Jin Eun Kim

Publications (3)6.31 Total impact

• Article: N-Nicotinoyl dopamine, a novel niacinamide derivative, retains high antioxidant activity and inhibits skin pigmentation.

  Bora Kim, Jin Eun Kim, Su Min Lee, Soung-Hoon Lee, Jin Won Lee, Myung Kyoo Kim, Kye Jong Lee, Hyuk Kim, Joo Dong Lee, Kang-Yell Choi
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  ABSTRACT: We synthesized a novel derivative of a well-known skin-lightening compound niacinamide, N-nicotinoyl dopamine (NND). NND did not show inhibitory effects of tyrosinase and melanin synthesis in B16F10 mouse melanoma cells. However, NND retains high antioxidant activity without affecting viability of cells. In a reconstructed skin model, topical applications of 0.05% and 0.1% NND induced skin lightening and decreased melanin production without affecting the viability and morphology of melanocytes and overall tissue histology. Moreover, no evidence for skin irritation or sensitization was observed when 0.1% NND emulsion was applied onto the skin of 52 volunteers. The effect of NND on skin lightening was further revealed by pigmented spot analyses of human clinical trial. Overall, NND treatment may be a useful trial for skin lightening and treating pigmentary disorders.
  Experimental Dermatology 07/2011; 20(11):950-2. · 3.54 Impact Factor
• Article: Retinyl retinoate induces hyaluronan production and less irritation than other retinoids.

  Jin Eun Kim, Bora Kim, Hyuk Kim, Hyojung Kim, Joo Dong Lee, Hyun Jung Kim, Kang Yell Choi, Seung Hun Lee
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  ABSTRACT: Hyaluronan, a non-sulfated glycosaminoglycan, retains water, maintains the extracellular spaces and facilitates the transport of ion solutes and nutrients. Hyaluronan is closely involved in keratinocyte proliferation, migration and differentiation. The synthesis of hyaluronan in vitro can be stimulated by several growth factors, including retinoids, dibutyryl cyclic adenosine monophosphate and peroxisome proliferator-activated receptor-alpha agonist. In this study, we examined retinyl retinoate (a novel retinol derivative) on hyaluronan expression in primary human keratinocytes and in hairless mouse epidermal skin. Histochemistry using hyaluronan-binding protein revealed that topical retinyl retinoate increased the intensity of hyaluronan staining in murine skin. Moreover, topical retinyl retinoate increased CD44 (hyaluronan receptor) expression. Using reverse transcription polymerase chain reaction, we assessed the expression level of the hyaluronan synthase 2 (HAS2) gene in primary human keratinocytes and in hairless mouse epidermal skin. We found that retinyl retinoate upregulated mouse HAS2 and human HAS2 mRNA. Application of retinyl retinoate induced increasing transepidermal water loss less than retinol, retinoic acid and retinaldehyde. Taken together, we suggest that retinyl retinoate is more effective on hyaluronan production and less of an irritant than other retinoids.
  The Journal of Dermatology 05/2010; 37(5):448-54. · 1.49 Impact Factor
• Source

  Available from: Won-Yoon Chung

  Article: Pleurospermum kamtschaticum extract induces apoptosis via mitochondrial pathway and NAG-1 expression in colon cancer cells.

  Jin-Eun Kim, Won-Yoon Chung, Kyung-Soo Chun, Chang Ki Lee, Hee-Juhn Park, Won-Bae Kim, Kwang-Kyun Park
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  ABSTRACT: To evaluate the anticarcinogenic activity of methanol extract of Pleurospermum kamtschaticum (PKE), we assessed its apoptosis-inducing capability in HT-29 colon carcinoma cells. PKE treatment for 2 h reduced cell viability in a dose-related manner, and induced apoptotic morphological changes. Flow cytometric analysis indicated that PKE treatment at 0.05 mg/ml induced early apoptosis in 66.2% of HT-29 cells. Additionally, Bcl-2 expression was substantially reduced in PKE-treated HT-29 cells, increasing the Bax/Bcl-2 ratio. The protein levels of procaspase-9 and procaspase-3 were decreased markedly, reflecting caspase-9 and caspase-3 activation, and resulting PARP cleavage was noted in the PKE-treated HT-29 cells. Furthermore, we detected increased NAG-1 expression in the PKE-treated HT-29 cells. In an in vivo study, intraperitoneal PKE administration suppressed the formation of tumor nodules in the lungs of mice. These results indicate that PKE can serve as a beneficial supplement in the treatment and the prevention of colon cancer.
  Bioscience Biotechnology and Biochemistry 04/2010; 74(4):788-92. · 1.28 Impact Factor