Sid Ahmed Merzouk

Abou Bakr Belkaid University of Tlemcen, Tlemsen, Tlemcen, Algeria

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Publications (24)47.83 Total impact

  • F.Z. Baba Ahmed · H. Merzouk · S. Merzouk · S. Bouanane ·

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    ABSTRACT: To investigate the oxidative profile and thrombotic markers in obese and hypertensive mothers. Thirty obese, 28 hypertensive and 34 healthy control mothers were recruited from Tlemcen Hospital, Algeria. Plasma vitamin C, nitric oxide, superoxide anion, erythrocyte glutathione, malondialdehyde, carbonyl proteins and erythrocyte antioxidant enzyme activities and coagulation markers [protein C, protein S, fibrinogen, prothrombin, antithrombin, activated partial thromboplastin time (APTT), lupus anticoagulants (LACs)] were measured. Changes in plasma urea, creatinine, uric acid, glucose and lipid levels were also determined. Plasma glucose concentrations were high in obese mothers, and plasma urea, uric acid and creatinine levels were increased in hypertensive compared with healthy mothers. Obese and hypertensive mothers had low vitamin C and glutathione values, catalase and superoxide dismutase activities, and high triglyceride, superoxide anion, malondialdehyde and carbonyl protein levels compared with control mothers. Plasma nitric oxide levels were enhanced in obese mothers but reduced in hypertensive mothers. Fibrinogen and prothrombin levels were significantly enhanced in obese and hypertensive mothers. Protein C, protein S, antithrombin and APTT values were significantly higher in hypertensive mothers. Only hypertensive mothers were positive for LACs. Obese and hypertensive mothers presented oxidative stress and a pro-thrombotic state. Their oxidative and hemostasis profile should be carefully considered and appropriate management organized.
    Blood pressure 04/2015; 24(4):1-8. DOI:10.3109/08037051.2015.1032517 · 1.81 Impact Factor
  • Nawel Benaissa · Hafida Merzouk · Sid Ahmed Merzouk · Michel Narce ·
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    ABSTRACT: Because linseed oil may influence maternal and fetal metabolisms, we investigated its role in the modulation of lipid metabolism in cafeteria diet-induced obese rats and their offspring. Female Wistar rats were fed control or cafeteria food, which were either supplemented or not supplemented with linseed oil (5%) for 1 month before and during gestation. At parturition, serum and tissue lipids and enzyme activities were analyzed. Cafeteria diet induced adverse metabolic alterations in both mothers and offspring. Linseed oil improved metabolic status. In conclusion, linseed oil displayed health benefits by modulating tissue enzyme activities in both obese mothers and their newborns. Copyright © 2015 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.
    Biomedical and Environmental Sciences 04/2015; 28(4):298-302. DOI:10.3967/bes2015.041 · 1.65 Impact Factor
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    ABSTRACT: The effects of calcium antagonists (amlodipine) and angiotensin II receptor antagonists (telmisartan) on lipid profile and oxidative markers are investigated in Algerian hypertensive patients. At the beginning and after one year of antihypertensive therapy, blood samples are collected for biochemical parameters (glucose, cholesterol, triglycerides, urea, creatinine) and oxidative markers (malondialdehyde, carbonyl proteins, nitric oxide, superoxide anion, vitamin C, glutathione, catalase, superoxide dismutase) determinations. The results of this study indicate that telmisartan and amlodipine are effective antihypertensive agents in the treatment of hypertension since a significant reduction in systolic and diastolic blood pressure is observed in all hypertensive patients after one year of treatment. Our results show also that telmisartan and amlodipine treatments counteracted hypertension-dependent lipid abnormalities and oxidative stress. Telmisartan treatment appears to be more efficient than amlodipine treatment. In addition, telmisartan, which reverse all lipid and redox changes associated with hypertension, should be prescribed, especially in hypertensive patients with hypertriglyceridemia and with severe oxidative stress. Copyright © 2014. Published by Elsevier Inc.
