You Chan Kim

Ajou University Medical Center, 수원시, Gyeonggi-do, South Korea

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Publications (137)281.78 Total impact

  • Young Joon Park · Hee Young Kang · Eun-So Lee · You Chan Kim
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    ABSTRACT: Confluent and reticulated papillomatosis (CRP) is an uncommon dermatosis with a reticular pattern. As differentiation between CRP and benign acanthosis nigricans (AN) can be challenging because of their similar clinicopathological features, we aimed to distinguish the two diseases. We retrospectively reviewed the clinical characteristics of 60 CRP and 30 AN patients. Histological examinations were conducted on 33 CRP and 30 AN lesions. While CRP was concentrated on the trunk, AN mostly appeared in the axilla. In the AN group, the number of obese patients was higher, and acanthosis and papillomatosis were more evident. In both group, increases in Ki-67 and keratin 16 expression were similar. Bacterial infection was detected at a higher rate in CRP lesions than in AN lesions.AN lesions had greater pigmentation because of a high number of melanocytes than CRP lesions. The location of skin lesions and body mass index are the main clinical factors that enable differentiation between CRP and AN. The epidermal histological changes in CRP are milder than those in AN. AN lesions also showed a greater degree of pigmentation and melanocytic proliferation. This article is protected by copyright. All rights reserved.
    Journal of Cutaneous Pathology 08/2015; DOI:10.1111/cup.12581 · 1.58 Impact Factor
  • Soo-Eun Jung · You Chan Kim
    Annals of Dermatology 08/2015; 27(4):478-80. DOI:10.5021/ad.2015.27.4.478 · 1.39 Impact Factor
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    ABSTRACT: Deep cutaneous fungal infections (DCFI) occur worldwide and their prevalence is influenced by personal factors of the affected patients and the geographic and cultural features. Surveillance studies of DCFI with respect to the various clinical backgrounds of affected patients can ultimately help to improve their outcome. Expanding on our previous study, we performed a retrospective analysis of patients with DCFI who were treated in a group of university teaching hospitals in Korea to determine the trends within a 5-year period. A retrospective medical record review of patients with DCFI treated between 2006 and 2010 at 16 university teaching hospitals located throughout Korea was performed. Among the 51 cases of DCFI (median patient age, 47.0 years), opportunistic infections in immunocompromised hosts accounted for half. Patients in this group included 11 who were transplant recipients and 12 with malignancies. Overall, Candida (13/51) was the most common causative organism, followed by Sporothrix (12) and Aspergillus (6). Papuloplaques and nodular lesions were the typical presentation, with maculopatches and ulcers also occurring in considerable numbers. Ten patients had systemic involvement. Eight immunocompromised patients did not recover from the disease despite systemic antifungal treatment. Our results highlight the equal involvement of opportunistic and primary pathogens in DCFI, as determined in cases from a 5-year period. Especially in immunocompromised hosts with non-specific skin findings, clinical suspicion is important because failure to diagnose a DCFI causes significant morbidity and possibly even death. © 2015 Japanese Dermatological Association.
    The Journal of Dermatology 06/2015; DOI:10.1111/1346-8138.12968 · 2.25 Impact Factor
  • 06/2015; DOI:10.1684/ejd.2015.2554
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    ABSTRACT: Background/purposeA relatively long incubation time is needed for photosensitizer absorption in conventional photodynamic therapy (PDT) for actinic keratosis (AK). The use of ablative CO2 fractional lasers (AFXLs) to increase drug delivery could shorten the incubation time. Here, we aimed to compare the efficacy between AFXL-assisted PDT with a short incubation time and conventional PDT for AK.Methods Patients with histopathologically confirmed facial AK were randomly divided into 2 groups. The lesions were histopathologically classified into grades I–III. In the AFXL-assisted PDT group, an ablative fractional laser was used for pretreatment, prior to the application of methyl aminolevulinate, with an incubation time of 90 minutes. Irradiation was performed with a 630-nm light-emitting diode. In the conventional PDT group, the incubation time was 180 minutes. All the patients received 2 rounds of PDT at 2-week intervals and underwent clinical or histological evaluation at 10 weeks after the first PDT course.ResultsTwenty-two patients underwent conventional PDT and 24 patients underwent AFXL-assisted PDT. Thirty-four AKs were included in the conventional PDT group and 35 AKs were included in the AFXL-assisted PDT group. The clearance rate was 64.7% in the conventional PDT and 71.4% in the AFXL-assisted PDT group; no significant differences in the clearance rate were noted between the groups (p = 0.55). The clearance rates for each grade also did not significantly differ between the 2 groups.Conclusions The use of AFXL before PDT reduced the incubation time, but yielded similar treatment efficacy as compared to conventional PDT.This article is protected by copyright. All rights reserved.
