Fang Pu

Chinese Academy of Sciences, Peping, Beijing, China

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Publications (109)415.47 Total impact

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    ABSTRACT: We display a nucleic acid controlled AgNC platform for latent fingerprint visualization. The versatile emission of aptamer-modified AgNCs was regulated by the nearby DNA regions. Multi-color images for simultaneous visualization of fingerprints and exogenous components were successfully obtained. A quantitative detection strategy for exogenous substances in fingerprints was also established.
    Chemical Communications 11/2015; DOI:10.1039/C5CC08534A · 6.83 Impact Factor
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    ABSTRACT: Unrecognized spatial disorientation (SD) which is intimately linked with brain cognitive function is always a fatal issue for the safety of pilots. To explore its effects on human brain cognitive functions, electroencephalography (EEG) functional network analysis methods were adopted to examine topological changes in the connection of cognitive regions when experiencing unrecognized SD. Twelve male pilots participated in the study. They were subjected to a SD scene, namely visual rotation, which evoked unrecognized SD. For the main EEG frequency intervals, the phase lag index (PLI) and normalized mutual information (NMI) were calculated to quantify the EEG data. Then weighted connectivity networks were constructed and their properties were characterized in terms of an average clustering coefficient and global efficiency. A T-test was performed to compare PLI, NMI and network measures under unrecognized SD and non-SD conditions. It indicated a weak functional connectivity level in the theta band under unrecognized SD based on the significant decrease of mean values of PLI and NMI (p<0.05). Meanwhile, both the average clustering coefficient and global efficiency in the theta band reduced under the unrecognized SD condition. The decrease of the average clustering coefficient and global efficiency demonstrates a lack of small-world characteristics and a decline in processing efficiency of brain cognitive regions. All the experimental results show that unrecognized SD may have a negative effect on brain functional networks in the theta band.
    Bio-medical materials and engineering 09/2015; 26(s1):S1115-S1124. DOI:10.3233/BME-151408 · 1.09 Impact Factor

  • Journal of Mechanics in Medicine and Biology 08/2015; DOI:10.1142/S0219519416500378 · 0.73 Impact Factor
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    ABSTRACT: This chapter focuses on the structure and stabilization of triplex DNA. The canonical DNA triplex structure is generally formed between an oligonucleotide and a homopurine– homopyrimidine duplex. The third strand (triplex-forming oligonucleotide (TFO)) binds in the major groove of the duplex and forms hydrogen bonds with the hydrogen bond donor and acceptor groups available on the major groove edge of the purine bases. According to where the TFO originates from, triplexes can be classified as intramolecular and intermolecular triplexes. The third strand in the triplex can also result from an exogenously applied molecule to form an intermolecular triplex structure. The pH of the solution is an essential parameter for the CGC+ triplet. Basic oligopeptides, another class of biologically relevant polycations, can stabilize triplex DNA. Cationic amino acid residues of basic peptides might bind to and neutralize phosphate groups of triple-helical nucleic acids. One important emerging field is the use of synthetic molecules to tune and modify the stability, functionality, and assembly of DNA-based structures. These molecules can be incorporated into the structures through one of two methods: covalent insertion or non-covalent interactions. Due to the ease of automated synthesis and the efficiency of coupling approaches, a plethora of synthetic modifications are available. Insertion of synthetic linkers has several direct effects on the DNA duplexes. Covalently inserting synthetic molecules into the DNA backbone introduces many unique properties for DNA assembly and represents a powerful tool towards controlling structure. For the purposes of guiding DNA assembly, groove binders and intercalators have interesting properties. The application of these properties to DNA self-assembly is discussed in this chapter. Intercalators and groove binders have demonstrated the ability to stabilize fully duplexed structures, modify assembly outcomes, increase yields, functionalize assemblies, and connect blunt-ended duplexes. Oligodeoxynucleotides are readily synthesized in automatic fashion in lengths of up to 100–50 nucleotides, and they form antiparallel duplex structures, based