G A Ermolin

Publications (62)8.54 Total impact

• Article: [Circulating complexes of plasma fibronectin (fibronectin-fibrin) in human diseases].

  S A Vasil'ev, E E Efremov, T A Savenko, G A Ermolin, G V Ignashenkova, L V Zherdeva
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  ABSTRACT: The study of circulating complexes fibronectin-fibrin in 21 patients with immunocomplex affections revealed their high levels which occurred in inverse relationships with fibronectin concentrations in the blood, but in direct correlation with indicators of inflammation (fibrinogen, cialic acid). It is suggested that the complexes are involved in the development of fibrosis at the sites of chronic inflammation in immune disorders.
  Terapevticheskii arkhiv 02/1994; 66(2):63-6. · 0.14 Impact Factor
• Article: [The detection of preventive hypofibronectinemia in diagnosing the development of disseminated intravascular coagulation in patients with myocardial infarction at the hospital rehabilitation stage].

  A V Solov'ev, G A Ermolin, V R Soroka
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  ABSTRACT: Postmyocardial infarction patients on hospital rehabilitation in case of no complications were examined for time course changes in the levels of fibrinogen degradation products (FDP), free hemoglobin (fHg) and fibronectin (Fn) using enzyme immunoassay. As shown by FDP and fHg values, the patients had DIC syndrome with its maximum on observation days 6-12 and 22-24. Fn fall occurred on the disease day 2-4 preceding maximum hemostasis activation up to 6-12th day. Less marked Fn reduction on the disease day 15-17 predicted a rise in hemocoagulation on day 22-24. It is recommended to determine FDP, fHg and Fn levels in blood of postmyocardial infarction patients to detect DIC syndrome and prevent hemostasis activation.
  Terapevticheskii arkhiv 02/1993; 65(9):22-4. · 0.14 Impact Factor
• Article: [The content of ceruloplasmin, fibronectin and selenium in the blood of patients with an acute myocardial infarct].

  P P Chaialo, A V Solov'ev, Ia M Ena, V R Soroka, G A Ermolin, M N Padalka, G M Chobot'ko, I R Shekhter
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  ABSTRACT: The content of ceruloplasmin, fibronectin and selenium was evaluated in the blood plasma of acute myocardial infarction patients within the first three days after onset if the disease. Results showed a reduction of fibronectin during the first hours after onset of the disease. The content of ceruloplasmin was increased, selenium reduced during the entire period of examination indicating pronounced disturbances of lipid peroxidation in the acute period of myocardial infarction as well as potentiation of antioxidant processes.
  Likars'ka sprava / Ministerstvo okhorony zdorov'ia Ukrainy 04/1992;
• Article: [Selective lymphapheresis (a method for the selective elimination of cellular elements and fibronectin complexes from the lymph) in systemic scleroderma].

  S A Vasil'ev, V G Archvadze, G I Alekseev, V Iu Baranovich, E E Efremov, G A Ermolin, L V Zherdeva, N G Guseva, A A Baranauskaĭte
  Terapevticheskii arkhiv 02/1992; 64(7):93-7. · 0.14 Impact Factor
• Article: [Intravascular blood coagulation in patients with ischemic heart disease].

  A V Solov'ev, Ia M Ena, G A Ermolin, V R Soroka
  Terapevticheskii arkhiv 02/1991; 63(9):64-9. · 0.14 Impact Factor
• Article: [Analysis of fibrinogen, fibrin-monomer complexes, fibrin-fibrinogen degradation products and plasminogen levels in the capillary blood].

  V A Makarov, N A Rogacheva, T M Shelepova, E N Mamochkina, G V Ignashenkova, G A Ermolin, G G Belozerskaia
  Gematologiia i transfuziologiia 07/1990; 35(6):33-4. · 0.09 Impact Factor
• Article: [The protein-binding properties of Treponema].

