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Publications (6)6.22 Total impact

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    ABSTRACT: La fréquence et le mauvais pronostic des cancers bronchopulmonaires justifient les nombreuses études consacrées à cette pathologie. Pour avoir une approche épidémiologique et anatomoclinique de ces affections, nous avons réalisé une étude rétrospective d’une série de 163 cas colligés au service d’anatomie pathologique de l’hôpital militaire d’instruction Mohamed-V de Rabat (HMIM-V) [de 1994 à 2003]. Il ressort ainsi de notre étude une augmentation générale du nombre de cas diagnostiqués chaque année avec une tendance à l’inversion des fréquences durant les dernières années: l’adénocarcinome et le carcinome à petites cellules (CPC) deviennent plus fréquents; un âge moyen global de 53 ans; une large prédominance masculine (93 %) avec un sex-ratio de 12,1. Les symptômes ayant motivé la consultation sont dominés par la toux, la douleur thoracique et l’hémoptysie. La nocivité reconnue du tabac est retrouvée dans 54%des cas, cela pourrait souligner le rôle du tabagisme passif et/ou d’autres facteurs étiologiques. Les carcinomes non à petites cellules représentent 60,8 % avec une large prédominance du carcinome épidermoïde (37,4 %) avec un âge moyen de 54 ans, suivi par l’adénocarcinome (21,4 %) avec un âge moyen de 48 ans, puis le carcinome à grandes cellules (2 %) avec un âge moyen de 53 ans. Les carcinomes à petites cellules et assimilés représentent 11 %, avec un âgemoyen de 63 ans. L’immunohistochimie est généralement nécessaire pour préciser le type histologique d’une forme peu différenciée (8,6 % de notre série). Ainsi, le pathologiste dans ce domaine doit se tenir informé continuellement des progrès sur l’histogenèse de ces affections et l’apport des méthodes de recherche et de prises en charge nouvelles. The frequency and the bad prognosis of broncopulmonary cancers justify the numerous studies dedicated to this pathology. To have an epidemiological and a clinical approach to these disorders, we performed a retrospective study of a series of 163 cases of bronco-pulmonary cancers collected from the anatomy pathology department of the Mohamed V Military Hospital of Instruction in Rabat (1994 to 2003).We observed in general an increase in the number of diagnosed cases every year, with a trend reversal during the later years: the adenocarcinoma and the small cells carcinoma (CPC) became more frequent than the squam cells carcinoma; a mean age of intervening of 53 years; a large masculine predominance (93%) with a high sex-ratio (12.1). The symptoms that prompted the consultation are dominated by cough, thoracic pain and haemoptysis. The effect of tobacco was found in 54% of the cases, underlining the probable role of passive tobacco and/or of other etiologic factors. Non-small cells carcinomas represent 60.8%, of which squam cells carcinoma constitute a predominant portion (37.4%), with a mean age of 54 years, followed by adenocarcinoma (21.4%), with a mean age of 48 years, and large cells carcinoma (2%) with a mean age of 53 years. Small cells carcinoma and related disorders represent 11%, with a mean age of 63 years. Immunochemistry is generally necessary to specify the histological type of a poorly differentiated form (8.6% of our series). So, pathologists in this domain must constantly keep themselves abreast of progress on the histogenesis of these disorders and the contribution of new research methods. Mots clésPoumon–Carcinome–Type histologique–Cancer bronchopulmonaire KeywordsLung–Carcinoma–Histological type–Broncopulmonary cancer
    Journal africain du cancer / African Journal of Cancer 01/2011; 3(1):29-35.
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    ABSTRACT: Rosai-Dorfman disease (RDD), also known as sinus histocytosis with massive lymphadenopathy, is a rare idiopathic histioproliferative disease affecting the lymph nodes. Although extranodal involvement has been reported in diverse sites, central nervous system manifestations, particularly in the absence of nodal disease with clinical and radiological findings suggestive of meningioma, are extremely rare. Histopathology and immunohistochemistry are essential for a positive diagnosis. We report a case of RDD in a patient presenting multiple meningeal nodules with a review of the literature and discussion of differential diagnosis.
    Neurochirurgie 11/2010; 57(2):82-4. · 0.32 Impact Factor
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    ABSTRACT: Acral myxoinflammatory fibroblastic sarcoma is a rare low-grade malignant soft tissue tumor, usually observed in the extremities of middle-aged patients. We report a case involving the third finger of the left hand of a middle-aged man. The tumor showed a nodular architecture, with cellular areas, occasional foci of hyalinized fibrosis, and hypocellular areas with a myxoid background. Various neoplastic cells were identified including spindled or rounded epithelioid cells and occasional bizarre giant cells, morphologically mimicking ganglion cells. Tumor cells were strongly immunoreactive for vimentin and variably positive for CD68 and CD34. The tumor was completely removed, without further treatment.
    Orthopaedics & Traumatology Surgery & Research 09/2010; 96(5):597-9. · 1.06 Impact Factor
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    ABSTRACT: The authors report a case of chronic invasive rhinosinusitis due to Aspergillus fumigatus with pseudo-tumoral presentation, diagnosed in an immunocompetent 72-year old woman. This is a rare infection and diagnosis is difficult. It usually occurs on a defective predisposed ground. The varied and nonspecific character of the clinical signs is often the cause of a delayed and difficult diagnosis, and its invasive pseudotumoral nature at the origin of osseous lysis instead indicating a malignant process. Surgery with anatomopathologic and mycological examination appears to be both a diagnostic and therapeutic means. Treatment must be rapidly started in order to avoid complications with frightening prognosis.
    Journal de Mycologie Médicale/Journal of Medical Mycology 06/2010; 20(2):120-123. · 0.74 Impact Factor
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    ABSTRACT: Le sarcome fibroblastique myxo-inflammatoire acral est une tumeur rare des tissus mous, de bas grade. Elle intéresse principalement les extrémités de l’adulte d’âge moyen. Nous en rapportons une observation, localisée au troisième doigt de la main gauche, chez un homme d’âge moyen. La tumeur était nodulaire, caractérisée par une alternance de zones cellulaires fibreuses, siège d’un infiltrat inflammmatoire polymorphe et de zones paucicellulaires sur un fond myxoïde. Les cellules tumorales étaient représentées majoritairement par des cellules atypiques, d’aspect pseudoganglionnaire et des cellules vacuolisées pseudolipoblastique. L’étude immunohistochimique révélait une positivité diffuse avec la vimentine et focale avec les anticorps CD34 et CD68. Le patient a bénéficié d’une exérèse chirurgicale complète, sans traitement adjuvant.
    Resuscitation 01/2010; 96(5):668-671. · 4.10 Impact Factor
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    ABSTRACT: Mucormycosis is a rare fungal infection which is usually hard and late to diagnose. It is an opportunist infection due to a fungus of the group of the mucorales present in the environment. There are various clinical forms of the disease which generally occurs on a defective predisposed ground. Diagnosis is based on a mycologic and anatomopathologic examination. The therapeutic approach must be multidisciplinary; the vital and functional forecast depends on the precocity of treatment. We report a case of mucormycosis in a 36-year-old pregnant woman.
    Journal De Mycologie Medicale - J MYCOLOGIE MEDICALE. 01/2009; 19(4):294-296.