    Free Radical Biology and Medicine 12/2014; 79. DOI:10.1016/j.freeradbiomed.2014.12.003 · 5.74 Impact Factor
  • Farah Djelti · Hafida Merzouk · Sid Ahmed Merzouk · Michel Narce ·
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    ABSTRACT: Background The aim of this investigation was to determine the in-vitro effects of linseed, olive and Nigel oils on T cell proliferation and function in gestational diabetes.Methods Blood samples were collected from 40 control healthy and 32 gestational diabetic mothers and their newborns. Peripheral blood lymphocytes were isolated using a density gradient of Ficoll. T cell proliferation, interleukin-2 and -4 (IL-2, IL-4) secretion, fatty acid composition and intracellular oxidative status were investigated.ResultsMitogen (Concanavalin A) stimulated lymphocyte proliferation, IL-2 secretion, intracellular reduced glutathione levels, SOD and catalase activities were lower while intracellular MDA and carbonyl proteins were higher in diabetic mothers and in their newborns as compared to their respective controls. Linseed oil induced a reduction in T-lymphocyte proliferation and IL-2 production, and alpha linolenic acid membrane enrichment in both diabetic and control groups. In the presence of Nigel oil, T-lymphocyte proliferation and IL-2 secretion, phospholipid linoleic and oleic acids were enhanced. Olive oil had no effect on lymphocyte proliferation in all groups. Linseed, olive and Nigel oils induced an increase in T cell levels of reduced glutathione levels and in activities of catalase and SOD with a concomitant decrease in MDA and carbonyl protein contents.Conclusion Linseed, olive and Nigel oils had beneficial effects on T cell functions in gestational diabetes.
    Journal of Diabetes 08/2014; 7(4). DOI:10.1111/1753-0407.12210 · 1.93 Impact Factor
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    ABSTRACT: The aim of this work was to determine the effect of dietary n - 3 PUFA on oxidant/antioxidant status, in vitro very low and low density lipoprotein (VLDL-LDL), and VLDL-LDL-fatty acid composition in macrosomic pups of diabetic mothers. We hypothesized that n - 3 PUFA would improve oxidative stress in macrosomia. Diabetes was induced in female Wistar rats fed with the ISIO diet (control) or with the EPAX diet (enriched in n - 3 PUFAs), by streptozotocin. The macrosomic pups were killed at birth (day 0) and at adulthood (day 90). Lipid parameters and VLDL-LDL-fatty acid composition were investigated. The oxidant/antioxidant status was determined by measuring plasma oxygen radical absorbance capacity (ORAC), hydroperoxides, carbonyl proteins, and VLDL-LDL oxidation. Macrosomic rats of ISIO fed diabetic mothers showed an increase in plasma and VLDL-LDL-triglycerides and VLDL-LDL-cholesterol levels and altered VLDL-LDL-fatty acid composition. Plasma ORAC was low with high hydroperoxide and carbonyl protein levels. The in vitro oxidizability of VLDL-LDL was enhanced in these macrosomic rats. The EPAX diet corrected lipid parameters and improved oxidant/antioxidant status but increased VLDL-LDL susceptibility to oxidation. Macrosomia is associated with lipid abnormalities and oxidative stress. n - 3 PUFA exerts favorable effects on lipid metabolism and on the oxidant/antioxidant status of macrosomic rats. However, there are no evident effects on VLDL-LDL oxidation.
    BioMed Research International 06/2014; 2014(7):368107. DOI:10.1155/2014/368107 · 2.71 Impact Factor
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    N. Malti · H. Merzouk · S.A. Merzouk · B. Loukidi · N. Karaouzene · A. Malti · M. Narce ·
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    ABSTRACT: Objective To determine oxidative stress markers in maternal obesity during pregnancy and to evaluate feto-placental unit interaction, especially predictors of fetal metabolic alterations. Patients and methods 40 obese pregnant women (prepregnancy BMI > 30 kg/m²) were compared to 50 control pregnant women. Maternal, cord blood and placenta samples were collected at delivery. Biochemical parameters (total cholesterol and triglycerides) and oxidative stress markers (malondialdehyde, carbonyl proteins, superoxide anion expressed as reduced Nitroblue Tetrazolium, nitric oxide expressed as nitrite, reduced glutathione, catalase, superoxide dismutase) were assayed by biochemical methods. Results Maternal, fetal and placental triglyceride levels were increased in obese group compared to control. Maternal malondialdehyde, carbonyl proteins, nitric oxide and superoxide anion levels were high while reduced glutathione concentrations and superoxide dismutase activity were low in obesity. In the placenta and in newborns of these obese mothers, variations of redox balance were also observed indicating high oxidative stress. Maternal and placental interaction constituted a strong predictor of fetal redox variations in obese pregnancies. Discussion Maternal obesity compromised placental metabolism and antioxidant status which strongly impacted fetal redox balance. Oxidative stress may be one of the key downstream mediators that initiate programming of the offspring. Conclusion Maternal obesity is associated with metabolic alterations and dysregulation of redox balance in the mother- placenta – fetus unit. These perturbations could lead to maternal and fetal complications and should be carefully considered.