on the base-paring rules of Watson and Crick. Duplexes of DNA strands have a typical persistence length in aqueous buffer of over 100 base pairs. Shortly after the publication on assemblies of hybrids with dimers as DNA arms, Seeman and coworkers succeeded in crystallizing DNA folding motifs into lattices with designed crystal structure. In order to develop the next generation of hybrids, the authors sought a collaboration with theoreticians. Wolfgang Wenzel and coworkers took it upon themselves to develop a system for simulating the assembly of DNA hybrids, using a coarse-grained model. The strength of the association of the second-generation hybrids warranted a special approach for melting curves. Branched oligonucleotide hybrids with rigid cores will remain interesting only if they show their usefulness in practical applications. Controlled assembly of soft nanoparticles requires a recognition event to trigger the formation of a non-covalent assembly. A large number of soft nanoparticles are known, and among the most important class of natural soft nanoparticles are vesicles. Vesicles are lipid nanoparticles based on natural lipids and are of particular interest due to their occurrence in nature as intraor extracellular transport vehicles. However, soft nanoparticles based on lipid bilayers possess a universal mode for encoding surfaces by membrane anchoring of lipid modified DNA. In light of the technically demanding procedures for solid nanoparticles, non-covalent attachment of DNA to lipid bilayer surfaces becomes a very attractive technology. Incorporation of one or more lipid-membrane anchors into DNA leads to different sequence designs, which in general all allow assembly of liposomes. Ultraviolet spectroscopy in the presence of liposomes allows monitoring of DNA controlled assembly processes based on double or triple helix formation. This chapter provides a concise overview of the delicate relationship between biologically relevant metal ions or metal complexes and the two classes of naturally occurring functional RNAs: ribozymes or riboswitches. It first introduces the most important types of metal ion– RNA interactions, concentrating on the biologically most significant metal ions and discussing the various coordination modes and most frequent specific binding sites. The chapter then presents the world of both small and large ribozymes giving special attention to the influence of cations on the structure, folding, and function. It further explains how metal ions and metal complexes are involved in the correct structure formation and functioning of riboswitches. Riboswitches usually bind only a single metabolite to undergo the structural rearrangement required for gene regulation. The mgtA and the M-box riboswitches are well-defined examples of metal-sensing RNA. A major research area in DNA nanotechnology involves the development of DNA switching systems and DNA machines. This chapter exemplifies several principles to assemble DNA switching devices and DNA machines and discusses the potential applications. It highlights the existing structural and functional “tool-boxes” of nucleic acids to assemble DNA switches and machines. The chapter explains the perspectives of the area within the broad topic of DNA nanotechnology. It exemplifies the tailoring of DNA switches by ions or physical triggers such as photonic or electrical signals. The use of DNA switches and machines in nano-medicine has sparked substantial interest and several preliminary reports highlighting the future potential of such systems. The dynamic and switchable control of the organization of plasmonic particles or fluorophore–plasmonicnanoparticle conjugates holds great promise in material science. DNA switches and machines are expected to provide effective scaffolds for programmed synthesis by the dictated stimuli-triggered interactions of chemical reactants. This chapter describes the use of DNA as chiral bio-scaffold in the design of hybrid catalysts and their application in asymmetric catalysis. Some current and relevant examples are discussed, followed by an overview of mechanistic studies. DNA-based asymmetric catalysis is an exponent of the general concept of hybrid catalysts, which aims to merge the attractive properties of homogeneous and bio-catalysis. There are two main approaches to the anchoring of a transition metal complex to DNA. In covalent anchoring, the ligand for the metal is attached to the DNA via a chemical bond. A particularly attractive aspect of supramolecular anchoring is the easy formation of the catalyst since it involves spontaneous self-assembly of the transition metal complex with DNA. Moreover, in this approach it is usually DNA from natural sources, such as calf thymus or salmon testes DNA, that is used.
