O E Teebken

Hannover Medical School, Hanover, Lower Saxony, Germany

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Publications (120)239.55 Total impact

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    ABSTRACT: Background: Pericytes surround endothelial cells at the perivascular interface. Signaling between endothelial cells and pericytes is crucial for capillary homeostasis, as pericytes stabilize vessels and regulate many microvascular functions. Recently it has been shown that pericytes are able to detach from the vascular wall and contribute to fibrosis by becoming scar-forming myofibroblasts in many organs including the kidney. At the same time, the loss of pericytes within the perivascular compartment results in vulnerable capillaries which are prone to instability, pathological angiogenesis, and, ultimately, rarefaction. Aims: This review will give an overview of pericyte-endothelial cell interactions, summarize the signaling pathways that have been identified to be involved in pericyte detachment from the vascular wall, and present pathological endothelial responses in the context of disease of the kidney. © 2014 S. Karger AG, Basel.
    Journal of Vascular Research 09/2014; 51(4):247-258. · 2.44 Impact Factor
  • Critical Care Medicine 09/2014; 42(9):e632-3. · 6.15 Impact Factor
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  • European Journal of Vascular and Endovascular Surgery 06/2014; 47(6):696–697. · 3.07 Impact Factor
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    ABSTRACT: Myocardial infarction after major surgery is frequent, drives outcome, and consumes health resources. Specific prediction and detection of perioperative myocardial infarction is an unmet clinical need. With the widespread use of high-sensitive cardiac troponin T assays, positive tests become frequent, but their diagnostic or prognostic impact is arguable. We, therefore, studied the association of routinely determined pre- and postoperative high-sensitive cardiac troponin T with the occurrence of major adverse cardiac events. This study was a prospective noninterventional trial. This study was conducted at Hannover Medical School in Germany. A total of 455 patients undergoing open vascular surgery were followed for 30 days for the occurrence of major adverse cardiac events. None. Preoperative and 24-hour postoperative high-sensitive cardiac troponin T measurements and the respective changes were correlated to medical history and the occurrence of major adverse cardiac events (cardiovascular death, myocardial infarction, and ischemia). Pre- and postoperative high-sensitive cardiac troponin T measurements demonstrated a majority of patients with detectable troponin levels preoperatively and an increase over the 24 hours after surgery. The level of high-sensitive cardiac troponin T was significantly associated with preexisting diseases that constitute the Lee's Revised Cardiac Risk Index. A preoperative high-sensitive cardiac troponin T greater than or equal to 17.8 ng/L and a perioperative high-sensitive cardiac troponin T change greater than or equal to 6.3 ng/L are independently associated with the occurrence of major adverse cardiac events. Adding high-sensitive cardiac troponin T absolute change to the Revised Cardiac Risk Index improves the risk predictive accuracy of the score as evidenced by increased area under receiver operating characteristic and significant reclassification effects. The risk predictive power of high-sensitive cardiac troponin T change in addition to the Revised Cardiac Risk Index could facilitate 1) detection of patients at highest risk for perioperative myocardial ischemia, 2) evaluation and development of cardioprotective therapeutic strategies, and 3) decisions for admission to and discharge from high-density care units.
    Critical care medicine 02/2014; · 6.15 Impact Factor
  • VASA.: Zeitschrift für Gefässkrankheiten. Journal for vascular diseases 01/2014; 43(1):78-80. · 1.21 Impact Factor
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    ABSTRACT: A thoracic outlet syndrome (TOS) is caused by arterial or nervous obstruction because of skeletal or muscular anomalies and hypertrophies. Congenital rib anomalies occur with low incidences (0.15-0.31%), predominantly affect the right side and are normally diagnosed at a young age or remain asymptomatic throughout life. Here, we report on the unusual case of a 71-year-old female patient with subacute ischemia of the left arm due to a TOS resulting from Srb anomaly, a very rare congenital rib anomaly.
    The Thoracic and cardiovascular surgeon reports. 12/2013; 2(1):50-2.
