Publications (21)54.65 Total impact
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Article: Response to intra-arterial cisplatin and concurrent radiotherapy in a patient with primary mucosal malignant melanoma of the nasal cavity.
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ABSTRACT: BACKGROUND: The prognosis for patients with mucosal malignant melanoma (MMM) of the nasal cavity is very poor because of the radioresistance of melanoma cells. METHODS: We present the first case report of the efficacy of superselective intra-arterial cisplatin (CDDP) infusion concurrent with hypofractionated radiotherapy (RT) for MMM of the nasal cavity. RESULTS: A pink, polypoid mass, histopathologically diagnosed as an amelanostic melanoma, occupied the right nasal cavity. After the treatment, a nasal tumor disappeared, leaving only a small bulge in the medial wall of the middle turbinate. Histopathologic examination revealed scattered degenerated melanoma cells, remaining only in the small restricted area in the medial surface of the excised middle turbinate. Twelve months after the treatment, the patient has not experienced any local recurrence or regional and distant metastasis. CONCLUSIONS: The superselective intra-arterial CDDP infusion concurrent with hypofractionated RT might be useful for the management of nasal MMM. © 2011 Wiley Periodicals, Inc. Head Neck, 2011.Head & Neck 12/2011; · 2.40 Impact Factor -
Article: [Case of antiamphiphysin antibody-positive stiff-person syndrome with breast cancer diagnosed by FDG-PET].
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ABSTRACT: We report a case of antiamphiphysin antiboddy-positive stiff-person syndrome associated with breast cancer, which was detected only by FDG-PET. A 46-year-old woman was admitted to our hospital because of painful muscle cramp and stiffness of both legs. Laboratory results were negative for anti-GAD antibody, but highly positive for antiamphiphysin antibody (1: 61,440). She had been diagnosed as having paraneoplastic stiff-person syndrome. However, mammogram, thoracic CT, breast MRI and ultrasonic echography showed no abnormal findings. A whole-body fluorodeoxyglucose (FDG) PET was performed, showing an increased uptake in the left axillary lymph nodes. Then, the left axillary lymph nodes were resected and immunohistochemically diagnosed as breast adenocarcinoma. Treatment of stiff-person syndrome was initiated with corticosteroids followed by chemotherapy against breast cancer, which led to a remarkable improvement of her neurological symptoms. If there is possibility of paraneoplastic syndromes like stiff-person syndrome, FDG-PET is very useful for detecting the occult carcinoma.Rinsho shinkeigaku = Clinical neurology 07/2008; 48(6):410-4. -
Article: Dural arteriovenous fistula involving the transverse sigmoid sinus after treatment: assessment with magnetic resonance digital subtraction angiography.
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ABSTRACT: The purpose of this study was to evaluate the utility of magnetic resonance digital subtraction angiography (MRDSA) in showing the presence or absence of retrograde venous drainage (RVD) in patients with intracranial dural arteriovenous fistula (DAVF) involving the transverse sigmoid sinus (TSS) after treatment. Of 16 patients with DAVF involving the TSS, 13 underwent digital subtraction angiography (DSA) and MRDSA before and after treatment, and 3 underwent DSA before treatment and DSA and MRDSA after treatment. Five patients underwent these procedures twice after treatment. A total of 21 examinations after treatment were evaluated retrospectively. The presence or absence of DAVF and RVD was decided on the basis of the DSA findings. Two neuroradiologists reviewed the MRDSA findings concerning the presence or absence of DAVF and RVD. DSA showed residual DAVF in 9 and residual RVD in 5 of 21 examinations. MRDSA revealed residual DAVF in 8 of 21 examinations. MRDSA did not show residual DAVF in one examination because of a very small (low-flow) residual DAVF without RVD. MRDSA identified residual RVD in 5 of 21 examinations. MRDSA was completely consistent with DSA concerning the presence or absence of residual RVD. MRDSA could evaluate the presence or absence of RVD in patients with DAVF involving TSS after treatment. MRDSA may give reliable information as to whether patients with DAVF involving the TSS should undergo additional DSA after treatment.Neuroradiology 09/2007; 49(8):639-43. · 2.82 Impact Factor -
Article: Positron emission tomography for predicting malignancy of sinonasal inverted papilloma.