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    Wei Chen · Fang Pu · Yang Yang · Jie Yao · Lizhen Wang · Hong Liu · Yubo Fan ·
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    ABSTRACT: Equinus, varus, cavus, and adduction are typical signs of congenital talipes equinovarus (CTEV). Forefoot adduction remains a difficulty from using previous corrective methods. This study aims to develop a corrective method to reduce the severity of forefoot adduction of CTEV children with moderate deformities during their walking age. The devised method was compared with 2 other common corrective methods to evaluate its effectiveness.A Dennis Brown (DB) splint, DB splint with orthopedic shoes (OS), and forefoot abduct shoes (FAS) with OS were, respectively, applied to 15, 20, and 18 CTEV children with moderate deformities who were scored at their first visit according to the Diméglio classification. The mean follow-up was 44 months and the orthoses were changed as the children grew. A 3D scanner and a high-resolution pedobarograph were used to record morphological characteristics and plantar pressure distribution. One-way MAVONA analysis was used to compare the bimalleolar angle, bean-shape ratio, and pressure ratios in each study group.There were significant differences in the FAS+OS group compared to the DB and DB+OS groups (P < 0.05) for most measurements. The most salient differences were as follows: the FAS+OS group had a significantly greater bimalleolar angle (P < 0.05) and lower bean-shape ratio (P < 0.01) than the other groups; the DB+OS and FAS+OS groups had higher heel/forefoot and heel/LMF ratios (P < 0.01 and P < 0.001) than the DB group.FAS are critical for correcting improper forefoot adduction and OS are important for the correction of equinus and varus in moderately afflicted CTEV children. This study suggests that the use of FAS+OS may improve treatment outcomes for moderate CTEV children who do not show signs of serious torsional deformity.
    Medicine 07/2015; 94(28):e1004. DOI:10.1097/MD.0000000000001004 · 5.72 Impact Factor
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    ABSTRACT: The biomaterials science has advanced in a high speed with global science and technology development during the recent decades, which experts predict to be more obvious in the near future with a more significant position for medicine and health care. Although the three traditional subjects, such as medical science, materials science and biology that act as a scaffold to support the structure of biomaterials science, are still essential for the research and education of biomaterials, other subjects, such as mechanical engineering, mechanics, computer science, automatic science, nanotechnology, and Bio-MEMS, are playing more and more important roles in the modern biomaterials science development. Thus, the research and education of modern biomaterials science should require a logical integration of the interdisciplinary science and technology, which not only concerns medical science, materials science and biology, but also includes other subjects that have been stated above. This article focuses on multidisciplinary nature of biomaterials, the awareness of which is currently lacking in the education at undergraduate stage. In order to meet this educational challenge, we presented a multidisciplinary course that referred to not only traditional sciences, but also frontier sciences and lasted for a whole academic year for senior biomaterials undergraduate students with principles of a better understanding of the modern biomaterials science and meeting the requirements of the future development in this area. The course has been shown to gain the recognition of the participants by questionaries and specific “before and after” comments and has also gained high recognition and persistent supports from our university. The idea of this course might be also fit for the education and construction of some other disciplines.
    Journal of Science Education and Technology 04/2015; DOI:10.1007/s10956-015-9559-3 · 1.21 Impact Factor
  • Enguo Ju · Kai Dong · Zhen Liu · Fang Pu · Jinsong Ren · Xiaogang Qu ·
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    ABSTRACT: Photothermal ablation has provided emerging and promising opportunities to further potentiate the efficacy of postoperative chemotherapy of tumor. However, it still cannot achieve a high level of selectivity because extraneous photodamage along the optical path to the tumor is unavoidable as the result of the uncontrollable distribution of the photothermal agents. In addition, it is technically difficult to keep photoirradiation localizing only on cancer cells. In this report, a new strategy is introduced for precisely controlled ablation of tumor through tumor microenvironment activated near-infrared (NIR) photothermal therapy. By taking advantage of the pH-dependent light-heat conversion property of Au@PANI nanoparticles, much higher photothermal effect at pH 6.5 than that at pH 7.4 is achieved. Therefore, in normal tissues and blood vessels, NIR irradiation cannot lead to a lethal temperature with little or no harm to normal cells. In contrast, in acidic tumor microenvironment, the photothermal effect is activated. Consequently, NIR irradiation can effectively kill cancer cells through local hyperthermia. Importantly, with the benefit of the internal and external control to switch on the photothermal ablation, the technical difficulty to precisely localize laser irradiation on tumor cells can be circumvented.