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    ABSTRACT: Introduction: At present the generation of a small-calibre (≤ 5 mm) vascular replacement for artificial bypasses remains a challenge for tissue engineering. The biocompatibility of bioartificial vessel replacements is of decisive significance for function and depends on the materials used. A completely autologous vessel substitute must exhibit high biocompatibility and functionality. For this purpose we developed and optimised a technique for the engineering of an autologous bypass material from a fibrin scaffold and vascular cells isolated from the same sample of peripheral blood in a porcine model.Materials and Methods: Fibrinogen, late outgrowth endothelial and smooth muscle cells were isolated from peripheral blood samples (n = 14, 100 mL each). Fibroblasts were isolated from porcine aortic adventitial tissue (n = 4). Tubular seeded fibrin segments were obtained using an injection moulding technique with the simultaneous incorporation of the in vitro expanded cells into the fibrin matrix. The segments were cultivated under dynamic conditions with pulsatile perfusion in a bioreactor. Morphological and functional characterization was done.Results: Artificial vascular segments with a length of 150 mm were reproducibly obtained with a hierarchical arrangement of incorporated cells similar to the structure of the vascular wall. By additional seeding of fibroblasts, suturable segments with biomechanical properties suitable for implantation into the arterial system were obtained.Conclusions: Implantable bioartificial vascular grafts can be generated from blood. After cultivation under dynamic conditions the vascular segments possess a structure similar to that of the vascular wall and exhibit biomechanical properties sufficient for implantation as arterial substitutes.
    Zentralblatt für Chirurgie 01/2013; · 0.69 Impact Factor
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    ABSTRACT: BACKGROUND: We report on a 62-year-old gentleman presenting at our urological department with an advanced renal cell cancer of the right kidney (10 cm in diameter), with an extensive caval vein thrombus (level IV) and bilateral pulmonary metastases. Another suspicious lesion at the left hemithorax was radiologically described. METHOD: A presurgical, neoadjuvant systemic therapy with sunitinib, a tyrosine kinase inhibitor, was initiated for 4 cycles in total (50 mg/day; 4 weeks on/2 weeks off). The cytoreductive nephrectomy was performed following the fourth cycle of sunitinib and after a 14-day break. Transesophageal echocardiography was used for intraoperative monitoring of the caval vein thrombus. Systemic treatment with sunitinib was continued 4 weeks after surgery. RESULTS: A significant reduction in tumor size, metastatic sites and down-staging of IVC from level IV to level III according to Novick classification was achieved. CONCLUSION: Significant down-staging of the tumor caval vein thrombus which initially reached the right atrium enabled us to perform surgery limited to the abdominal cavity without extracorporeal circulation nor hypothermia.
    World Journal of Urology 09/2012; 32(1). · 3.42 Impact Factor
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    ABSTRACT: SUMMARY Surgical site infection (SSI) after vascular surgery is a serious complication increasing morbidity, mortality, and costs for healthcare systems. A 4-year retrospective cohort study was performed in a university hospital with patients who had undergone arterial vascular surgery below the aortic arch. Investigated variables included demographics and clinical data. Forty-four of 756 patients experienced SSI, 29 of which were superficial, five were deep, and 10 had organ/space infections. Coagulase-negative staphylococci (22%), enterococci (20%), and Staphylococcus aureus (18%) were the most common pathogens. Independent risk factors for SSIs were femoral grafting [odds ratio (OR) 6·7], peripheral atherosclerotic disease, Fontaine stages III-IV (OR 4·1), postoperative drainage >5 days (OR 3·6), immunosuppression (OR 2·8), duration of operation >214 min (OR 2·8), and body mass index >29 (OR 2·6). The application of perioperative antibiotic prophylaxis was an independent protective factor (OR 0·2). Patients with certain risk factors for SSIs warrant special attention for infection prevention.
    Epidemiology and Infection 08/2012; · 2.49 Impact Factor
  • Omke E Teebken, Theodosios Bisdas
    VASA.: Zeitschrift für Gefässkrankheiten. Journal for vascular diseases 05/2012; 41(3):161-2. · 1.21 Impact Factor
  • Journal of Bioengineering and Biomedical Science. 04/2012; J Bioengineer & Biomedical Sci(2; 3):115.