    Placenta 06/2014; 35(6). DOI:10.1016/j.placenta.2014.03.010 · 2.71 Impact Factor
  • M. Saker · H. Merzouk · N.A. Malti · S.A. Merzouk · A. Malti · M. Narce ·

    Nutrition Clinique et Métabolisme 12/2013; 27:S113-S114. DOI:10.1016/S0985-0562(13)70449-7 · 0.29 Impact Factor
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    Amina Ayad · Hafida Merzouk · Sid Ahmed Merzouk · Michel Narce ·

    Biomedical and Environmental Sciences 09/2013; 26(9):765-768. DOI:10.3967/0895-3988.2013.09.008 · 1.65 Impact Factor
  • F.Z. Chiali · H. Merzouk · S.A. Merzouk · A. Medjdoub · M. Narce ·
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    ABSTRACT: In this work we evaluated the in vivo effects of chronic metribuzin exposure at doses that mimic human exposure through diet. Male and female rats were fed a potato diet containing metribuzin at low doses (D1, 1.3 mg/kg or D2, 13 mg/kg) for 3 months. Plasma biochemical parameters (glucose, lipid, urea, creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST)), as well as lipid and protein contents, markers of oxidative stress in different organs (liver, adipose tissue, muscle, intestine) were determined.
    Pesticide Biochemistry and Physiology 05/2013; 106(1-2):38-44. DOI:10.1016/j.pestbp.2013.03.011 · 2.01 Impact Factor
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    ABSTRACT: In this study, plasma lipids, lipoproteins and markers of oxidant/antioxidant status were investigated in young (n = 45) and older (n = 40) obese men and compared to those in young (n = 65) and older (n = 55) normal weight controls. The purpose was to determine whether obesity exacerbates or not lipid, lipoprotein abnormalities and oxidative stress in older men. Our findings showed that all obese patients had increased plasma triglyceride, cholesterol, LDL-cholesterol, -triglyceride and HDL-triglyceride levels concentrations compared to controls (P < 0.01). However, the younger obese men had relatively larger and accentuated changes in plasma lipids and lipoproteins than the older patients. Additionally, total antioxidant capacity (ORAC), vitamins C and E were lower while hydroperoxides and carbonyl proteins were higher in young and older obese patients compared to their respective controls (P < 0.001). Erythrocyte antioxidant SOD and catalase activities were enhanced in obese young patients, but reduced in obese older men. Glutathione peroxidase activity was low in obesity irrespective of age. In multiple regression analysis, BMI significantly predicted total cholesterol, LDL-C, LDL-TG and HDL-TG (P < 0.0001). These relationships were not modified by age. BMI alone was a not a significant predictor for ORAC, vitamins C, E, catalase and Glutathione peroxidase. However, the interaction BMI-age significantly predicted these parameters and explained 28-45% of their changes. BMI was a significant predictor of SOD, carbonyl proteins and hydroperoxides. This effect became more significant (P < 0.0001) and worsened with BMI-age interaction. In conclusion, lipoprotein metabolism and oxidant/antioxidant status are altered in obesity irrespective of age. However, obesity-related lipid and lipoprotein alterations were attenuated while oxidative stress was aggravated in older adults.
