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ABSTRACT: We have found that N-cholinolytic drug benzohexonium produces a hypolipidemic effect: it reduces dyslipoproteinemia, fatty infiltration of the liver, and risk of atherosclerotic lesions.
Bulletin of Experimental Biology and Medicine 08/2012; 153(4):487-9. · 0.27 Impact Factor
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ABSTRACT: Experiments on rats with myocardial ischemia modeled by occlusion of the left coronary artery aggravated by alimentary dislipoproteinemia showed that therapy with taurepar (50 mg/kg), a taurine derivative, decreased blood corticosterone concentration and increased the level of endogenous testosterone, which attests to normalization of the compensatory-adaptive and gonadotropic functions of the organism.
Bulletin of Experimental Biology and Medicine 05/2010; 149(5):601-3. · 0.27 Impact Factor
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ABSTRACT: Diabetes mellitus (DM) is often combined with arterial hypertension, which increases the risk of serious complications. The purpose of this review was analysis of the peculiarities of pharmacotherapy with drugs belonging to different groups (ACE inhibitors, calcium channel blockers, alpha- and beta-adrenoblockers, diuretics, angiotensin II blockers, and imidazoline receptor agonists) as a part of combined therapy of compensated DM.
Klinicheskaia meditsina 02/2007; 85(1):52-7.
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ABSTRACT: A method for evaluation of the initial weight of the liver is developed for calculating the regeneration coefficient after partial hepatectomy on the basis of linear regression analysis. Experiments on rats showed that the model reflecting the relationship between liver weight and body weight for calculation of regeneration coefficient after partial resection of the liver expressed by the equation P0=0.033 x M can be used for screening of potential hepatoprotectors for quantitative evaluation of the regeneration processes.
Bulletin of Experimental Biology and Medicine 03/2006; 141(2):269-71. · 0.27 Impact Factor
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ABSTRACT: An antiischemic effect of a new n-phenylalkyl derivative of taurine was shown in experiments with rats. The effect is predetermined by an improvement of energetic metabolism in the myocardium, by the restoration of the activity of energetic exchange enzymes and by a reduction of the lipid peroxidation intensity. Besides, it was found that the drug can inhibit the activity of cytokines (IL-l gamma, and TNF gamma), which can be of significant practical importance in the treatment of myocardial ischemia and chronic heart insufficiency.
Vestnik Rossiĭskoĭ akademii meditsinskikh nauk / Rossiĭskaia akademiia meditsinskikh nauk 02/2002;
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ABSTRACT: The effects of new taurine derivatives TAU-15 and TAU-60 with normal and branched alkyl chains, respectively, in a dose of 25 mg/kg on the primary immune response in rats were studied in rats. Intraperitoneal injections of test compounds for 24 days caused transient inhibition of immune reactions to thymus-dependent antigen, which was related to suppressed production of interleukin-1beta playing a key role in antigen presentation. This effect was probably associated with activation of cortisol secretion. TAU-15 inhibited production of tumor necrosis factor-alpha and, therefore, prevented tissue damages. The immune response was normalized after withdrawal of these preparations.
Bulletin of Experimental Biology and Medicine 03/2001; 131(2):142-4. · 0.27 Impact Factor
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Biulleten' eksperimental'noĭ biologii i meditsiny 04/2000; 129(3):283-6.
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Biulleten' eksperimental'noĭ biologii i meditsiny 03/2000; 129(2):149-51.
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ABSTRACT: The results of examining the mechanisms of development of neurogenic visceral abnormalities induced by the body's extreme exposures, search for modes of its pharmacological correction are presented. Experiments have provided evidence for that the neutropic agents recovering the functional activity of the sympathetic nervous system, normalizing energy and plastic exchange have a positive effect in the treatment of the cardiovascular and gastroduodenal diseases which are caused by a neurogenic agent. A basically new approach to treating peptic ulcer, coronary heart diseases, and myocardial infarction is proposed depending on the stage of a disease.
Vestnik Rossiĭskoĭ akademii meditsinskikh nauk / Rossiĭskaia akademiia meditsinskikh nauk 01/1998;
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Voprosy pitaniia 02/1997;
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Voprosy pitaniia 02/1996;
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ABSTRACT: Neurogenic gastric lesions in rats were induced by combination of immobilization with 3-h long electrostimulation. After this stress a distinct decrease of noradrenalin and creatine phosphate content and then the activation of lipid peroxidation (LPO) in the stomach tissue was recorded. If the stress treatment was preceded by application of piracetam and fenibute, gastric tissue trophic was protected by way of prevention from a decrease of the content of noradrenalin, creatine phosphate and the activation of LPO.