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    ABSTRACT: To compare the in vitro efficacy of graft impregnation with nebacetin versus rifampin versus daptomycin against vascular graft infections caused by Staphylococcus epidermidis and Staphylococcus aureus and nebacetin versus rifampin against Pseudomonas aeruginosa and Escherichia coli. Twenty-three Dacron-grafts (1 cm2) for each micro-organism were microbiologically tested and eight grafts per antibiotic underwent viability tests against human umbilical vein endothelial cells (ECs). Fifteen grafts (5/antibiotic agent) underwent 15 min impregnation and contamination with 4 ml bacterial solution (optical density (OD (600 nm)): 0.20 ± 0.02). After 24-h-incubation, all grafts were washed with phosphate-buffered saline and underwent sonification to release viable adherent bacteria. OD (600 nm) of the solution was measured. Afterwards, six 1:10 dilution steps took place and colony-forming units (CFUs) were counted. Nebacetin showed comparable efficacy to daptomycin against Gram-positive bacteria. Both eradicated more efficiently S. epidermidis than rifampin (daptomycin:0, rifampin:5 ± 7.3, nebacetin:0 CFU ml(-1), P = 0.0003). All antibiotics showed comparable antibacterial activity against S. aureus. Nebacetin was more efficient than rifampin to eradicate Gram-negative organisms (P. aeruginosa: rifampin:1308 ± 252, nebacetin:8 ± 8 CFU ml(-1), P = 0.01, E. coli: rifampin:294 ± 159, nebacetin:0.2 ± 0.5 CFU ml(-1), P = 0.001), while only rifampin was toxic against ECs (daptomycin:30.88 ± 5.44, rifampin:5.13 ± 5.08, nebacetin:28.50 ± 3.82 ECs/field, P = 0.0003). Nebacetin showed excellent in vitro antibacterial activity against both Gram-positive and -negative pathogens representing an effective candidate for vascular graft impregnation.
    European journal of vascular and endovascular surgery: the official journal of the European Society for Vascular Surgery 01/2012; 43(4):448-56. · 2.92 Impact Factor
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    ABSTRACT: Ovine animal models are widely used to conduct preclinical studies, e.g., to evaluate cardiovascular prostheses intended to be applied in man. However, although analyzed in many of those studies, information about ovine blood reference values is scanty. The aim of this study is to establish a reference list of ovine blood parameters relevant for blood coagulation. A cohort of 47 mature ewes was evaluated. Parameters comprised the following: cells and cellular components-platelet, red, and white cell counts (including subsets), hemoglobin (Hb), hematocrit (HCT), mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV), and MCH concentration (MCHC); global tests of coagulation-prothrombin time (Quick's time) and activated partial thromboplastin time (aPTT); and parameters relevant for blood coagulation-fibrinogen, antithrombin (AT), and von Willebrand Factor. After explorative data analysis, a list of ovine reference values was established. Interestingly, a comparison with human reference values revealed some interspecies differences between sheep and man, i.e., much higher ovine ranges for some cell counts (neutrophils, lymphocytes, basophils, eosinophils, and platelets) but lower values for some other parameters (Hb, HCT, MCV, MCH, AT, and Quick's test). We established a reference list of ovine blood count and blood coagulation parameters. Because of some peculiarities of the ovine blood, this list may have implications for the interpretation of experimental data.
    ASAIO journal (American Society for Artificial Internal Organs: 1992) 01/2012; 58(1):79-82. · 1.39 Impact Factor
  • O E Teebken, T Bisdas, O Assadian, J-B Ricco
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    ABSTRACT: The purpose of these recommendations is to provide a standard format for reporting treatment results and standardised epidemiologic data after aortic vascular graft infection to improve the comparison of clinical outcomes between different therapeutic approaches and different study populations. Analytical reporting standards for patients' characteristics, type and extent of the disease, type of treatment and study design are described. Adherence to these recommendations will improve clinical relevance, quality and comparability of future studies dealing with aortic vascular graft infections.
    European journal of vascular and endovascular surgery: the official journal of the European Society for Vascular Surgery 12/2011; 43(2):174-81. · 2.92 Impact Factor
  • Thomas Aper, A. Haverich, O.E. Teebken
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    ABSTRACT: Die chronische Veneninsuffizienz ist eine Volkskrankheit mit großer sozioökonomischer Bedeutung. Ursächlich sind Klappendysfunktionen oder Obstruktionen in den Becken- und Beinvenen. Mit dem „tissue engineering“ hat sich in den letzten Jahrzehnten ein Forschungsbereich etabliert, mit dem die Konstruktion klappentragender Venensegmente möglich ist. Neben einem Überblick über die bislang entwickelten chirurgischen Behandlungsmöglichkeiten berichten wir in dieser Übersichtsarbeit über die Herstellung klappentragender Venensegmente und die Voraussetzungen für deren klinischen Einsatz.