    Photodermatology Photoimmunology and Photomedicine 05/2015; DOI:10.1111/phpp.12184 · 1.26 Impact Factor
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    Tae Hyung Kim · Seung Joon Oh · You Chan Kim · Mi Ryung Roh
    Annals of Dermatology 04/2015; 27(2):218-20. DOI:10.5021/ad.2015.27.2.218 · 1.39 Impact Factor
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    ABSTRACT: Toxic Epidermal Necrolysis (TEN) is a severe adverse drug reaction involving extensive keratinocyte death in the epidermis. Histologically, skin from TEN patients exhibits separation at the dermoepidermal junction and accompanying necrosis of epidermal keratinocytes. Receptor-interacting protein kinase-3 (RIP3, or RIPK3) is an essential part of the cellular machinery that executes 'programmed', or 'regulated', necrosis and plays a key role in spontaneous cell death and inflammation in keratinocytes under certain conditions. Here we show that RIP3 expression is highly upregulated in skin sections from TEN patients, and may therefore contribute to the pathological damage in TEN through activation of programmed necrotic cell death. The expression level of mixed lineage kinase domain-like protein (MLKL), a key downstream component of RIP3 was not significantly different in skin lesions of TEN. However, elevated MLKL phosphorylation was observed in skin from TEN patients, indicating the presence of RIP3-dependent programmed necrosis. Importantly, in an in vitro model of TEN, dabrafenib, an inhibitor of RIP3, prevented RIP3-mediated MLKL phosphorylation and decreased cell death. Results from this study suggest that the high expression of RIP3 in keratinocytes from TEN patients potentiates MLKL phosphorylation/activation and necrotic cell death. Thus, RIP3 represents a potential target for treatment of TEN.Journal of Investigative Dermatology accepted article preview online, 06 March 2015. doi:10.1038/jid.2015.90.
    Journal of Investigative Dermatology 03/2015; 135(8). DOI:10.1038/jid.2015.90 · 7.22 Impact Factor
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    Young Joon Park · You Chan Kim
    Annals of Dermatology 02/2015; 27(1):99-100. DOI:10.5021/ad.2015.27.1.99 · 1.39 Impact Factor
  • Dong Jun Lee · Soo-Eun Jung · You Chan Kim
    Cutis; cutaneous medicine for the practitioner 02/2015; 95(2):67-68. · 0.72 Impact Factor
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    Soo-Eun Jung · Sue Kyung Kim · You Chan Kim
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    ABSTRACT: Bowen disease (BD), or intraepithelial squamous cell carcinoma (SCC), may progress to an invasive SCC. Although surgery is preferred because of the low recurrence rate, it can result in hypertrophic scarringor contracture, particularly in lesions on the hands. We report a case of BD in the first web space of the hand, which was treated with ablative fractional laser-assisted photodynamic therapy (AFXL-assisted PDT). After multiple AFXL-assisted PDT sessions, the lesion showed no clinical or pathological abnormalities. Thus, we believe that PDT can be an alternative treatment for BD occurring in the web space of the hand.
    Annals of Dermatology 02/2015; 27(1):76-8. DOI:10.5021/ad.2015.27.1.76 · 1.39 Impact Factor
  • Tae Hyung Kim · Ji Hye Lee · You Chan Kim · Sang Eun Lee
    Journal of Cutaneous Pathology 12/2014; 42(3). DOI:10.1111/cup.12425 · 1.58 Impact Factor
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    ABSTRACT: Pigmented mammary Paget disease is a very rare clinicopathologic variant of mammary Paget disease. Diagnosis is often difficult because its clinical and histological features are very similar to those of malignant melanoma. Herein, we report a case of pigmented mammary Paget disease misdiagnosed as malignant melanoma.
    Annals of Dermatology 12/2014; 26(6):747-750. DOI:10.5021/ad.2014.26.6.747 · 1.39 Impact Factor
  • Hye Rang On · Sang Eun Lee · You Chan Kim · Soo‐Chan Kim
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    ABSTRACT: Isolated benign primary cutaneous plasmacytosis in a child is a very rare and benign disease. Herein we present a case of this condition occurring in a child who showed good response to topical corticosteroid.
