Yang Li

Renmin University of China, Peping, Beijing, China

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Publications (148)504.48 Total impact

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    ABSTRACT: The increasing demand for energy has triggered tremendous research effort for the development of high-performance and durable energy-storage devices. Advanced graphene-based electrodes with high electrical conductivity and ion accessibility can exhibit superior electrochemical performance in energy-storage devices. Among them, binder-free configurations can enhance the electron conductivity of the electrode, which leads to a higher capacity by avoiding the addition of non-conductive and inactive binders. Graphene, a 2D material, can be fabricated into a porous and flexible structure with an interconnected conductive network. Such a conductive structure is favorable for both electron and ion transport to the entire electrode surface. In this review, the main processes used to prepare binder-free graphene-based hybrids with high porosity and well-designed electron conductive networks are summarized. Then, the applications of free-standing binder-free graphene-based electrodes in energy-storage devices are discussed. Future research aspects with regard to overcoming the technological bottlenecks are also proposed. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Advanced Materials 08/2015; DOI:10.1002/adma.201501115 · 17.49 Impact Factor
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    ABSTRACT: Graphene oxide supported l-proline (GO-Proline) bifunctional catalyst was prepared by covalent bonds via a succinate spacer. Fourier transform infrared spectrum (FTIR), Raman spectroscopy, scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), high-resolution transmission electron microscopy (HRTEM), and X-ray photoelectron spectroscopy (XPS) were employ to characterize the structure and morphology. The characterizations demonstrated l-proline molecules could be readily introduced to the graphene oxide sheets with homogeneous distributions. Systematic studies demonstrated it was an efficient, recoverable, and recyclable catalyst in the solvent free ketene forming reaction. Effect of different solvents on its catalytic properties was also investigated.
    Chemical Engineering Science 05/2015; DOI:10.1016/j.ces.2015.04.050 · 2.61 Impact Factor
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    ABSTRACT: Visible light photoredox catalysis has been demonstrated to be a promising and green strategy for organic synthesis. In this study, nanocomposite of PbBiO2Br nanoparticles and NbSe2 nanosheet was prepared as a high performance photocatalyst for the visible light-driven asymmetric alkylation of aldehyde. It was found that the introduction of a small amount of NbSe2 (0.5 wt%) to the PbBiO2Br semiconductor could result in ~50% increase in the yield of the final product. This study shows that NbSe2 nanosheets can be used as an efficient support to suppress the recombination of photo-induced electron-hole pairs and contribute to the enhanced photocatalytic performances of semiconductors in the visible light-driven catalysis.
    ACS Sustainable Chemistry & Engineering 04/2015; 3(5):150415073556006. DOI:10.1021/acssuschemeng.5b00182 · 4.64 Impact Factor
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    ABSTRACT: The Rh(I)-catalyzed direct re-organization of organic frameworks and group exchanges between carboxylic acids and aryl ketones was developed with the assistance of directing group. Biaryls, alkenylarenes, and alkylarenes were produced in high efficiency from aryl ketones and the corresponding carboxylic acids by releasing the other molecule of carboxylic acids and carbon monoxide. A wide range of functional groups were well compatible. The exchanges between two partners were proposed to take place on the Rh-(III) centre of key intermediates, supported by experimental mechanistic studies and computational calculations. The transformation unveiled the new catalytic pathway of the group transfer of two organic molecules.
    Journal of the American Chemical Society 04/2015; 137(15). DOI:10.1021/ja512003d · 11.44 Impact Factor
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    ABSTRACT: Whether paroxysmal nocturnal hemoglobinuria (PNH) clone in aplastic anemia (AA) is a prognostic factor to immunosuppressive therapy is a subject of debate. We evaluated hematological responses to immunosuppressive therapy (IST) in severe AA (SAA) patients with or without the presence of a PNH clone. In 97 SAA patients who received first-line IST between January and December 2011, 24 (24.7 %) had a PNH clone prior to treatment, with a median clone size of 7.82 % (range 1.19-45.46 %). The response rates to IST for patients with or without a PNH clone were 66.7 and 50.7 % (P < 0.172), 79.2 and 57.5 % (P < 0.057), and 79.2 and 67.1 % (P < 0.264) at 3, 6, and 12 months, respectively. Combined rate of complete and good partial responses differed between patients with or without a PNH clone: insignificantly at 3 months (41.7 vs. 21.9 %, P < 0.058), but significantly at 6 (66.7 vs. 31.5 %, P < 0.002) and 12 (75.0 vs. 46.6 %, P < 0.015) months. Multivariate analysis revealed that a pretreatment neutrophil count of >0.2 × 10(9)/L is indicative of a better response, while the presence of a PNH clone is predictive to a higher combined rate of complete and good partial responses. This study demonstrated that the presence of a PNH clone could predict a better hematological response instead of a higher response rate in patients with SAA.
