Chihiro Yamazaki,
Rie Miyamoto,
Katsuaki Hoshino,
Yuri Fukuda,
Izumi Sasaki,
Masuyoshi Saito, Hironori Ishiguchi,
Takahiro Yano,
Takahiro Sugiyama,
Hiroaki Hemmi,
Takashi Tanaka,
Eri Hamada,
Takeshi Hirashima,
Ryuichi Amakawa,
Shirou Fukuhara,
Shosaku Nomura,
Tomoki Ito,
Tsuneyasu Kaisho
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ABSTRACT: Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8alpha(+) conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8(+) T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3(+) DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8(+) T cells through XCR1.
Biochemical and Biophysical Research Communications 07/2010; 397(4):756-61. · 2.48 Impact Factor
