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ABSTRACT: BACKGROUND: Third occipital nerve block (TONB) is commonly used in the diagnosis and treatment of upper neck pain and cervicogenic headaches. Although fluoroscopy is the current imaging standard for TONB, ultrasound (US) guidance offers a promising, radiation-free alternative. In this randomized, observer-blinded trial, we compared the 2 imaging modalities. Our research hypothesis was that US guidance would result in a shorter performance time. METHODS: Forty patients undergoing TONB were randomized to fluoroscopy or US guidance. A mixture of local anesthetic and radiographic contrast was injected in both groups. The primary outcome was performance time. Secondary outcomes included success rate, pain levels before and after block, area of sensory hypoesthesia, quality of the block (assessed by electrical perceptual threshold), and procedure-related complications. RESULTS: Ultrasound guidance was associated with a significantly shorter performance time (212.8 vs 396.5 seconds; P = 0.000) and fewer needle passes (2 vs 6; P = 0.000). Both imaging modalities, however, resulted in similar success rates (95%-100%). Furthermore, no intergroup differences were found in preblock and postblock pain scores. In both groups, TONB produced hypoesthesia that was most profound in the suboccipital region. In the fluoroscopy group, C2-C3 intra-articular spread of radiographic contrast and vascular breach were noted in 15% and 10% of patients, respectively. In contrast, no adverse events occurred with US guidance. CONCLUSIONS: Fluoroscopy and US guidance provide similar success rates for TONB. However, ultrasonography is associated with improved efficiency (decreased performance time, fewer needle passes).
Regional anesthesia and pain medicine 04/2013; · 4.16 Impact Factor
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ABSTRACT: BACKGROUND: This prospective, randomized, observer-blinded study compared 3 combinations of volume and concentration using the same total dose of lidocaine for ultrasound-guided infraclavicular block. METHODS: Ninety patients were randomized to 1 of 3 combinations of volume and concentration for lidocaine: (1) 52.5 mL of lidocaine 1%, (2) 35 mL of lidocaine 1.5%, and (3) 26.25 mL of lidocaine 2%. In all 3 groups, the total dose administered (525 mg) was the same. In addition, epinephrine 5 fg/mL was used in all subjects. The main outcome variable was onset time. The performance time, number of needle passes, block-related pain scores, success rate (surgical anesthesia), and the incidence of vascular puncture and paresthesia were also recorded. The total anesthesia-related time was defined as the sum of the performance and onset times. RESULTS: The onset times, which were 18.8 ± 5.6 minutes (95% confidence interval [CI], 16.4-21.1 minutes), 20.7 ± 7.0 minutes (95% CI, 18.0-23.5 minutes), and 21.7 ± 6.0 minutes (95% CI, 19.1-24.2 minutes) for the 1%, 1.5%, and 2% groups, respectively, were not statistically different.Furthermore, the performance times (4.4-4.7 minutes), total anesthesia-related times (23.7-26.3 minutes), and rates of surgical anesthesia (90.0%-96.7%) were comparable among the 3 groups. The number of needle passes and procedural discomfort, as well as the incidence of paresthesia and vascular puncture, were also similar. There were minor differences in the patterns of block for individual nerves. In terms of sensory block, compared with the 2% group, more patients in the 1.5% group displayed a complete block of the ulnar and radial nerves at 10 and 20 minutes, respectively. In terms of motor block, the 2% group yielded the lowest of rate of complete block of the musculocutaneous nerve from 15 minutes onward. CONCLUSIONS: Using an identical dose (525 mg) of adrenalized lidocaine for ultrasound-guided infraclavicular block, we found no differences in onset time among 3 commonly used concentrations (1%, 1.5%, and 2%). Further studies are required to determine the optimal combination of volume and concentration of lidocaine for other ultrasound-guided approaches to the brachial plexus.
