[Show abstract][Hide abstract] ABSTRACT: A relative increase in deoxyhemoglobin levels in hypoperfused tissue can cause prominent hypointense signals in the draining veins (PHSV) within areas of impaired perfusion in susceptibility-weighted imaging (SWI). The purpose of this study is to evaluate the usefulness of SWI in patients with acute cerebral infarction by evaluating PHSV within areas of impaired perfusion and to investigate the usefulness of PHSV in predicting prognosis of cerebral infarction.
[Show abstract][Hide abstract] ABSTRACT: PURPOSE
Susceptibility weighted image (SWI) is sensitive to paramagnetic material such as iron. Iron deposition is considered not only as phenotype of neurodegenerative disease but also as normal aging. Decreased uptake of putamen on FP-CIT PET has been known as one of imaging biomarkers of Parkinson disease. The purpose of this study is to evaluate difference in phase value of putamen between patient with Parkinsonian syndrome and age matched control.
METHOD AND MATERIALS
We retrospectively enrolled patients of three groups with idiopathic Parkinson disease (IPD) (n=20), atypical Parkinsonian syndrome or 2ndary Parkinsonism (n=14), and age matched control (n=16). SWI were taken from all the enrolled subjects (n=50). Region of interest (ROI) was drawn to measure phase values of bilateral caudate head and putamen on the axial images at the level of foramen of Monro. Patient with IPD (n=20) and atypical Parkinsonian syndrome or 2ndary Parkinsonism (n=14) underwent F-18 FP-CIT PET/CT. Tracer activity of ROI was measured in caudate, putamen and a reference region of occipital cortex. Statistical analyses were performed to compare phase values and tracer activity between groups.
Mean age was 64.7±8.3 year-old in idiopathic Parkinson disease; 66.1±1.5 year-old, in atypical Parkinsonian syndrome or 2ndary Parkinsonism; and 65.7±6.0 year-old, in control. The mean ages were not different among 3 groups. The phase values of right and left putamen in IPD (0.068±0.038, 0.062±0.031 radian) were higher than those of age matched control (0.030±0.030, 0.037±0.032 radian). The phase values of atypical Parkinsonian syndrome or 2ndary Parkinsonism (0.079±0.039, 0.084±0.039 radian) were higher than those of age matched control. There was no difference of phase value between IPD and atypical Parkinsonian syndrome or 2ndary Parkinsonism. However, normalized FP-CIT tracer activity of right and left putamen in IPD (3.1±0.6, 2.9±0.5) were lower than those of atypical Parkinsonian syndrome or 2ndary Parkinsonism (3.9±1.2, 3.9±1.2).
Phase value of Parkinsonian syndrome was higher than that of age matched control. Further investigation of phase value is needed with larger population.
Iron deposition and metabolism of normal aging brain and neurodegenerative disease has been poorly understood. Phase value of SWI is a quantifiable variable which can be obtained from SWI.
Radiological Society of North America 2013 Scientific Assembly and Annual Meeting; 12/2013
[Show abstract][Hide abstract] ABSTRACT: A simple and efficient method for the asymmetric synthesis of alpha-alkylidene-beta-hydroxy-gamma-butyrolactones and related natural products was developed based on the catalytic asymmetric tandem Michael-aldol reaction and simple transformations. The synthetic utility of this method was illustrated by the facile synthesis of trisubstituted gamma-butyrolactone natural products.
The Journal of Organic Chemistry 12/2012; 78(2). DOI:10.1021/jo302369q · 4.72 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: There are very few reports assessing middle cerebral artery (MCA) stents using multidetector computed tomography (MDCT).
To assess MCA stents using multidetector CT angiography (CTA) in vivo evaluation: the differences in the CTA results according to the three different kernels.
We retrospectively evaluated 27 MCA stents from 26 patients who underwent CTA with 16- and 64-slice MDCT after percutaneous transluminal angioplasty and stenting (PTAS). By CTA, using medium-smooth kernel (B30), medium-sharp kernel (B50), and sharp kernel (B60), the lumen diameter, artificial luminal narrowing (ALN), and subjective visibility score of the stented vessels were evaluated. The subjective visibility score ranged from 1 (poor quality) to 5 (excellent) using a five-point scale.