    Pediatric Dermatology 11/2014; 31(6). DOI:10.1111/pde.12449 · 1.02 Impact Factor
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    Hyo Sang Song · Sue Kyung Kim · You Chan Kim
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    ABSTRACT: Background: Among the various types of folliculitis, differentiation of Malassezia folliculitis (MF) from other forms of folliculitis is important because it is usually treated with antifungal agents. Objective: We attempted to find a method to enhance the detection rate of MF, and examined the differences in the clinical manifestation between MF and non-MF (NMF). Methods: We performed a retrospective study involving patients with folliculitis who were previously diagnosed with MF or NMF on the basis of serial tissue sectioning and diastase-Periodic acid-Schiff (d-PAS) staining findings. The clinical features of ME and NMF were compared. Results: Among a total of 100 folliculitis patients, 20 were diagnosed with MF and 80 with NMF. Tissues from the 80 patients with NMF were sectioned serially into 10 slices and stained with hematoxyl in and eosin stain; among these, 10 had many round-to-oval yeast organisms in the hair follicles that confirmed ME. Finally, d-PAS staining was used to detect the presence of yeast in the NMF slides. Notably, among the 70 d-PAS-stained samples, yeast organisms were found in 6 samples, confirming ME. As a result, the diagnosis of 16 patients changed from NMF to MF. Compared with NMF, ME showed major involvement of the trunk and low involvement of the face and legs as well as male predilection. Conclusion: Physicians should consider serial sectioning and/or d-PAS staining of folliculitis lesions, particularly of those on the trunk of male patients, even if no yeast organisms are detected initially.
    Annals of Dermatology 10/2014; 26(5):598-602. DOI:10.5021/ad.2014.26.5.598 · 1.39 Impact Factor
  • Hyo Sang Song · Soo-Eun Jung · You Chan Kim · Eun-So Lee
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    ABSTRACT: : Nipple eczema exhibits as a minor manifestation of atopic dermatitis (AD) or occurs as a single skin symptom on the nipple. To characterize the relationship between nipple eczema and AD, a clinical evaluation and an immunohistochemical study were performed. All cases of nipple eczema were confirmed histopathologically. We divided the patients with nipple eczema into 2 groups, namely, those with AD and those without AD, and compared several clinical features. Upon histological examination, the degree of inflammation was subjectively graded as mild, moderate, or severe by 2 separate investigators. Immunohistochemical stainings were performed by using antiinterleukin (IL)-4, anti-IL-13, anti-CD4, and anti-CD8 antibodies, and the results were scored semiquantitatively. In 43 cases evaluated, 12 were nipple eczema with AD. The clinical analysis and histological examination showed no significant differences between the groups. There were consistent findings of IL-4 expressions throughout the epidermis and IL-13 expression mainly in the perivascular area of the dermis. Although CD4 and CD8 were expressed in the cells in the dermis, CD8 expression was detected in the serocrusts of the epidermis. Expression levels of IL-4, IL-13, CD4, and CD8 exhibited no significant differences between the nipple eczema group with AD and the nipple eczema group without AD. Although nipple eczema may accompany AD, we found no definite differences in the degree or pattern of inflammation and cytokine expression level regardless of whether AD was present or not. Serocrust formation seemed to be mainly a collection of CD8-positive cells.
    American Journal of Dermatopathology 07/2014; 37(4). DOI:10.1097/DAD.0000000000000195 · 1.39 Impact Factor
  • Soo-Eun Jung · Hee Young Kang · Eun-So Lee · You Chan Kim
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    ABSTRACT: : The stratum corneum and epidermal pigmentation have protective roles against ultraviolet radiation. Because vitiligo skin lacks melanocytes and has no potential to produce pigment, some studies suggested that the epidermis in vitiligo skin is thicker than in normal skin. However, only a few studies investigated epidermal thickness changes in vitiligo, and some of these had relatively small sample sizes. Thus, this study aimed to compare epidermal thickness between vitiligo skin and adjacent normal-appearing skin in a large cohort. Photos of hematoxylin and eosin-stained slides of vitiligo skin and adjacent normal-appearing skin were taken under a microscope. The thicknesses of the stratum corneum, viable epidermis, and full epidermis were then measured by a computerized image analyzer. A total of 206 patients (412 sections) were included. There were significant differences between vitiligo skin and adjacent normal-appearing skin in the thickness of the stratum corneum (P = 0.009), viable epidermis (P = 0.001), and total epidermis (P = 0.001). An analysis comparing skin biopsied from a sun-exposed area versus a sun-protected area showed that the stratum corneum, viable epidermis, and total epidermis were significantly thicker in vitiligo skin than in normal-appearing skin in sun-exposed areas (P < 0.05), but not in sun-protected areas. We revealed that the epidermis was thicker in vitiligo skin than in normal-appearing skin, especially on sun-exposed skin, and that this may represent a photoprotective role compensating for absent pigmentation.