  N I Rasskazov, V V Chalov, G A Ermolin
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  ABSTRACT: A new type of substances is described, related to T. pallidum cultural strain structure and interacting with human and animal blood serum proteins, named T-PBC. T-PBC were found to react with albumin, immunoglobulins G, M, and A, fibronectin, CIg component of human blood serum complement, goat and bovine blood serum immunoglobulins. When injected to animals, T-PBC induced production of specific antibodies identifying 4 components in T-PBC, 2 of these components being resistant to heating at 100 degrees C for 5 min. All these components could be stained with protein stains.
  Vestnik dermatologii i venerologii 02/1990;
• Article: [The use of immunoenzyme analysis for recording specific IgM antibodies in syphilis patients].

  N I Rasskazov, G A Ermolin, V V Chalov, O V Magaryshkina, L V Kurmanova, T I Umenko
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  ABSTRACT: Specific IgM antibodies were assayed in blood sera of 230 patients with various forms of syphilis and of 561 controls. Enzyme immunoassay (EIA) sensitivity has made up 95.8 percent for primary syphilis, 93.8 percent for secondary new, 78.3 percent for secondary recurrent, 35.4 percent for early latent, 37.5 percent for late latent, and 80 percent for unknown syphilis. False-positive reactions were recorded in 5.5 percent of cases and were as a rule seen in the sera from patients with diffuse diseases of connective tissue. IgM EIA has proved highly effective in testing the sera from patients with primary seronegative syphilis and from subjects who had sexual intercourse with patients suffering from contagious forms of syphilis.
  Vestnik dermatologii i venerologii 02/1990;
• Article: [Age-related changes in fibronectin of the eye outflow drainage system].

  Iu E Batmanov, M V Brodskaia, G A Ermolin, E E Efremov
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  ABSTRACT: The content of the fibronectin, an extracellular glycoprotein in the drainage outflow system of human eyes was determined by the indirect immunoperoxidase staining technique. The degree of fibronectin accumulation in ocular tissues was evaluated by quantitative morphometric analysis. It was shown that the fibronectin level was elevated in ageing. Increased deposit of fibronectin in trabecular tissues, mainly, in the inner wall of Schlemm's canal and juxta-canalicular zone was demonstrated along with ageing. Comparison of fibronectin accumulation in glaucoma and ageing support the idea that ageing is a risk factor of glaucoma.
  Biulleten' eksperimental'noĭ biologii i meditsiny 12/1989; 108(11):637-9.
• Article: [Myoglobin and nickel in the blood of patients in the acute period of myocardial infarct].

  A V Solov'ev, G A Ermolin, M M Dikov, V R Soroka, N V Riabkova
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  ABSTRACT: The content of blood nickel and myoglobin was studied in 25 patients with macrofocal and transmural myocardial infarction during the acute stage. It was established that acute myocardial infarction results in an increase of the content of nickel and myoglobin in the blood of these patients. The diagnostic importance of these examinations is discussed.
  Vrachebnoe delo 11/1989;
• Article: FN-C1q and C1 INH C1r-C1s complexes as indicators of complement activation in patients with chronic lymphocytic leukaemia.

  T Hidvégi, G A Ermolin, E E Efremov, M M Dikov, L V Kurmanova, G V Vnashenkova, M V Merkulova, M Kókai, A Panya, G Füst
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  ABSTRACT: We have previously found low levels of C1 and C4 INH in the sera of chronic lymphocytic leukaemia (CLL) patients. Hypocomplementaemia was supposed to be the consequence of a permanent activation of the classical pathway. We have compared the levels of C1 INH-C1rC1s and C1q-FN complexes in the sera of 95 CLL patients and 100 healthy controls, because these complexes are known to be formed in the early stage of classical pathway activation. A significant increase in the level of both types of complexes was found in sera of CLL patients as compared to the controls. These findings support the assumption that the classical complement pathway is activated in the patients with CLL.
  Immunology Letters 08/1989; 22(1):1-6. · 2.53 Impact Factor
• Article: [Clinico-immunological parallels in patients with focal scleroderma].

  T N Suchkova, L V Kurmanova, G A Ermolin, S V Suchkov
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  ABSTRACT: Combined immunological examination of patients with focal scleroderma included studies of the humoral and cellular immunity parameters. The findings evidence that mainly immunological disorders underlie the pathogenesis of this disease, whose various combinations form this of that immunopathological pattern. An immunological classification of focal scleroderma is suggested. Clinical and immunological parallels in patients with different immunological variants of focal scleroderma are analyzed. The results permit a conclusion on the two basic mechanisms in the pathogenesis of focal scleroderma: (1) immunodeficiency involving the effector B component and (2) an isolated hyperfunction of natural killer cells.
  Vestnik dermatologii i venerologii 02/1989;
• Article: [Plasma fibronectin in patients with the syndrome of acute hepatorenal insufficiency (review of the literature)].