Regional anesthesia and pain medicine 03/2013; · 4.16 Impact Factor
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ABSTRACT: BACKGROUND:In this prospective, randomized, observer-blinded trial, we compared ultrasound-guided subparaneural popliteal sciatic nerve blocks performed either at or proximal to the neural bifurcation (B). We hypothesized that the total anesthesia-related time (sum of performance and onset times) would be decreased with the prebifurcation (PB) technique.METHODS:Ultrasound-guided posterior popliteal sciatic nerve block was performed in 68 patients. All subjects received an identical volume (30 mL) and mix of local anesthetic agent (1% lidocaine-0.25% bupivacaine-5 µg/mL epinephrine). In the PB group, the local anesthetic solution was deposited at the level of the common sciatic trunk, just distal to the intersection between its circular and elliptical sonographic appearances, inside the paraneural sheath. In the B group, the injection was performed inside the sheath between the tibial and peroneal divisions. A blinded observer recorded the success rate (complete tibial and peroneal sensory block at 30 minutes) and onset time. The performance time, number of needle passes, and adverse events (paresthesia, neural edema) were also recorded. All subjects were contacted 7 days after the surgery to enquire about the presence of persistent numbness or motor deficit.RESULTS:Both techniques resulted in comparable success rates (85%-88%; 95% confidence interval [CI] of the intergroup difference, -14% to 19%) and required similar performance times (8.1 minutes; 95% CI of the difference, -1.65 to 1.71 minutes), onset times (15.0-17.7 minutes; 95% CI of the difference, -7.65 to 2.31 minutes), and total anesthesia-related times (23.4-26.0 minutes; 95% CI of the difference, -7.83 to 2.74 minutes). The number of needle passes and incidence of paresthesia (25%-34%) were also similar between the 2 groups. Sonographic neural swelling was detected in 2 and 3 subjects in the PB and B groups, respectively. In all 5 cases, the needle was carefully withdrawn and the injection completed uneventfully. Patient follow-up 1 week after the surgery revealed 2 patients with residual numbness. In both instances, the latter had resolved by 1 month.CONCLUSION:When local anesthetic is injected inside the paraneural sheath, B and PB posterior popliteal sciatic nerve blocks result in comparable success and total anesthesia-related times. However, in light of the 95% CIs, we cannot exclude the possibility that an intergroup difference of 19% and 7.83 minutes might have gone undetected for success rate and total time, respectively.
Anesthesia and analgesia 03/2013; · 3.08 Impact Factor
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Regional anesthesia and pain medicine 03/2013; 38(2):168-9. · 4.16 Impact Factor
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ABSTRACT: BACKGROUND: The aim of this study was to determine the minimum effective volume of lidocaine 1.5% with epinephrine 5 μg/mL in 90% of patients (MEV90) for double-injection ultrasound-guided axillary block (AXB). METHODS: All subjects received a double-injection ultrasound-guided AXB with lidocaine 1.5% and epinephrine 5 μg/mL. A 17-gauge, 8-cm Tuohy needle was initially advanced until its tip was positioned next to the musculocutaneous nerve. Volume assignment was carried out using a biased coin design up-and-down sequential method, where the volume of local anesthetic administered to each patient depended on the response of the previous one. In case of failure, the next subject received a higher volume (defined as the previous volume with an increment of 1.0 mL). If the previous patient had a successful block, the next subject was randomized to a lower volume (defined as the previous volume with a decrement of 1.0 mL), with a probability of b = 0.11, or the same volume, with a probability of 1 - b = 0.89. After injection of the musculocutaneous nerve, the needle was redirected toward the dorsal aspect of the axillary artery. For this second injection, volume assignment was carried out in a similar fashion; however, volume increments/decrements were 3.0 instead of 1.0 mL. Using a composite scale encompassing sensory and motor block, success was defined, at 30 minutes, as a composite score of 4 points (out of 4 points), and 10 points (out of 12 points) for the musculocutaneous and perivascular injection, respectively. Patients undergoing surgery of the forearm, wrist, or hand were prospectively enrolled until 45 successful musculocutaneous blocks or 45 successful perivascular injections were obtained. RESULTS: Fifty patients were included in the study. Using isotonic regression and bootstrap confidence interval (CI), the MEV90 was estimated to be 5.5 mL (95% CI, 3.0-6.7 mL) and 23.5 mL (95% CI, 23.1-23.9 mL) for the musculocutaneous and perivascular injection, respectively. CONCLUSIONS: For double-injection ultrasound-guided AXB, the MEV90 of lidocaine 1.5% with epinephrine 5 μg/mL is 5.5 and 23.5 mL for the musculocutaneous nerve and perivascular injection, respectively. Further dose-finding studies are required for other concentrations of lidocaine, other local anesthetic agents, and other techniques for ultrasound-guided AXB.