    Advanced Functional Materials 03/2015; 25(10). DOI:10.1002/adfm.201403885 · 11.81 Impact Factor
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    ABSTRACT: The aim of this study is to investigate whether the anatomical organization of large-scale brain systems would change in ADHD patients compared to healthy controls. We utilized a structural covariance network (SCN) mapping approach to investigate large-scale networks in 30 drug-naïve ADHD boys and 30 gender- and age-matched controls. The regions showing significant between-group differences in gray matter (GM) volume were defined as seed regions of interest. Then, the SCNs derived from these seeds were statistically compared between ADHD and controls. Significant regional GM volume decreases (P<0.05, corrected) were observed in the right insula and the right orbito-frontal cortex (OFC) in ADHD relative to controls. Both SCNs derived from these two seeds showed more localized topology in ADHD group. Furthermore, significantly decreased structural connectivity were found between insula and right hippocampus, bilateral olfactory cortex, and between OFC and bilateral caudate nucleus (P<0.05, corrected) in ADHD group. Significantly increased association was observed between insula and left middle temporal gyrus (P<0.05, corrected) in ADHD group. Taken together, our results reveal abnormal regional brain anatomy as well as aberrant structural covariance networks in ADHD, supporting previous findings of dysfunction in distributed network organization in patients with ADHD. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    Psychiatry Research: Neuroimaging 01/2015; 231(3). DOI:10.1016/j.pscychresns.2015.01.006 · 2.42 Impact Factor
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    Xiang Ran · Fang Pu · Jinsong Ren · Xiaogang Qu ·
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    ABSTRACT: In this work, we developed a CuS-based sensor array having high stability and selectivity for complex protein analytes on a quartz chip. Our platform also exhibited excellent discrimination ability for the complex analytes of real biological samples such as bacteria extracts.
    Chemical Communications 01/2015; 51(13). DOI:10.1039/c4cc08863h · 6.83 Impact Factor
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    Yang Yang · Fang Pu · Xiaoning Lv · Shuyu Li · Jing Li · Deyu Li · Minggao Li · Yubo Fan ·
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    ABSTRACT: Galvanic vestibular stimulation (GVS) can be used to study the body's response to vestibular stimuli. This study aimed to investigate whether postural responses to GVS were different between pilots and the general populace. Bilateral bipolar GVS was applied with a constant-current profile to 12 pilots and 12 control subjects via two electrodes placed over the mastoid processes. Both GVS threshold and the center of pressure's trajectory (COP's trajectory) were measured. Position variability of COP during spontaneous body sway and peak displacement of COP during GVS-induced body sway were calculated in the medial-lateral direction. Spontaneous body sway was slight for all subjects, and there was no significant difference in the value of COP position variability between the pilots and controls. Both the GVS threshold and magnitude of GVS-induced body deviation were similar for different GVS polarities. GVS thresholds were similar between the two groups, but the magnitude of GVS-induced body deviation in the controls was significantly larger than that in the pilots. The pilots showed less GVS-induced body deviation, meaning that pilots may have a stronger ability to suppress vestibular illusions.
    BioMed Research International 01/2015; 2015:567690. DOI:10.1155/2015/567690 · 1.58 Impact Factor
  • Chi Zhang · Sheng Xie · Shuyu Li · Fang Pu · Yubo Fan · Deyu Li ·
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    ABSTRACT: Geometry of arteries has been considered as an important risk factor for atherosclerosis, because it influences the local hemodynamics. But the effect of the arterial shape on the internal carotid arterial (ICA) stenosis remains unknown. Four subjects with two geometrically different ICAs, diagnosed with unilateral stenosis, were investigated to clarify the association between the ICA shape and the stenosis. Magnetic resonance angiography (MRA) images of the two branches of ICA were acquired from the subject, and reconstructed into 3D models. The bifurcations and taper of the ICAs were removed. The pulsatile flow in the models was computationally simulated to evaluate the effect of the arterial geometry on hemodynamics. Because of the different geometry between the two branches of ICAs, the hemodynamic pattern is obviously different. The wall shear stress gradient (WSSG) and oscillating shear index (OSI) is lower in the left ICA branches, where helical flow is found, because of the large nonplanarity of bends. The difference of the arterial geometry is probably the only reason for the stenosis in this study. Furthermore, the planarity of the carotid siphon is the only geometric factor that is significantly different between the two branches. Consequently, the planarity is considered as the most important geometric factor for stenosis in ICAs.