  S K Osmanov, A A Nazarenko, O M Voloshchuk, Ia S Purkin, G A Ermolin
  Laboratornoe delo 02/1989;
• Article: [Comparative characterization of the polystyrene plates used in enzyme immunoassay].

  T M Shelepova, G A Ermolin, O M Voloshchuk, E E Efremov, M M Dikov
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  ABSTRACT: The data on the comparison of the quality of polystyrene plates manufactured in the USSR with those manufactured by a number of foreign producers are presented. These data indicate that the capacity of antibodies adsorbed on a polystyrene plate for the sorption of antigens depend on the properties of the polymer surface and vary for different plates.
  Zhurnal mikrobiologii, epidemiologii, i immunobiologii 08/1988;
• Article: [Possible mechanisms of false positive reactions in immunoenzyme analysis].

  N I Rasskazov, G A Ermolin, V V Chkalov, E E Efremov
  Vestnik dermatologii i venerologii 02/1988;
• Article: [Clinical evaluation of Soviet immunoenzyme test systems for the quantitative determination of myoglobin, fibrinogen and fibrin-fibrinogen degradation products].

  T M Shelepova, G A Ermolin, S K Osmanov, M M Dikov, E E Efremov
  Laboratornoe delo 02/1988;
• Article: [Anti-insulin antibodies in diabetes mellitus in children].

  M I Martynova, G A Ermolin, V V Smirnov, A A Galybin, L F Marchenko
  Pediatriia 02/1988;
• Article: [Kinetics of myoglobin and anti-myoglobin antibodies in the blood of patients with myocardial infarction].

  L T Malaia, G A Ermolin, N I Iabluchanskiĭ, M M Dikov, L V Kurmanova
  Klinicheskaia meditsina 02/1988; 66(1):34-6.
• Article: [Effect of exogenous fibronectin on the healing of skin wounds as evidenced by tensiometric data].

  R I Litvinov, S G Izmaĭlov, O D Zinkevich, O S Kochev, G A Ermolin
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  ABSTRACT: Fibronectin (FN) solution purified from human blood plasma significantly increased the breaking strength of skin wounds in rats, when applied locally and/or intravenously. The best effect (more than 2-fold) was revealed after combined local and i. v. application of FN. Maximum stimulating activity was observed on the 3rd postoperative day, directly indicating the importance of FN for the early phases of wound healing. The data suggest the possibility of using FN preparations for the stimulation of tissue repair processes.
  Biulleten' eksperimental'noĭ biologii i meditsiny 01/1988; 104(12):727-30.
• Article: [Comparative study of the binding of human blood plasma fibronectin with clinical strains of staphylococci].

  F Buchwald, A L Tabachnik, G A Ermolin, N I Zhidkova, V E Kotelianskiĭ
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  ABSTRACT: The interaction of 62 S. aureus clinical strains and, respectively, 20 and 17 isolated S. epidermidis and S. saprophyticus strains with human blood plasma fibronectin (FN) has been studied. The specific interaction of FN with bacteria has been evaluated simultaneously by the binding of 125I with FN (method 1), the FN-mediated agglutination of staphylococci (method 2) and the character of colonies formed in 0.15% agar medium containing FN (method 3). The data obtained in this investigation indicated that all S. aureus strains under study react with FN to a different extent. When evaluating the binding of FN with bacteria, the most pronounced correlation was observed between methods 1 and 3. None of the methods used in this investigation has revealed interaction between FN and S. epidermidis and S. saprophyticus strains under study. The authors suggest that a preliminary inference on the capacity of the isolated clinical strains of staphylococci for reaction with FN may be made from the character of colonies formed in 0.15% agar medium containing FN.
  Zhurnal mikrobiologii, epidemiologii, i immunobiologii 01/1988;