Regional anesthesia and pain medicine 11/2012; · 4.16 Impact Factor
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Pain Practice 07/2012; 12(6):497. · 2.21 Impact Factor
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ABSTRACT: Pruritus associated with intrathecal opioid administration is a common side effect. There is evidence that κ-opioid receptor agonists have antipruritic activity. Butorphanol has agonist actions at both κ-opioid and μ-opioid receptors. This study was designed to evaluate the antipruritic efficacy of butorphanol after intrathecal morphine administration in the setting of a randomized, double-blind study of parturients undergoing cesarean section.
Ninety-one women who received combined spinal-epidural anesthesia with 1.2 ml 0.5 % isobaric bupivacaine and 0.1 mg preservative-free morphine were included in this study. After delivery of the baby, the parturients were randomly allocated to two groups: butorphanol group (n = 46) and physiological saline group (n = 45). In the butorphanol group, parturients received an intravenous loading dose of 1 mg butorphanol followed by infusion of 0.2 mg/h butorphanol. The physiological saline group received an infusion of the same volume of physiological saline. The presence of pruritus, visual analog scores for pain, sedation scores, and adverse effects were recorded 1, 2, 4, 6, 8, 10, 12, and 24 h after intrathecal morphine administration.
The incidence of pruritus at 24 h was significantly more frequent in the physiological saline group than in the butorphanol group (48.9 vs. 13.0 %, P < 0.001). The severity of pruritus was significantly greater in the saline group than in the butorphanol group 2, 4, 6, 8 and 10 h after intrathecal morphine injection (P = 0.004, 0.001, 0.002, and 0.003, respectively). The visual analog scale scores at 24 h were significantly lower in the butorphanol group than in physiological saline group (P < 0.001). The Ramsay sedation score in the butorphanol group was significantly higher than that in the physiological saline group after 1, 2, 4, 6, 8, 10, 12, and 24 h (P < 0.05). There were no significant differences between the two groups in nausea/vomiting and other adverse effects.
Administration of intravenous butorphanol after delivery of the baby can reduce pruritus that has been induced by intrathecal morphine administration in cesarean delivery with combined spinal-epidural anesthesia.
Journal of Anesthesia 06/2012; 26(5):752-7. · 0.83 Impact Factor
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ABSTRACT: This prospective, randomized, observer-blinded study compared perivascular (PV) and perineural (PN) ultrasound-guided axillary brachial plexus block (AXB) for upper extremity surgery.
Fifty patients were randomly allocated to receive a PV (n = 25) or PN (n = 25) ultrasound-guided AXB. The local anesthetic agent (lidocaine 1.5% with epinephrine 5 μg/mL) and total volume (32 mL) were identical in all subjects. For both groups, the musculocutaneous nerve was first located and then anesthetized using 8 mL. Subsequently, in the PV group, 24 mL was deposited dorsal to the axillary artery (6-o'clock position). In contrast, for the PN group, the median, ulnar, and radial nerves were individually anesthetized with volumes of 8 mL. During the performance of the block, the performance time, number of needle passes, and complications (vascular puncture, paresthesia) were recorded. Subsequently, a blinded observer assessed the onset time, block-related pain scores, and success rate (surgical anesthesia). The main outcome variable was the total anesthesia-related time (sum of performance and onset times).
No differences were observed between the 2 groups in terms of success rate (92%-96%), total anesthesia-related time (27.1-29.0 min), and block-related pain scores. However, the PV technique required fewer needle passes (3.5 [SD, 1.0] vs 8.2 [SD, 2.2]; P = 0.000) as well as a shorter performance time (8.2 [SD, 2.3] vs 15.7 [SD, 3.2] min; P = 0.000) and was associated with a lower incidence of paresthesia (8 vs 52%; P = 0.001). In contrast, the PN technique resulted in a quicker onset time (13.8 [SD, 7.0] vs 18.9 [SD, 7.0] min; P = 0.021) and a decreased incidence of vascular puncture (0 vs 24%; P = 0.01).
Perivascular and PN ultrasound-guided AXBs result in comparable success rates and total anesthesia-related times. Because of fewer needle passes and a shorter performance time, the PV technique provides a simple alternative for ultrasound-guided AXB.