    Biomedical Engineering Applications Basis and Communications 12/2014; 26(06):1450065. DOI:10.4015/S1016237214500653 · 0.23 Impact Factor
  • Fang Pu · Li Wu · Xiang Ran · Jinsong Ren · Xiaogang Qu ·
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    ABSTRACT: Artificial light-harvesting systems have received great attention for use in photosynthetic and optoelectronic devices. Herein, a system involving G-quartet-based hierarchical nanofibers generated from the self-assembly of guanosine 5′-monophosphate (GMP) and a two-step Förster resonance energy transfer (FRET) is presented that mimics natural light-harvesting antenna. This solid-state property offers advantages for future device fabrication. The generation of photocurrent under visible light shows it has potential for use as a nanoscale photoelectric device. The work will be beneficial for the development of light-harvesting systems by the self-assembly of supramolecular nanostructures.
    Angewandte Chemie International Edition 11/2014; 54(3). DOI:10.1002/anie.201409832 · 11.26 Impact Factor
  • Yan Li · Xue Rui · Shuyu Li · Fang Pu ·
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    ABSTRACT: Background Graph theoretical analysis has recently become a popular research tool in neuroscience, however, there have been very few studies on brain responses to music perception, especially when culturally different styles of music are involved. Methods Electroencephalograms were recorded from ten subjects listening to Chinese traditional music, light music and western classical music. For event related potentials, phase coherence was calculated in the alpha band and then constructed into correlation matrices. Clustering coefficients and characteristic path lengths were evaluated for global properties, while clustering coefficients and efficiency were assessed for local network properties. Results Perception of light music and western classical music manifested small-world network properties, especially with a relatively low proportion of weights of correlation matrices. For local analysis, efficiency was more discernible than clustering coefficient. Nevertheless, there was no significant discrimination between Chinese traditional and western classical music perception. Conclusions Perception of different styles of music introduces different network properties, both globally and locally. Research into both global and local network properties has been carried out in other areas; however, this is a preliminary investigation aimed at suggesting a possible new approach to brain network properties in music perception.
    Computers in Biology and Medicine 11/2014; 54. DOI:10.1016/j.compbiomed.2014.08.017 · 1.24 Impact Factor
  • Chi Zhang · Shuyu Li · Fang Pu · Yubo Fan · Deyu Li ·
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    ABSTRACT: The anatomic variation of Circle of Willis (CoW) has great impact on its compensatory capacity during stroke and cerebral ischemia. In the present study, a series of lumped parameter models were developed and used to simulate the effect of postural changes on the cerebral blood flow in ICA stenosis patients with different anatomic variants of the CoW. The results showed that the asymmetric distribution of cerebral blood flow caused by stenosis was attenuated in standing position in complete and half-complete CoW. However, in incomplete CoW, the decrease in blood flow in the ipsilateral cerebral arteries caused by unilateral ICA stenosis was dramatic in both supine and standing positions, a likely result of inadequate collateral circulation within the CoW. In conclusion, the anatomic variation of CoW plays a significant role in maintaining the balance of cerebral blood supply in patients with ICA stenosis, especially during postural change.
