[show abstract][hide abstract] ABSTRACT: Enchytraeids are an important group of soil animals, which plays a key role in many ecosystems. However, the ecological studies related to this group have not still been conducted in China. The effect of different forest types on community, and the influence of environmental variables on faunal distributional patterns were investigated in Changbaishan Mountain Natural Reserve (CMNR) in northeastern China. Altogether 30 enchytraeid species belonging to 8 genera were identified, among which, Fridericia was the species-richest group, followed by Henlea and Mesenchytraeus. Mesenchytraeus, Henlea, Fridericia and Bryodrilus were the numerically dominant genera. The most abundant species were Mesenchytraeus monodiverticulus, Mesenchytraeus megachaetus, Fridericia vixdiverticulata and Fridericia bretshceri. There were no significant differences in total enchytraeid richness and abundance across five forest types. However, significant differences were detected in major genera. Bryodrilus had higher species number and abundance in spruce-fir forests compared to other forest types. Fridericia spp. mainly occurred in hardwood forest, Henlea spp. in mixed forest, and Mesenchytraeus spp. in higher altitude regions. The depth of litter layer was strongly correlated with the faunal gradient revealed by canonical correspondence analysis. Other predictor variables were altitude, soil moisture and the content of potassium.Graphical abstractHighlights► We probe the key environmental factors sharping enchytraeid structure in one best-preserved mountainous ecosystem. ► The high vegetation heterogenicity plays key roles on harbouring high diversity of this fauna. ► Cool-peferent taxa are much abundant. ► Environmental factors regulate both solely and/or jointly soil organisms biodiversity. ► The local environmental parameters more important than regional ones in this system.
European Journal of Soil Biology 06/2011; 47(4):223-229. · 1.84 Impact Factor
[show abstract][hide abstract] ABSTRACT: Sixteen novel depsides were synthesized for the first time. Their chemical structures were clearly determined by (1)H NMR, ESI mass spectra, and elemental analyses. All the compounds were assayed for antibacterial activities against three Gram-positive bacterial strains (Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 6538, and Streptococcus faecalis ATCC 9790) and three Gram-negative bacterial strains (Escherichia coli ATCC 35218, Pseudomonas aeruginosa ATCC 13525, and Enterobacter cloacae ATCC 13047) by the MTT method. Compound 2-(2-methoxy-2-oxoethyl)phenyl 5-bromonicotinate (5) exhibited significant antibacterial activities against E. coli ATCC 35218 with an MIC of 0.78 microg/mL, which was superior to the positive control kanamycin B. In addition, compound 5 showed potent inhibitory activity against E. coli-induced interleukin-8 production.
Journal of Enzyme Inhibition and Medicinal Chemistry 03/2010; 25(4):590-5. · 1.50 Impact Factor
[show abstract][hide abstract] ABSTRACT: A series of long-chain derivatives of chrysin (compounds 3-22) were synthesized to evaluate for their antiproliferative activities against the human liver cancer cell line HT-29 and EGFR inhibitory activity. Among the compounds tested, compounds hexadecyl 2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetate (10) and N-hexadecyl 2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetamide (20) displayed potent EGFR inhibitory activity with IC(50) values of 0.048 microM and 0.035 microM), comparable to the positive control erlotinib. Docking simulation of compounds 10 and 20 was carried out to illustrate the binding mode of the molecular into the EGFR active site, and the result suggested that compound 10 and 20 can bind the EGFR kinase well. Thus, compounds 10 and 20 with potent EGFR inhibitory activity would be potential anticancer agents.
[show abstract][hide abstract] ABSTRACT: Fatty acid biosynthesis is essential for bacterial survival. Components of this biosynthetic pathway have been identified as attractive targets for the development of new antibacterial agents. FabH, beta-ketoacyl-acyl carrier protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation of fatty acid biosynthesis and is highly conserved among Gram positive and negative bacteria. Three series of Schiff bases containing thiazole template were synthesized and developed as potent inhibitors of FabH. This inhibitor class demonstrates strong antibacterial activity. Escherichia coli FabH inhibitory assay and docking simulation indicated that the compounds 11 and 18 were potent inhibitors of E. coli FabH.
[show abstract][hide abstract] ABSTRACT: Two series of thiazolidinone derivatives designing for potential EGFR and HER-2 kinase inhibitors have been discovered. Some of them exhibited significant EGFR and HER-2 inhibitory activity. Compound 2-(2-(5-bromo-2-hydroxybenzylidene)hydrazinyl)thiazol-4(5H)-one (12) displayed the most potent inhibitory activity (IC(50)=0.09 microM for EGFR and IC(50)=0.42 microM for HER-2), comparable to the positive control erlotinib. Docking simulation was performed to position compound 12 into the EGFR active site to determine the probable binding model. Antiproliferative assay results indicating that some of the thiazolidinone derivatives own high antiproliferative activity against MCF-7. Compound 12 with potent inhibitory activity in tumor growth inhibition would be a potential anticancer agent.