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ABSTRACT: Sinonasal inverted papilloma (IP) is an uncommon nasal tumor. It is known for being locally invasive and recurrent, with a high probability of malignant transformation. Accurate initial staging and close surveillance are critical in the management of the disease. Fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET) was performed in 5 patients with IP. High FDG uptake (maximum standardized uptake (SUVmax) value >3.0) was observed in all patients, and 2 patients with IP associated with squamous cell carcinoma (SCC) exhibited higher SUVmax values. The SUVmax value of a sinonasal tumor can warn the surgeon of the probability of an associated malignancy, even when preoperative biopsy demonstrates a purely benign papilloma.Clinical Nuclear Medicine 04/2007; 32(4):275-8. · 3.67 Impact Factor -
Article: Acute dural venous sinus thrombosis without brain parenchymal abnormality: assessment with cerebral blood volume using dynamic susceptibility contrast magnetic resonance imaging.
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ABSTRACT: We report results applying the dynamic susceptibility contrast (DSC) magnetic resonance (MR) technique to a patient with dural venous sinus thrombosis (DVST) of the right transverse-sigmoid sinus without brain parenchymal abnormality. The DSC-MR technique clearly demonstrated increased regional cerebral blood volume of the right temporo-parieto-occipital region adjacent to a right transverse-sigmoid sinus thrombosis in a patient with DVST without cerebral edema or hemorrhage.Radiation Medicine 12/2006; 24(9):635-8. -
Article: FDG-PET imaging in cutaneous anaplastic large cell lymphoma.
Clinical Nuclear Medicine 10/2006; 31(9):564-5. · 3.67 Impact Factor -
Article: F-18 FDG PET imaging in a primitive neuroectodermal tumor.
Clinical Nuclear Medicine 09/2006; 31(8):484-5. · 3.67 Impact Factor -
Article: F-18 FDG PET imaging in gastric neuroendocrine carcinoma.
Clinical Nuclear Medicine 07/2006; 31(6):345-6. · 3.67 Impact Factor -
Article: FDG-PET imaging in duodenal cancer.
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ABSTRACT: F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) imaging is a useful modality in the detection of various tumors, including colon cancer and gastric cancer. We evaluated a patient with duodenal cancer with multiple metastases including brain metastases using FDG-PET imaging. It revealed multiple tumor uptake in the brain, clavicular fossa, mediastinum, right adrenal gland and duodenum. These results suggest that FDG-PET imaging may be useful in detecting the primary and metastatic lesions of duodenal adenocarcinoma.Annals of Nuclear Medicine 07/2004; 18(4):351-3. · 1.50 Impact Factor -
Article: A case of renal pelvic tumor visualized by 18F-FDG-PET imaging.
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ABSTRACT: 18F fluorodeoxyglucose positron emission tomography (18F-FDG PET) imaging is a useful modality in detecting various tumors, including renal cell carcinoma. We evaluated a patient with renal pelvic tumor (transitional cell carcinoma) with multiple metastases using 18F-FDG PET imaging and detected abnormal increased uptake of a right renal pelvic tumor extending to the renal cortex with liver metastasis and paraaortic lymph node metastases. These results suggest that 18F-FDG PET imaging may be useful in detecting primary and metastatic lesions of renal pelvic tumor (transitional cell carcinoma).Annals of Nuclear Medicine 05/2004; 18(2):161-3. · 1.50 Impact Factor -
Article: The radiotoxicity of 131I therapy of thyroid cancer: assessment by micronucleus assay of B lymphocytes.