    Annals of Hematology 03/2015; 94(7). DOI:10.1007/s00277-015-2348-5 · 2.40 Impact Factor
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    ABSTRACT: Trimetallic NiPdPt alloy nanoclusters with diameter of about 10 nm are successfully dispersed on the deoxyribonucleic acid-modified reduced graphene oxide (DNA-rGO) by using NaBH4 as reductant. The prepared NiPdPt nanoclusters grown on DNA-rGO (NiPdPt/DNA-rGO) composite are used as electrocatalysts for ethanol electrooxidation in alkaline solution. Cyclic voltammetry and chronoamperometry are used to investigate the electrochemical activities and stabilities of the catalysts. The Ni1Pd1Pt1/DNA-rGO (molar ratio of Ni, Pd, Pt is 1:1:1) has extraordinary electrocataltic activity, with their mass current density reaching 3.4 A mg−1metal and better stability. As compared with the bimetallic counterparts and NiPdPt grown on multi-wall carbon nanotubes, Ni1Pd1Pt1/DNA-rGO retains the highest mass current density after a 2000 s current-time test at 0 V.
    Journal of Power Sources 03/2015; 278. DOI:10.1016/j.jpowsour.2014.12.040 · 6.22 Impact Factor
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    ABSTRACT: A visible-light photoredox with homogeneous catalyst-like transition metal complexes and organic dyes shows promising applications in organic synthesis. However, the practical applications of these photocatalysts are hampered by the difficulty of separating and recycling them from the reaction mixtures. In this study, we report the covalent immobilization of Eosin Y on reduced graphene oxide and demonstrate the obtained hybrid can be used as a recyclable photocatalyst with excellent catalytic performances in the aerobic oxidation of α-aryl halogen derivatives.Keywords: Photocatalysis; graphene; Eosin Y; metal-free; covalent immobilization
    ACS Sustainable Chemistry & Engineering 03/2015; 3(3):468-474. DOI:10.1021/sc5006654 · 4.64 Impact Factor
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    ABSTRACT: To evaluate the impact of recombinant human thrombopoietin (rhTPO) on short-term response of immunosuppressive therapy (IST) in patients with newly diagnosed acquired severe aplastic anemia (SAA). The clinical data of forty adult acquired SAA patients, who treated with IST combined with rhTPO, were retrospective analyzed and the hematologic recovery were compared with patients by the IST alone during the same period. The factors affecting the short-term response were also analyzed. At 3 months after IST, both the total response rate and CR+GPR rate in rhTPO group were much higher than those in control group (75.0% vs 50.0%, P=0.022; and 17.5% vs 2.5%, P=0.025). At 6 months after IST, there was no difference of total hematologic response rate in rhTPO group and control group (77.5% vs 57.5%, P=0.058), while the CR+GPR rate was still higher in rhTPO group (45.0% vs 22.5%, P=0.033). The median time of platelet transfusion independence was much shorter in rhTPO group [33(0-90) vs 53(0-75) d, P=0.019]. Patients in rhTPO group needed less platelets transfusion support. The median platelet count in rhTPO group was 29(4-95)×10⁹/L at 3 months after IST, which was much higher than that in control group [29(4-95)×10⁹/L, P=0.006]. There was no significant difference regarding overall survival between the two groups (100.0% vs 91.0%, P=0.276). rhTPO is effective in promoting platelet recovery and improving the hematopoietic response for SAA patients with IST.