Regional anesthesia and pain medicine 05/2012; 37(5):473-7. · 4.16 Impact Factor
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Regional anesthesia and pain medicine 05/2012; 37(3):361. · 4.16 Impact Factor
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ABSTRACT: Cervical medial branch blocks are commonly performed for the diagnosis and treatment of head, neck, and shoulder pain. Intermittent fluoroscopy is widely used for needle positioning and visualization of contrast distribution before medication injection. The purpose of this study was to examine the use of ultrasound as an alternative imaging technique to block the third occipital nerve and the C3 to C6 medial branches.
The study involved 2 phases with a total of 53 patients. The purpose of phase 1 was to assess the reliability of needle positioning using an ultrasound target corresponding to the middle of the bony contour of the articular pillar. Twenty patients undergoing 46 cervical medial branch blocks between C3 and C6 were recruited, and the needle tip position was graded on a 3-point scale based on its proximity to the centroid on lateral radiograph. In phase 2, 50 patients undergoing 163 levels were recruited. Using ultrasound guidance, each of the targeted levels was injected with 0.3 mL of a 1:1 mixture of local anesthetic and contrast agent. A blinded assessor reviewed contrast distribution in the anteroposterior and lateral radiograph views.
In phase 1, all needle tips were positioned on the articular pillars; furthermore, 80.1% were located in the middle 2 quarters of the latter. In phase 2, the contrast was found to cover the appropriate level in 94.5% of cases, and no complications were noted. The incidence of aberrant spread to adjacent levels (13.5%) was similar to that reported with fluoroscopy.
Ultrasound guidance offers a reliable alternative to fluoroscopy for third occipital nerve and C3-C6 cervical medial branch blocks. Further studies are required to validate the clinical efficacy of our technique.
Regional anesthesia and pain medicine 03/2012; 37(2):219-23. · 4.16 Impact Factor
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ABSTRACT: This prospective, randomized, observer-blinded study compared double-, triple-, and quadruple-injection ultrasound (US)-guided axillary brachial plexus block (AXB) for upper-extremity surgery.
One hundred twenty patients were randomly allocated to receive a double- (n = 40), triple- (n = 40), or quadruple-injection (n = 40) US-guided AXB. The local anesthetic agent (lidocaine 1.5% with epinephrine 5 μg/mL) and total volume (35 mL) were identical in all subjects. For all 3 groups, the musculocutaneous nerve was identified and anesthetized first. Subsequently, a perivascular technique was performed. Lidocaine was deposited at the 6-o'clock position of the axillary artery for the 2-injection group. For the 3- and 4-injection groups, injections were carried out at the 12-/6-o'clock and 2-/10-/6-o'clock positions, respectively. During the performance of the block, the performance time, number of needle passes, and complications (vascular puncture, paresthesia) were recorded. Subsequently, a blinded observer assessed the onset time, block-related pain scores, and success rate (surgical anesthesia). The main outcome variable was the total anesthesia-related time (sum of performance and onset times).
No differences were observed among the 3 groups in terms of total anesthesia-related time (29.2-31.4 mins), success rate (90.0%-97.5%), block-related pain scores, vascular puncture, and paresthesia. Compared with its 3- and 4-injection counterparts, the double-injection technique required fewer needle passes (4.0 ± 1.6 vs 5.2-6.0 ± 1.7-2.8; both P ≤ 0.001).
Double-, triple-, and quadruple-injection US-guided perivascular AXB result in comparable success rates and total anesthesia-related times. Because it requires fewer needle passes, the double-injection technique provides a simple alternative for US-guided AXB.
Regional anesthesia and pain medicine 02/2012; 37(3):248-53. · 4.16 Impact Factor
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Regional anesthesia and pain medicine 01/2012; 38(1):75. · 4.16 Impact Factor
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ABSTRACT: The aim of this study was to determine the minimum effective volume of lidocaine 1.5% with epinephrine 5 μg/mL in 90% of patients (MEV90) for double-injection ultrasound-guided supraclavicular block (SCB).
