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ABSTRACT: To identify obstetric and maternal factors related to Group B Streptococcus (GBS) colonization in pregnant women in Korea.
The study was conducted between the years 2006-2008 in four hospitals, Cheil and Eulji hospital in Seoul, and Motae and Eulji hospital in Daejeon. We recruited 2,644 pregnant women between 35 to 37 weeks of gestation who had visited for antenatal care. Participants completed a questionnaire, and urine, vaginal and rectal specimens were obtained and cultured using selective broth media. After delivery, medical records were reviewed.
GBS colonization was significantly associated with hospital, age group, education, frequency of pregnancy, and premature rupture of membranes (PROM, more than 18 hours). After adjustment for other variables, Cheil hospital (odds ratio [OR], 2.05; 95% confidence interval [CI], 1.20-3.52), and the first pregnancy (OR, 2.32; 95% CI, 1.12-4.81) remained significant. History of vaginitis showed marginal significance (OR, 1.50; 95% CI, 0.98-2.29).
To prevent GBS infection of neonates, clinicians should be alert to the potentially higher risk of GBS colonization in pregnant women in their first pregnancy, and women with premature rupture of membranes (PROM) (18 hours+) or who have a history of vaginitis.
Epidemiology and health. 01/2011; 33:e2011010.
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Usha Srinivasan,
Brady Miller,
Joan Debusscher,
Carl F Marrs,
Lixin Zhang, Yong Soo Seo,
Kwan-Young Oh,
Moon Young Kim,
Hye-Ryung Yoon,
Moran Kl,
Betsy Foxman
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ABSTRACT: Our objective was to characterize 46 unique, erythromycin-sensitive, and clindamycin-resistant Streptococcus agalactiae strains from S. Korea that displayed a novel phenotype in double-disk diffusion assay. We used polymerase chain reaction to determine presence of erythromycin and clindamycin resistance genes, disc diffusion assays to determine resistance phenotype, and microbroth dilution to determine minimal inhibitory concentration. We detected a novel phenotype in the double-disk diffusion assay for inducible resistance among 46 S. agalactiae strains that were both erythromycin sensitive and clindamycin resistant. Thirty-two strains with the novel phenotype tested positive for erm(B) by DNA-DNA hybridization; sequencing of the erm(B) gene revealed mutations in the ribosomal binding site region in the erm(B) open reading frame, which is consistent with a lack of erythromycin resistance phenotype. Although identified from patients at multiple hospitals, genotyping suggested that the strains are closely related. The new phenotype shows increased sensitivity to clindamycin in the presence of erythromycin.
Microbial drug resistance (Larchmont, N.Y.) 12/2010; 17(1):121-4. · 1.99 Impact Factor
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Yong Soo Seo,
Usha Srinivasan,
Kwan-Young Oh,
Jung-Hwan Shin,
Jeong Don Chae,
Moon Young Kim,
Jae Hyug Yang,
Hye-Ryung Yoon,
Brady Miller,
Joan DeBusscher,
Betsy Foxman,
Moran Ki
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ABSTRACT: The prevalence of group B streptococcus (GBS) among pregnant women and disease burdens in neonates and adults are increasing in Korea. Colonizing isolates, collected by screening pregnant women (n=196), and clinical isolates collected from clinical patients throughout Korea (n=234), were serotyped and screened for antibiotic resistance. Serotype III (29.8%) and V (27.7%) predominated, followed by Ia (17.0%). Antibiotic resistance was higher among clinical than colonizing isolates for erythromycin (35.1% and 26.9%; P=0.10) and for clindamycin (49.4% and 42.1%; P=0.17). erm(B) occurred in 91.9% of erythromycin resistant isolates, and 84.0% of isolates resistant to clindamycin. Only five isolates (4.2%) resistant to erythromycin were susceptible to clindamycin; by contrast, and unique to Korea, 34% of isolates resistant to clindamycin were erythromycin susceptible. Among these 60 erythromycin-susceptible & clindamycin-resistant isolates, 88% was serotype III, and lnu(B) was found in 89% of strains. Four fifths of the serotype V isolates were resistant to both erythromycin and clindamycin. Further characterization of the genetic assembly of these resistance conferring genes, erm(B) and lnu(B), will be useful to establish the clonal lineages of multiple resistance genes carrying strains.
Journal of Korean medical science 06/2010; 25(6):817-23. · 0.84 Impact Factor
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ABSTRACT: We constructed nomograms of fetal renal length and parenchymal area derived from ultrasound images to develop a standard for normal fetal renal growth.
Longitudinal and transverse ultrasound renal images from 216 normal fetuses (16 to 41 weeks of gestation) were evaluated to construct growth charts. We measured the parenchymal area as well as the longitudinal and transverse lengths of each kidney using computer software for image analysis. Data were separately plotted as a mean +/- 2 SD determined by polynomial regression analysis.
Nomograms for a renal growth chart were constructed independently for the right and left fetal kidneys. No statistically significant difference was noted between the right and left renal measurements. The polynomial regression equations for the left renal longitudinal length and parenchymal area, respectively, were y = -0.0002x(3) + 0.0139x(2) - 0.2162 x 2.3929 (r(2) = 0.9842), and y = -0.0009x(3) + 0.0724x(2) - 1.5643 x 11.68 (r(2) = 0.9779). The longitudinal and transverse fetal renal growth curves displayed significant growth associated with gestational age (p <0.001). Our data on left longitudinal renal length exhibited an intermediate level compared to 2 published Western growth charts. However, statistical comparisons revealed the differences were partially, but not universally, significant.
We present our nomogram of fetal renal growth expressed in length and parenchymal area. To our knowledge this is the first report of a fetal renal growth chart in Asia that includes the parenchymal area. This nomogram may serve as a valuable tool for evaluation of fetal renal growth.
The Journal of Urology 11/2007; 178(5):2150-4. · 3.75 Impact Factor
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ABSTRACT: We present a case report of an ovarian pregnancy after ipsilateral partial salpingectomy. A 19-year-old woman was admitted with vaginal bleeding and right lower abdominal pain. She had a history of right partial salpingectomy caused by a tubal pregnancy. The pregnancy test result was positive, and a right adnexal mass was identified by ultrasonography. Laparoscopy revealed a right ovarian pregnancy. Thus the possibility of ipsilateral ectopic pregnancy should be considered even when the patient has a history of salpingectomy total or partial.
Journal of Minimally Invasive Gynecology 17(3):397-8. · 1.74 Impact Factor