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ABSTRACT: We investigated cytologic radiation damage in thyroid cancer after (131)I therapy using micronucleus assay (MNA) of B lymphocytes exclusively, as opposed to our previous study in which MNA of all lymphocyte subsets was used. We studied 22 thyroid cancer patients treated with 3.7 GBq of (131)I. Peripheral lymphocytes were harvested, and B lymphocytes were isolated by an immunomagnetic method and assayed for the frequency of micronuclei. The frequency of micronuclei among B cells after (131)I therapy was significantly increased relative to that in untreated control subjects, and the (131)I-induced increase in micronuclei frequency among B cells was significantly greater than that among all lymphocytes. Compared with the MNA of all lymphocytes, the MNA among specifically B cells may more sensitively detect cytologic radiation damage associated with (131)I therapy of thyroid cancer.Journal of Nuclear Medicine 05/2004; 45(4):608-11. · 6.38 Impact Factor -
Article: A case of renal pelvic tumor visualized by18F-FDG-PET imaging
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ABSTRACT: 18F fluorodeoxyglucose positron emission tomography (18F-FDG PET) imaging is a useful modality in detecting various tumors, including renal cell carcinoma. We evaluated a patient with renal pelvic tumor (transitional cell carcinoma) with multiple metastases using18F-FDG PET imaging and detected abnormal increased uptake of a right renal pelvic tumor extending to the renal cortex with liver metastasis and paraaortic lymph node metastases. These results suggest that18F-FDG PET imaging may be useful in detecting primary and metastatic lesions of renal pelvic tumor (transitional cell carcinoma).Annals of Nuclear Medicine 01/2004; 18(2):161-163. · 1.50 Impact Factor -
Article: Extrarenal adult nephroblastoma.
Clinical Nuclear Medicine 03/2003; 28(2):154-5. · 3.67 Impact Factor -
Article: Cardiac sympathetic denervation modulates the sympathoexcitatory response to acute myocardial ischemia.
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ABSTRACT: This study was designed to elucidate the influence of cardiac sympathetic denervation on the sympathoexcitatory response to acute myocardial ischemia during balloon coronary occlusion (BCO) in humans. Alterations of cardiac sympathetic nerve function could modulate sympathetic reflexes originating from the ischemic area. In 23 patients with angina pectoris, we quantified the baseline cardiac sympathetic denervation of the ischemia-related area by iodine-123 metaiodobenzylguanidine ((123)I-MIBG), and transient changes in sympathetic activity during BCO by wavelet analysis of RR interval variability. Balloon coronary occlusion resulted in a transient augmentation of low-frequency (LF: 0.04 to 0.14 Hz) spectral components of RR interval variability in 4 of 12 patients with cardiac denervation and in 8 of 11 patients without denervation (p < 0.01 by the chi-square test). Consequently, the increase in LF components was significantly less during BCO in patients with cardiac denervation (34%) than in those without denervation (273%) (interaction: p < 0.05). In seven patients with severe ischemia provoked by a fall of > or = 10% in the left ventricular ejection fraction, LF components increased by 506% during BCO, regardless of the condition of cardiac denervation. In contrast, in patients with mild ischemia provoked by a fall of <10% in the ejection fraction, changes of LF components during BCO were significantly less in patients with denervation than in those without denervation (84 vs. 344%, p < 0.05). These findings suggest that if the provoked ischemia is not severe, cardiac sympathetic denervation could prevent ischemia-induced sympathoexcitation.Journal of the American College of Cardiology 02/2002; 39(3):436-42. · 14.16 Impact Factor -
Article: Extensive soft-tissue involvement of dermatomyositis detected by whole-body scintigraphy with99mTc-MDP and201Tl-chloride
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ABSTRACT: The authors present a case of extensive soft-tissue radioactivity visualized on both99mTc-MDP and201Tl-chloride scintigrams in a patient with dermatomyositis and colon cancer. Incidentally, diffuse and intense uptake of99mTc-MDP was observed in the shoulder girdles, anterior chest wall, psoas muscles, both proximal thighs and right lower limb, corresponding to the sites of symptomatic muscles, even though skin lesions were limited and no calcification was detected on radiographs. Moreover,201Tl-chloride was also intensely accumulated in nearly the same sites as the symptomatic muscles as shown on the99mTc-MDP bone scintigrams. Whole-body scintigraphy with99mTc-MDP and201Tl-chloride is a useful tool to detect occult muscle lesions with dystrophic calcification and hyperemia in dermatomyositis.Annals of Nuclear Medicine 04/1996; 10(1):127-130. · 1.50 Impact Factor -