Using an in-plane technique and a lateral to medial direction, a double-injection ultrasound-guided SCB was performed. A 17-gauge, 8-cm Tuohy needle was initially advanced until its tip was positioned at the intersection of the first rib and subclavian artery ("corner pocket"). Half the volume of lidocaine was injected in this location. Subsequently, the needle was redirected toward the neural cluster formed by the trunks and divisions of the brachial plexus. The remaining volume of lidocaine was deposited in this location. Volume assignment was carried out using a biased coin design up-and-down sequential method, where the total volume of local anesthetic administered to each patient depended on the response of the previous one. In case of failure, the next subject received a higher volume (defined as the previous volume with an increment of 2.5 mL). If the previous patient had a successful block, the next subject was randomized to a lower volume (defined as the previous volume with a decrement of 2.5 mL), with a probability of b = 0.11, or the same volume, with a probability of 1 - b = 0.89. Each increment or decrement was evenly distributed between the "corner pocket" (1.25 mL) and neural cluster (1.25 mL). Lidocaine 1.5% with epinephrine 5 μg/mL was used in all subjects. Success was defined, at 30 minutes, as a minimal score of 14 of 16 points using a composite scale encompassing sensory and motor block. Patients undergoing surgery of the elbow, forearm, wrist, or hand were prospectively enrolled until 45 successful blocks were obtained.
Fifty-four patients were included in the study. Using isotonic regression and bootstrap confidence interval, the MEV90 for double-injection ultrasound-guided SCB was estimated to be 32 mL (95% confidence interval, 30-34 mL). All patients with a minimal composite score of 14 points at 30 minutes achieved surgical anesthesia intraoperatively.
For double-injection ultrasound-guided SCB, the MEV90 of lidocaine 1.5% with epinephrine 5 μg/mL is 32 mL. Further dose finding studies are required for other concentrations of lidocaine, other local anesthetic agents and single-injection techniques.
Regional anesthesia and pain medicine 08/2011; 36(5):466-9. · 4.16 Impact Factor
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ABSTRACT: In contrast to fluoroscopy, ultrasonography allows visualization of structures such as muscles, tendons, vessels, and nerves. We describe a case where ultrasonography in conjunction with fluoroscopy led to the incidental diagnosis of bowel herniation in a patient undergoing a caudal block.
A 71-yr-old woman presented to our chronic pain clinic with a long-standing history of coccydynia for which she had undergone a partial coccygectomy. A trial caudal block was planned. Fluoroscopy of the lower sacral area revealed the presence of a gas bubble inferoposteriorly to the coccygeal remnant. A confirmatory ultrasound scan revealed a hollow structure compatible with bowel. The procedure was abandoned. Subsequently, a non-enhanced computed tomographic scan of the pelvis confirmed the diagnosis of large bowel herniation. The patient was referred to a colorectal surgeon, and she subsequently underwent successful laparoscopic repair of the coccygeal hernia.
Ultrasonography can be a valuable adjunct in identifying non-neural pathologies in patients undergoing interventional procedures in chronic pain management. This case report highlights the importance of being vigilant for unanticipated pathologies during ultrasound examinations while performing chronic pain block procedures.
Canadian Anaesthetists? Society Journal 03/2011; 58(6):551-4. · 2.31 Impact Factor
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ABSTRACT: The aim of this study was to determine the minimum effective volume of lidocaine 1.5% with epinephrine 5 μg/mL in 90% of patients (MEV(90)) for single-injection ultrasound-guided infraclavicular block (ICB).
Using an in-plane technique, a single-injection ultrasound-guided ICB was performed: a 17-gauge, 8-cm Tuohy needle was advanced until the tip was located dorsal to the axillary artery. Volume assignment was carried out using a biased coin design up-and-down sequential method, where the volume of local anesthetic administered to each patient depended on the response of the previous one. In case of failure, the next subject received a higher volume (defined as the previous volume with an increment of 2.5 mL). If the previous patient had a successful block, the next subject was randomized to a lower volume (defined as the previous volume with a decrement of 2.5 mL), with a probability of b=0.11, or the same volume, with a probability of 1-b=0.89. Lidocaine 1.5% with epinephrine 5 μg/mL was used in all subjects. Success was defined, at 30 mins, as a minimal score of 14 of 16 points using a composite scale encompassing sensory and motor block. Patients undergoing surgery of the elbow, forearm, wrist, or hand were prospectively enrolled until 45 successful blocks were obtained.
Fifty-five patients were included in the study. Using isotonic regression and bootstrap confidence interval (CI), the MEV(90) for single-injection ultrasound-guided ICB was estimated to be 35 mL (95% CI, 30-37.5 mL). The probability of a successful response at 35 mL was estimated to be 0.91 (95% CI, 0.8-1.0). All patients with a minimal composite score of 14 points at 30 mins achieved surgical anesthesia intraoperatively.
