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Medicina Clínica 04/1986; 86(10):425-7. · 1.38 Impact Factor
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Medicina Clínica 12/1983; 81(14):649. · 1.38 Impact Factor
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Revista Clínica Española 12/1981; 163(4):285-6. · 2.01 Impact Factor
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Revista Clínica Española 11/1981; 163(1):29-31. · 2.01 Impact Factor
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Medicina Clínica 10/1981; 77(4):146-9. · 1.38 Impact Factor
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The Journal of Infectious Diseases 01/1981; 142(6):945. · 6.41 Impact Factor
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ABSTRACT: Cryoglobulins are serum immunoglobulins which precipitate in the cold and redissolve on warming at 37 degrees C. According to its immunochemical composition three different types have been described. Cryoglobulins have been reported associated with hematologic disorders, systemic diseases, infectious conditions, and diseases of the liver and kidneys. There is also an idiopathic variant called essential cryoglobulinemia. Five patients (four males) with mixed essential cryoglobulinemia are reported. Common clinical manifestations included fever, articular symptoms, purpura, glomerulonephritis, Raynaud's phenomenon, erythematomacular cutaneous eruption, polyneuritis and abdominal pain. Serum activity of rheumatoid factor has been detected in three cases; in other three decreased levels of serum complement have been found. Serum HBsAg was negative in four cases (passive hemagglutination technique). It is possible that all cases of mixed essential cryoglobulinemia may correspond to bacterial, viral or fungal occult infections.
Medicina Clínica 08/1980; 75(3):98-103. · 1.38 Impact Factor
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ABSTRACT: Cryoglobulins are immunoglobulins characterized by precipitating when serum is cooled and redissolving when serum is heated. There is strong evidence to consider mixed cryoglobulins as circulating immunocomplexes, and various investigators have applied the precipitating physical property as a method to isolate immunocomplexes. In the recent years some authors have reported the presence of cryoglobulins in acute and chronic liver diseases of diverse etiology. This study investigates the presence of cryoglobulins in 34 patients with different liver diseases. Mixed cryoglobulins were detected in eight patients (23.5 percent), but only three of them had clinical symptoms attributable to the existence of cryoglobulins. In relation to the etiology of the liver disease, the highest frequency has been found among patients with hepatopathies of undetermined origin.
Medicina Clínica 05/1980; 74(7):252-6. · 1.38 Impact Factor
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ABSTRACT: Cryoglobulins are immunoglobulins characterized by precipitating when serum is cooled and redissolving when serum is heated. There is strong evidence to consider mixed cryoglobulins as circulating immunocomplexes. Cryoglobulins have been demonstrated in association to hematologic, hepatic, lymphoproliferative, autoimmune and infectious conditions. There is also an essential or idiopathic variant. The present report studies a series of 70 patients with several rheumatic and systemic diseases, and a group of ten patients with cutaneous vasculitis. Significant levels of cryoglobulins have been detected in nine cases (overall incidence 12.8 percent). The diagnoses corresponding to these patients were as follows: systemic lupus erythematosus in three cases, dermatopolymyositis in three cases, Sjögren's syndrome in two cases, and Wegener's granulomatosis in one case. Cryoglobulins could not be demonstrated in patients with rheumatoid artritis, sclerodermia, periarteritis nodosa, cutaneous vasculitis, Reiter's syndrome, ankylosing spondilitis and acute articular rheumatism. Among patients with systemic lupus erythematosus a good correlation has been observed between the presence of serum cryoglobulins, the activity and severity of the diseases and the decrease of serum complement levels.
Medicina Clínica 04/1980; 74(6):209-13. · 1.38 Impact Factor
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Revista Clínica Española 04/1980; 156(5):329-32. · 2.01 Impact Factor
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Revista Clínica Española 04/1980; 156(6):441-3. · 2.01 Impact Factor
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Revista Clínica Española 03/1980; 156(3):221-2. · 2.01 Impact Factor
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Revista Clínica Española 11/1979; 155(2):149-51. · 2.01 Impact Factor
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Revista Clínica Española 11/1979; 155(2):93-6. · 2.01 Impact Factor
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Revista Clínica Española 07/1979; 153(5):349-53. · 2.01 Impact Factor
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ABSTRACT: Results are presented for a series of 29 patients, 14 males and 15 females, with serious respiratory infections, in which fosfomycin proved effective. In all cases the study was completed by bacteriological, clinical, radiological and analytical controls. The average dose was 6 g/day (3 g orally and 3 g intramuscularly) for 1 or 2 weeks. The four isolated were P. aeruginosa, E. coli, Klebsiella-Enterobacter and D. pneumoniae. Overall sensitivity percentages were best for fosfomycin, gentamicin and colistin. Of the 29 germs isolated, only one strain of P. aeruginosa became resistant: this represents 3% resistance development. No side effects of intolerance or signs of hepatorenal insufficiency were observed during the treatment. Of the 29 patients treated, 22 were clinically cured, denoting 76% success.
Chemotherapy 02/1977; 23 Suppl 1:343-7. · 1.82 Impact Factor
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La semaine des hôpitaux : organe fondé par l'Association d'enseignement médical des hôpitaux de Paris. 04/1975; 51(14):963-5.
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ABSTRACT: Four women with fever, arthromyalgias, pericarditis, pleural effusion, high erythrocyte sedimentation rates, and lymphopenia had mitochondrial antibodies in the serum in the absence of antinuclear antibody. Their illness lasted 5-12 weeks and the antibody test results became negative on remission. Absence of specific bacteriological findings, normal antistreptolysin O titres, resistance to antibiotics, and good response to steroids suggested that these cases represented a milder and less persistent form of the syndrome resembling systemic lupus erythematosus described by German authors.
British medical journal 03/1975; 1(5954):370-1.
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Revista Clínica Española 01/1975; 135(6):545-51. · 2.01 Impact Factor
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Revista Clínica Española 10/1974; 134(6):553-7. · 2.01 Impact Factor
