[show abstract][hide abstract] ABSTRACT: : Peanut allergies have been increasing in prevalence in most industrialized countries. Onset is typically in early childhood, with a trend towards earlier ages of presentation. The allergy is lifelong in most affected children, although 15-22% will outgrow their peanut allergy, usually before their teenage years. Manifestations of peanut allergy range from mild to severe, and risk factors predisposing to severe reactions are discussed. However, even in the absence of risk factors, peanut allergic individuals may still experience life-threatening anaphylactic reactions. Approaches to investigation and treatment, patterns of cross-reactivity and possible causes of rising prevalence are discussed.
Allergy Asthma and Clinical Immunology 12/2008; 4(4):139-43.
[show abstract][hide abstract] ABSTRACT: Catamenial anaphylaxis, also called cyclical anaphylaxis, de-scribes recurrent episodes of multi-system allergic reactions occurring at the time of menstruation. This case reports dem-onstrates the management of three women with catamenial anaphylaxis. The first patient is a 38 years old woman who presented with symptoms consistent with anaphylaxis in rela-tion to her menstrual cycle. Her symptoms were controlled with cetirizine at a dose of 20 mg daily. The second patient is 33 years old with similar symptoms coinciding with her men-ses. We were able to control her symptoms with leuprolide (Lupron), a luteinizing hormone releasing hormone (LHRH) agonist. The third was a 29 years old woman with catamenial anaphylaxis who was successfully treated with Depo-Provera (medroxyprogesterone). Catamenial anaphylaxis is a rare yet an important presentation to the Allergist/Clinical immu-nologist. The management of the patients we present here represents a spectrum of the different therapies tried in the medical literature. Here, we report the first successful use of medroxyprogesterone for such rare, yet critical medical con-dition.