For single-injection ultrasound-guided ICB, the MEV(90) of lidocaine 1.5% with epinephrine 5 μg/mL is 35 mL. Further dose-finding studies are required for other concentrations of lidocaine, other local anesthetic agents as well as techniques involving multiple injections, a more medial approach to ICB, or precise location of all 3 cords of the brachial plexus.
Regional anesthesia and pain medicine 03/2011; 36(2):190-4. · 4.16 Impact Factor
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ABSTRACT: This prospective, randomized, observer-blinded study compared ultrasound guidance and the conventional landmark-based technique for superficial cervical plexus blockade.
Forty patients were randomly allocated to receive a block of the superficial cervical plexus using ultrasound guidance (n = 20) or the traditional landmark-based technique (n = 20). The main outcome, success, was defined as the absence of cold sensation for all 4 branches of the superficial cervical plexus at 15 mins. A blinded observer recorded success rate, onset time, block-related pain scores, and the incidence of complications. Performance time and the number of needle passes were also recorded during the performance of the block. Total anesthesia-related time was defined as the sum of performance and onset times.
Success rate (80%-85%) was similar between the 2 groups. Performance time was slightly longer with ultrasonography (119 versus 61 sec, P < 0.001); however, no differences in onset and total anesthesia-related times were found. There were also no differences in the number of passes and procedural discomfort.
Ultrasound guidance does not increase the success rate of superficial cervical plexus block compared with a landmark-based technique. Additional confirmatory trials are required.
Regional anesthesia and pain medicine 11/2010; 35(6):539-43. · 4.16 Impact Factor
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ABSTRACT: The purpose of this brief narrative review is to summarize the evidence derived from randomized controlled trials pertaining to the nonsurgical treatment of lumbar spinal stenosis (LSS).
The MEDLINE (January 1950 to the fourth week of January 2010) and EMBASE (January 1980 to 2009, week 53) databases, the MESH term "spinal stenosis", and the key words, "vertebral canal stenosis" and "neurogenic claudication", were searched. Results were limited to randomized controlled trials (RCTs) conducted on human subjects, written in English, and published in peer-reviewed journals. Only RCTs pertaining to nonsurgical treatment were considered. Studies comparing conservative and surgical management or different surgical techniques were not included in the review.
The search criteria yielded 13 RCTs. The average enrolment was 54 subjects per study. Blinded assessment and sample size justification were provided in 85% and 39% of RCTs, respectively. The available evidence suggests that parenteral calcitonin, but not intranasal calcitonin, can transiently decrease pain in patients with LSS. In the setting of epidural blocks, local anesthetics can improve pain and function, but the benefits seem short-lived. The available evidence does not support the addition of steroids to local anesthetic agents. Based on the limited evidence, passive physical therapy seems to provide minimal benefits in LSS. The optimal regimen for active physiotherapy remains unknown. Although benefits have been reported with gabapentin, limaprost, methylcobalamin, and epidural adhesiolysis, further trials are required to validate these findings.
Because of their variable quality, published RCTs can provide only limited evidence to formulate recommendations pertaining to the nonsurgical treatment of LSS. In this narrative review, no study was excluded based on factors such as sample size justification, statistical power, blinding, definition of intervention allocation, or clinical outcomes. This aspect may represent a limitation as it may serve to overemphasize evidence derived from "weaker" trials. Further well-designed RCTs are warranted.
Canadian Anaesthetists? Society Journal 07/2010; 57(7):694-703. · 2.31 Impact Factor
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ABSTRACT: This narrative review summarizes the evidence derived from randomized controlled trials pertaining to the treatment of complex regional pain syndrome (CRPS).
Using the MEDLINE (January 1950 to April 2009) and EMBASE (January 1980 to April 2009) databases, the following medical subject headings (MeSH) were searched: "Complex Regional Pain Syndrome", "Reflex Sympathetic Dystrophy", and "causalgia" as well as the key words "algodystrophy", "Sudeck's atrophy", "shoulder hand syndrome", "neurodystrophy", "neuroalgodystrophy", "reflex neuromuscular dystrophy", and "posttraumatic dystrophy". Results were limited to randomized controlled trials (RCTs) conducted on human subjects, written in English, published in peer-reviewed journals, and pertinent to treatment.