There were excellent inter-observer agreements for the lumen diameter measurements (P < 0.001). The mean diameter of the stented vessels was 2.10 ± 0.31 mm on digital subtraction angiography (DSA), 0.93 ± 0.20 mm on CTA using B30, 1.18 ± 0.27 mm on CTA using B50, and 1.29 ± 0.29 mm on CTA using B60. The mean ALN was 55.7 ± 6.0% on CTA using B30, 43.8 ± 7.5% on CTA using B50, and 38.7 ± 8.3% on CTA using B60. CTA with higher kernels had a smaller ALN than images with smaller kernels. The median subjective visibility score on the CTA using B50 was 3, which was higher than for the other kernels. The differences in the lumen diameter, ALN, and the subjective visibility score of the stented vessels on CTA using the three different kernels was statistically significant (P < 0.001).
The sharp kernel was better to assess the lumen diameter and ALN, but was inferior to the medium-sharp kernel for in-stent evaluation due to high image-to-noise. CTA with medium-sharp kernel showed good lumen visibility and acceptable ALN for MCA stents. This could therefore be a non-invasive, readily applicable clinical method for assessing MCA stent patency after stent placement.
[Show abstract][Hide abstract] ABSTRACT: To evaluate the complications of high-intensity focused ultrasound (HIFU) in patients with hepatic and pancreatic cancer. Materials and
From January 2006 to December 2008, 133 sessions of HIFU treatment were performed in 114 consecutive patients with primary hepatic tumor (n = 57), hepatic metastasis (n = 22), and pancreatic cancer (n = 35) under general anesthesia. The extracorporeal, ultrasound-guided Model-JC system (HAIFU, Chongqing, China) was used. Artificial pleural effusion was created to obtain an adequate sonographic window for ablating hepatic dome masses in 53 patients. We reviewed medical records and imaging findings before, during, and after HIFU.
All patients had skin redness, edema, and pain in the treatment regions. All hepatic tumor patients had necrosis of the ribs along the main ultrasound beam path that did not require further treatment. Major complications included biliary obstruction, symptomatic pleural effusion, pneumothorax and fistula formation between an abdominal wall abscess and the ablated hepatic tumor. In 35 pancreatic cancer patients, major complications included third-degree burns and fistula formation between the tumor and duodenum. Delayed complications in hepatic tumor patients included a diaphragmatic rupture and rib fractures along the ultrasound pathway.
The complications of HIFU develop mainly around the targeted lesions or along the ultrasound beam pathway. It is essential to have awareness of the possible complications related to HIFU and its imaging features for to avoiding serious complications.
[Show abstract][Hide abstract] ABSTRACT: PURPOSE
To evaluate the local and systemic complications of high intensity focused ultrasound (HIFU) in patients with hepatic and pancreatic cancer
METHOD AND MATERIALS
From Jan 2006 to Dec 2008, 133 sessions of HIFU treatment was performed in 114 consecutive patients with hepatocellular carcinoma (n=57), hepatic metastasis (n=22), and pancreatic cancer (n=35) under general anesthesia. The extracorporeal, ultrasound-guided Model-JC system (HAIFU, Chongqing, China) was used. Artificial pleural effusion was created to obtain adequate sonographic window for ablating hepatic dome masses in 53 patients. We reviewed medical records and imaging findings before, during, and after HIFU for assessment of vital signs, liver and renal functions, skin burn, local reaction and systemic effects. MRI was performed prior to ablation and 2 weeks after HIFU in all patients. During follow-up, delayed complication was also assessed using CT and MRI.
All 105 patients had skin redness, edema, and pain in the treatment regions; two of them showed 3rd degree burns. All hepatic tumor patients had necrosis of the ribs along the main ultrasound beam path which did not require further treatment, one had biliary obstruction and death, one had periprocedural symptomatic pleural effusion requiring drainage, and one had pneumothorax related to artificial pleural effusion. In 35 pancreas cancer patients, vertebral body necrosis due to unwanted deep penetration occurred, 10 had fat necrosis of the subcutaneous layer of the anterior abdominal wall, and two had fistula formation between the tumor and duodenum. Delayed complications developed in hepatic tumor patients. There were fistula formation between abdominal wall abscess and ablated hepatic tumor on 4 weeks follow up in one, diaphragmatic rupture on 24 month follow up in one, and rib fractures along the ultrasound path on 32 month follow up in one patient.