    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 03/2015; 36(3):181-5. DOI:10.3760/cma.j.issn.0253-2727.2015.03.002
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    ABSTRACT: Rabbit antithymocyte globulin Rabbit(rATG) was proven effective as salvage therapy for refractory aplastic anemia, or for relapse after initial therapy with horseATG(hATG). Several clinical trials were performed to assess the efficiency of rATG as first-line therapy for AA patients; however, their results were variable. The aim of the present study was to assess hematologic response and survival in SAA and VSAA patients treated with rATG and CsA in our centre. The factors involved in these outcomes were also explored. A total of 292 patients with newly diagnosed acquired severe aplastic anemia (SAA) or very severe aplastic anemia (VSAA) received a combination of rabbit antithymocyte globulin (rATG) and cyclosporin A (CsA) as first-line therapy, and the results were retrospectively assessed. Median age was 18 years (range: 2-73). The early death (ED) rate was 5.5%, and the total response rates were 49.0% (143 responders), 60.3% (176 responders), 65.8% (192 responders), and 68.5% (200 responders) at 3, 6, 9, and 12 months, respectively, after immunosuppressive therapy (IST). In multivariate analysis, initial response to granulocyte colony-stimulating factor (G-CSF) was the predictive factor for response to therapy at 12 months. Median follow-up of surviving patients was 34 months (range: 0-117). Five-year overall survival (OS) was 83.2%, and the 5-year event-free survival was 67.2%. Independent prognostic factors for overall survival (OS) were neutrophil count and achievement of any response following rATG therapy. Our results indicate that rATG/CsA is a safe and effective first-line treatment for SAA/VSAA. Copyright © 2015 ISEH - International Society for Experimental Hematology. Published by Elsevier Inc. All rights reserved.
    Experimental Hematology 01/2015; 43(4). DOI:10.1016/j.exphem.2014.12.002 · 2.81 Impact Factor
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    ABSTRACT: Background: NHL (non-Hodgkin lymphoma) consists of over 60 subtypes, ranging from slow-growing to very aggressive. The three largest subtypes are DLBCL (diffuse large B-cell lymphoma), FL (follicular lymphoma), and CLL/SLL (chronic lymphocytic leukemia/small lymphocytic lymphoma). For each subtype, different racial groups have different presentations, etiologies, and prognosis patterns. Methods: SEER (Surveillance, Epidemiology, and End Results) data on DLBCL, FL, and CLL/SLL patients diagnosed between 1992 and 2010 were analyzed. Racial groups studied included NHW (non-Hispanic whites), HW (Hispanic whites), blacks, and API (Asians and Pacific Islanders). Patient characteristics, age-adjusted incidence rate, and survival were compared across races. Stratification and multivariate analysis were conducted. Results: There are significant racial differences for patients' characteristics, including gender, age at diagnosis, stage, lymph site, and age, and the patterns vary across subtypes. NHWs have the highest incidence rates for all three subtypes, followed by HWs (DLBCL and FL) and blacks (CLL/SLL). The dependence of the incidence rate on age and gender varies across subtypes. For all three subtypes, NHWs have the highest five-year relative survival rates, followed by HWs. When stratified by stage, racial difference is significant in multiple multivariate Cox regression analyses. Conclusions: Racial differences exist among DLBCL, FL, and CLL/SLL patients in the U.S. in terms of characteristics, incidence, and survival. The patterns vary across subtypes. More data collection and analysis are needed to more comprehensively describe and interpret the across-race and subtype differences.
    Cancer Epidemiology 01/2015; 39(1). DOI:10.1016/j.canep.2014.12.001 · 2.56 Impact Factor
  • Statistics and its interface 01/2015; 8(3):355-365. DOI:10.4310/SII.2015.v8.n3.a9 · 0.46 Impact Factor
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    ABSTRACT: Graphene oxide (GO) has shown promising applications as supports for heterogeneous catalysts. This study reports the functionalization of GO by (3-mercaptopropyl) trimethoxysilane to immobilize lipase. The immobilization is carried out by the site-specific covalent binding between thiol groups of lipase and thiolsulfonate groups on modified GO. For the hydrolysis of p-nitrophenylpalmitate, the obtained GO–lipase shows catalytic performance (93.4%) comparable with that of the free lipase, and the reusability after 10 times is 69.9%. Compared with the free lipase, the GO–lipase exhibits good pH, thermal, and storage stability, which are important in practical applications.
    Industrial & Engineering Chemistry Research 12/2014; 53(51):19878-19883. DOI:10.1021/ie503596j · 2.59 Impact Factor
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    ABSTRACT: It is well known that statistical classifiers trained from imbalanced data lead to low true positive rates and select inconsistent significant variables. In this article, an improved method is proposed to enhance the classification accuracy for the minority class by differentiating misclassification cost for each group. The overall error rate is replaced by an alternative composite criterion. Furthermore, we propose an approach to estimate the tuning parameter, the composite criterion, and the cut-point simultaneously. Simulations show that the proposed method achieves a high true positive rate on prediction and a good performance on variable selection for both continuous and categorical predictors, even with highly imbalanced data. An illustrative example of the analysis of the suboptimal health state data in traditional Chinese medicine is discussed to show the reasonable application of the proposed method.
