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The Chinese-German Journal of Clinical Oncology 04/2012; 8(4):240-241.
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Tiecheng Pan,
Hua Yan,
Ni Zhang,
Youming Pan,
Yingxiong Tang,
Xiang Wen,
Dingwei Song,
Ming Hu,
Ligang Liu,
Zixiong Liu,
Mingshan Yang,
Jinzhi Xu,
Bitao Pu,
Boting Gao
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ABSTRACT: ObjectiveTo investigate the theoretical basis and clinical significance of thymectomy in the treatment of myasthenia gravis (MG).
MethodsAnalyze the changes in the contents of serum AchRab and sIL-2R, lymphocyte subtypes in peripheral blood lymphocytes before
and after thymectomy in 69 patients.
ResultsIn the study group significant changes were found in serum contents of AchRab and sIL-2R before and after operation and there
was also remarkable change in the number and constitution of peripheral blood lymphocyte subtypes.
ConclusionThymectomy is an effective therapy for MG.
The Chinese-German Journal of Clinical Oncology 04/2012; 1(1):36-37.
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ABSTRACT: Primary malignant melanoma of the esophagus (PMME) is an extremely rare and aggressive tumor, comprising less than 0.2% of
all primary esophageal neoplasms. There are fewer than 270 reported cases in worldwide literature, most of which are scattered
cases reported. This tumor has usually been reported as a pedunculated, polypoid lesion in the middle and lower third of the
esophagus. Hematogenic and lymphogenic metastases are commonly reported for PMME cases. Although surgical resection has been
considered as the best possible option, the prognosis has been nonetheless poor, even combined with adjuvant chemotherapy
postoperatively, according to the literatures. Here we reported such a case on its clinical presentations and treatment.
The Chinese-German Journal of Clinical Oncology 04/2012; 7(2):121-123.
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ABSTRACT: ObjectiveBeing considered as a bridge between the innate immunity and acquired immunity, Toll-like receptors (TRLs) are very important
innate immunity moleculars. Recent researchs on the innate immunity have focused on the relationship between TLRs and human
tumor. This paper investgated the expression and significance of TLR9 in human pulmonary adenocarcinoma cell (A549 cell) and human bronchial epithelial cell (HBE cell).
MethodsAfter culturing A549 cell and HBE cell in vitro, the expression of TLR9 mRNA and protein in both cells were detected by immunocytochemistry, Real-time Quantitative Reverse Transcriptase-Polymerase
Chain Reaction (Real-time Quantitative PCR) and Western blot, respectively.
ResultsBy immunocytochemistry staining, TLR9 was mainly expressed in both cells’ cell membrane and endochylema as brown-yellow material. It showed that the expressions
of TLR9 mRNA and protein in A549 cell were stronger than those in HBE cell (P < 0.01).
ConclusionThe results suggest TLR9 might cause the progression of human pulmonary adenocarcinoma, and the mechanism needs to be further investgatied.
The Chinese-German Journal of Clinical Oncology 04/2012; 8(7):393-396.
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ABSTRACT: Juvenile xanthogranuloma (JXG) is an uncommon benign disease, which usually occurs on the skin of head and neck region, as
a single or multiple nodular lesions. Tracheal involvement of JXG is extremely rare, and only few cases have been reported
in literature. Herein we presented an additional new case and discussed the optimal management of this uncommon disease.
The Chinese-German Journal of Clinical Oncology 04/2012; 5(3):219-221.
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ABSTRACT: Focal organizing pneumonia is a unique form of organizing pneumonia. Little is known regarding its clinical and radiological feature, diagnosis, management, and outcome. Twenty patients with focal organizing pneumonia were investigated and compared with 40 patients with bronchogenic carcinoma. There were 38 men (63.3%) and 22 women (36.7%). The mean age was 55 ± 9.9 years. No specific feature in clinical and radiological manifestation was found to distinguish between focal organizing pneumonia and bronchogenic carcinoma. In patients with focal organizing pneumonia, wedge resection was performed in 12 cases and lobectomy in eight cases. Follow-up was complete with a median period of 26 months (range, 6 to 104 months). All patients were free from recurrence of organizing pneumonia. Clinical and radiologic findings of focal organizing pneumonia are nonspecific, and this unique form of organizing pneumonia is difficult to differentiate from lung cancer. Surgical resection allows both diagnosis and cure. However, considering the benign nature of this disease, major pulmonary resections should be avoided.
The American surgeon 01/2012; 78(1):133-7. · 1.28 Impact Factor
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The American surgeon 08/2011; 77(8):1098-100. · 1.28 Impact Factor
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Interactive cardiovascular and thoracic surgery 06/2011; 12(6):1078.