Biulleten' eksperimental'noĭ biologii i meditsiny 12/1990; 110(11):504-6.
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ABSTRACT: Experiments were conducted on male rats; a study was made of the activity of pituitary-adrenal cortex system under conditions of electrolyte destruction of various hypothalamic areas. Pharmacological analysis pointed to the irregular distribution in the hypothalamus of the cholinergic and adrenergic systems controlling the secretion of ACTH-glucocorticoids. As suggested, the cholinergic systems are situated in the mammillary region, alpha-adrenergic ones--in the anterior or the posterior regions of the hypothalamus, and beta-adrenergic receptors--in the ventromedial nuclei of the hypothalamus. The latter possibly play an inhibitory role.
Biulleten' eksperimental'noĭ biologii i meditsiny 07/1978; 85(6):645-8.
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ABSTRACT: It was found that 3 hours after electrostimulation of the immobilized rats there was observed in addition to destructive lesions in the gastric mucosa a significant decrease of noradrenaline, dopamine, DOPA, homovanillic acid and creatine phosphate levels in the brain tissue involving the hypothalamus and the midbrain surrounding it. The use before the extreme impact of neurotropic agents blocking transmission of the damaging impulses from the site of stimulation of reflexogenic zones through the central adrenergic synapses which activate genome in the nerve cell or prevent depletion of catecholamine stores and disturbance of energy formation processes in the brain tissue protects against the development of neurogenic damage of the stomach.
Farmakologiia i toksikologiia 53(2):36-8.
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ABSTRACT: Neurogenic gastric lesions in rats were induced by a combination of immobilization and 3-hour electrostimulation. Neurogenic cardiac injury in rabbits were induced by 3-hour electrical stimulation of the aortic arch. Thereafter the activation of lipid peroxidation in the stomach and heart was recorded. There was an increase in MDA levels and a decrease in antioxidative enzyme activity in the tissues and serum (catalase and superoxide dismutase). The administration of the neurotropic drugs which restore the activity of the sympathetic nervous system (L-DOPA, aethimizol, fenibut and piracetam) was shown to normalize the processes of lipid peroxidation.
Eksperimental'naia i klinicheskaia farmakologiia 57(3):18-20.
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ABSTRACT: Therapeutic properties of a novel taurin N-phenylakyl derivative (TAU-15) in a dose 25 mg/kg were studied in male rats on models of chronic toxic hepatitis and partial hepatectomy. A hepatoprotective action of TAU-15 was established which is due to antioxidative action of TAU-15 and its ability to normalize protein-synthetizing activity of hepatocytes.
Patologicheskaia fiziologiia i eksperimental'naia terapiia
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L K Khnychenko
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ABSTRACT: The influence of a new N-phenylalkyl derivative of taurine in combination with a diet enriched with soybean proteins was studied in rats with nutritional dystrophia induced by 3/4 reduced standard diet. It is shown biochemically and morphologically that usage of the drug simultaneously with the diet stimulated protein synthesis, reduced lipid peroxidation, normalized spermatogenesis and compensatory adaptation of different functions.
Patologicheskaia fiziologiia i eksperimental'naia terapiia
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Farmakologiia i toksikologiia 43(2):164-6.
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ABSTRACT: The effects of TAU-5, a new N-phenylalkyl derivative of taurine, on the metabolic changes in heart were studied in rats with experimental myocardial infarction. The new drug exhibits a pronounced antiischemic effect related to recovery of the activity of enzymes involved in the energy exchange, decrease in the rate of lipid peroxidation, and normalization of the function of enzymes responsible for the antioxidant activity. The results of the pathomorphologic analysis and data on the state of cardiac metabolism showed that the antiischemic effect of TAU-5 is comparable with that of neoton.
Eksperimental'naia i klinicheskaia farmakologiia 64(2):38-40.
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ABSTRACT: The possibility of using cycloferon (interferon inductor) for a complex treatment (in combination with the main drug solcoseryl possessing pronounced therapeutic properties) of duodenum ulcers was experimentally studied in male rats. The experiments showed a considerable difference in the interferon status of animals with model duodenum ulcers treated with cycloferon, solcoseryl, their combination, and placebo (control). The healing effect of solcoseryl administered in combination with cycloferon exceeded that of each component administered separately.
Eksperimental'naia i klinicheskaia farmakologiia 64(6):41-4.