    Bio-medical materials and engineering 09/2014; 24(6):2371-80. DOI:10.3233/BME-141050 · 1.09 Impact Factor
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    ABSTRACT: Background and aims: Previous studies have focused mainly on individual factors affecting the balance function of older adults. However, it is largely unknown whether the balance functions of older adults are affected by multiple factors occurring simultaneously, and what is predominant among these factors. Methods: We adopted a cross-sectional study design and recruited 100 older adults from the community. Each participant was required to complete a questionnaire consisting of 20 questions related to four factors: sociodemographic, physical exercise, sleep condition and mental condition. We then evaluated all participants' static and dynamic balance abilities using two balance tests performed using the Microsoft Kinect™ system. We used MANOVA and FDR corrections to analyze each factor to determine which factors affected the balance parameters. Last, we identified the major factors related to balance by computing the percentage of primary factors with significant effects for each factor. Results: We found that static balance function was mainly affected by sociodemographic factors, sleep condition and mental condition. The dynamic balance function showed close relationships with physical exercise and sleep condition. Furthermore, sleep condition had a larger effect on static balance function than on dynamic balance function. We also observed an association between static balance function and mental condition. Conclusion: A wide range of factors were associated with balance function in these older adults. The static and dynamic balance functions were related with different factors; this might provide useful information for older adults on maintaining good balance ability.
    Aging - Clinical and Experimental Research 09/2014; 27(2). DOI:10.1007/s40520-014-0253-8 · 1.22 Impact Factor
  • Fang Pu · Jinsong Ren · Xiaogang Qu ·
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    ABSTRACT: Logic gates can convert input signals into a defined output signal, which is the fundamental basis of computing. Inspired by molecular switching from one state to another under an external stimulus, molecular logic gates are explored extensively and recognized as an alternative to traditional silicon-based computing. Among various building blocks of molecular logic gates, nucleic acid attracts special attention owing to its specific recognition abilities and structural features. Functional materials with unique physical and chemical properties offer significant advantages and are used in many fields. The integration of nucleic acids and functional materials is expected to bring about several new phenomena. In this Progress Report, recent progress in the construction of logic gates by combining the properties of a range of smart materials with nucleic acids is introduced. According to the structural characteristics and composition, functional materials are categorized into three classes: polymers, noble-metal nanomaterials, and inorganic nanomaterials. Furthermore, the unsolved problems and future challenges in the construction of logic gates are discussed. It is hoped that broader interests in introducing new smart materials into the field are inspired and tangible applications for these constructs are found.
    Advanced Materials 09/2014; 26(33). DOI:10.1002/adma.201401617 · 17.49 Impact Factor
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    ABSTRACT: Previous studies have suggested that amnestic mild cognitive impairment (aMCI) is associated with changes in cortical morphological features, such as cortical thickness, sulcal depth, surface area, gray matter volume, metric distortion, and mean curvature. These features have been proven to have specific neuropathological and genetic underpinnings. However, most studies primarily focused on mass-univariate methods, and cortical features were generally explored in isolation. Here, we used a multivariate method to characterize the complex and subtle structural changing pattern of cortical anatomy in 24 aMCI human participants and 26 normal human controls. Six cortical features were extracted for each participant, and the spatial patterns of brain abnormities in aMCI were identified by high classification weights using a support vector machine method. The classification accuracy in discriminating the two groups was 76% in the left hemisphere and 80% in the right hemisphere when all six cortical features were used. Regions showing high weights were subtle, spatially complex, and predominately located in the left medial temporal lobe and the supramarginal and right inferior parietal lobes. In addition, we also found that the six morphological features had different contributions in discriminating the two groups even for the same region. Our results indicated that the neuroanatomical patterns that discriminated individuals with aMCI from controls were truly multidimensional and had different effects on the morphological features. Furthermore, the regions identified by our method could potentially be useful for clinical diagnosis.
