Anna Pros

Publications (2)7.39 Total impact

• Article: The functional polymorphism 844 A>G in FcαRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility.

  Jasper C A Broen, Marieke J H Coenen, Blanca Rueda, Torsten Witte, Leonid Padyukov, Lars Klareskog, Roger Hesselstrand, Dirk M Wuttge, Carmen Simeon, Norberto Ortego-Centeno, [......], Alexander Kreuter, Madelon Vonk, Rafaella Scorza, Lorenzo Beretta, Paulo Airò, Piet L C M van Riel, Robert Kimberly, Javier Martin, Jeffrey Edberg, Timothy R D J Radstake
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  ABSTRACT: To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.
  The Journal of Rheumatology 03/2011; 38(3):446-9. · 3.69 Impact Factor
• Source

  Available from: Roger Hesselstrand

  Article: Functional variants of Fc gamma receptor (FCGR2A) and FCGR3A are not associated with susceptibility to systemic sclerosis in a large European Study (EUSTAR).

  Behrooz Z Alizadeh, Jasper Broen, Blanca Rueda, Roger Hesselstrand, Dirk Wuttge, Carmen Simeon, Norberto Ortego-Centeno, Miguel A Gonzalez-Gay, Miguel Gonzalez-Gay, Anna Pros, [......], Frank van den Hoogen, Serena Guiducci, Marco Matucci-Cerinic, Rafaella Scorza, Lorenzo Beretta, Paolo Airó, Marieke Coenen, Javier Martin, Bobby P C Koeleman, Timothy R D J Radstake
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  ABSTRACT: To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>C functional variants in 6 independent European cohorts of white patients with SSc, and white controls. The cohorts comprised 165 Dutch patients with SSc and 1326 controls, 236 Spanish patients with SSc and 257 controls, 267 German patients with SSc and 270 controls, 202 Swedish patients with SSc and 261 controls, 416 Italian patients with SSc and 157 controls, and additionally 280 English patients with SSc. Genotyping was performed using Taqman 5' allelic discrimination assay. The study reached a 99% power to detect the effect of a polymorphism at an OR of 1.3. Neither FCGR2A 519A>G nor FCGR3A 559A>C was significantly associated with susceptibility to SSc. We did not find an association with specific disease phenotypes, limited or diffuse cutaneous involvement, autoantibody profiles, or pulmonary involvement. Our study strongly suggests the lack of a role for the FCGR2A 519A>G and FCGR3A 559A>C polymorphisms in SSc susceptibility or clinical phenotype in 6 independent European cohorts.
  The Journal of Rheumatology 08/2010; 37(8):1673-9. · 3.69 Impact Factor