Yingying Su

Sichuan University, Hua-yang, Sichuan, China

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Publications (19)56.68 Total impact

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    ABSTRACT: A new fluorescent probe for lead ions (Pb2+) was reported in this work. Positively charged UCPs capped with ethylene imine polymer (PEI) and negatively charged AuNPs capped with 11-mercaptoundecanoic acid (MUA) were used as fluorescence donor and acceptor, respectively. The fluorescence quenching process was initiated by the electrostatic interaction between PEI-UCPs and MUA-AuNPs. Upon the addition of Pb2+, functionalized AuNPs were aggregated by an ion-templated chelation process, causing the departure of AuNPs from UCPs. As a result, the fluorescence of the donor was restored and the recovery was found to be proportional within the range of 0.5-10 μM to the concentration of Pb2+. The detection limit was found to be 20 nM. This method was easy to operate with satisfactory selectivity and remarkable sensitivity which would be meaningful in Pb2+-related detection.
    Analytical methods 09/2014; · 1.86 Impact Factor
  • Yingying Su, Yani Xie, Xiandeng Hou, Yi Lv
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    ABSTRACT: In recent years, many nanomaterials-assisted chemiluminescence (CL) systems have been developed to improve the sensitivity and to expand the scope of their analytical applications. In these new systems, nanomaterials participate in CL reactions as catalysts, labels, reductants, luminophors, or energy acceptors. This review mainly focuses on the recent analytical applications of metal nanoparticles, magnetic nanoparticles, quantum dots (QDs), and carbon-based nanomaterials (carbon nanotubes and graphene) in liquid-phase CL systems. Recent advances in electrochemiluminescence based on nanotechnology and its analytical applications, especially in immunoassay, DNA analysis, and other biological analyses, are also summarized. Finally, we discuss some critical challenges in this field and speculate about their solutions. A total of 177 references mainly in the last 5 years are included in this review.
    Applied Spectroscopy Reviews 04/2014; 49(3):201-232. · 2.92 Impact Factor
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    ABSTRACT: A facile one-step microwave-assisted approach for the preparation of strong fluorescent carbon nitride quantum dots (g-CNQDs) by using guanidine hydrochloride and EDTA as the precursors was developed. Strong chemiluminescence (CL) emission was observed when NaClO was injected into the prepared g-CNQDs and a novel CL system for in direct detection of free chlorine was established. Free residual chlorine in water was sensitively detected with a detection limit of 0.01 μM and had a very wide detection range of 0.02 μM to 10 μM. Based on CL spectral, UV-visible absorption spectral, and electron spin resonance (ESR) spectral studies, as well as investigations on the effects of various free radical scavengers, a possible CL mechanism was proposed. It was suggested that the radiative recombination of oxidant-injected holes and electrons in the g-CNQDs accounted for the CL emission. Meanwhile, 1O2 on the surface of g-CNQDs, generated from some reactive oxygen species in the g-CNQDs-NaClO system, could transfer energy to g-CNQDs and thus further enhanced the CL emission. The CL system is highly sensitive and differentiable, opening a new field for the development of novel CL emitting species, but also expanding the conventional optical utilizations of g-CNQDs.
    Analytical Chemistry 03/2014; · 5.70 Impact Factor
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    ABSTRACT: In this work, we demonstrated that metal–organic frameworks (MOFs) and ZnO quantum dots (QDs) were successfully employed to design an effective fluorescent sensing platform for phosphate (Pi), thanks to the interactions among the ZnO QDs, MOFs and phosphate ions. The amine–Zn interaction and electrostatic interaction between negatively charged MOFs and positively charged ZnO QDs resulted in the quenching of ZnO QDs fluorescence due to electron-transfer processes, along with the formation of flower-like complex. After introducing Pi ions into the QDs–MOFs system, the burst of Pi ions could inhibit the quenching effect, and recover the fluorescence of ZnO QDs. Furthermore, the fluorescence intensities were dependent on the concentrations of Pi ions and scarcely affected by other possible interfering species. The present fluorescent sensing platform had good sensitivity (the slope of the calibration curve), with a linear range of 0.5–12 μM and detection limit of 53 nM (S/N = 3). The sensing mechanism of Pi was also investigated by scanning electron microscope (SEM) and X-ray diffraction (XRD), and the results indicated that the Pi ions inhibited the quenching effect via breaking the interactions between MOFs and ZnO QDs, and caused the collapsing of MOFs. Finally, the proposed methodology was used satisfactorily for the assessment of Pi in environmental aqueous samples, which opened a new avenue for Pi determination.
