Joanna Rosińczuk-Tonderys

Publications of Joanna Rosińczuk-Tonderys

• The risk for syncope and presyncope during surgery in surgeons and nurses.

  Authors: Jerzy Rudnicki, Dorota Zyśko, Jacek Gajek, Wiktor Kuliczkowski, Joanna Rosińczuk-Tonderys, Dominika Zielińska, Łukasz Terpiłowski, Anil Kumar Agrawal

  Pacing and clinical electrophysiology : PACE. 07/2011; 34(11):1486-91.

  Surgeons and nurses are exposed to orthostatic stress. To assess the lifetime incidence of syncopal and presyncopal events during surgery in operation room staff and reveal the predictingSurgeons and nurses are exposed to orthostatic stress. To assess the lifetime incidence of syncopal and presyncopal events during surgery in operation room staff and reveal the predicting factors. The study included 317 subjects (161 F, 156 M) aged 43.9 ± 9.6; 216 surgeons and 101 instrumenters. The study included filling of an anonymous questionnaire on the syncope and presyncope history. At least one syncopal event during operation was reported by 4.7% and presyncope by 14.8% of the studied population. All but one subject reported prodromal symptoms before syncope. In the medical history, syncope outside the operating room was reported by 11% of the studied group. Syncope and presyncope during operation was related to syncope in the medical history outside the operation room, respectively: odds ratio (OR) 20.2 95% confidence interval (CI): 2.0-70.5 and OR 10.8; CI: 5.0-23.4 and to presyncope in the medical history, respectively: OR 23.5; CI: 7.4-74.4 OR 8.9; CI: 3.6-11.2 (P < 0.001). (1) Syncope and presyncope may occur during surgery in the staff of the operating room. (2) Syncope in the operating room is usually preceded by prodromal symptoms and has vasovagal origin. (3) Both lower then expected occurrence of syncope in the operating room staff and absence of any difference between genders in this regard indicate preselection in the process of choosing profession and specialization. (4) Syncope and presyncope outside the operating room in medical history increases the risk of syncope and presyncope inside the operation room.

• [High doses of tocopherol in the prevention and potentiation of dioxin in experimental inflammation-potential application].

  Authors: Ireneusz Całkosiński, Joanna Rosińczuk-Tonderys, Monika Szopa, Maciej Dobrzyński, Andrzej Gamian

  Postȩpy higieny i medycyny doświadczalnej (Online). 01/2011; 65:143-57.

  Emission of toxic and persistent organochlorine compounds into the environment is known to have been recently a very important environmental and health problem. One of the major groups of theseEmission of toxic and persistent organochlorine compounds into the environment is known to have been recently a very important environmental and health problem. One of the major groups of these compounds is the polychlorinated dibenzodioxins (PCDDs), commonly named dioxins, including 75 compounds composed of benzene rings with bound chlorine atoms in different positions and quantities. Polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) are known to have a similar structure and properties. The biological effects of dioxins in food chains have been widely studied in the literature on the subject for the last four years. The major pathways of their impact on the organism are suspected to stimulate the cascade of inflammatory cytokines and the induction of oxidative stress. An effective way to prevent poisoning may, therefore, be expected to be administration of antioxidants and anti-inflammatory agents. Recent studies in experimental animals have confirmed the protective action of high doses of tocopherol and mentioned substances against dioxins.

• [The composition, biochemical properties and toxicity of snake venoms].

  Authors: Ireneusz Całkosiński, Ewa Seweryn, Arkadiusz Zasadowski, Katarzyna Małolepsza-Jarmołowska, Katarzyna Dzierzba, Agnieszka Bronowicka-Szydełko, Magdalena Mierzchała, Ireneusz Ceremuga, Joanna Rosińczuk-Tonderys, Maciej Dobrzyński, Andrzej Gamian

  Postȩpy higieny i medycyny doświadczalnej (Online). 01/2010; 64:262-72.

  2.5 million cases of snake bites are noticed in the world every year (within 100,000 is mortal). These bites occur frequently in Asia and Africa. Some reports proved the toxicity and composition2.5 million cases of snake bites are noticed in the world every year (within 100,000 is mortal). These bites occur frequently in Asia and Africa. Some reports proved the toxicity and composition changes of well-known venoms from the same snake species according to the climatic zone. Snake venom is a natural source of many biologically active substances, including those with potential therapeutic properties. These substances contain peptides, proteins, and enzymes which are divided into five subfamilies: three-finger toxins, serine protease inhibitors of the Kunitz type, phospholipases A2, serine proteases, and metalloproteases. All snake venoms are grouped depending on their mode of action. They usually cause neurotransmission disorders, cardiotoxic action, hemostasis disorders, and have central nervous system and necrotic activity.

• Estimation of the action of three different mechlorethamine doses on biochemical parameters during experimentally induced pleuritis in rats.

  Authors: Ireneusz Całkosiński, Joanna Rosińczuk-Tonderys, Katarzyna Dzierzba, Agnieszka Bronowicka-Szydełko, Ewa Seweryn, Jacek Majda, Monika Całkosińska, Andrzej Gamian

  Pharmacological reports : PR. 63(2):501-17.

  Nitrogranulogen (NTG) may modify the character of inflammatory reactions. These modifications are a result of cytotoxic and mutagenic effects. NTG has high affinity to DNA and causes disorders in theNitrogranulogen (NTG) may modify the character of inflammatory reactions. These modifications are a result of cytotoxic and mutagenic effects. NTG has high affinity to DNA and causes disorders in the synthesis of acute phase proteins (e.g., haptoglobin, transferrin, fibrinogen, and complement protein C3). Our previous studies have shown that small doses of NTG can enhance immunological defense reactions in the organism. The aim of the current studies was to determine how different NTG doses cause changes in the values of biochemical parameters in pleuritis-induced rats. The animals were randomized into five groups: Group I - control group; Group II - IP (induced pleuritis) group; Group III - NTG5 group; Group IV - NTG50 group; Group V - NTG600 group. Blood was collected from all groups of animals at 24, 48, and 72 h after the initiation of the carrageenin-induced inflammatory reaction. These investigations revealed that a dose of 5 μg NTG/kg b.w. (body weight) can change the character of the inflammation. Our studies also show that a dose of 600 μg NTG/kg b.w. causes a rapid decrease in the level of C3 at the 72 h of the experiment (after 3 applications every 24 h), which indicates a cytotoxic action of such a large NTG dose. NTG used at doses of 50 and 600 μg/kg b.w. causes the opposite metabolism of albumins and other serum proteins. Our studies show that the different doses of NTG have distinct effects on the inflammatory reaction.