    The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 08/2014; 34(32):10541-53. DOI:10.1523/JNEUROSCI.4356-13.2014 · 6.34 Impact Factor
  • Fang Pu · Li Wu · Enguo Ju · Xiang Ran · Jinsong Ren · Xiaogang Qu ·
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    ABSTRACT: Artificial light-harvesting antenna materials as potential mimics for photosynthetic systems have attracted intense attention recently. Herein, a new modular approach to construct light-harvesting material, which involves the self-assembly of coordination polymer nanoparticles (CPNs) at room temperature, is presented. Fluorescence resonance energy transfer (FRET) occurs between donor and acceptor molecules encapsulated in the CPNs, and the emission signal of acceptor is amplified significantly. To the best of our knowledge, this is the first example of artificial light-harvesting material generated from biomolecule-based coordination polymer nanoparticles. The modularity of the material makes it convenient to manipulate the system by changing the composite of CPNs and the type and amount of dyes confined, implying it is a general strategy. The material functions not only in fluid medium, but also in the form of solid state, which extends its application areas greatly. Furthermore, photocurrent generation can be realized by the dye-encapsulated CPNs system upon irradiation with visible light, implying the potential usefulness in light-energy conversion and photoelectronic applications. Besides, the creation of FRET system provides a platform to mimic dual-channel logic gate at nanoscale level, which is beneficial to the construction of integrated logic devices with multiple functions.
    Advanced Functional Materials 07/2014; 24(28). DOI:10.1002/adfm.201400276 · 11.81 Impact Factor
  • Fang Pu · Jinsong Ren · Xiaogang Qu ·
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    ABSTRACT: Molecular logic gates in response to chemical, biological or optical input signals at a molecular level have received much interest over the past decade. Herein, we construct "plug and play" logic systems based on the fluorescence switching of guest molecules confined in coordination polymer nanoparticles generated from nucleotide and lanthanide ions. In the system, the addition of new modules directly enables new logic functions. PASS 0, YES, PASS 1, NOT, IMP, OR, and AND gates are successfully constructed in sequence. Moreover, different logic gates (AND, INH, and IMP) can be constructed using different guest molecules and the same input combinations. The work will be beneficial to the future logic design and expand the applications of coordination polymers.
    ACS Applied Materials & Interfaces 05/2014; 6(12). DOI:10.1021/am501949t · 6.72 Impact Factor
  • Yang Yang · Fang Pu · Yan Li · Shuyu Li · Yubo Fan · Deyu Li ·
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    ABSTRACT: Microsoft Kinect uses a built-in RGB-D sensor and the skeleton tracking algorithm to capture 3-D movements of the human body. It also has the potential for assessing postural stability, which is fundamental for most motor activities. The aim of this paper was to investigate whether standing balance can be evaluated reliably and validly by this low-cost device. Nine healthy subjects were required to maintain balance during three standing positions (double limb stance with feet apart, double limb stance with feet together and single limb stance). The center of mass (COM) was calculated from the body's kinematic data acquired by the Kinect system and Optotrak Certus motion capture system. The position variability and average velocity of the COM in the horizontal plane were calculated and used to evaluate the subject's balance. These COM parameters from the two systems showed excellent and comparable test-retest reliability (intraclass correlation coefficient $({rm ICC}){>}{0.75}$). In addition, although the average velocity of the COM calculated from Kinect was significantly lower, each COM parameter showed excellent concurrent validity $({rm ICC}{>}0.88)$ and a significant linear relationship $(p<0.001,r>0.930)$ existed between the two systems, which meant that biases may be corrected using linear calibration equations. Therefore, Kinect may be a valid, reliable, and convenient device for assessing standing balance when its measured COM parameters are properly calibrated.
    IEEE Sensors Journal 05/2014; 14(5):1633-1638. DOI:10.1109/JSEN.2013.2296509 · 1.76 Impact Factor

Publication Stats

1k Citations
415.47 Total Impact Points


  • 2009-2015
    • Chinese Academy of Sciences
      • • Laboratory of Chemical Biology
      • • Graduate School
      Peping, Beijing, China
  • 2007-2015
    • Beijing University of Aeronautics and Astronautics (Beihang University)
      • • School of Biological and Medical Engineering
      • • State Key Laboratory for Virtual Reality Technology and Systems
      Peping, Beijing, China
  • 2005
    • Sichuan University
      • Biomedical Engineering Center
      Hua-yang, Sichuan, China
  • 2004
    • Shanxi Medical University
      • Department of Cardiothoracic Surgery
      Yangkü, Shanxi Sheng, China