    Sensors and Actuators B Chemical 01/2014; 197:50–57. · 3.54 Impact Factor
  • Liying Hao, Hongjie Song, Yingying Su, Yi Lv
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    ABSTRACT: In this work, a graphene oxide functionalized Zn-based metal-organic framework (ZnMOF) was synthesised under a one-pot condition. This ZnMGO composite had high luminescence and good water dispersibility. The luminescence of the aqueous ZnMGO composite was efficiently and selectively quenched by Cu(2+) ions through interactions between Cu(2+) and the ligand. The detection limit was measured at concentrations as low as 1.00 μM. This robust ZnMGO composite demonstrated a fast response and high sensitivity (Ksv = 3.07 × 10(4) M(-1)) for Cu(2+) ions in aqueous solution. Moreover, the possible luminescence mechanism in terms of energy migration or electron transfer was further explored, and the quenching mechanism was discovered to be based on the collapse of the crystal structure with the help of various characterizations. Remarkably, it is the first time that this excellent ability possessed by the ZnMGO composite has been used to rapidly detect Cu(2+) ions in aqueous solution. The work does not only contribute to extend the potential application of ZnMGO composites, but it also aims to make a contribution within the biological sciences.
    The Analyst 12/2013; · 4.23 Impact Factor
  • Yurong Tang, Hongjie Song, Yingying Su, Yi Lv
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    ABSTRACT: Herein, we present a novel strategy based on a "turn-on" persistent luminescence imaging chemical system of graphitic carbon nitride (g-C3N4) for detecting biothiols in biological fluids. Graphitic carbon nitride (g-C3N4) as persistent luminescence probe is fabricated via a new procedure based on pyrolysis of guanidine hydrochloride under ambient atmospheric conditions. The prepared g-C3N4 nanosheets give intensively long-persistent luminescence that can avoid interference from biological media such as tissue autofluorescence and scattering light. The original persistent luminescence of g-C3N4 turns off due to the adsorption of silver ion (Ag+) onto g-C3N4 materials with an electron transfer process. The presence of biothiols induces the onset of persistent luminescence emission by interrupting the quenching interaction, thereby turning on the imaging probe. The approach exhibits high specificity and high sensitivity to biothiols with low detection limit for cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) with 6.4, 8.1, and 9.6 nM, respectively. It is also successfully applied for imaging detection of biothiols in human urine, plasma, and cell lysates, demonstrating its great value of practical application in biological systems.
    Analytical Chemistry 11/2013; · 5.70 Impact Factor
  • Yurong Tang, Yu Zhang, Yingying Su, Yi Lv
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    ABSTRACT: Ag nanoclusters (NCs) possessed distinct physical and chemical attributes that made them excellent scaffolds for the development of novel bio-analytical methodology. In the present work, a green approach for the preparation of Ag nanoclusters (NCs) was proposed on the basis of templated polyethyleneimine (PEI) assisted in-situ reductive crystallization of Ag (I), and then a sensitive resonance light scattering bioassay for the determination of heparin was established on the basis of the enhanced resonance light scattering of the PEI-capped Ag NCs during the presence of heparin. Further investigation indicated that the molecular weight of PEI, the PEI/Ag (I) ratio and the pH value of reaction conditions had great influence on the formation of Ag NCs, which was directly correlated to resonance light scattering. The bioassay allows sensitive and selective detection of heparin with a detection limit of 27.5nM, and successfully applied for the determination of heparin in human serum samples.