The search criteria yielded 41 RCTs with a mean of 31.7 subjects per study. Blinded assessment and sample size justification were provided in 70.7% and 19.5% of RCTs, respectively. Only biphosphonates appear to offer clear benefits for patients with CRPS. Improvement has been reported with dimethyl sulfoxide, steroids, epidural clonidine, intrathecal baclofen, spinal cord stimulation, and motor imagery programs, but further trials are required. The available evidence does not support the use of calcitonin, vasodilators, or sympatholytic and neuromodulative intravenous regional blockade. Clear benefits have not been reported with stellate/lumbar sympathetic blocks, mannitol, gabapentin, and physical/occupational therapy.
Published RCTs can only provide limited evidence to formulate recommendations for treatment of CRPS. In this review, no study was excluded based on factors such as sample size justification, statistical power, blinding, definition of intervention allocation, or clinical outcomes. Thus, evidence derived from "weaker" trials may be overemphasized. Further well-designed RCTs are warranted.
Canadian Anaesthetists? Society Journal 02/2010; 57(2):149-66. · 2.31 Impact Factor
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ABSTRACT: Ultrasound-guided infraclavicular block can be performed using the double bubble sign. Previously described, the double bubble sign consists superiorly of the axillary artery (in short axis) superimposed on an inferior bubble created by local anesthetic injection. In this study, we compared this new method of brachial plexus anesthesia to the traditional triple-nerve stimulation axillary block.
Seventy patients were randomized to receive a single-injection, ultrasound-guided infraclavicular block using the double bubble sign or a triple-stimulation axillary block.
Both methods produced similar success rates (89%-91%). However, infraclavicular blocks were associated with a shorter performance time (3.90 +/- 2.27 vs 8.03 +/- 3.92 min; P < 0.001) and lower block-related pain scores (2.70 +/- 2.02 vs 4.17 +/- 2.57 on a 0-10 scale; P = 0.01).
Compared to triple-stimulation axillary block, ultrasound-guided infraclavicular block using the double bubble sign provided a similar efficacy, a shorter performance time and lower procedural pain scores.
Anesthesia and analgesia 10/2008; 107(3):1075-8. · 3.08 Impact Factor
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ABSTRACT: This narrative review summarizes the evidence derived from randomized controlled trials (RCTs) offering blinded assessment and sample size justification, in order to determine the benefits associated with adjunctive ultrasonography (US) and stimulating perineural catheters for nerve blocks.
The literature search for this review was conducted during the second week of December 2007 using the MEDLINE (January 1950 to November 2007) and EMBASE (January 1980 to November 2007) databases. For US-guided peripheral and neuraxial blocks, the following medical subject heading (MeSH) terms were searched: "nerve block", "epidural anesthesia", "epidural analgesia", "epidural injection", "epidural space", "spinal anesthesia", and "spinal injection", the results were combined with "ultrasonography" (MeSH term) and "ultrasound" (key word). For stimulating perineural catheters, the following MeSH terms were cross referenced with the MeSH term, "nerve block": "peripheral catheterization", "indwelling catheterization", "catheterization", and keywords, "nerve catheter" and "continuous". Subsequently, the result of this search was combined to "stimulating" (key word). Fifteen RCTs, offering blinded assessment and sample size justification, were retained for analysis.
For axillary blocks, US guidance yields a higher success rate than a double-injection, transarterial and a triple-injection, neurostimulation-guided technique. Compared to a quadruple-stimulation technique, no major differences can be found. The addition of nerve stimulation to US guidance offers no clear benefits for axillary blocks. For femoral blocks, compared to neurostimulation, echoguidance is associated with a local anesthetic (LA) sparing effect (up to 42%). In children, US guidance yields a LA sparing effect and a longer duration of action for lower extremity nerve blocks.Compared to their blind counterparts, stimulating catheters seem to offer limited clinical benefits. Despite providing a sparing effect on LA and opioid consumption, stimulating catheters are not associated with a decrease in side effects or analgesia-related expenditures.
Published reports of RCTs provide evidence to formulate limited recommendations regarding the use of adjunctive US and stimulating perineural catheters. Further well-designed and meticulously executed RCTs are warranted.
Canadian Journal of Anaesthesia 08/2008; 55(7):447-57. · 2.35 Impact Factor
