Publications (6)9.07 Total impact
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Article: Simultaneous detection of influenza A, influenza B, and respiratory syncytial viruses and subtyping of influenza A H3N2 virus and H1N1 (2009) virus by multiplex real-time PCR.
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ABSTRACT: A multiplex real-time PCR assay was developed to simultaneously detect and discriminate influenza A virus subtypes, including novel H1N1 (2009) and seasonal H3N2 virus, influenza B virus, and respiratory syncytial virus (RSV) in a single test tube, with detection sensitivity and specificity of 99% and 100%, respectively, for the four pathogens.Journal of clinical microbiology 01/2011; 49(4):1653-6. · 4.16 Impact Factor -
Article: Novel double-antigen sandwich immunoassay for human hepatitis B core antibody.
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ABSTRACT: A novel diagnostic immunoassay testing procedure for hepatitis B virus core antibody (anti-HBc) using homogeneous purified full-length hepatitis B virus core antigen (HBcAg) capsids obtained from Escherichia coli was compared with Abbott Architect anti-HBc chemiluminescent microparticle immunoassay (CMIA; indirect method) against a library of specimens. A monoclonal anti-HBc neutralization confirmatory assay was then used to determine the degree of discordance between specimens. The new assay was found to be superior in both sensitivity and specificity.Clinical and vaccine immunology: CVI 03/2010; 17(3):464-9. · 2.37 Impact Factor -
Article: [Relationship between alcohol consumption and risk factors for cardiovascular disease].
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ABSTRACT: To investigate the relationship between alcohol consumption and risk factors for cardiovascular disease. Two hundreds and twenty six subjects were enrolled in the study and grouped to non-drinkers, mild drinkers, moderate drinkers and heavy drinkers. Serum GGT, hs-CRP, %CDT, HCY, lipoprotein were measured in all groups. There were significantly higher GGT levels with heavy drinkers than those with other groups (P <0.05), and GGT levels were increased with increasing alcohol intake; and there were significantly higher %CDT levels with heavy drinkers compared with those with no-drinkers; there was significant higher hs-CRP levels with heavy drinkers compared with those with mild and moderate drinkers (P<0.05); but in moderate drinkers there was significantly lower hs-CRP levels than non drinkers (P<0.05). Compared with non-drinkers, there were significantly lower LDL-C and TG levels with mild and moderate drinkers. There were no significant differences in CHOL, HDL-C, HCY, WBC, MCV levels among all groups. Heavy drinkers had higher smoking rate and higher prevalence of hypertension (P <0.05). Heavy alcohol consumption results in increasing GGT,%CDT and hs-CRP and may increase cardiovascular disease risk along with other risk factors.Mild to moderate alcohol consumption is associated with lower hs-CRP concentration,which may protect the cardiovascular system through anti-inflammatory mechanism.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 01/2009; 38(1):89-94. -
Article: Comparison of the results for three automated immunoassay systems in determining serum HBV markers.
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ABSTRACT: Automated immunoassay analyzers are used to identify hepatitis B virus (HBV) serum markers. In regions with high prevalence of HBV, it is imperative to compare test results from different immunoassay analyzers. Samples from 496 subjects were collected and HBV markers were determined (double-blind, parallel manner) using Abbott AxSYM, Roche Modular Analytics E170, and Abbott Architect i2000). Concurrence between AxSYM and E170 was 97.78% for HBsAg, 91.13% for anti-HBs, 98.79% for anti-HBc, 98.39% for HBeAg, and 88.91% for anti-HBe. Positive rates of anti-HBs and anti-HBe from AxSYM were lower than E170 (P<0.01). Concurrence between AxSYM and Architect i2000 was 98.79% for HBsAg, 91.33% for anti-HBs, 95.97% for anti-HBc, 98.39% for HBeAg, and 95.77% for anti-HBe. Positive anti-HBs rates from AxSYM were lower than Architect i2000 (P<0.01). Concurrence between E170 and Architect i2000 was 97.38% for HBsAg, 94.15% for anti-HBs, 95.56% for anti-HBc, 99.60% for HBeAg, and 88.10% for anti-HBe. Positive anti-HBe rates using Architect i2000 were lower than E170 (P<0.01). Overall, the greatest differences were observed in samples with low-level serum HBV markers. Significant discrepancies were observed among results for the 3 automated immunoassay analyzers, especially for low-level anti-HBs and anti-HBe results.Clinica Chimica Acta 10/2006; 372(1-2):129-33. · 2.54 Impact Factor -
Article: A wavelet-based metric for visual texture discrimination with applications in evolutionary ecology
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ABSTRACT: Much work on natural and sexual selection is concerned with the conspicuousness of visual patterns (textures) on animal and plant surfaces. Previous attempts by evolutionary biologists to quantify apparency of such textures have involved subjective estimates of conspicuousness or statistical analyses based on transect samples. We present a method based on wavelet analysis that avoids subjectivity and that uses more of the information in image textures than transects do. Like the human visual system for texture discrimination, and probably like that of other vertebrates, this method is based on localized analysis of orientation and frequency components of the patterns composing visual textures. As examples of the metric's utility, we present analyses of crypsis for tigers, zebras, and peppered moth morphs.Mathematical Biosciences. -
Article: ART2 neural network interacting with environment
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ABSTRACT: It is common to train a neural network by using samples so that it can realize the required input–output characteristics. However, to obtain such samples is difficult or even impossible in some cases. This paper proposes the use of on-line reinforcement learning (RL) algorithms to train adaptive-resonance-theory-based (ART2) neural networks through interaction with environments, namely RL-ART2 neural network. By utilizing its adaptation ability to a dynamic environment, RL is able to evaluate and select ART2 classification patterns without training samples. The connection weights can be automatically modified according to the running effect evaluation of classification pattern of neural networks. The proposed novel RL-ART2 neural network is applied to implement the collaboration movement of mobile robots. Simulation results are presented to demonstrate the feasibility and performance of the proposed algorithm.Neurocomputing.