    Talanta 10/2013; 115:830-6. · 3.50 Impact Factor
  • Tao Liu, Yingying Su, Hongjie Song, Yi Lv
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    ABSTRACT: In this article, we established a fluorescent chiral recognition and detection method for cysteine based on the l-glutathione (l-GSH)-stabilized Ag nanoclusters (AgNCs) with high selectivity and sensitivity. A fast and green microwave (MW)-assisted strategy has been employed for synthesizing water-soluble fluorescent l-GSH-AgNCs. The reaction time was shortened from hours to several minutes. The synthetic process utilized l-glutathione as a stabilizing agent and a reducing agent without any other toxic reducing agent, such as NaBH4 or N2H4. The method is environmental friendly. Due to the different responses to AgNCs from chiral cysteine, we found d-cysteine hardly affects the fluorescence intensity of the AgNCs, whereas l-cysteine distinctly weakened its fluorescence intensity. This experiment indicated that fluorescence quenching efficiency of AgNCs was proportional to the concentration of l-cysteine in the range from 0.025 to 50 μmol L(-1).
    The Analyst 09/2013; · 4.23 Impact Factor
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    ABSTRACT: In this paper, a novel and simple colorimetric method for the determination of glutathione (GSH) was developed. The BSA–MnO2 NPs possess oxidase-like activity that can catalyze the oxidization of 3,3′,5,5′-tetramethylbenzidine (TMB), and the existence of GSH can cause reduction of oxidized TMB along with a visual color variation. A good linear relationship can be obtained from 0.26 to 26 μM with a limit of detection of 0.1 μM. Furthermore, the good recoveries for serum samples indicated that the present colorimetric methodology was feasible, simple and sensitive, with a promising application in routine analysis of biosamples.
    New Journal of Chemistry 06/2013; 37(7):2174-2178. · 2.97 Impact Factor
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    ABSTRACT: A simple and rapid capillary electrophoresis method was developed for the separation and determination of ephedrine (E) and pseudoephedrine (PE) in a buffer solution containing 80 mM of NaH2PO4 (pH 3.0), 15 mM of β-cyclodextrin and 0.3% of hydroxypropyl methylcellulose. The field-amplified sample injection (FASI) technique was applied to the online concentration of the alkaloids. With FASI in the presence of a low conductivity solvent plug (water), an approximately 1,000-fold improvement in sensitivity was achieved without any loss of separation efficiency when compared to conventional sample injection. Under these optimized conditions, a baseline separation of the two analytes was achieved within 16 min and the detection limits for E and PE were 0.7 and 0.6 µg/L, respectively. Without expensive instruments or labeling of the compounds, the limits of detection for E and PE obtained by the proposed method are comparable with (or even lower than) those obtained by capillary electrophoresis laser-induced fluorescence, liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry. The method was validated in terms of precision, linearity and accuracy, and successfully applied for the determination of the two alkaloids in Ephedra herbs.
    Journal of chromatographic science 04/2013; · 0.79 Impact Factor
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    ABSTRACT: In the present work, In2O3 hierarchical hollow microsphere and flower-like microstructure were achieved controllably by a hydrothermal process in the sodium dodecyl sulfate (SDS)-N,N-dimethyl-formamide (DMF) system. XRD, SEM, HRTEM and N2 adsorption measurements were used to characterize the as-prepared indium oxide materials and the possible mechanism for the microstructures formation was briefly discussed. The cataluminescence gas sensor based on the as-prepared In2O3 was utilized to detect H2S concentrations in flowing air. Comparative gas sensing results revealed that the sensor based on hierarchical hollow microsphere exhibited much higher sensing sensitivity in detecting H2S gas than the sensor based on flower-like microstructure. The present gas sensor had a fast response time of 5 s and a recovery time of less than 25 s, furthermore, the cataluminescence intensity vs. H2S concentration was linear in range of 2–20 μg mL−1 with a detection limit of 0.5 μg mL−1. The present highly sensitive, fast-responding, and low-cost In2O3-based gas sensor for H2S would have many practical applications.