    American Journal of Dermatopathology 07/2014; 37(4). DOI:10.1097/DAD.0000000000000171 · 1.39 Impact Factor
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    Jaeyoung Shin · You Chan Kim
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    ABSTRACT: Notalgia paresthetica refers to an isolated mononeuropathy involving chronic localized itch or paresthesia most often at the skin of the scapula or surrounding regions. There are no specific skin manifestations except those arising from chronic scratching and rubbing. The specific etiology remains unknown; however, it has been theorized that the neuropathic itch is caused by sensory nerve entrapment involving the posterior rami of the T2 to T6 nerve root. The entrapment is due to degenerative changes in the vertebrae. We report here a particular case of notalgia paresthetica in a 55-year-old woman. The patient visited our hospital for tingling pain around the left inferior angle of the scapula. Pruritus was first reported seven years ago with tingling pain developing only four months ago. There were no specific skin lesions observed except for excoriation and vague hyperpigmentation. A skin biopsy revealed only epidermal thinning with pigmentary incontinence. The patient was treated with 600 mg of gabapentin daily as well as capsaicin cream. The response was deemed unsatisfactory.
    Annals of Dermatology 06/2014; 26(3):392-4. DOI:10.5021/ad.2014.26.3.392 · 1.39 Impact Factor
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    Hyo Sang Song · You Chan Kim
    Annals of Dermatology 06/2014; 26(3):419-21. DOI:10.5021/ad.2014.26.3.419 · 1.39 Impact Factor
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    Ji-Youn Park · Hee Young Kang · You Chan Kim
    Annals of Dermatology 06/2014; 26(3):411-3. DOI:10.5021/ad.2014.26.3.411 · 1.39 Impact Factor
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    ABSTRACT: Importance We evaluated 13 distinct patients with multiple telangiectatic pigmented macules confined mostly to the upper arms to determine if the clinical and histopathological features of these cases might represent a specific clinical entity.Observations We retrospectively investigated the clinical, histopathologic, and immunohistochemical features of 13 patients with multiple telangiectatic pigmented macules on the upper arms who presented between January 2003 and December 2012. Epidermal pigmentation, melanogenic activity, melanocyte number, vascularity, epidermal thickness, and perivascular mast cell number of the specimens were evaluated. Clinically, the condition favored middle-aged men. On histopathologic examination, the lesional skin showed capillary proliferation and telangiectasia in the upper dermis. Histochemical and immunohistochemical analysis revealed basal hyperpigmentation and increased melanogenic activity in the lesional skin (P < .05). No significant difference in epidermal thickness or mast cell number was observed between the normal perilesional skin and the lesional skin.Conclusions and Relevance The clinical and histopathologic features of these lesions were relatively consistent in all patients. In addition, the features are quite distinct from other diseases. Based on clinical and histologic features, we suggest the name acquired bilateral telangiectatic macules for this new entity.
    05/2014; 150(9). DOI:10.1001/jamadermatol.2013.10238

Publication Stats

725 Citations
281.78 Total Impact Points


  • 2007–2015
    • Ajou University Medical Center
      수원시, Gyeonggi-do, South Korea
  • 2005–2015
    • Ajou University
      • • Department of Medicine
      • • Department of Dermatology
      Sŏul, Seoul, South Korea
  • 2009
    • Eulji University
      • Department of Dermatology
      Daiden, Daejeon, South Korea
  • 2008
    • Inha University
      • Department of Dermatology
      Seoul, Seoul, South Korea
  • 2003–2006
    • Dankook University
      Eidō, North Chungcheong, South Korea
  • 2000–2004
    • Dankook University Hospital
      Anjŏ, Gyeonggi-do, South Korea
    • Mayo Clinic - Rochester
      • Department of Dermatology
      Rochester, Minnesota, United States
  • 2002
    • Hanyang University
      • College of Medicine
      Sŏul, Seoul, South Korea