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ABSTRACT: Differentiation between pulmonary tuberculoma and malignancy by preoperative diagnostic imaging sometimes proves difficult. The purpose of this study is to investigate variable manifestations of pulmonary tuberculoma mimicking lung cancer on fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) image and pathologic correlation.
Twenty-five patients with a high suspicion of malignancy and histopathologically diagnosed as pulmonary tuberculoma were included. Their FDG PET/CT images, clinical data, and pathologic findings were investigated.
There were 18 men and seven women. The mean age was 52 ± 8.8 years. The maximal diameter of pulmonary tuberculoma ranged from 1.7 to 4.2 cm. CT scan revealed that abnormal signs associated with malignancy such as spicular radiation, notching, and pleural indentation also frequently manifested in tuberculoma. During early imaging, positive FDG uptake was identified in 21 patients (84%), intermediate uptake in 3 patients (12%) and negative uptake in 1 patient (4%). During delayed imaging, 16 patients (64%) showed persistent elevated FDG accumulation and 8 patients (32%) experienced a slight drop of FDG accumulation. Pathologically active tuberculoma showed significantly higher FDG radioactivity during both early and delayed imaging than inactive lesion (P < 0.05). Lymphadenopathy with positive FDG uptake was identified in nine patients (36%).
Pulmonary tuberculomas mimicking lung cancer, most of which were pathologically active lesions, commonly displayed abnormal appearances in CT scan and an increase in FDG uptake, similar to changes seen on malignancy. Coexistent lymphadenopathy made differential diagnosis even more complicated. These results suggested that positive FDG PET/CT findings should be interpreted with caution in tuberculosis-endemic regions.
Southern medical journal 06/2011; 104(6):440-5. · 0.92 Impact Factor
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The Annals of thoracic surgery 03/2011; 91(3):e43. · 3.74 Impact Factor
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ABSTRACT: Congenital communication between left coronary artery to left ventricle is a rare anomaly. A 52-year-old male patient visited our institution complaining of paroxysmal palpitation and echocardiography revealed a large fistula draining into the left ventricle. Coronary angiography and computed tomography (CT) scanning confirmed the fistula located between the left circumflex coronary artery (LCX) and left ventricle (LV). A simple fistula ligation was performed, and postoperative three-dimensional coronary CT scanning confirmed the patient got a complete cure.
European journal of cardio-thoracic surgery: official journal of the European Association for Cardio-thoracic Surgery 03/2011; 40(4):1020-1. · 2.40 Impact Factor
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ABSTRACT: A 26-year-old male presented with radiographical evidence of enlargement of the right side of the heart. Echocardiography and computed tomography-scan revealed a diffuse, hugely enlarged right coronary artery (RCA) aneurysm, with the distal portion flowing directly into the left ventricle (LV). A radical correction operation was performed successfully. The RCA was reconstructed with an autograft of a greater saphenous vein after the aneurysm was removed and the RCA-to-LV fistula was closed. The postoperative course was uneventful and the patient was discharged on 12th day after operation.
Interactive cardiovascular and thoracic surgery 01/2011; 12(4):639-41.
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ABSTRACT: A 23-year-old man presented with cyanosis since birth. Precordial echocardiography failed to detect any structural heart abnormality except for enlarged left atrium. Pulmonary angiography revealed a type I right pulmonary artery-to-left atrial fistula. Simple ligation of the fistula without cardiopulmonary bypass was performed successfully, and the cyanosis disappeared postoperatively.
Asian cardiovascular & thoracic annals 08/2010; 18(4):373-5.
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European journal of cardio-thoracic surgery: official journal of the European Association for Cardio-thoracic Surgery 02/2010; 37(4):958. · 2.40 Impact Factor
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The Annals of thoracic surgery 05/2009; 87(4):e30. · 3.74 Impact Factor
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ABSTRACT: Patients with resectable lung cancer and unstable coronary heart disease are at high risks of postoperative death or severe cardioovascular complications. They always pose a therapeutic challenge for thoracic surgeons. The aim of this study is to summarize clinical experience of radical lung resection for cancer with simultaneous off-pump coronary artery bypass grafting.
