Cheng-Wei Tzeng

Publications (3)9 Total impact

• Article: Prenylated flavonoids from Artocarpus altilis: Antioxidant activities and inhibitory effects on melanin production.

  Wen-Chun Lan, Cheng-Wei Tzeng, Chun-Ching Lin, Feng-Lin Yen, Horng-Huey Ko
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  ABSTRACT: Flavonoids, 10-oxoartogomezianone (1), 8-geranyl-3-(hydroxyprenyl)isoetin (2), hydroxyartoflavone A (3), isocycloartobiloxanthone (4), and furanocyclocommunin (5), together with 12 known compounds, were isolated from heartwood and cortex of Artocarpus altilis, and their structures were identified by comparing their spectra with those of similar compounds. To identify natural antioxidants and whitening agents, the ability of these prenylated flavonoids was assessed to scavenge the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+) radical cation, and the superoxide anion (O2-), and their abilities to inhibit tyrosinase and melanin production. It was found that compounds 3, 4, and artoflavone A (15) had moderate DPPH-scavenging activity, whereas compound 4 exhibited significant ABTS+-scavenging activity, and that norartocarpetin (7) and artogomezianone (8) exhibited moderate ABTS+-scavenging activity, with compounds 2, 7, and artocarpin (6) displaying good superoxide anion-scavenging activity. In addition, compounds 7, 8, cudraflavone A (14), and artonin M (17), inhibited melanin production by strongly suppressing tyrosinase activity. Compound 6 reduced the melanin content without inhibiting tyrosinase activity. These results suggest that flavonoids isolated from A. altilis may be candidate antioxidants and/or skin-whitening agents. However, further investigations are required to determine their mechanisms of action.
  Phytochemistry 02/2013; · 3.35 Impact Factor
• Article: Enhancement of dissolution and antioxidant activity of kaempferol using a nanoparticle engineering process.

  Cheng-Wei Tzeng, Feng-Lin Yen, Tzu-Hui Wu, Horng-Huey Ko, Chiang-Wen Lee, Wen-Sheng Tzeng, Chun-Ching Lin
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  ABSTRACT: Kaempferol (KAE) is a strong antioxidant flavonoid compound, but its clinical application is limited by quantity and poor dissolution property. However, the dissolution mechanism of a kaempferol nanoparticle formulation (KAEN) has not yet been elucidated. The aim of the present study was therefore to use a nanoparticle engineering process to resolve the dissolution problem. Our data indicated that KAEN effectively increased the dissolution percentage by particle size reduction, high encapsulation efficiency, amorphous transformation, and hydrogen-bond formation with excipients. In addition, we used several different antioxidant activity assays to evaluate KAE and KAEN. The data indicated that KAEN retained potent antioxidant activity after the nanoparticle engineering process and showed better antioxidant activity than KAE dissolved in water (P < 0.05). According to these findings, we concluded that KAEN could be a low-dose alternative to KAE in health food and future clinical research.
  Journal of Agricultural and Food Chemistry 03/2011; 59(9):5073-80. · 2.82 Impact Factor
• Article: Curcumin nanoparticles improve the physicochemical properties of curcumin and effectively enhance its antioxidant and antihepatoma activities.

  Feng-Lin Yen, Tzu-Hui Wu, Cheng-Wei Tzeng, Liang-Tzung Lin, Chun-Ching Lin
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  ABSTRACT: Curcumin (CUR), a natural polyphenol isolated from tumeric ( Curcuma longa ), has been documented to possess antioxidant and anticancer activities. Unfortunately, the compound has poor aqueous solubility, which results in poor bioavailability following high doses by oral administration. To improve the solubility of CUR, we developed a novel curcumin nanoparticle system (CURN) and investigated its physicochemical properties as well as its enhanced dissolution mechanism. Our results indicated that CURN improved the physicochemical properties of CUR, including a reduction in particle size and the formation of an amorphous state with hydrogen bonding, both of which increased the drug release of the compound. Moreover, in vitro studies indicated that CURN significantly enhanced the antioxidant and antihepatoma activities of CUR (P < 0.05). Consequently, we suggest that CURN can be used to reduce the dosage of CUR and improve its bioavailability and merits further investigation for therapeutic applications.
  Journal of Agricultural and Food Chemistry 06/2010; 58(12):7376-82. · 2.82 Impact Factor