    Nutrition, metabolism, and cardiovascular diseases: NMCD 10/2011; 21(10):792-9. DOI:10.1016/j.numecd.2010.02.007 · 3.32 Impact Factor
  • A. Medjdoub · S. A. Merzouk · H. Merzouk · F.Z. Chiali · M. Narce ·
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    ABSTRACT: Pesticides have been shown to possess marked immunotropic activity. The aim of this work was to study the in vitro effects of different concentrations (1–100μM) of Mancozeb (fungicide) and Metribuzin (herbicide), on the proliferative responses of human and rat spleen lymphocytes stimulated by concanavalin A (ConA, mitogen), the Th1- (IL-2, INFγ) and Th2- (IL-4) cytokine secretion and on the intracellular oxidative status. The results showed that Mancozeb significantly reduced ConA lymphocyte proliferation in a dose-dependent manner in both humans and rats. It also decreased IL-2, INFγ and IL-4 secretion with a a shift away to Th1 phenotype. Metribuzin at low concentrations (1–10μM) resulted in activation of ConA stimulated lymphocyte proliferation and cytokine production in both human and rat spleen cells. However, at high concentrations (25–100μM), Metribuzin induced a dose-dependent inhibition of lymphocyte proliferation and cytokines. Changes in intracellular levels of reduced Glutathione, hydroperoxides and carbonyl proteins and in the activities of catalase and SOD were observed after Mancozeb and Metribuzin exposure reflecting oxidative stress and DNA damage specially at high concentrations.In conclusion, Mancozeb and Metribuzin had significant immunomodulatory properties with oxidative stress induction at high concentrations.
    Pesticide Biochemistry and Physiology 09/2011; 101(1):27-33. DOI:10.1016/j.pestbp.2011.06.002 · 2.01 Impact Factor
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    ABSTRACT: Background: Obesity has reached epidemic proportions world-wide. Its risk factors are poorly studied, especially among children in developing countries such as Algeria.Objectives: The purpose of this study was therefore to determine the prevalence and risk factors of obesity in Algerian schoolchildren 6 to 8 years aged by conducting a school-site retrospective cohort study in Tlemcen Department (western Algeria).Material and Mthods: From 2008 to 2010, socio-demographic characteristics, body mass index (BMI), physical activity categories, lifestyle and nutritional habits of 1520 children (839 boys and 681 girls), at entrance into primary school, were recorded using a self-administered questionnaire.Results: Among the 1520 participants, 99 (6.5%) were obese. Birthweight ≤ 2.5 kg and ≥ 4 kg, early introduction of solid foods and low physical activity were significantly associated with obesity (p<0.001). Additionally, mother's and grandmother's BMI ≥30 kg/m(2), fewer children in the household, higher parental education, household income and the presence of familial obesity may predispose significantly to childhood obesity (p<0.001). Furthermore, child's BMI was significant positively correlated with total energy, fat and saturated fatty acid (SFA) intakes (p<0.01). Mother's and grandmother's BMI were significant positively correlated with child total energy, fat and SFA intakes. Physical activity score was significant negatively correlated with child total energy, fat and SFA (p<0.01) intakes in obese children.Conclusions: Mother's and grandmother's obesity, excess energy and fat intakes and low physical activity are the strong predictors of childhood obesity in Algeria. Preventive measures should focus on the promotion of physical activity and maternal and children nutritional education.
    04/2011; 6(2):90-9.
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    ABSTRACT: The combined effects of developmental programming and high-fat feeding at weaning on fatty acid metabolism of the offspring are not well known. In the present study, we aim at characterizing the influence of maternal and offspring's own diets on liver and very low-density lipoprotein (VLDL) lipids; fatty acid profiles of VLDL and liver phospholipids, triglycerides, and cholesteryl esters; and hepatic enzyme activities. Twenty obese male rats born to cafeteria diet-fed dams and 20 control rats born to control diet-fed dams were selected. At weaning, 10 rats of each group were fed control or cafeteria diet. Obese rats had a significant increase in serum glucose, insulin, leptin, VLDL apolipoprotein B100 and lipid levels, and hepatic fatty acid synthase and a reduction in acyl-coenzyme A oxidase and dehydrogenase activities compared with control pups at day 21 and day 90. Hepatic steatosis was apparent only at day 90. The proportions of saturated fatty acids and monounsaturated fatty acids and the oleic to stearic acid ratio were significantly increased, whereas polyunsaturated fatty acids and the arachidonic to linoleic acid ratio were decreased, in liver and VLDL lipids of obese pups compared with controls. The cafeteria diet at weaning induced more severe abnormalities in obese rats. In conclusion, maternal cafeteria diet induced a permanent reduction in hepatic β-oxidation and an increase in hepatic lipogenesis that caused liver steatosis and VLDL and fatty acid alterations in adult offspring. These preexisting alterations in offspring were worsened under a high-fat diet from weaning to adulthood. Nutritional recommendations in obesity must then target maternal and postnatal nutrition, especially fatty acid composition.