Seven patients who suffered from non small cell lung cancer concomitant arrhythmia, unstable angina and recent history of myocardial infarction had been carried out simultaneous radical lobectomy and off-pump coronary artery bypass grafting. Preoperative 6 patients had been confirmed to be misfit for either coronary arterioplasty or stent implanting by performing the coronary angiography. One patient had undergone stenting before the lung cancer had been diagnosed. The procedure through median sternotomy performed offpump coronary artery bypass grafting preceded lobectomy and mediastinal lymphadenectomy. Left upper lobectomy was performed in 2 patients, right upper lobectomy was performed in 1 patient, right upper and middle lobectomy was performed in one patient, video thoracoscopy assisted left lower lobectomy was performed in 1 patient, right lower lobectomy was performed in 2 patients.
There was no death of patient in hospital, however, a patient died 7th month postoperatively because of cerebrovascular accident. Atrial fibrillation was observed postoperatively in 1 patient. Five patients were diagnosed as squamous cell lung cancer by pathology examination, and 2 patients were adenocarcinoma. Follow-up ranging from 2 months to 59 monthswas available for these patients postoperatively. None of the patients showed evidence of angina and myocardial infarction after surgery. In one patient, who underwent left superior lobectomy, local recurrence was found at 19 months after surgery.
In selected patients, simultaneous radical lung resection and off-pump coronary artery bypass grafting is a safe and effective treatment when unstable coronary heart disease and lung cancer coexist. The therapeutic strategy may decrease the incidence of postoperative complications.
Zhongguo fei ai za zhi = Chinese journal of lung cancer 04/2009; 12(4):332-6.
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Zhongguo fei ai za zhi = Chinese journal of lung cancer 02/2009; 12(2):179-82.
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ABSTRACT: Bilateral giant tension bronchogenic cysts were detected by computed tomography in a 13-year-old girl who presented with fever and severe cough. One was located in the right upper lobe, the other in the left lower lobe. The cysts, both measuring 10 cm in diameter, were removed in 2 operations 2 months apart.
Asian cardiovascular & thoracic annals 02/2009; 17(1):64-6.
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ABSTRACT: It has been known that facilitative glucose transporter (GLUT) is the main carrier which intervenes the glucose uptake of cell. The expression of Glut-1, Glut-3 has close relationship with the uptake of (18)Fluoro-2-deoxyglucose (FDG). The aim of this study is to discuss the relationship between expression of glucose transporter-1, 3 (Glut-1, Glut-3) and FDG uptake in NSCLC and benign pulmonary lesion.
Eighty-four NSCLC patients and twenty-four benign pulmonary lesion patients received PET/CT scan before operation. The expression of Glut-1, Glut-3 was detected by immunohistochemistry. The relationship among these factors was investigated.
The range of average SUV (SUVave) of the eighty-four patients was 3.6-13.2, and the average value was 7.8+/-3.0. The range of average SUV (SUVave) of the twenty-four patients was 1.2-9.2, and the average value was 3.2+/-1.9. In NSCLC tissues, the average immunohistochemical staining intensity of Glut-1, Glut-3 was 4.4+/-1.3 and 2.6+/-1.9, respectively. In benign pulmonary lesion, the average immunohistochemical staining intensity of Glut-1, Glut-3 was 0.9+/-0.9 and 1.2+/-1.4, respectively. Both of the Glut-1 and the Glut-3 expression levels were significantly higher in NSCLC than those in benign pulmonary lesion (P <0.01). Glut-1 expression was positively correlated to SUVave (r =0.78, P <0.01) in NSCLC patients. Glut-3 expression was positively correlated to SUVave (r =0.45, P =0.03) in benign pulmonary lesion patients.
The results show Glut-1 and Glut-3 express not only in NSCLC but also in benign pulmonary lesion. Glut-1 play an important role in FDG uptake in NSCLC. Glut-3 play an important role in FDG uptake in benign pulmonary lesion.
Zhongguo fei ai za zhi = Chinese journal of lung cancer 08/2008; 11(4):555-8.
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ABSTRACT: Esophageal tuberculosis (ET) is a rare clinical entity; the clinical features of this infection may be similar to the esophageal
carcinoma. The differential diagnosis is very difficult and some cases may result in an unnecessary esophagectomy. We reported
herein a 48-year-old man with symptoms of dysphagia and pectoralgia for one month. Our primary diagnosis was established as
esophageal carcinoma and the patient underwent surgical therapy. Histopathological examination of the excised tumor lesion
and lymph nodes showed epithelioid granulomas, Langhans’giant cells, caseous necrosis. No evidence of malignancy has been
found. The Mantoux test revealed a positive reaction with 20 mm in diameter. Antituberculous treatment was given after operation.
Clinicians should aware the features of ET and this rare disease should be considered in the differential diagnosis of esophageal
lesions.
The Chinese-German Journal of Clinical Oncology 02/2008; 7(3):140-141.
