-
[show abstract]
[hide abstract]
ABSTRACT: To evaluate the GH response to the clonidine test in a group of infertile women and to determine their ovulatory response to clomiphene citrate (CC) stimulation.
Prospective study.
Reproductive endocrinology unit.
Thirty-three anovulatory infertile women (age range, 25-36 years) and 9 healthy controls with normal ovulation.
In the early follicular phase, 0.3 mg of clonidine was administered between 8:30 and 9:00 A.M. and blood samples were collected for 120 minutes thereafter for measurement of serum GH levels. Plasma levels of insulin and glucose were measured after a 75-g glucose load, and CC was given at a dosage of 50-250 mg/d for ovulation-induction.
Serum concentrations of GH, insulin-like growth factor I, insulin, and insulin-like growth factor binding protein-1.
On the basis of their ovulatory response to CC, 15 patients were considered nonresponsive (group 1) and 18 patients were considered responsive (group 2). Baseline levels of GH, insulin-like growth factor I, and insulin-like growth factor binding protein-1 were similar in the two groups of patients and the controls. The GH response to clonidine was significantly greater in group 2 and in the controls than in group 1. Concentrations of insulin and glucose after the glucose load were not different among the three groups.
Women who were resistant to CC had a reduced GH response to clonidine. These data suggest that adequate GH secretory capacity is important for CC action.
Fertility and Sterility 02/2000; 73(1):78-84. · 3.56 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: The Authors have studied the effects of Norethisterone enantate given i.m. every one or two months to 75 patients complaining of climacteric syndrome either spontaneous or induced surgically. An overall evaluation of the effectiveness of the treatment allowed the conclusion that with both timing of administration it is possible to obtain in the majority of patients (80%) a very good control of the climacteric symptoms with negligible side effects. A more careful clinical and laboratory evaluation has shown a fast regression of the symptoms already after one month of drug administration. Therefore norethisterone enantate may be considered an effective therapeutic alternative to estrogens and androgens in the management of the climacteric syndrome.
Acta Europaea fertilitatis 07/1982; 13(2):95-100.
-
[show abstract]
[hide abstract]
ABSTRACT: Lisuride, a new semisynthetic ergot derivative, was given to 53 women to inhibit lactation; 26 women had 300 micrograms daily and 27 had 600 micrograms daily for seven days. Eight lactating women acted as controls. Lisuride effectively inhibited lactation and also suppressed the serum prolactin levels; the latter effect was dose related. Lisuride produced no untoward side effects.
British Journal of Obstetrics and Gynaecology 12/1979; 86(11):905-8.
-
[show abstract]
[hide abstract]
ABSTRACT: A new semisynthetic ergot derivative, Lisuride, has been administered to 40 women who wanted to have lactation inhibited. Purpose of the study was to evaluate the drug's effect on serum PRL levels. Treatment was carried out for 7 days with daily doses of 300 or 600 microgram. Lisuride lowered PRL levels, and the decrease was significantly more marked for the 600 microgram dose.
Acta Europaea fertilitatis 07/1979; 10(2):51-5.
-
[show abstract]
[hide abstract]
ABSTRACT: Intravenous injections of 50 mg dehydroepiandrosterone sulfate (DHEAS) were given to 7 women with normal pregnancies and 5 with pathologic pregnancies and the serum levels of 17 beta-estradiol and estetrol were assayed before and at 15 or 30-minute intervals for three hours after the injection. All tests were carried out during the 25th to 36th week of amenorrhea. Serum estradiol rose rapidly in normal subjects and remained high to the end of the test. In patients with gestational pathology the estradiol pattern was not significantly different from that of the controls. Esterol plasma levels showed a biphasic pattern with an initial rise at 30 min. and a second rise at 90 min. in normal pregnancies, whereas in pathologic pregnancies this response was either lacking completely or was markedly reduced compared to the controls.
Acta Europaea fertilitatis 04/1979; 10(1):1-13.
-
[show abstract]
[hide abstract]
ABSTRACT: Plasma prolactin levels during intravenous Trazodone infusion have been evaluated. Although the modifications were not statistically significant, a slight decrease of plasma prolactin levels was noted. This result suggests that Trazodone has no remarkable effect on hypothalamic function.
International pharmacopsychiatry 02/1979; 14(5):260-3.
-
[show abstract]
[hide abstract]
ABSTRACT: Eleven women with secondary amenorrhoea and hyperprolactinaemia were treated with lisuride, a new semisynthetic ergot derivative. Acute administration of lisuride (100 microgram orally) significantly suppressed serum prolactin (PRL) levels in nine out of eleven subjects. In these nine patients, prolonged treatment with lisuride (50--200 microgram daily) lowered PRL levels into the normal range, menstrual cycles were resumed and eight patients ovulated. Two patients, in whom lisuride failed to lower PRL levels into the normal range, did not resume normal menstruation. These data demonstrate that lisuride may be used clinically to lower PRL levels and to restore cyclic gonadotrophin secretion and ovulation in amenorrhoeic patients with hyperprolactinaemia.
Clinical Endocrinology 01/1979; 9(6):491-8. · 3.17 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: An attempt has been made of demonstrating the beta subunit of HCG in the plasma of 13 regularly menstruating women wearing a copper IUD. Eighteen menstrual cycles were explored with a total of 94 specimens obtained at 3-day intervals starting from the 16th day of the cycle. A cross reaction with LH was excluded by simultaneous assay of this hormone. Progesteron was also assayed so as to exclude anovulatory cycles. Five out of 12 ovulatory cycles yelded positive results with HCG values ranging from 171 to 692 mIU per ml. We therefore agree with the hypothesis according to which copper IUDs do not interfere with fecundation but with subsequent stages, specifically about the time of nidation of the blastocyst in the uterus.
Acta Europaea fertilitatis 04/1978; 9(1):11-9.
-
[show abstract]
[hide abstract]
ABSTRACT: The authors examined biopsy material obtained from women wearing inert and copper-coiled IUDs, under the light and electron microscopes. Examination of this material leads to the conclusion that there are no specific lesion attributable to either type of IUD. It can also be said that lesions characteristic for an inflammatory reaction prevail over all other possible endometrial changes.
Acta Europaea fertilitatis 10/1977; 8(3):193-210.
-
Minerva ginecologica 01/1977; 28(12):977-84.
-
[show abstract]
[hide abstract]
ABSTRACT: Recent progress in the field of radioimmunology, especially as regards prolactin (PRL) assay, as well as the use of new drugs have opened new perspectives for a better understanding of the "amenorrhoea-galactorrhea syndrome" both from the diagnostic and therapeutic points of view. This syndrome which formerly was considered infrequent, is now observed more and more often, perhaps as a result of the more widespread use of drugs such as phenothiazines, reserpine derivatives, alpha-methyldopa and tricyclic antidepressants, as well as owing to the large-scale use of estrogens and above all of estrogen-progestogen contraceptives. The problems of etiopathogenesis and management of the amenorrhea-galactorrhea syndrome are complicated by the fact that a variety of factors are responsible, as is shown also by the classical nosographic classification with the Forbes-Albright syndrome in the presence of a pituitary tumour, the Chiari-Frommel syndrome of amenorrhea-galactorrhea following pregnancy, and the Argonz-del Castillo-Ahumada syndrome in the absence of lither pregnancy or tumor.
Acta Europaea fertilitatis 01/1976; 6(4):331-8.