    Materials Research Bulletin. 09/2012; 47(9):2212–2218.
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    ABSTRACT: Inorganic nanomaterials that mimic enzymes are fascinating as they potentially have improved properties relative to native enzymes, such as greater resistance to extremes of pH and temperature and lower sensitivity to proteases. Although many artificial enzymes have been investigated, searching for highly-efficient and stable catalysts is still of great interest. In this paper, we first demonstrated that bovine serum albumin (BSA)-stabilized MnO(2) nanoparticles (NPs) exhibited highly peroxidase-, oxidase-, and catalase-like activities. The activities of the BSA-MnO(2) NPs were evaluated using the typical horseradish peroxidase (HRP) substrates o-phenylenediamine (OPD) and 3,3',5,5'-tetramethylbenzidine (TMB) in the presence of either hydrogen peroxide or dissolved oxygen. These small-sized BSA-MnO(2) NPs with good dispersion, solubility and biocompatibility exhibited typical Michaelis-Menten kinetics and high affinity for H(2)O(2), OPD and TMB, indicating that BSA-MnO(2) NPs can be used as satisfactory enzyme mimics. Based on these findings, BSA-MnO(2) NPs were used as colorimetric immunoassay tags for the detection of goat anti-human IgG in place of HRP. The colorimetric immunoassay using BSA-MnO(2) NPs has the advantages of being fast, robust, inexpensive, easily prepared and with no HRP and H(2)O(2) being needed. These water-soluble BSA-MnO(2) NPs may have promising potential applications in biotechnology, bioassays, and biomedicine.
    The Analyst 08/2012; 137(19):4552-8. · 4.23 Impact Factor
  • He Chen, Ying Gao, Yingying Su, Yi Lv
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    ABSTRACT: In the present study, a simple and sensitive photo-induced chemiluminescence (CL) method for the quantitation of reducing sugars, including fructose, glucose, sucrose and lactose, was developed. This method was based on the on-line photocatalytic reaction of the reducing sugars, using a home-made photoreactor consisting of PTEF tube helically coiling around a high-pressure mercury UV lamp. Reducing sugars were detected by direct CL emission resulting from the reaction between the photoproducts and luminol. To maximize the signal intensity, the effects of irradiation time, flow rate, luminol concentration, buffer pH and concentration were tested. Under optimum conditions, the linear dynamic ranges were all 0.36-18 mg/L and the relative standard deviations (RSDs) were 1.8-2.3%, with limits of detection (3sigma) of 0.06 mg/L for fructose, glucose, sucrose and lactose. Finally, interference effects from ascorbic acid, amino acids (alanine, glycine, serine, leucine and methionine) and some metal ions and anions were also investigated.
    Luminescence 05/2008; 23(5):287-91. · 1.27 Impact Factor
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    ABSTRACT: Active oxygen species from the photocatalytic reaction in aqueous solution react with luminol to emit strong chemiluminescence (CL), and this can be inhibited by the UV decomposed-products of selenocystine (SeCys) or selenomethionine (SeMet). Based on this phenomenon, a novel hyphenated technique, HPLC-UV/nano-TiO2-CL, was established for the determination of SeCys and SeMet. The effects of pH, the UV irradiation time, the TiO2 coated on the inner surface of the reaction tubing, and the Co2+ catalyst concentration on the CL intensity and/or chromatographic resolution were systematically investigated. Under these optimized conditions, the inhibited CL intensity has a good linear relationship with the concentration of SeCys in the range of 0.04–10.6μgmL−1 or SeMet in the range of 0.05–12.4μgmL−1, with a limit of detection (S/N=3) of 6.4μgL−1 for SeCys or 12μgL−1 for SeMet. As an example, the method was preliminarily applied to the determination of the selenoamino acids in garlic and rabbit serum, with a recovery of 88–104%.
