N Cavallari

Sapienza University of Rome, Roma, Latium, Italy

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Publications (18)35.39 Total impact

  • Digestive and Liver Disease 10/2011; 43. DOI:10.1016/S1590-8658(11)60640-3 · 2.96 Impact Factor
  • Digestive and Liver Disease 10/2010; 42. DOI:10.1016/S1590-8658(10)60555-5 · 2.96 Impact Factor
  • Digestive and Liver Disease 10/2010; 42. DOI:10.1016/S1590-8658(10)60558-0 · 2.96 Impact Factor
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    ABSTRACT: Patients with ulcerative colitis often receive thiopurines as immunomodulators (IMs) to maintain remission and avoid corticosteroids. If unresponsive or intolerant to these agents, patients are treated with methotrexate, an antimetabolite never assessed in paediatric ulcerative colitis. To describe the experience with methotrexate in children with ulcerative colitis. Thirty-two patients (median age 13.9 years) received methotrexate. Pediatric Ulcerative Colitis Activity Index (PUCAI) and use of corticosteroids were the main outcomes evaluated at baseline and at 3, 6 and 12 months. Indications to methotrexate were azathioprine unresponsiveness in 18 patients, azathioprine intolerance/toxicity in 10 and spondyloarthropathy in four. Response or remission was achieved in 72%, 63% and 50% of patients at 3, 6 and 12 months respectively. Mean PUCAI were 49.5 ± 23.3 at baseline and 32.9 ± 21.9, 29.5 ± 21.8 and 29.4 ± 19.9 at 3, 6 and 12 months respectively (P: 0.03). At the beginning of methotrexate, 16 patients (50%) received corticosteroids that were discontinued in 13 of them (81%) by 6 months. At the end of the study, 11 patients (33%) needed short courses of corticosteroids for disease relapse. Methotrexate may be useful in treating children with ulcerative colitis, although large, controlled trials are warranted to define better its effectiveness.
    Alimentary Pharmacology & Therapeutics 10/2010; 32(8):1017-22. DOI:10.1111/j.1365-2036.2010.04433.x · 5.73 Impact Factor
  • Digestive and Liver Disease 10/2009; 41. DOI:10.1016/S1590-8658(09)60473-4 · 2.96 Impact Factor
  • M Aloi · F Conte · N Cavallari · O Iacono · F Viola · F Civitelli · F Nuti · S Cucchiara
    Journal of Pediatric Gastroenterology and Nutrition 04/2009; 48(Suppl 2). DOI:10.1097/01.mpg.0000348230.14277.d1 · 2.63 Impact Factor
  • M Aloi · N Cavallari · F Conte · O Iacono · F Viola · EF Romeo · O Borrelli · S Cucchiara
    Journal of Pediatric Gastroenterology and Nutrition 04/2009; 48(Suppl 2). DOI:10.1097/MPG.0b013e3181a116b1 · 2.63 Impact Factor
  • Digestive and Liver Disease 10/2008; 40(10). DOI:10.1016/j.dld.2008.07.209 · 2.96 Impact Factor
  • Digestive and Liver Disease 10/2008; 40(10). DOI:10.1016/j.dld.2008.07.201 · 2.96 Impact Factor
  • N Cavallari · A Polistena · A Cavallaro
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    ABSTRACT: To examine the effect of University of Wisconsin solution (UWS) on the formation of postoperative peritoneal adhesions. Laboratory experiment. University hospital, Italy. 42 Sprague-Dawley rats. A standard lesion was made consisting of serosal trauma of the caecum and a parietal peritoneal defect. Rats were randomly divided into seven groups (n = 6 each): the first group acted as controls; the second had instilled normal saline 6 ml; the third Ringer's lactate 6 ml; the fourth UWS 6 ml; the fifth normal saline 12 ml; the sixth Ringer's lactate 12 ml; and the seventh UWS 12 ml. Adhesions were scored two weeks later for extent (0 to 4) and type (0 to 4). Adhesion strength was measured by a tensiometer. The mean (SEM) scores for extent and type of adhesions were significantly lower (p < 0.05) after instillation of Ringer's lactate 12 ml [1.0 (0.4) and 1.2 (0.4), respectively] than controls [3.5 (0.3) and 2.7 (0.2), respectively]. Adhesions were also significantly weaken (p < 0.05) [101 (33) g] than in controls [207 (6) g]. Intraperitoneal instillation of normal saline and UWS were ineffective in reducing the extent and type of adhesions. Although Ringer's lactate produced a significant reduction in severity, the effect was strongly volume related. This amount of fluid may be detrimental to a patient's postoperative course.
    The European Journal of Surgery 09/2000; 166(8):650-3. DOI:10.1080/110241500750008330