    Journal of Statistical Computation and Simulation 12/2014; 85(13):1-14. DOI:10.1080/00949655.2014.899362 · 0.71 Impact Factor
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    ABSTRACT: To evaluate the prognostic value of residual bone marrow hematopoiesis in severe aplastic anemia (SAA) patients with immunosuppressive therapy (IST). Clinical data and hematologic responses of 38 SAA patients treated with IST regimen (antithymocyte globulin combined with cyclosporine) in our hospital were retrospectively analyzed. Correlation of pre-IST baseline reticulocyte (Ret), absolute neutrophils count (ANC), soluble transferrin receptor (sTfR) concentration, corrected TPO value and hematologic response rate were statistically analyzed and receiver operating characteristic (ROC) curve was used to estimate the value of Ret, ANC, sTfR, and corrected TPO in predicting early IST response. Responders to IST had significantly higher pre-IST baseline Ret, ANC, sTfR concentration [19.9(2.7-84.4)×10⁹/L, 0.59(0.12-2.67)×10⁹/L, 0.82(0.22-1.58) mg/L] and lower corrected TPO value [142.9(31.8-1 035.0)] than non-responders [5.1(1.5-23.1)×10⁹/L, 0.20(0.04-1.33)×10⁹/L, 0.45(0.19-0.72)mg/L and 2 335.0(1 308.3-7 771.2)](P<0.05). Optimizing parameter cutoff levels obtained from ROC curve was Ret 6.75×109/L, ANC 0.30×109/L, sTfR 0.76 mg/L and corrected TPO 148.6, respectively. Combining the four parameters to predict 6 month hemotologic response showed that all the 7 patients with high Ret, ANC, sTfR and low corrected TPO, while only 1 among those 9 with low Ret, ANC, sTfR and high corrected TPO. Such parameters evaluating residual bone marrow hematopoiesis as Ret, ANC, sTfR, corrected TPO are practical in predicting early IST response in SAA.
  • Communication in Statistics- Simulation and Computation 12/2014; DOI:10.1080/03610918.2013.818691 · 0.29 Impact Factor
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    ABSTRACT: A novel method for the preparation of β-cyclodextrin grafted graphene oxide (GO-β-CD) has been developed. The GO-β-CD was characterized by Fourier transform infrared spectroscopy, 13C NMR spectroscopy, Raman spectroscopy and thermogravimetric analysis. The ability of GO-β-CD to remove fuchsin acid from solution was also studied. The GO-β-CD had an excellent adsorption capacity for fuchsin acid and could be recycled and reused. The adsorption capacities of GO-β-CD for other dye pollutants such as methyl orange and methylene blue were also investigated. The absorption capacities for the three dyes are in the order: fuchsin acid>methylene blue>methyl orange.
    Frontiers of Chemical Science and Engineering 12/2014; 9(1). DOI:10.1007/s11705-014-1450-x
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    ABSTRACT: In this study, we develop a facile strategy to combine an organic amine with a palladium complex on graphene oxide (GO) as a cooperative catalyst for Tsuji–Trost allylation. The tertiary amine and palladium-diamine complex are simultaneously immobilized on the GO support through silylation and further in situ coordination processes. PdCl2 is employed as the palladium precursor, with no necessary for extra coordination ligands. Various characterizations confirm the successful preparation of the cooperative supported catalyst (GO-NEt2-2N-Pd). Systematic investigation reveals the immobilized palladium-diamine complex (GO-2N-Pd) with very low Pd-loading is effective for Tsuji–Trost allylation, and incorporation of the tertiary amine shows significantly promoted effect towards the catalytic activity. GO-NEt2-2N-Pd can be readily recovered and recycled for several times without reduction of the efficiency. The excellent performance should be ascribed to cooperative dual effect, excellent support properties, and the robust immobilization interaction.
    12/2014; 3(6). DOI:10.1039/C4TA05205F
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    ABSTRACT: A microwave-assisted green and facile route has been developed to disperse sub-6-nm Au–Ag alloy bimetallic nanoparticles on the surface of partially reduced graphene oxide (PRGO). The properties of the resulting materials were characterized by high-resolution transmission electron microscopy, scanning electron microscopy, EDX line scanning, UV–vis spectroscopy, ICP spectrometry, and X-ray photoelectron spectroscopy. The reduction reaction of 4-nitrophenol (4-NP) was investigated to evaluate the catalytic performance of AuAg–graphene hybrids, and it was found that this unique catalytic system exhibits excellent activity for this reaction. It is hoped that this fast route can be extended to prepare other preferred bimetallic nanoparticle structures with PRGO supports.