    Metabolism: clinical and experimental 12/2010; 59(12):1701-9. DOI:10.1016/j.metabol.2010.04.003 · 3.89 Impact Factor
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    ABSTRACT: To show that lipid and lipoprotein levels and cell sodium and potassium content and transport could change depending on the degree of hypertension. Forty-three hypertensive patients and 20 healthy subjects were recruited at the Cardiology and Biochemistry Departments of Tlemcen University Hospital Centre (Northwest of Algeria). Levels of CHOL, TG, PL, HDL-TG, LDLc, LDL-TG, LDL-PL, HDL2-TG and HDL3-TG were significantly higher in hypertensive patients than those in controls. HDL-PL levels were significantly lower in patients compared with controls and decreased according to the grade of hypertension. HDL2c, HDL2-PL and HDL3-TG and cell content and fluxes of sodium and potassium change gradually with higher grades of hypertension. Hypertensive patients with circulating lipid alterations are associated to ion cell content and transport abnormalities, which were worsened progressively with higher grade of hypertension.
    Clinical biochemistry 08/2010; 43(12):942-7. DOI:10.1016/j.clinbiochem.2010.05.012 · 2.28 Impact Factor
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    ABSTRACT: This study was carried out to determine the relationships between leptin concentrations, lipid alterations, oxidant/ antioxidant status, in vitro LDL oxidizability and LDL-fatty acid composition in overweight breast cancer patients. Glucose, insulin, leptin, lipids, LDL-cholesteryl ester fatty acids, markers of oxidant status (MDA, Hydroperoxides, carbonyl proteins, conjugated dienes) and markers of antioxidant status (vitamins A, C, E, erythrocyte activities of the enzymes superoxide dismutase, SOD, catalase, glutathione peroxidase,GPx, and glutathione reductase, GR and the serum total antioxidant status, ORAC) were investigated in breast cancer patients and in control women. Our findings showed that insulin, leptin, triglyceride, cholesterol and LDL-C concentrations were increased in patients compared to controls. ORAC and vitamin C and E values were lower while plasma hydroperoxide, carbonyl protein and conjugated diene levels, SOD and GPx activities were higher than in controls. Alterations in LDL-fatty acid composition were associated with their enhanced oxidative susceptibility. There were significant positive correlations between leptin concentrations and LDL-C, hydroperoxides, carbonyl proteins, SOD activity, baseline conjugated diene levels and oxidation rate, and significant negative correlations between leptin and ORAC, lag time and LDL-PUFA in patients. In conclusion, breast cancer is associated with lipid alterations and enhanced oxidative stress linked to high leptin levels in overweight.
    Pathology & Oncology Research 10/2009; 16(2):159-67. DOI:10.1007/s12253-009-9199-0 · 1.86 Impact Factor
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    ABSTRACT: The aim of this study is to determine the oxidant and antioxidant status in Algerian mothers and their newborns according to birth weight. Subjects for the study were consecutively recruited from Tlemcen hospital. 139 pregnant women and their newborns were included. The plasma total antioxidant activity (ORAC), vitamins A, C, E, hydroperoxides, carbonyl proteins, and erythrocyte antioxidant enzyme activities (catalase, glutathione peroxidase, glutathione reductase and superoxide dismutase) were measured on mothers and their newborns. Lipid and lipoprotein parameters were also determined. The results were assessed in accordance with small for gestational age (SGA), appropriate (AGA) and large (LGA) birth weight of the newborn. SGA newborns and their mothers had low ORAC, vitamin C and E values (P<0.01) and high plasma hydroperoxide and carbonyl protein levels (P<0.01) compared to AGA groups. The SGA group showed also altered erythrocyte antioxidant enzyme activities and several lipid and lipoprotein changes. In LGA compared to control newborns, hydroperoxide, carbonyl protein levels and SOD activity were enhanced while ORAC, vitamin A and E levels were reduced. However, oxidant and antioxidant status in their mothers was similar to that in control mothers. Oxidative stress is present in both SGA and LGA newborns, with a concomitant alteration in maternal oxidant and antioxidant status only in intrauterine growth restriction.
