus, Blaschko subtype].

  L Boussofara, S Hamdi, N Ghariani, C Belajouza, B Sriha, M Denguezli, R Nouira
  Annales de Dermatologie et de Vénéréologie 06/2008; 135(5):433-4. · 0.72 Impact Factor
• Article: [Pseudocondylomatous lymphangiectasia of the vulva secondary to lipoedema].

  N Kenani, N Ghariani, M Trimèche, C Belajouza, M Denguezli, R Nouira
  Annales de Dermatologie et de Vénéréologie 05/2008; 135(4):341-3. · 0.72 Impact Factor
• Article: Dyschromatosis universalis hereditaria: two cases.

  N Kenani, N Ghariani, M Denguezli, B Sriha, C Belajouza, R Nouira
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  ABSTRACT: Dyschromatosis universalis hereditaria is a rare genodermatosis reported initially and mainly in Japan. However, subsequent cases have been reported from other countries. We describe two Tunisian cases of dyschromatosis universalis hereditaria in a 3-year-old and a 3-month-old girl. They presented to our department with asymptomatic progressive mottled pigmentation over the trunk and limbs, which had been noted since birth and had become more noticeable with age. Palms and soles were also affected in the first case. The two patients did not have any systemic or other cutaneous illness. They were born to healthy, second-degree consanguineous parents (case 1) and non consanguineous parents (case 2), following an uneventful pregnancy. No family members had a similar appearance. Physical examination revealed numerous, generalized, hyperpigmented macules interspersed with spotty de-pigmented macules. Hair, nails, teeth, and mucosae were normal. Systemic examination did not reveal abnormalities. Histological exam revealed basal layer hypermelanosis with pigmentary incontinence in some areas. So based on those findings a clinical diagnosis of DUH was made and the patients were followed up in our department for periodic general evaluation of their skin. After a follow up of 12 months, the first child didn't develop other lesions, but palms and soles were also involved in the second case.
  Dermatology online journal 02/2008; 14(2):16.
• Article: [Sweet's syndrome complicating isotretinoin therapy in acne].

  D Ammar, M Denguezli, N Ghariani, B Sriha, C Belajouza, R Nouira
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  ABSTRACT: We report a case of juvenile acne aggravated in the form of Sweet's syndrome by isotretinoin treatment. The late onset of ulcerative-hemorrhagic rectocolitis in this patient raised doubts about a possible relationship between Sweet's syndrome, acne and inflammatory colitis. A 19 year-old male patient with no disease history of note was treated for juvenile polymorphous acne resistant to standard topical acne treatment using isotretinoin (Roaccutane) at a dose of 0.5 mg/kg/d. After one week of treatment, the patient presented a fever of 38.5 degrees C, joint pain and congestive, erythematous-edematous, maculopapular plaques in ring-like layout subsequently becoming pustular and necrotic. These lesions occurred on the face, neck and pinna of the ear. Some nodules were also noted on the lower limbs. Biological tests and histology examination of a skin biopsy were evocative of Sweet's syndrome. The outcome was rapidly favorable following discontinuation of isotretinoin and institution of systemic corticosteroids (0.5 mg/kg/d). Two years later, ulcerative-hemorrhagic rectocolitis was diagnosed with episodes of bloody diarrhea. Treatment of acne with isotretinoin can occasionally induce inflammatory episodes of acne. To date there have been no reported cases of isotretinoin-induced Sweet's syndrome. The subsequent onset of ulcerative-hemorrhagic rectocolitis provides an indication of the complexity of the pathogenic mechanisms involved.
  Annales de Dermatologie et de Vénéréologie 03/2007; 134(2):151-4. · 0.72 Impact Factor
• Article: [Fox-Fordyce disease].

  D Baccouche, M Denguezli, N Ghariani, L Boussofara, M Mokni, C Belajouza, R Nouira
  Annales de Dermatologie et de Vénéréologie 02/2007; 134(1):101-2. · 0.72 Impact Factor
• Article: [Verrucous epidermoid carcinoma as a complication in cutaneous lichen planus].

  L Boussofara, C Belajouza-Noueiri, N Ghariani, A Tefifha, B Sriha, M Denguezli, R Nouira
  Annales de Dermatologie et de Vénéréologie 05/2006; 133(4):404-5. · 0.72 Impact Factor
• Article: [Verrucas on the back of the hand].

  N Ghariani, L Boussofara, M Denguezli, J Boukadida, B Sriha, C Belajouza, R Nouira
  Annales de Dermatologie et de Vénéréologie 05/2006; 133(4):387-9. · 0.72 Impact Factor
• Article: [Indented keratosic macules on the face].

  D Baccouche, M Denguezli, B Sriha, N Ghariani, C Belajouza, R Nouira
  Annales de Dermatologie et de Vénéréologie 12/2004; 131(11):1002-3. · 0.72 Impact Factor
• Article: [Multiple cephalic tumors].

  R Ben Fraj, M Denguezli, N Ghariani, B Sriha, M Kourda, C Belajouza, R Nouira
  Annales de Dermatologie et de Vénéréologie 01/2004; 130(12 Pt 1):1161-3. · 0.72 Impact Factor
• Article: [Mycetomas in central Tunisia].

  M Denguezli, M Kourda, N Ghariani, C Belajouza, B Mokni, F Chebil, B Riahi, B Jomaa, R Nouira
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  ABSTRACT: Mycetomas are inflammatory pseudo-tumors containing fungal or actinomycosic-type grains. They are frequent in tropical and subtropical countries and unknown in Tunisia. We conducted a retrospective study of 12 cases of mycetoma registered in the Dermatological department of the university hospital in Sousse (central Tunisia) over a period of 27 years, from 1974 to 2001. The diagnosis was confirmed by anatomopathological and/or mycological examination. The mean age at the onset was of 49 years and the sex ratio of 1. A notion of a traumatism was reported in two cases and eight patients had various agricultural activities. The mean duration of progression was of eight years. The localization was the foot in 10 cases. The mycetoma was of actinomycosic origin in 10 cases, due to Actinomadura madurae in nine cases, to Nocardia spp in one case and of fungal origin in 2 cases:Pseudoallescheria boydii in one case and Madurella mycetomi in the other. Antibiotic therapy was associated with surgical exeresis in nine cases and amputation in the other two cases. Confrontation of our results with those of Tunisian series and a review of the literature, helped to specify the clinico-epidemiological characteristics and progression of mycetoma in Tunisia. These characteristics are: the rareness of the infection, the relative frequency of affection in women, the proximal involvement of the foot, the frequency of agricultural activity and the rareness of traumatic past history, the predominance of the actinomycosic origin due to Actinomadura madurae, and the need to associate surgical exeresis with the medical treatment or amputation in order to stop the progress of the disease.
  Annales de Dermatologie et de Vénéréologie 06/2003; 130(5):515-8. · 0.72 Impact Factor