    Industrial & Engineering Chemistry Research 11/2014; 53(46):17976-17980. DOI:10.1021/ie503251h · 2.59 Impact Factor
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    ABSTRACT: To testify whether absolute neutrophil count (ANC) response to preimmunosuppressive-therapy (pre-IST) granulocyte-stimulating factor (G-CSF) treatment could predict early response to IST in severe aplastic anemia (SAA). Clinical data and hematologic response of 125 SAA patients treated with antithymocyte globulin (r-ATG) combined with cyclosporine were retrospectively analyzed. Correlation of ANC response to pre-IST G-CSF treatment and early response to IST were statistically analyzed, and receiver operating characteristic (ROC) curve was used to estimate the value of increased ANC (∆ANC) in predicting early IST response. The hematologic response (HR) rate to IST in ANC reponded patients was significantly higher than non-responded group (3-month HR 49.0% vs 28.9%, P=0.023; 6-month HR 61.2% vs 40.8%, P=0.026). With ∆ANC≥0.5×10⁹/L as cutoff level, the best point to predict early IST response was 10 days after G-CSF (d 10). Response of ANC to pre-IST G-CSF treatment at d 10 was among the independent factors of predicting 3-month (P=0.004), but not for 6-month response to IST. The overall 5-year survival rate was 92.8% and 69.5% in ANC responded and non-responed groups, respectively (P=0.025). Responding to pre-IST G-CSF treatment reflected the residual bone marrow hematopoiesis, and could act as a convenient and practical predictor to early IST response as well as long-term survival in SAA.
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    ABSTRACT: In this article, we introduce the L1 regularized support vector machine (L1-SVM) as an effective feature selection technique into the modeling of financial early warning system (EWS), for the purpose of establishing compact financial EWSs for Chinese-listed companies. By introducing LASSO penalty into the SVM framework, the L1-SVM is a capable methodology to select causative features in classification problem. We evaluate the feature selection performance of L1-SVM under different circumstances through numerical simulations and find it suitable for selecting features for financial EWS. In the real study, we establish four financial EWSs with features selected by L1-SVM and compare them with those trained with full features. The empirical result illustrates that our EWSs, with only minority of features, outperform significantly than full ones in the respect of generalization performance, which indicates the feasibility of L1-SVM in real applications. Copyright © 2014 John Wiley & Sons, Ltd.
    Quality and Reliability Engineering 10/2014; 30(6). DOI:10.1002/qre.1684 · 0.99 Impact Factor

Publication Stats

2k Citations
504.48 Total Impact Points

Institutions

  • 2014–2015
    • Renmin University of China
      • School of Statistics
      Peping, Beijing, China
  • 2008–2015
    • Tianjin University
      • School of Chemical Engineering and Technology
      T’ien-ching-shih, Tianjin Shi, China
    • University of Utah
      • Department of Ophthalmology and Visual Sciences
      Salt Lake City, Utah, United States
    • Beijing Normal University
      Peping, Beijing, China
  • 2010–2014
    • Peking University
      • • Institute of Molecular Medicine
      • • Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education
      • • Beijing National Laboratory for Molecular Science
      Peping, Beijing, China
  • 2004–2014
    • Capital Medical University
      Peping, Beijing, China
  • 2012–2013
    • Yale University
      • Department of Public Health
      New Haven, Connecticut, United States
    • University of Science Malaysia
      • Department of Ophthalmology
      Penang, Penang, Malaysia
  • 2011
    • Soochow University (PRC)
      Wu-hsien, Jiangsu Sheng, China
  • 2007–2008
    • Beijing University of Aeronautics and Astronautics (Beihang University)
      • State Key Laboratory for Environmental Software Development
      Peping, Beijing, China
  • 2002–2007
    • Stevens Institute of Technology
      • Department of Electrical & Computer Engineering
      Hoboken, New Jersey, United States
    • Johns Hopkins University
      • Wilmer Eye Institute
      Baltimore, Maryland, United States
  • 2004–2006
    • Beijing Institute of Microbiology and Epidemiology
      Peping, Beijing, China
  • 2001–2004
    • Cleveland Clinic
      Cleveland, Ohio, United States