Charles Newstead

Publications (2)9.88 Total impact

• Source

  Available from: Girish L Gupte

  Article: Management of post-transplant lymphoproliferative disorder in adult solid organ transplant recipients - BCSH and BTS Guidelines.

  Anne Parker, Kristin Bowles, J Andrew Bradley, Vincent Emery, Carrie Featherstone, Girish Gupte, Robert Marcus, Jayan Parameshwar, Alan Ramsay, Charles Newstead
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  ABSTRACT: A joint working group established by the Haemato-oncology subgroup of the British Committee for Standards in Haematology (BCSH) and the British Transplantation Society (BTS) has reviewed the available literature and made recommendations for the diagnosis and management of post-transplant lymphoproliferative disorder in adult recipients of solid organ transplants. This review details the therapeutic options recommended including reduction in immunosuppression (RIS), transplant organ resection, radiotherapy and chemotherapy. Effective therapy should be instituted before progressive disease results in declining performance status and multi-organ dysfunction. The goal of treatment should be a durable complete remission with retention of transplanted organ function with minimal toxicity.
  British Journal of Haematology 06/2010; 149(5):693-705. · 4.94 Impact Factor
• Source

  Available from: Girish L Gupte

  Article: Diagnosis of post‐transplant lymphoproliferative disorder in solid organ transplant recipients – BCSH and BTS Guidelines

  Anne Parker, Kristin Bowles, J. Andrew Bradley, Vincent Emery, Carrie Featherstone, Girish Gupte, Robert Marcus, Jayan Parameshwar, Alan Ramsay, Charles Newstead
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  ABSTRACT: SummaryA joint working group established by the Haemato-oncology subgroup of the British Committee for Standards in Haematology (BCSH) and the British Transplantation Society (BTS) has reviewed the available literature and made recommendations for the diagnosis and management of post-transplant lymphoproliferative disorder (PTLD) in adult recipients of solid organ transplants. This review details the risk factors predisposing to development, initial features and diagnosis. It is important that the risk of developing PTLD is considered when using post transplant immunosuppression and that the appropriate investigations are carried out when there are suspicions of the diagnosis. These must include tissue for histology and computed tomography scan to assess the extent of disease. These recommendations have been made primarily for adult patients, there have been some comments made with regard to paediatric practice.
  British Journal of Haematology 05/2010; 149(5):675 - 692. · 4.94 Impact Factor