    European journal of obstetrics, gynecology, and reproductive biology 09/2008; 141(2):95-9. DOI:10.1016/j.ejogrb.2008.07.013 · 1.70 Impact Factor
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    ABSTRACT: In this work, we assessed the in-vitro effects of eicosapentaenoic acid (EPA; C20:5n-3) and docosahexaenoic acid (DHA; C22:6n-3) (final concentration, 15 microM) on T cell blastogenesis, interleukin-2 and -4 (IL-2, IL-4) secretion, fatty acid composition and intracellular oxidative status in type I diabetic patients with or without complications. Con A stimulated lymphocyte proliferation, glucose uptake, intracellular reduced glutathione levels and catalase activity were lower in diabetics as compared to controls, regardless to the presence of complications. EPA and DHA diminished T-lymphocyte proliferation and IL-2 production but enhanced IL-4 secretion in both diabetic and control groups. No changes in the levels of reduced glutathione and in the activities of catalase and SOD were observed in control T cells cultured in the presence of EPA and DHA. However, in diabetic patients, addition of n-3 PUFA to culture induced an increase in T cell levels of reduced glutathione and hydroperoxide, and in activities of catalase and SOD. Low levels of arachidonic acid (C20:4n-6) were found in plasma membrane phospholipids of lymphocytes from diabetic patients compared to controls. Incubation of lymphocytes with EPA and DHA was associated with an incorporation of these fatty acids in membrane phospholipids. In conclusion, the beneficial effects of n-3 PUFA on T cell functions in type I diabetes could be attributed to their suppressive action and modulation of cytokine secretion, and to the improvement of intracellular oxidative status.
    Lipids 07/2008; 43(6):485-97. DOI:10.1007/s11745-008-3176-3 · 1.85 Impact Factor
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    ABSTRACT: The aim of this study was to determine serum lecithin:cholesterol acyltransferase (LCAT) activity in parallel with HDL2 and HDL3 amounts and composition in pregnancy induced hypertension (PIH) and chronic hypertensive (CH) mothers and in their small for gestational age (SGA) newborns. LCAT activity was assayed by conversion of [3H] cholesterol to labelled cholesteryl ester. HDL2 and HDL3 were separated by ultracentrifugation. At term, cholesterol values were similar in PIH, CH and controls. However, higher levels of triglycerides were observed in PIH and CH (+20% and +21%, respectively) as compared with normotensive control mothers (NC). HDL2 and HDL3-phospholipids, HDL2-cholesterol concentrations and LCAT activity were lower in PIH and CH mothers than in NC mothers. Similar changes were also observed in SGA newborns of PHI mothers and in SGA newborns of CH mothers when compared to appropriate for gestational age newborns of control mothers (AGA-NC). In addition, SGA newborns showed low HDL2 and HDL3 apoA-I contents. Maternal hypertension and foetal intrauterine growth retardation are associated with profound abnormalities in HDL metabolism, consistent with an atherogenic risk. SGA lipoprotein profiles appear to implicate later metabolic diseases.
    European Journal of Pediatrics 06/2008; 167(5):525-32. DOI:10.1007/s00431-007-0545-5 · 1.89 Impact Factor

Publication Stats

284 Citations
47.83 Total Impact Points


  • 2006-2015
    • Abou Bakr Belkaid University of Tlemcen
      • • Département des Sciences et Techniques
      • • Département de Physique
      • • Faculté des Sciences
      Tlemsen, Tlemcen, Algeria
  • 2009
    • Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf
      Wahrān, Oran, Algeria