The complications of HIFU develop mainly around the targeted lesions or along the ultrasound path. Although HIFU procedures are generally thought to be noninvasive and safe, serious complications can occur and awareness about complications is necessary.
Although HIFU are generally thought to be noninvasive and safe, it is essential to have awareness of the possible complications after HIFU and its imaging features for avoiding serious complications.
Radiological Society of North America 2009 Scientific Assembly and Annual Meeting; 12/2009
[Show abstract][Hide abstract] ABSTRACT: Mesenteric lymphangiomas are rare abdominal masses that are seldom associated with small bowel volvulus, and especially in adult patients. We report here on an unusual case of small bowel volvulus that was induced by a mesenteric lymphangioma in a 43-year-old man who suffered from repeated bouts of abdominal pain. At multidetector CT, we noticed whirling of the cystic mesenteric mass and the adjacent small bowel around the superior mesenteric artery. Small bowel volvulus induced by the rotation of the mesenteric lymphangioma was found on exploratory laparotomy. Lymphangioma should be considered as a rare cause of small bowel volvulus in adult patients.
Korean journal of radiology: official journal of the Korean Radiological Society 04/2009; 10(3):319-22. DOI:10.3348/kjr.2009.10.3.319 · 1.57 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: PURPOSE
To evaluate the value of the findings of the engorged vessels around the early gastric cancer, as an indicator of tumor detection with the 2D multiplanar reformatting images and 3D volume rendering images of Multi-detector row CT.
METHOD AND MATERIALS
Thirty five patients (23 males, 12 females; mean age 57 years, 24 to 76) with surgically proven early gastric cancer underwent contrast material-enhanced multi-detector row CT gastrography, with effervescent granules used as oral contrast material. Two experienced radiologists evaluated the images in consensus in the following order. First, 2D multiplanar reformatting images were evaluated for detection of gastric cancer by wall thickening and mucosal enhancement. Then, 3D volume rendering images were evaluated to find gastric cancer by surface contour abnormality. And then, we made navigation view at the site of the subjective engorgement of vessel in the perigastric area on 2D image. The difference of the detectability of cancer among 2D image, 3D volume rendering and navigator view were evaluated. The detectability of cancer was also analyzed by size, location and morphologic type on 2D and 3D images. The accuracy of staging was assessed.
The detectability of early gastric cancer with 2D image and 3D volume rendering was only 31.4% and 54.3%, respectively. With 3D navigation view, the detectability was 88.6%. And the engorged vessel was found around the lesion in 85.7%. The lesions located in the lesser curvature side of antrum were not detected in 2D image (none of eight), but they were seen in 3D navigation view excellently (all of eight), and all of the lesions showed the engorged vessels around the lesions. There was no significant difference in detectability according to the size and morphologic type of lesions. The overall staging accuracy was 82.9%.
Multi-detector row CT with 3D volume rendering reconstruction with navigation view can improve the detection of early gastric cancer, and the findings of the engorged vessel around the lesion is very supportive for detection of tumor in 2D MPR images.
The findings of the engorged vessel around the malignant tumor can make increase the detectability of early gastric cancer on CT scan.
Radiological Society of North America 2006 Scientific Assembly and Annual Meeting; 11/2006
[Show abstract][Hide abstract] ABSTRACT: We developed a multimedia presentation authoring system supporting a mechanism for conceptually representing the temporal relations of different media. Our authoring system represents media (such as images, videos, sounds, etc.) as objects and provides various editing functionalities for temporal compositions and spatial compositions. It is based on the SMIL (Synchronized Multimedia Integration Language). The system contains a temporal relation editor, a timeline editor, a layout editor, an attribute editor, a tag editor, a text editor, and a SMIL Object Manager. Among the many editors that make up our system, the temporal relation editor provides users with an intuitive mechanism for representing the conceptual flow of a presentation by simple and direct graphical manipulations. The SMIL Object Manager is responsible for the dynamic modification of each editor. The conceptual temporal relation editor and other editors of our system exchange their information in real-time and automatically generate SMIL codes through the SMIL Object Manager. Together they form an easy and efficient multimedia authoring environment. In this paper, we present the design and implementation of a SMIL-based multimedia authoring system and we also propose some ideas to extend the current SMIL specification concerning the reusability of SMIL code.