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    ABSTRACT: The significance of ambulatory venous pressure measurement in the diagnosis of chronic venous insufficiency of the lower limbs is evaluated. 190 limbs of 120 outpatients were investigated from 1991 through 1997; the study was performed whenever clinical and ultrasound evaluation did not allow to establish the diagnosis of "simple varices". The technique standardized according to Nicolaides was followed. The results of the study confirm the importance of ambulatory venous pressure measurement in the differential diagnosis of chronic venous hypertension of the lower limbs, especially when caused by vein compression, as well as in the follow-up of these patients when submitted to surgical treatment.
    Minerva cardioangiologica 07/1999; 47(6):185-9. · 0.53 Impact Factor
  • A Mingoli · P Sapienza · J D Edwards · N Cavallari
    Journal of Vascular Surgery 02/1998; 27(2):385-6. · 3.02 Impact Factor
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    ABSTRACT: Aneurysmal dilatation of the femoral artery is a rare condition of uncertain aetiology. Between January 1972 and December 1992, 31 atherosclerotic femoral aneurysms in 22 patients were seen. There were 21 men and 1 woman; mean(s.d.) age was 70.1(10.4) years. Thirteen (42%) femoral aneurysms (group 1) were isolated aneurysms, two being bilateral. Eighteen (58%) were associated with a non-contiguous abdominal aortic aneurysm, four being unilateral and seven bilateral femoral aneurysms (group 2). The mean(s.d.) size of these aneurysms was 4.7(1.5) and 3.5(0.7)cm in groups 1 and 2 respectively (P< 0.01). Of the limbs in group 1,12 were treated by an interposition bypass. A ruptured profunda femoris artery aneurysm was ligated in one limb as an emergency operation. All patients in group 2 underwent an aortobifemoral graft. There was one operative death. Three early thromboses were observed; two autogenous saphenous vein interposition grafts and one limb of an aortobifemoral. One late thrombosis occurred in an expanded polytetrafluoroethylene graft in group 1. The five-year patency rate was 80% for group 1 and 88.9% for group 2 (P=n.s.). The overall 10-year limb salvage rate was 100%. These findings suggest that isolated femoral aneurysms are larger and more frequently symptomatic than femoral aneurysms associated with an abdominal aortic aneurysm. The association between femoral aneurysm and abdominal aortic aneurysm was found to be higher in patients with bilateral femoral aneurysms compared with those with unilateral lesions (P< 0.05). In the treatment of isolated femoral aneurysms better early results were obtained with expanded polytetrafluoroethylene interposition grafts.
    Cardiovascular Surgery 05/1996; 4(2):181-84. DOI:10.1016/0967-2109(96)82311-8
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    ABSTRACT: In 1992 The International Registry of Inferior Vena Cava (IVC) Leiomyosarcomas was established to study the pathogenesis and natural history of the tumor and to support the most rational treatment. We collected 218 patients through a literature review and personal communications. We corresponded with several Authors to obtain up-to-date follow-up and any other data lacking at the initial review. The series was analyzed to identify predictive factors for clinical outcome. Tumors arose from the IVC lower segment in 80 patients, from the middle in 94 and from the upper in 41. A radical tumor resection was undertaken in 134 (61.5%) patients, 26 (11.9%) had a palliative resection and 58 (26.6%) were inoperable. An increased risk of death was associated with upper IVC segment involvement (p < 0.001), lower limb edema (p < 0.001), Budd-Chiari's syndrome (p < 0.001), intraluminal tumor growth (p < 0.001) and IVC occlusion (p < 0.001). Radical tumor resection was associated with better 5- and 10-year survival rates (49.4% and 29.5%). Tumors which arose from the middle segment fared better (56.7% and 47.3%) than those of the lower segment (37.8% and 14.2%) (p < 0.002). No palpable abdominal mass and abdominal pain were associated, in patients radically operated, with a better outcome and longer survival (p < 0.03 and p > 0.04 respectively). Despite the high rate of recurrence, radical tumor resection is the only long-term cure.
    Anticancer research 11/1995; 16(5B):3201-5. · 1.83 Impact Factor
  • AV Sterpetti · N Cavallari · P Allegrucci · F Agosta · A Cavallaro
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    ABSTRACT: In order to determine any possible influence of climatic variables on the incidence of abdominal aortic aneurysm rupture, we reviewed 49,144 autopsies performed in two major hospitals in Rome, Italy, from January 1956 to March 1986. There were 297 subjects who were found to be sufferers of atherosclerotic abdominal aortic aneurysm for a prevalence of 0.6%. The aneurysm was intact in 220 cases (74%) and ruptured in 77 cases (26%). The highest incidence of ruptured aneurysm occurred during the Autumn and in the months May and July. The incidence of ruptured aneurysm was highest in case of significant changes of the atmospheric temperature. There was no correlation between the incidence of ruptured aneurysm and barometric pressure or humidity.
