Mohammed Sohaib Mustafa

Moorfields Eye Hospital - Dubai, Dubayy, Dubai, United Arab Emirates

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Publications (4)10.42 Total impact

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    ABSTRACT: Objective: To investigate the effect of socioeconomic deprivation on cornea graft survival in the United Kingdom. Design: Retrospective cohort study. Participants: All the recipients (n = 13 644) undergoing their first penetrating keratoplasty (PK) registered on the United Kingdom Transplant Registry between April 1999 and March 2011 were included. Methods: Data of patients' demographic details, indications, graft size, corneal vascularization, surgical complication, rejection episodes, and postoperative medication were collected at the time of surgery and 1, 2, and 5 years postoperatively. Patients with endophthalmitis were excluded from the study. Patients' home postcodes were used to determine the socioeconomic status using a well-validated deprivation index in the United Kingdom: A Classification of Residential Neighborhoods (ACORN). Kaplan-Meier survival and Cox proportional hazards regression were used to evaluate the influence of ACORN categories on 5-year graft survival, and the Bonferroni method was used to adjust for multiple comparisons. Main Outcome Measures: Patients' socioeconomic deprivation status and corneal graft failure. Results: A total of 13 644 patients received their first PK during the study periods. A total of 1685 patients (13.36%) were lost to follow-up, leaving 11 821 patients (86.64%) for analysis. A total of 138 of the 11 821 patients (1.17%) developed endophthalmitis. The risk of graft failure within 5 years for the patients classified as hard-pressed was 1.3 times that of the least deprived (hazard ratio, 1.3; 95% confidence interval, 1.1-1.5; P = 0.003) after adjusting for confounding factors and indications. There were no statistically significant differences between the causes of graft failure and the level of deprivation (P = 0.14). Conclusions: Patients classified as hard-pressed had an increased risk of graft failure within 5 years compared with the least deprived patients. (C) 2013 by the American Academy of Ophthalmology.
    Ophthalmology 12/2013; 120(12):2436–2441. DOI:10.1016/j.ophtha.2013.07.050 · 6.17 Impact Factor
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    ABSTRACT: Purpose: To evaluate the influence of socioeconomic factors on visual acuity before cataract surgery. Methods: The medical case notes of 240 consecutive patients listed for cataract surgery from January 1, 2010, at Grampian University Hospital, Aberdeen, were reviewed retrospectively. Patients with ocular comorbidity were excluded. Demographics, postal codes, and visual acuity were recorded. Scottish Index of Multiple Deprivation was used to determine the deprivation rank. Home location was classified as urban or rural. The effect of these parameters on preoperative visual acuity was investigated using chi-square tests or Fisher exact test as appropriate. Results: A total of 184 patients (mean 75 years) were included. A total of 127 (69%) patients had visual acuity of 6/12 or better. An association was found between affluence and preoperative visual acuity of 6/12 or better (χ2trend = 4.97, p = 0.03), with a significant rising trend across quintile of deprivation. There was no evidence to suggest association between geographical region and preoperative visual acuity (p = 0.63). Conclusion: Affluence was associated with good visual acuity (6/12 or better) before cataract surgery. There was no difference in preoperative visual acuity between rural and urban populations.
    European journal of ophthalmology 05/2013; 23(6). DOI:10.5301/ejo.5000302 · 1.06 Impact Factor
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    ABSTRACT: To evaluate the changes in the Visual Field Index (VFI) in eyes with perimetric glaucomatous progression, and to compare these against stable glaucoma patients. Consecutive patients with open angle glaucoma with a minimum of 6 reliable visual fields and 2 years of follow-up were identified. Perimetric progression was assessed by 4 masked glaucoma experts from different units, and classified into 3 categories: "definite progression," "suspected progression," or "no progression." This was compared with the Glaucoma Progression Analysis (GPA) II and VFI linear regression analysis, where progression was defined as a negative slope with significance of <5%. Three hundred ninety-seven visual fields from 51 eyes of 39 patients were assessed. The mean number of visual fields was 7.8 (SD 1.1) per eye, and the mean follow-up duration was 63.7 (SD 13.4) months. The mean VFI linear regression slope showed an overall statistically significant difference (P<0.001, analysis of variance) for each category of progression. Using expert consensus opinion as the reference standard, both VFI analysis and GPA II had high specificity (0.93 and 0.90, respectively), but relatively low sensitivity (0.45 and 0.41, respectively). The mean VFI regression slope in our cohort of eyes without perimetric progression showed a statistically significant difference compared with those with suspected and definite progression. VFI analysis and GPA II both had similarly high specificity but low sensitivity when compared with expert consensus opinion.
    Journal of glaucoma 03/2011; 20(4):223-7. DOI:10.1097/IJG.0b013e3181e08137 · 2.43 Impact Factor
  • Source
    Mohammed Sohaib Mustafa, Augusto Azuara-Blanco
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    ABSTRACT: A 42-year-old man has been under long-term follow-up since he was a child for congenital glaucoma and buphthalmos in both eyes. His left eye best corrected visual acuity (BCVA) was counting fingers, due to end-stage glaucoma. He was on maximal medical therapy with an intraocular pressure (IOP) maintained at mid to low twenties. His right eye, the only seeing eye, had a BCVA of 6/9. This eye had undergone multiple glaucoma laser and surgical procedures, including an initial first Molteno drainage device inserted superonasally that failed in April 2003 due to fibrotic membrane over the tube opening. As a result, he subsequently had a second Molteno drainage device inserted inferotemporally. To further maximize his vision he had an uncomplicated cataract extraction and intraocular lens implant in December 2004, after which he developed postoperative cystoid macular edema and corneal endothelial failure. He underwent a penetrating keratoplasty in the right eye thereafter in March 2007. After approximately a year, the second Molteno device developed drainage tube retraction, which was managed surgically to maintain optimum IOP in the right eye. His right eye vision to date is maintained at 6/12.
    Clinical Ophthalmology 03/2011; 5:307-10. DOI:10.2147/OPTH.S14844 · 0.76 Impact Factor

Publication Stats

9 Citations
10.42 Total Impact Points


  • 2013
    • Moorfields Eye Hospital - Dubai
      Dubayy, Dubai, United Arab Emirates
  • 2011
    • NHS Grampian
      Aberdeen, Scotland, United Kingdom