Article: The value of combined99mTc-Sn-colloid and99mTc-RBC scintigraphy in the evaluation of a wandering spleen
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ABSTRACT: Wandering spleen is the term commonly applied to splenic hypermobility that results from laxity or maldevelopment of its suspensory ligaments. It comes to medical attention usually as an abdominal mass, or when the spleen undergoes torsion. Diagnosis on clinical grounds alone is rarely made, and ultrasonography, CT and MRI findings have no specific characteristics for this condition.99mTc-labeled colloid taken up by the spleen may provide a specific diagnosis. We report a case of wandering spleen, in which the preoperative diagnosis was made on the basis of sequential liverspleen scintigraphy with99mTc-Sn-colloid and blood-pool scintigraphy with99mTc-RBC. This is a rare case, in which hypermobility was assessed by sequential99mTc-Sn-colloid scintigraphy, and to our knowledge, is the first case in which99mTc-RBC scintigraphy provided useful information on splenic blood volume and its location.Annals of Nuclear Medicine 04/1995; 9(3):145-147. · 1.50 Impact Factor -
Article: Sequential subtraction scintigraphy with99mTc-RBC for the early detection of gastrointestinal bleeding
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ABSTRACT: To improve the early detectability of gastrointestinal (GI) bleeding, we have developed a new subtraction scintigraphic technique usingin vivo labeled99mTc red blood cells (RBC). Use of this new sequential subtraction method every 5 min makes it possible to detect early the bleeding site and calculate the bleeding rate. In phantom experiments, focal activity was detected on subtraction images at pump rates of more than 0.20 ml/min at any urethane thickness, but was negative on conventional scintigrams. The calculated pump rate by the subtraction method correlated well with the actual syringe pump rate (y = 1.07x-0.02, r = 0.99, p < 0.01) in the case of an 8-cm urethane board as an abdominal wall. Twenty-four of 50 patients with suspected GI bleeding were confirmed to be positive within 24 hr. The subtraction method showed 15 true positive and 2 false positive cases within 60 min. On the other hand, the conventional scintigraphic method showed only 7 true positive and 1 false positive cases. Sensitivity of the subtraction method was 62.5%, which was significantly higher (p < 0.05) than that of the conventional scintigraphic method (29.2%). These results suggest that sequential subtraction scintigraphy with99mTc-RBC is an effective method for the early detection of GI bleeding and shortening the examination time as compared with conventional scintigraphy.Annals of Nuclear Medicine 04/1995; 9(4):203-208. · 1.50 Impact Factor -
Article: Postgastrectomy osteomalacia with pseudofractures assessed by repeated bone scintigraphy
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ABSTRACT: A patient with osteomalacia secondary to vitamin D deficiency after gastrectomy for gastric cancer is presented. Initial bone scintigrams showed both asymmetric and symmetric focal areas of intense uptake due to pseudofractures reminiscent of bone metastases. Radiographs only confirmed the presence of pseudofractures at some, but not all, of the abnormal sites demonstrated by bone scintigraphy. At first, metastatic bone disease was suspected. However, the appearance of repeated bone scintigram was normalized after treatment with vitamin D. A diagnosis of osteomalacia was established. The present case serves to illustrate that symmetric focal lesions are important features of pseudofractures secondary to osteomalacia, and comparison with radiographs and repeated bone scintigraphy are necessary in distinguishing between bone metastases and pseudofractures.Annals of Nuclear Medicine 04/1995; 9(1):29-32. · 1.50 Impact Factor -
Article: 放射線医学
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Article: 99mTcーMIBI(methyloxyisobutylisonitrile)による異所性副甲状腺のより明瞭な視覚化 201Tlと比較して(英語)
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ABSTRACT: 原著論文/症例報告
Top co-authors
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Institutions
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2011
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University of Toyama
- Department of Otorhinolaryngology
Toyama-shi, Toyama-ken, Japan
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2006–2007
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Toyama University
Toyama-shi, Toyama-ken, Japan
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1995–2006
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Toyama Medical and Pharmaceutical University
Toyama-shi, Toyama-ken, Japan
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