    Journal of Chromatography B 01/2008; 870(2):216-221. · 2.49 Impact Factor
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    ABSTRACT: A new method based on ultrasonic slurry sampling atomic absorption spectrometry (AAS) was established for the determination of trace mercury in geological samples by use of recently developed mercury cold vapor generation using formic acid under ultraviolet (UV) irradiation. The generated mercury cold vapor was rapidly separated from the matrix and swept into a T-tube for the measurement of atomic absorbance. Under the optimal experimental conditions, up to 1000-fold of Cu(II), Co(II), Ni(II), Cr(VI), Mn(II), Fe(III), and Zn(II) caused no significant interference with the determination of 50 µg L−1 Hg. The limit of detection at sub-ppb level was obtained for mercury. The method was applied to the determination of mercury in geological samples with satisfactory results.
    Microchimica Acta 12/2007; 160(1):191-195. · 3.43 Impact Factor
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    ABSTRACT: A simple, sensitive and interference-free method was proposed for the determination of arsenic, based on the generation of volatile arsenic trichloride coupled with atomic fluorescence spectrometry. Thiourea, together with l-ascorbic acid, was used to reduce As(V) to As(III), and the chloride generation was based on the reaction between As(III) and hydrochloric acid. Under the optimized experimental conditions, the present procedure allows for the quantification of arsenic in the concentration range of 0.01-4.0 mg L(-1), with a limit of detection (3sigma) of 6.0 microg L(-1). The relative standard deviation (R.S.D.) is 4.0% for 0.1 mg L(-1) arsenic (n=7). Finally, the proposed method was successfully applied to the determination of arsenic in several certified reference samples (stainless steel, alloy steel, copper alloy and water sample) and real samples (brass material and spiked cobalt material), with analytical results well-agreed with those by ICP-MS.
    Talanta 08/2007; 72(5):1728-32. · 3.50 Impact Factor
  • Source
    Yingying Su, He Chen, Zhimeng Wang, Yi Lv
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    ABSTRACT: This article reviews the development and application of chemiluminescence (CL) published in the literature between January 2004 and October 2006, with regard to instrumentation, systems, applications, and conclusions.
    Applied Spectroscopy Reviews 01/2007; 42(2):139-176. · 2.92 Impact Factor
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    ABSTRACT: A novel on-line method based on the combination of UV photolysis and chemiluminescence detection was established and experimentally validated for the determination of chemical oxygen demand (COD). A quantitative amount of free radicals can be produced by analytes in the UV irradiation process. By utilizing the phenomenon that luminol can be oxidized by the free radicals to produce luminescence, COD was successfully determined indirectly. This new approach overcomes many problems associated with the conventional COD determination techniques such as long analysis time, tedious operations, consumption of expressive and toxic reagents, production of secondary toxic waste and poor reproducibility. The method was successfully applied to the determination of COD in synthetic samples, certified reference samples and real samples of river water and lake water. A limit of detection of 0.08 mg/L COD with a linear dynamic range of 0.2–20 mg/L was achieved under the optimum experimental conditions. The proposed method is a unique method that is environmentally friendly (without using any strong oxidizing reagent and any catalysts such as titanium dioxide), rapid (with only 5–10 min required for each sample), sensitive (with the lowest limit of detection for COD so far), simple (mainly with a photo-reactor and a chemiluminescence detector) and automated (using an intermittent flow system).
    Microchemical Journal. 01/2007;
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    ABSTRACT: A new capillary zone electrophoresis method with laser-induced fluorescence detection is presented for the determination of noradrenaline (NA) and dopamine (DA). The fluorescent reagent, 5-(4,6-dichloro-s-triazin-2-ylamino) fluorescein, which readily reacts with amine group under mild conditions, was initially used to label the two compounds. Under optimized separation and labeling conditions, linear relationship between peak area and analyte concentration was obtained with high sensitivity (nM level). The applicability of the method for complex sample analysis was validated by determining the two compounds in a human serum and an herb, Portulaca oleracea L with recoveries ranging from 89% to 102%.
    Microchimica Acta 166(3):289-294. · 3.43 Impact Factor