    Journal of the Royal College of Surgeons of Edinburgh 03/1995; 40(1):14-5.
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    ABSTRACT: From April, 1990, to April, 1992, peripheral atherectomy using a Simpson AtheroCath was performed in 46 patients (56 limbs) with a total of 106 lesions. There were 100 stenoses (74 eccentric, 26 concentric) and 6 occlusions. Success was achieved in 103/106 (97%) procedures (97 stenoses and 6 occlusions), reducing the lesion to < 35% (stenoses: 81 +/- 13% to 22 +/- 9%, p < 0.0001, and the occlusions: 100% to 16 +/- 8%; p < 0.0001). Ankle/brachial index (ABI) improved from 0.58 +/- 0.17 to 0.85 +/- 0.22 (p < 0.0001). Clinical success was achieved in 42 patients (91%). Complications occurred in 6 patients (13%): groin hematoma in 5, and in 1, acute occlusion of the femoral artery with distal embolization. There were 13 hemodynamic failures in 11 patients (28%) with an ABI reduction of more than 0.15 with respect to the maximum early postoperative level, over a mean follow-up of 15.1 months. Failure of the procedure was confirmed by arteriography in only 4 cases. Cumulative eighteen-month patency rates were 60% using arteriographic assessment and 44% for hemodynamic assessment (p < 0.025). Patency rates were 56% for the patients with a runoff score ranging between 1 and 5 and 17% with a score > 5 (p < 0.0025). A reduction of ABI during follow-up is not a true indicator of procedural failure, but it correlates with possible progression of distal disease. Evaluation of preoperative run-off may be used as a prognostic indicator.
    Vascular and Endovascular Surgery 06/1993; 27(5):329-336. DOI:10.1177/153857449302700501 · 0.66 Impact Factor
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    ABSTRACT: The gross findings of 49,144 autopsies performed at two major hospitals in Rome were reviewed. There were 297 patients who were found to have atherosclerotic abdominal aortic aneurysm (AAA). The aneurysm was intact in 220 (74 per cent) and ruptured in 77 (26 per cent). The occurrence of aneurysm rupture was correlated to 17 variables by univariate and multivariate statistical analysis. Covariates found to be independently predictive of the rupture of AAA were the size of the aneurysm (p less than 0.001), arterial hypertension (p less than 0.001) and the presence of bronchiectasis (p less than 0.025.). Over-all, bronchiectasis was more common among patients with AAA than in the age-adjusted and sex-adjusted control population. The simultaneous presence of bronchiectasis and AAA suggests the presence of some inherited or acquired tendency to have ectasia of the connective tissue, aneurysm formation and rupture development.
    Surgery, gynecology & obstetrics 10/1991; 173(3):175-8.
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    ABSTRACT: Carotid endoarterectomy (CEA) is known to prevent cerebrovascular accidents. Between February 1987 and December 1993 we performed 97 CEA on 82 patients (62 male and 20 female, median age 66 +/- 7.6 years) 95.1% reported previous hemispheric neurological accidents; 4.9% were asymptomatic. Operative indications for asymptomatic patients were high degree stenosis (> 70%) of the internal carotid artery and ulcerated plaques with a moderate degree (50%) of stenosis. Major events (transient ischemic attack and stroke) were recorded in 73.2% cases. Preoperative investigations consisted of Duplex scan, arteriography, and cerebral CT scan or NMR. Operative mortality was 2.06% (2 cases) and perioperative stroke was 5.1% (5 cases). The sensibility, sensitivity and accuracy of Duplex scan to detect ulcerated plaques was 88.7%, 85.2% and 87.5% respectively. At a median follow-up of 33 months (range 6-81 months) 74 (92.5%) patients are free of strokes whereas 1 patient died for stroke. In our series the annual incidence of stroke was 0.5%. Our results suggest that Duplex scan is a reliable exam to investigate the carotid axis and CEA is a safe operation that prevents future cerebrovascular accidents.
    Annali italiani di chirurgia 66(3):313-8. · 0.60 Impact Factor

Publication Stats

232 Citations
35.39 Total Impact Points


  • 1991–2010
    • Sapienza University of Rome
      • • Department of Experimental Medicine
      • • Department of Surgery "Pietro Valdoni"
      Roma, Latium, Italy
  • 1993
    • Creighton University
      • Department of Surgery
      Omaha, Nebraska, United States