    Zeitschrift für Herz- Thorax- und Gefäßchirurgie 12/2011; 25(6).
  • T Bisdas, O E Teebken
    VASA.: Zeitschrift für Gefässkrankheiten. Journal for vascular diseases 11/2011; 40(6):427-8. · 1.21 Impact Factor
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    ABSTRACT: HintergrundDie In-vitro-Effektivität von Bakteriophagen (BPH) hinsichtlich der Prävention vaskulärer Graftinfektionen wurde getestet. MethodeWir setzten keimspezifische BPH gegen S. epidermidis, S. aureus, P. aeruginosa und E. coli ein. Jeweils 7 Prothesengewebe pro Gruppe wurden imprägniert (1cm2, 15min); weitere 7 dienten als Positiv- und 4 als Negativkontrolle. 5 Segmente wurden mittels Rasterelektronmikroskop (REM) analysiert. Nach einer Inkubation von 24h wurden die Segmente 3-mal in PBS gespült. Nach Ablösung lebensfähiger Bakterien mithilfe von Ultraschall wurde die optische Dichte (OD) der Bakterienlösung ermittelt. Dann erfolgten sechs 1:10 Verdünnungsreihen und eine Inkubation von 24h (37°C) auf Agarplatten. Die koloniebildenden Einheiten (KBE) der 4. und 6.Verdünnung wurden errechnet. ErgebnisseDie Imprägnierung mit BPH gegen S. epidermidis und E. coli führte zu einer statistisch signifikanten Reduktion der OD, der KBE-4 und -6. Bei S. aureus und P. aeruginosa waren alle Parameter vergleichbar mit der Kontrollgruppe. Die REM-Aufnahmen des Biofilms bestätigten die mikrobiologischen Ergebnisse. SchlussfolgerungenDie getesteten BPH waren effektiv gegen In-vitro-Graftinfektionen, die durch S. epidermidis und E. coli verursacht wurden, aber nicht durch S. aureus und P. aeruginosa. BackgroundThe in vitro antibacterial effect of bacteriophages (BPH) as impregnation agents was tested for prevention of vascular graft infections. MethodsPathogen-specific BPHs for S. epidermidis, S. aureus, P. aeruginosa and E. coli were tested. In each case 7 segments of prosthesis tissue sized 1cm2 were impregnated for each group (15min), a further 7 segments were used as a positive control and 4 as a negative control and 5 segments were observed under scanning electron microscopy (SEM). After 24h incubation (37°C) segments were washed 3 times in 20ml PBS. Viable adherent bacteria were released by sonification and the optical density (OD) of the bacterial solutions was measured. A total of 6 dilution steps of 1:10 of the solution was made and incubated for 24h (37°C) on agar plates. Colony formed units (CFU) after the 4th and 6th dilution were counted. ResultsImpregnation with BPHs against S. epidermidis and E. coli showed a statistically significant reduction of OD, CFU-4 and CFU-6. For S. aureus and P. aeruginosa, all parameters were comparable to the positive control group. The microbiological findings were confirmed by SEM bio-films. ConclusionsThe pathogen-specific BPHs tested were effective in prevention of in vitro graft infections caused by S. epidermidis and E. coli but not by S. aureus and P. aeruginosa. SchlüsselwörterGraftinfektion–Imprägnierung–Antibiotika–Bakteriophage–Protheseninfektion KeywordsVascular graft infection–Impregnation–Antibiotics–Bacteriophages–Prosthesis infection
    Gefässchirurgie 10/2011; 16(6):387-394. · 0.24 Impact Factor
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    ABSTRACT: Verletzungen der hirnversorgenden Gefäße im Rahmen von Hochrasanztraumen sind seltene aber potentiell das Outcome verschlechternde Verletzungen. Ein differenziertes Schockraummanagement sowie eine Ausweitung der CT-Diagnostik können die Gefahr des Übersehens einer derartigen Verletzung reduzieren. Bei Prell- und Kontusionsmarken im Halsbereich sowie Rasanztraumen mit Krafteinwirkung auf die Halsweichteile bei angelegtem Integralhelm sollte immer an eine mögliche Gefäßverletzung gedacht werden.
    Der Unfallchirurg 10/2011; 115(10). · 0.61 Impact Factor
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    ABSTRACT: Injuries of internal carotid arteries caused by high energy trauma are rare but often combined with poor outcome. Blunt trauma to the head and neck as well as the use of newer motorcycle helmets together with crash circumstances should promptly lead to a differentiated polytrauma management with expansion of radiologic diagnostics. This could lead to a reduction of overlooked dissections and an increase in promptly and correctly treated injuries.
    Der Unfallchirurg 09/2011; 115(10):930-5. · 0.61 Impact Factor

Publication Stats

959 Citations
239.55 Total Impact Points

Institutions

  • 1998–2014
    • Hannover Medical School
      • • Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG)
      • • Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO)
      • • Department of Gastroenterology, Hepatology and Endocrinology
      Hanover, Lower Saxony, Germany
  • 1996–1998
    • Christian-Albrechts-Universität zu Kiel
      • UKSH Klinik für Herz- und Gefäßchirurgie
      Kiel, Schleswig-Holstein, Germany